Reaction device for epinephrine production
By generating negative pressure at the throat to draw in palladium-carbon catalyst and adrenaline hydrochloride premixing, and using nitrogen purging and stirring devices, the problem of poor mixing between palladium-carbon catalyst and materials was solved, thereby improving the reaction yield and efficiency of adrenaline production.
Patent Information
- Application Number
- CN202422855263.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-21
- Publication Date
- 2025-11-18
- Estimated Expiration
- 2034-11-21
AI Technical Summary
In current adrenaline production processes, the mixing effect between the palladium-on-carbon catalyst and the raw materials is poor, resulting in low reaction yields and long reaction cycles.
A reaction device was designed to draw in palladium-carbon catalyst and adrenaline hydrochloride by generating negative pressure at the throat, and to improve the mixing effect by using nitrogen purging and stirring devices, combined with a circulating pump to accelerate the mixing of materials.
It improves the conversion rate of the reaction, shortens the reaction cycle, avoids material blockage, and enhances production efficiency.
Smart Images
Figure CN223555991U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to adrenaline production technical field, concretely relates to a reaction device for adrenaline production. BACKGROUND
[0002] Adrenaline is white or white-like crystalline powder, no smell, bitter taste, easy to oxidize and deteriorate when contacting with air or being irradiated by sunlight. It is slightly soluble in water, insoluble in ethanol, chloroform, ether, fatty oil or volatile oil, and soluble in inorganic acid or sodium hydroxide solution, but insoluble in ammonia solution or sodium carbonate solution. It is commonly used in cardiovascular drugs to increase the contractility of heart.
[0003] In the production of adrenaline, catechol is usually used as the starting material, 3', 4'-dihydroxy-2-chloroacetophenone is generated by acylation of chloroacetic acid, then RS-(±)-1-(3', 4'-dihydroxyphenyl)-2-methylaminoethanol is generated by hydrogenation reaction of adrenaline ketone hydrochloride with hydrogen under the catalysis of palladium-carbon catalyst, and finally the target product R-(-)-adrenaline is obtained by chiral resolution with L-tartaric acid. In the hydrogenation reaction process, the palladium-carbon catalyst is usually added at one time, and the mixing effect of the palladium-carbon catalyst with adrenaline ketone hydrochloride is not good, which leads to low reaction yield and long reaction period. SUMMARY
[0004] The technical problem to be solved by the utility model is to provide a reaction device for adrenaline production, which has good mixing effect of palladium-carbon catalyst with material, high reaction yield and short period, in view of the deficiencies of the prior art.
[0005] To solve the above technical problems, the technical scheme of the utility model is as follows:
[0006] A reaction device for adrenaline production, comprising a reaction kettle, an inlet of the reaction kettle is communicated with a feeder through a pipeline, the feeder comprises a cylindrical inlet section, a tapered contraction section is arranged at the lower part of the inlet section, a straight pipe-shaped throat is arranged at the lower part of the contraction section, and a tapered diffusion section is arranged at the lower part of the throat.
[0007] The inlet section is communicated with an adrenaline ketone hydrochloride tank through a feeding pump, and the throat is communicated with a palladium-carbon catalyst tank through a feeding pipe.
[0008] As an improved technical scheme, the throat is communicated with a first nitrogen gas inlet pipeline, and the first nitrogen gas inlet pipeline is located above the feeding pipe.
[0009] As an improved technical scheme, a first automatic regulating valve and a first pressure sensor are arranged on the first nitrogen gas inlet pipeline, and the first automatic regulating valve and the first pressure sensor are interlocked to a control system.
[0010] As the improved technical scheme, the palladium-carbon catalyst tank is provided with a stirring shaft, a plurality of connecting rods are arranged along the circumference and the axis direction respectively, and the free ends of the connecting rods are provided with a N-shaped stirring head.
