Mixing device for preparing norfloxacin

Abstract

The utility model discloses a mixing device for preparing norfloxacin, which comprises a mixing barrel, a fixing frame is arranged at the bottom of the mixing barrel, a first feeding pipe and a second feeding pipe are arranged on the mixing barrel, a plurality of feeding holes are formed in the circumferential direction of the second feeding pipe, a piston plate is arranged on the second feeding pipe in a sliding manner, and a piston rod is arranged on the piston plate. A supporting spring is arranged between the piston plate and the bottom of the second feeding pipe, an adsorption part is arranged at the bottom of the piston rod, a stirring rod is arranged on the mixing barrel, a spiral blade is arranged on the stirring rod, a supporting frame is arranged on the stirring rod, and a magnetic attraction part matched with the adsorption part is arranged on the supporting frame. A solute is added into the mixing barrel through the second feeding pipe, a stirring rod rotates to drive a supporting frame and a magnetic attraction part to rotate, the magnetic attraction part drives an adsorption part to move downwards, a piston rod and a piston plate are driven to move, a feeding hole is opened, intermittent feeding is achieved, and the solute dissolving efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of medicine production technology more specifically, it relates to a kind of for the mixing device for preparation of norfloxacin. BACKGROUND

[0002] Norfloxacin is a broad-spectrum quinolone antibiotic, it is mainly used to treat infection caused by sensitive bacteria, especially urinary system and intestinal infection, norfloxacin prevents the replication and repair of bacterial DNA by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby exerting its antibacterial effect, the production of norfloxacin needs dichlorobenzene or nitrochlorobenzene to be mixed with a variety of element materials and nitrification, reduction, reflux, heating, hydrolysis and a series of chemical processes made, and these chemical raw materials are often powdery or granular or liquid, in the preparation process of norfloxacin, a plurality of raw materials need to be uniformly mixed.

[0003] When mixing, adding a large amount of solute at one time can cause uneven distribution of solute in solvent, thereby forming a local high concentration area, such uneven distribution not only affects the dissolution rate of the drug, but also can cause part of the solute to be insufficiently dissolved, forming a precipitate or agglomerate, affecting the quality and stability of the final product, and the mixing efficiency of the mixing barrel is slow when mixing at room temperature. UTILITY MODEL CONTENT

[0004] (I) technical problem solved

[0005] In view of the problems existing in the prior art, the utility model provides a mixing device for preparing norfloxacin to solve the technical problem of inconvenient solute dissolution of one-time feeding mentioned in the background art.

[0006] (II) technical scheme

[0007] To achieve the above object, the utility model provides the following technical scheme: a kind of mixing device for preparing norfloxacin, including mixing barrel, the bottom of the mixing barrel is equipped with fixing frame, first feeding pipe and second feeding pipe are equipped on the mixing barrel, the second feeding pipe is equipped with a plurality of feeding holes in circumference, slidingly equipped with piston plate on the second feeding pipe, piston rod is equipped on the piston plate, support spring is equipped between the piston plate and the bottom of second feeding pipe, the bottom of piston rod is equipped with suction accessory, stirring rod is equipped on the mixing barrel, helical blade is equipped on the stirring rod, support frame is equipped on the stirring rod, magnetic attraction piece that cooperates with suction accessory is arranged on the support frame, the upper and lower ends of stirring rod are equipped with communication pipe, stirring rod and helical blade are hollowly communicated.

[0008] The utility model further provides for, be equipped with the drive motor on the mixing barrel, be equipped with first gear on the motor shaft of drive motor, be equipped with second gear on the stirring rod, cooperate through first gear and second gear, make drive motor drive stirring rod rotate.

[0009] The utility model further provides for, be equipped with sealing bearing between the top and bottom of stirring rod and mixing barrel, it is convenient for sealed rotation.

[0010] The utility model further provides for, be equipped with rotating ring on the top and bottom of stirring rod, rotating ring rotation is arranged in the communicating pipe, it is convenient for connecting rod and stirring rod are connected.

[0011] The utility model further provides for, be equipped with sliding block on rotating ring, be equipped with the sliding groove of cooperation with sliding block on communicating pipe, improved rotating ring rotation and the connection smoothness on communicating pipe.

[0012] The utility model further provides for, the fixed frame includes fixed plate, be equipped with installation groove on the fixed plate, be equipped with mounting bracket on the four around of mixing barrel, the cooperation of mounting bracket and fixed plate is installed through bolt and nut, the fixed plate and mounting bracket are connected through the cooperation of bolt and nut.