[0011] As the improved technical scheme, vertical rods are arranged between the upper and lower adjacent connecting rods, and the outer sides of the vertical rods are provided with auger blades along the axis direction.
[0012] As the improved technical scheme, the bottom of the stirring shaft is provided with a tapered spike part.
[0013] As the improved technical scheme, the outer side of the spike part is provided with a spiral groove.
[0014] As the improved technical scheme, the top of the palladium-carbon catalyst tank is communicated with a second nitrogen gas inlet pipeline.
[0015] As the preferred technical scheme, the second nitrogen gas inlet pipeline is provided with a second automatic regulating valve and a second pressure sensor, and the second automatic regulating valve and the second pressure sensor are interlocked to a control system.
[0016] As the preferred technical scheme, the bottom outlet of the reaction kettle is communicated to the inlet section through a circulating pump.
[0017] Due to the adoption of the above technical scheme, the beneficial effects of the present application are as follows:
[0018] The utility model discloses an adrenaline production reaction device, including the reaction kettle, the inlet of reaction kettle is communicated with feeder through the pipeline, and the feeder includes the inlet section of cylindrical, the lower part of inlet section is equipped with the tapering contraction section, the lower part of contraction section is equipped with the throat of straight pipe, and the lower part of throat is equipped with the tapering diffusion section, the inlet section is communicated with adrenaline ketone hydrochloride tank through the feed pump, and the throat is communicated with palladium-carbon catalyst tank through the feed pipe. Adrenaline ketone hydrochloride enters from the inlet section of feeder, generates negative pressure at the throat after contraction section, and the palladium-carbon catalyst is inhaled into the throat and mixes with adrenaline ketone hydrochloride, and the mixed material enters the reaction kettle from the diffusion section and occurs hydrogenation reaction with hydrogen. Adrenaline ketone hydrochloride and palladium-carbon catalyst are premixed before being added to the reaction kettle, which shortens the subsequent reaction time, improves the conversion rate of the reaction, and in addition, the palladium-carbon catalyst can enter the reaction kettle more smoothly under negative pressure, and is not easy to be blocked during feeding, which saves the trouble of maintenance.
[0019] The utility model discloses a first nitrogen gas inlet pipeline is communicated with the throat, and the first nitrogen gas inlet pipeline is located above the feed pipe.
[0020] A first automatic regulating valve and a first pressure sensor are arranged on the first nitrogen gas inlet pipeline, and the first automatic regulating valve and the first pressure sensor are interlocked to a control system.
[0021] The palladium carbon catalyst tank is provided with a stirring shaft, a plurality of connecting rods are arranged on the stirring shaft in the circumferential direction and the axial direction respectively, and the free ends of the connecting rods are provided with a U-shaped stirring head.
[0022] A vertical rod is arranged between the connecting rods adjacent to each other in the up-down direction, and auger blades are arranged on the outer side of the vertical rod in the axial direction.
[0023] A conical spike part is arranged at the bottom of the stirring shaft, the spike part extending into the outlet is used to break the palladium carbon catalyst at the bottom of the tank, so that the palladium carbon catalyst is prevented from being blocked at the outlet.
[0024] A spiral groove is arranged on the outer side of the spike part, so that the friction between the spike part and the palladium carbon catalyst is increased, and the breaking effect is better.
[0025] A second nitrogen gas inlet pipeline is communicated with the top of the palladium carbon catalyst tank, so that the activity of the palladium carbon catalyst is prevented from being affected under the nitrogen atmosphere.
[0026] A second automatic regulating valve and a second pressure sensor are arranged on the second nitrogen gas inlet pipeline, and the second automatic regulating valve and the second pressure sensor are interlocked to the control system.
[0027] The bottom outlet of the reaction kettle is communicated to the inlet section through a circulating pump, so that the material at the bottom of the reaction kettle can be conveyed to the feeder through the circulating pump, mixed in the feeder, and then re-entered into the reaction kettle, so that the mixing of the material is accelerated, the reaction period is shortened, and the conversion rate is improved. BRIEF DESCRIPTION OF DRAWINGS
[0028] The utility model will be further described in combination with the drawings and examples.