[0013] The utility model further provides for, the bottom of fixed plate is equipped with fixed rod, the bottom of fixed rod is equipped with fixed leg, the bottom of fixed leg is equipped with fixed seat, the fixed plate is supported through fixed rod, fixed leg and fixed seat.

[0014] The utility model further provides for, the bottom of fixed rod is equipped with fixed screw rod, the fixed leg is connected in screw thread between fixed screw rod, it is convenient for connecting fixed rod and fixed leg.

[0015] (Three) beneficial effects

[0016] Compared with the prior art, the utility model provides a kind of mixing device for norfloxacin preparation, with following beneficial effects:

[0017] 1, by first feed pipe to mixing barrel, by second feed pipe to mixing barrel, by stirring rod rotation drives support frame and magnetic attraction piece to rotate, by magnetic attraction piece drives suction accessory to move downward, drives piston rod and piston plate to move, opens feed hole, realizes intermittent feeding, improves solute dissolution efficiency.

[0018] 2, by communicating pipe to the hollow cavity of stirring rod and helical blade, heat is dissipated into mixing barrel by stirring rod and helical blade, in turn, improves norfloxacin drug mixing dissolution efficiency, promotes drug reaction.

[0019] 3, through the cooperation of bolt and nut by mounting frame and fixed plate, it is convenient to install on the fixed frame directly, through the fixed screw rod, it is convenient to connect the fixed rod and the fixed leg, through the cooperation of the fixed rod, the fixed leg and the fixed seat, it is convenient to stably support the mixing barrel. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is the whole structure schematic view of mixing barrel in the utility model;

[0021] Figure 2 It is the sectional structure schematic view of mixing barrel in the utility model;

[0022] Figure 3 It is Figure 2 It is the local structure enlarged schematic view of A in the utility model;

[0023] Figure 4 It is the sectional structure schematic view of second feed pipe in the utility model;

[0024] Figure 5 It is the explosion view of fixed frame in the utility model.

[0025] In the drawing: 1, mixing barrel; 2, fixed frame; 3, first feed pipe; 4, second feed pipe; 5, feed hole; 6, piston plate; 7, piston rod; 8, supporting spring; 9, suction accessory; 10, stirring rod; 11, helical blade; 12, support frame; 13, magnetic suction element; 14, communication pipe; 15, driving motor; 16, first gear; 17, second gear; 18, sealing bearing; 19, rotating ring; 20, sliding block; 21, sliding groove; 22, fixed plate; 23, mounting slot; 24, mounting frame; 25, fixed rod; 26, fixed leg; 27, fixed seat; 28, fixed screw rod. DETAILED DESCRIPTION

[0026] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The present application will be described in detail below with reference to the drawings and in combination with embodiments.

[0027] It should be noted that, unless otherwise specified, all technical and scientific terms used in the present application have the same meaning as generally understood by those skilled in the art to which the present application belongs.

[0028] In the present application, unless otherwise stated, the orientation such as "up, down" is generally with respect to the direction shown in the drawings, or with respect to the vertical, perpendicular or gravity direction; similarly, for the convenience of understanding and description, "left, right" is generally with respect to the left and right shown in the drawings; "inner, outer" refers to the inner and outer relative to the contour of each component itself, but the above orientation words are not used to limit the present application.

[0029] Please see Figures 1-5 A mixing device for the preparation of norfloxacin includes a mixing tank 1, a fixed frame 2 at the bottom of the mixing tank 1, a first feed pipe 3 and a second feed pipe 4 on the mixing tank 1, multiple feed holes 5 circumferentially arranged on the second feed pipe 4, a piston plate 6 slidably arranged on the second feed pipe 4, a piston rod 7 arranged on the piston plate 6, a support spring 8 between the piston plate 6 and the bottom of the second feed pipe 4, an adsorption element 9 at the bottom of the piston rod 7, a stirring rod 10 on the mixing tank 1, a spiral blade 11 on the stirring rod 10, a support frame 12 on the stirring rod 10, and a fitting for the adsorption element 9 on the support frame 12. The magnetic suction component 13 is combined with the stirring rod 10. The upper and lower ends of the stirring rod 10 are provided with connecting pipes 14. The stirring rod 10 and the spiral blade 11 are hollowly connected. The mixing tank 1 is provided with a drive motor 15. The motor shaft of the drive motor 15 is provided with a first gear 16. The stirring rod 10 is provided with a second gear 17. The top and bottom of the stirring rod 10 and the mixing tank 1 are provided with sealed bearings 18. The top and bottom of the stirring rod 10 are both fixedly provided with rotating rings 19. The rotating rings 19 are rotatably arranged in the connecting pipes 14. The rotating rings 19 are provided with sliding blocks 20. The connecting pipes 14 are provided with sliding grooves 21 that cooperate with the sliding blocks 20.