[0029] Figure 1 It is a structure schematic view of the embodiment of the utility model;
[0030] Figure 2 It is a sectional view of the embodiment of the utility model;
[0031] Figure 3 It is Figure 2 The enlarged view of A in Fig. 1;
[0032] Figure 4 It is Figure 2 The enlarged view of B in Fig. 1;
[0033] Wherein: 1, reaction kettle;2, feeder;3, inlet section;4, contraction section;5, throat;6, diffusion section;7, feed pump;8, adrenalone hydrochloride tank;9, feed pipe;10, palladium carbon catalyst tank;11, first nitrogen inlet pipeline;12, first automatic regulating valve;13, first pressure sensor;14, stirring shaft;15, connecting rod;16, stirring head;17, vertical rod;18, auger blade;19, thorn part;20, groove;21, second nitrogen inlet pipeline;22, second automatic regulating valve;23, second pressure sensor;24, circulating pump. DETAILED DESCRIPTION
[0034] The utility model is further described below in combination with the drawings and examples.
[0035] As Figures 1-4 Shown, an adrenaline production reaction device, including reaction kettle 1, the inlet of reaction kettle 1 is connected with feeder 2 through pipeline, feeder 2 includes cylindrical inlet section 3, the lower part of inlet section 3 is equipped with tapered contraction section 4, the lower part of contraction section 4 is equipped with straight pipe shaped throat 5, the lower part of throat 5 is equipped with tapered diffusion section 6;Inlet section 3 is connected with adrenalone hydrochloride tank 8 through feed pump 7, and throat 5 is connected with palladium carbon catalyst tank 10 through feed pipe 9.Adrenalone hydrochloride enters from the inlet section 3 of feeder 2, generates negative pressure at throat 5 after contraction section 4, and the palladium carbon catalyst is sucked into throat 5 and mixed with adrenalone hydrochloride, and the mixed material enters reaction kettle 1 from diffusion section 6 and reacts with hydrogen gas.Adrenalone hydrochloride and palladium carbon catalyst are premixed before being added to reaction kettle 1, which shortens the subsequent reaction time, improves the conversion rate of the reaction, and in addition, the palladium carbon catalyst can enter reaction kettle 1 more smoothly under negative pressure, and is not easy to be blocked during feeding, which saves the trouble of maintenance.
[0036] The throat 5 is connected with a first nitrogen inlet pipeline 11, which is located above the feed pipe 9. During the feeding of the palladium-carbon catalyst, the first nitrogen inlet pipeline 11 located above can apply a downward sweeping force to the mixture of adrenalone hydrochloride and palladium-carbon catalyst, greatly avoiding the blockage of the material in the throat 5 with a small diameter.
[0037] The first nitrogen inlet pipeline 11 is provided with a first automatic regulating valve 12 and a first pressure sensor 13, which are interlocked to the control system. During feeding, the opening of the first automatic regulating valve 12 can be adjusted to provide a larger sweeping force by the control system; and during the reaction, the opening of the first automatic regulating valve 12 is adjusted to provide a nitrogen atmosphere.
[0038] The palladium-carbon catalyst tank 10 is provided with a stirring shaft 14, which is provided with a plurality of connecting rods 15 in the circumferential and axial directions, respectively, and the free ends of the plurality of connecting rods 15 are provided with a U-shaped stirring head 16. By continuously stirring the palladium-carbon catalyst by the stirring shaft 14 and the stirring head 16, the material is less likely to accumulate in the tank, and the feeding is more smooth.
[0039] Vertical rods 17 are arranged between the connecting rods 15 adjacent to each other in the upper and lower directions, and the outer sides of the vertical rods 17 are provided with auger blades 18 in the axial direction. The vertical rods 17 and the auger blades 18 increase the contact area with the palladium-carbon catalyst, and the stirring and turning effect is better.
[0040] The bottom of the stirring shaft 14 is provided with a conical spike part 19, which pierces the palladium-carbon catalyst at the bottom of the tank to avoid blockage at the outlet.
[0041] The outer side of the spike part 19 is provided with a spiral groove 20, which increases the friction between the spike part 19 and the palladium-carbon catalyst, and the piercing effect is better.
[0042] The top of the palladium-carbon catalyst tank 10 is connected with a second nitrogen inlet pipeline 21, which can prevent the activity of the palladium-carbon catalyst from being affected under a nitrogen atmosphere.
[0043] The second nitrogen inlet pipeline 21 is provided with a second automatic regulating valve 22 and a second pressure sensor 23, which are interlocked to the control system. The opening of the second automatic regulating valve 22 is adjusted by the control system to switch the pressure between the pressure maintaining and the sweeping, which is more convenient to use.
[0044] The bottom outlet of the reactor 1 is communicated to the inlet section 3 through a circulating pump 24, and the material at the bottom of the reactor 1 can be transported to the feeder 2 through the circulating pump 24, and then enters the reactor 1 again after mixing in the feeder 2, so that the mixing of the material is accelerated, the reaction period is shortened, and the conversion rate is improved.
[0045] It should be understood that the embodiments are only used for illustrating the present application and not for limiting the scope of the present application. Furthermore, it should be understood that after reading the content taught by the present application, those skilled in the art can make various modifications or changes to the present application, and these equivalent forms also fall within the scope defined by the appended claims of the present application.
Claims
1. An apparatus for producing adrenaline comprising a reaction vessel, characterized by: The inlet of the reactor is communicated with a feeder through a pipeline, the feeder comprises a cylindrical inlet section, a tapered contraction section is arranged at the lower part of the inlet section, a straight pipe-shaped throat is arranged at the lower part of the contraction section, and a tapered diffusion section is arranged at the lower part of the throat. The inlet section is communicated with an adrenalone hydrochloride tank through a feed pump, and the throat is communicated with a palladium-carbon catalyst tank through a feed pipe.
2. The reaction apparatus for adrenaline production according to claim 1, characterized by: The throat is communicated with a first nitrogen inlet pipeline which is located above the feed pipe.
3. The reaction apparatus for adrenaline production according to claim 2, wherein: A first automatic regulating valve and a first pressure sensor are arranged on the first nitrogen inlet pipeline, and the first automatic regulating valve and the first pressure sensor are interlocked to a control system.
4. The reaction apparatus for adrenaline production according to claim 1, wherein: The palladium-carbon catalyst tank is provided with a stirring shaft, a plurality of connecting rods are arranged on the stirring shaft in the circumferential direction and the axial direction respectively, and a U-shaped stirring head is arranged at the free end of the connecting rods.
5. The reaction apparatus for adrenaline production according to claim 4, wherein: Vertical rods are arranged between the adjacent connecting rods in the up-down direction, and auger blades are arranged on the outer side of the vertical rods in the axial direction.
6. The reaction apparatus for adrenaline production according to claim 4, wherein: A tapered spike part is arranged at the bottom of the stirring shaft.
7. The reaction apparatus for adrenaline production according to claim 6, wherein: A spiral groove is arranged on the outer side of the spike part.
8. The reaction apparatus for adrenaline production according to claim 1, wherein: A second nitrogen inlet pipeline is communicated with the top of the palladium-carbon catalyst tank.
9. The reaction apparatus for adrenaline production according to claim 8, wherein: A second automatic regulating valve and a second pressure sensor are arranged on the second nitrogen inlet pipeline, and the second automatic regulating valve and the second pressure sensor are interlocked to the control system.
10. The reaction apparatus for adrenaline production according to claim 1, wherein: The bottom outlet of the reactor is communicated to the inlet section through a circulating pump.