[0030] In this embodiment, during use, the norfloxacin solvent is quickly added to the mixing tank 1 through the first feed pipe 3, and the solute is added to the second feed pipe 4. The gravity of the solute slightly compresses the piston rod 7 and the support spring 8, activating the drive motor 15. The drive motor 15 drives the first gear 16 to rotate, which in turn drives the second gear 17 and the stirring rod 10 to rotate slowly. The stirring rod 10, through the sealed bearing 18, drives the spiral blade 11 to rotate and mix the materials in the mixing tank 1. Simultaneously, it drives the support frame 12 and the magnetic suction component 13 to rotate. When the magnetic suction component 13 moves below the adsorption component 9, it causes the adsorption component 9 to move downwards, simultaneously driving the piston rod 7 and the piston plate 6 to move downwards. The piston plate 6 moves downwards, exposing the feed hole. 5. To achieve solute feeding, when the magnetic suction element 13 and the adsorption element 9 are misaligned, the support spring 8 supports the piston rod 7 upward to reset, blocking the feed hole 5, thereby achieving intermittent feeding and improving the mixing effect. The magnetic suction element 13 is made of magnet, and the adsorption element 9 is made of magnetically adsorbable metal. High-temperature medium is added to the hollow cavity of the stirring rod 10 and the spiral blade 11 through the connecting pipe 14, and the heat is dissipated into the mixing tank 1 through the stirring rod 10 and the spiral blade 11, thereby improving the drug mixing and dissolution efficiency and promoting drug reaction. When the stirring rod 10 rotates, it rotates in the connecting pipe 14 through the rotating ring 19, and the sliding block 20 on the rotating ring 19 rotates in the sliding groove 21, which improves the smoothness of the connection between the stirring rod 10 and the connecting pipe 14.

[0031] Please see Figure 5As an embodiment of the fixed frame 2: the fixed frame 2 comprises a fixed plate 22, the fixed plate 22 is provided with a mounting groove 23, the mixing barrel 1 is provided with a mounting frame 24 around the upper portion, the mounting frame 24 and the fixed plate 22 are mounted through the cooperation of bolts and nuts, the bottom of the fixed plate 22 is provided with a fixed rod 25, the bottom of the fixed rod 25 is provided with a fixed leg 26, the bottom of the fixed leg 26 is provided with a fixed seat 27, the bottom of the fixed rod 25 is provided with a fixed screw 28, and the fixed leg 26 is threadedly connected with the fixed screw 28.

[0032] More specifically, when assembling the fixed frame 2, the fixed rod 25 and the fixed leg 26 are connected through the fixed screw 28 and supported through the fixed seat 27, the mounting frame 24 of the mixing barrel 1 is placed on the fixed plate 22, the position of the mounting frame 24 is adjusted through the mounting groove 23, and the mixing barrel 1 is mounted on the fixed plate 22 through the cooperation of bolts and nuts, thereby facilitating the support and fixation of the mixing barrel 1.

[0033] In summary, when the overall device is in use or operation: when in use, the drug solvent of norfloxacin is quickly added into the mixing barrel 1 through the first feeding pipe 3, the solute is added into the second feeding pipe 4, the gravity of the solute slightly compresses the piston rod 7 and the supporting spring 8 downward, the driving motor 15 is started, the driving motor 15 drives the first gear 16 to rotate, the first gear 16 drives the second gear 17 and the stirring rod 10 to rotate slowly, the stirring rod 10 drives the helical blade 11 to rotate the mixture in the mixing barrel 1 through the sealing bearing 18, and simultaneously drives the support frame 12 and the magnetic attraction piece 13 to rotate, when the magnetic attraction piece 13 moves below the suction accessory 9, the suction accessory 9 is driven to move downward, and simultaneously drives the piston rod 7 and the piston plate 6 to move downward, the piston plate 6 moves downward to leak out of the feeding hole 5, thereby realizing the feeding of the solute, when the magnetic attraction piece 13 is misaligned with the suction accessory 9, the supporting spring 8 supports the piston rod 7 upward to reset, thereby blocking the feeding hole 5, and further realizing intermittent feeding, improving the mixing effect, the magnetic attraction piece 13 is selected to be a magnet, the suction accessory 9 is selected to be a metal that can be magnetically attracted, high-temperature medium is added into the hollow cavity of the stirring rod 10 and the helical blade 11 through the communication pipe 14, heat is dissipated into the mixing barrel 1 through the stirring rod 10 and the helical blade 11, thereby improving the drug mixing and dissolving efficiency and promoting drug reaction, when the stirring rod 10 rotates, the communication pipe 14 rotates through the rotating ring 19, and the sliding block 20 on the rotating ring 19 rotates in the sliding groove 21, thereby improving the connection smoothness of the stirring rod 10 and the communication pipe 14.

[0034] When assembling the fixed frame 2, the fixed rod 25 and the fixed leg 26 are connected through the fixed screw 28 and supported through the fixed seat 27, the mounting frame 24 of the mixing barrel 1 is placed on the fixed plate 22, the position of the mounting frame 24 is adjusted through the mounting groove 23, and the mixing barrel 1 is mounted on the fixed plate 22 through the cooperation of bolts and nuts, thereby facilitating the support and fixation of the mixing barrel 1.

[0035] The other parts not described in the utility model are all prior art, so they are not described here.

[0036] In all the above-mentioned solutions, the connection between the two components can be selected according to the actual situation, such as welding, bolt and nut connection, bolt or screw connection or other known connection methods, which are not described one by one. In the above, whenever there is a fixed connection, welding is preferred, although the embodiments of the utility model have been shown and described, those skilled in the art can understand that various changes, modifications, replacements and modifications can be made to these embodiments without departing from the principles and spirits of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.

[0037] In all the above-mentioned solutions, if there is no explicit description, the electrical element is controlled by the controller. Since the controller is matched with the commonly used equipment, its control principle and circuit connection are all known and mature technologies, and their electrical connection relationship and specific circuit structure are not described here.

[0038] In all the above-mentioned solutions, if actual needs, the motor can be matched with the speed reducer, and the connection structure and working principle between the motor and the speed reducer are known technologies, which are not described in the utility model.

Claims

1. A mixing device for the preparation of norfloxacin comprising a mixing tank (1), characterized by: The bottom of the mixing barrel (1) is provided with a fixed frame (2), the mixing barrel (1) is provided with a first feeding pipe (3) and a second feeding pipe (4), the second feeding pipe (4) is provided with a plurality of feeding holes (5) in the circumference, the second feeding pipe (4) is provided with a piston plate (6) slidingly, the piston plate (6) is provided with a piston rod (7), the piston plate (6) and the bottom of the second feeding pipe (4) are provided with a supporting spring (8), the bottom of the piston rod (7) is provided with a suction accessory (9), the mixing barrel (1) is provided with a stirring rod (10), the stirring rod (10) is provided with a spiral blade (11), the stirring rod (10) is provided with a support frame (12), the support frame (12) is provided with a magnetic suction piece (13) matched with the suction accessory (9), the stirring rod (10) is provided with a communication pipe (14) at the upper and lower ends, and the stirring rod (10) and the spiral blade (11) are arranged in hollow communication.

2. A mixing device for preparing norfloxacin according to claim 1, characterized in that: The mixing barrel (1) is provided with a driving motor (15), the motor shaft of the driving motor (15) is provided with a first gear (16), and the stirring rod (10) is provided with a second gear (17).

3. A mixing device for preparing norfloxacin according to claim 1, characterized in that: The stirring rod (10) and the top and bottom of the mixing barrel (1) are provided with a sealing bearing (18).

4. A mixing device for preparing norfloxacin according to claim 1, characterized in that: The top and bottom of the stirring rod (10) are both fixedly provided with a rotating ring (19), and the rotating ring (19) is rotatably arranged in the communication pipe (14).

5. A mixing device for the preparation of norfloxacin according to claim 4, characterized in that: The rotating ring (19) is provided with a sliding block (20), and the communication pipe (14) is provided with a sliding groove (21) matched with the sliding block (20).

6. A mixing device for the preparation of norfloxacin according to claim 1, characterized in that: The fixed frame (2) comprises a fixed plate (22), the fixed plate (22) is provided with a mounting groove (23), the mixing barrel (1) is provided with a mounting frame (24) around, and the mounting frame (24) and the fixed plate (22) are mounted through the cooperation of bolts and nuts.

7. A mixing device for the preparation of norfloxacin according to claim 6, characterized in that: The bottom of the fixed plate (22) is provided with a fixed rod (25), the bottom of the fixed rod (25) is provided with a fixed leg (26), and the bottom of the fixed leg (26) is provided with a fixed seat (27).

8. A mixing device for the preparation of norfloxacin according to claim 7, characterized in that: The bottom of the fixed rod (25) is provided with a fixed screw rod (28), and the fixed leg (26) and the fixed screw rod (28) are threadedly connected.

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