Uniform filling device for stem cell preparation

Abstract

The utility model provides a uniform filling device for stem cell preparations, which relates to the field of stem cell preparation filling, and comprises an appliance body, a sterile bottle, a quick connection mechanism, a peristaltic pump, a filling needle, a penicillin bottle and a liquid storage bag body, and the liquid storage bag body comprises a disposable liquid storage bag; according to the liquid storage bag, the liquid storage bag body is assembled in the B + A level environment, the whole liquid storage bag is subjected to irradiation sterilization, the risk of visible foreign matter is reduced, the contamination risk is reduced to the minimum, the whole liquid storage bag is a closed pipeline, the contamination risk caused by manual operation is avoided, and the service life of the liquid storage bag is prolonged. In the filling process, the defects that each bottle of preparation finished product filled by a liquid storage bottle and a bottle shaking device is unstable in volume and large in error are overcome, after filling is finished, almost no stem cell preparation is left in the liquid storage bag, the loss of the stem cell preparation is reduced, and the filling efficiency is improved by filling through a filling machine. And the loading stability and the cell concentration uniformity of each bottle of stem cell preparation finished product are superior to those of manual loading.

Description

TECHNICAL FIELD

[0001] The utility model belongs to stem cell preparation field, concretely is a stem cell preparation even filling device. BACKGROUND

[0002] Stem cell preparation refers to the treatment product that has certain curative effect biologically prepared through stem cell technology, and the core is stem cell itself or its derived cells, factors and other biological active substances, which are mainly used for repairing, replacing or regenerating damaged tissues and organs.

[0003] The existing automatic filling process technology is to assemble silica gel hose, pump pipe, Y-shaped joint, filling needle and liquid storage bottle into a loop and connect with the filling machine to fill the stem cell preparation into a Westlin bottle, but the silica gel pipe and hose need to be cut by oneself, various consumables need to be assembled into a loop, wet heat sterilization, the operation is complicated, the pipeline size error is large, the risk of bacterial contamination is high, and during filling, the liquid storage bottle containing stem cell preparation is installed in a square rocking bottle appliance, the rocking bottle appliance swings forward and backward during the filling process, bubbles are generated into the pipeline, thereby causing unstable filling volume of each stem cell preparation product, large error and affecting product quality.

[0004] Therefore, the utility model provides a stem cell preparation even filling device to solve the above problems. UTILITY MODEL CONTENTS

[0005] In order to solve the above technical problems, the utility model provides the following technical scheme:

[0006] A stem cell preparation even filling device, comprising an appliance body, a sterile bottle, a quick connection mechanism, a peristaltic pump, a filling needle, a Westlin bottle and a liquid storage bag body, the liquid storage bag body comprises a disposable liquid storage bag, both sides of the bottom of the disposable liquid storage bag are communicated with a first platinum sulfurized silica gel tube, a second platinum sulfurized silica gel tube is arranged on the left side of the first platinum sulfurized silica gel tube on the left side, a third platinum sulfurized silica gel tube is arranged on the right side of the first platinum sulfurized silica gel tube on the right side, and a fourth platinum sulfurized silica gel tube is arranged on the right side of the third platinum sulfurized silica gel tube.

[0007] Further, in the utility model, the appliance body comprises a bag rocking appliance, and the front and back surfaces of the bag rocking appliance are both provided with positioning grooves, and the number of the positioning grooves is eight.

[0008] Further, in the utility model, the both sides of the top of the bag shaking device are provided with limiting supports, the limiting supports are detachably connected with the inner cavities of the positioning grooves, the front end and the rear end of the bottom of the limiting support are fixedly connected with press clamps.

[0009] Further, in the utility model, the sterile bottle and the second platinum vulcanized silica gel pipe are connected through a quick connection mechanism, the quick connection mechanism comprises a quick mounting adapter, a quick mounting gasket, a quick mounting cover and a quick mounting clamp.

[0010] Further, in the utility model, a is arranged between the first platinum vulcanized silica gel pipe and the second platinum vulcanized silica gel pipe on the left side, the a comprises a male luer adapter and a female luer adapter.

[0011] Further, in the utility model, both sides of the third platinum vulcanized silica gel pipe are provided with b, the peristaltic pump is connected between the first platinum vulcanized silica gel pipe, the third platinum vulcanized silica gel pipe and the fourth platinum vulcanized silica gel pipe on the right side through b, and the surface of the first platinum vulcanized silica gel pipe is provided with c.

[0012] Beneficial effects, the utility model has following beneficial effects:

[0013] The liquid storage bag body is assembled in the "B+A" level environment, and the whole is subjected to irradiation sterilization, so that the risk of visible foreign matter is reduced, the risk of bacterial contamination is minimized, the whole is a closed pipeline, the risk of bacterial contamination caused by manual operation is avoided, the defects of unstable volume and large error of each bottle of preparation product in the filling process of the "liquid storage bottle + bottle shaking device" are compensated, there is almost no residual stem cell preparation in the liquid storage bag after filling, the loss amount of stem cell preparation is reduced, the filling is carried out through the filling machine, and the stability of the filling amount of each bottle of stem cell preparation product and the uniformity of the cell concentration are better than those of manual filling. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 It is the front view structural schematic diagram of the utility model device body;

[0015] Figure 2 It is the separation state structural schematic diagram of the utility model bag shaking device and limiting support;

[0016] Figure 3 It is the separation state structural schematic diagram of the utility model liquid storage bag body;

[0017] Figure 4 It is the process flow diagram of the utility model.

[0018] In the drawing:

[0019] 1. Instrument body; 101. Shaking bag device; 102. Positioning groove; 103. Limiting frame; 104. Clip; 2. Sterile bottle; 3. Quick-connect mechanism; 4. Peristaltic pump; 5. Filling needle; 6. Vial; 7. Liquid storage bag body; 701. Disposable liquid storage bag; 702. First platinum-cured silicone tubing; 703. Second platinum-cured silicone tubing; 704. Third platinum-cured silicone tubing; 705. Fourth platinum-cured silicone tubing. Detailed Implementation

[0020] To better understand the technical content of this utility model, specific embodiments are described below in conjunction with the accompanying drawings. Various aspects of this utility model are described in this disclosure with reference to the accompanying drawings, which illustrate numerous illustrative embodiments. The embodiments of this disclosure are not necessarily defined to include all aspects of this utility model. It should be understood that the various concepts and embodiments described above, as well as those described in more detail below, can be implemented in any of many ways, because the concepts and embodiments disclosed in this utility model are not limited to any particular implementation. Furthermore, some aspects of this utility model can be used alone or in any suitable combination with other aspects disclosed in this utility model.

[0021] Example 1

[0022] like Figures 1-4 As shown, this is the first embodiment of the present invention. This embodiment provides a uniform filling device for stem cell preparations, including an instrument body 1, a sterile bottle 2, a quick-connect mechanism 3, a peristaltic pump 4, a filling needle 5, a vial 6, and a liquid storage bag body 7. The liquid storage bag body 7 includes a disposable liquid storage bag 701. Both sides of the bottom of the disposable liquid storage bag 701 are connected to a first platinum-cured silicone tube 702. A second platinum-cured silicone tube 703 is arranged to the left of the first platinum-cured silicone tube 702 on the left side, a third platinum-cured silicone tube 704 is arranged to the right of the first platinum-cured silicone tube 702 on the right side, and a fourth platinum-cured silicone tube 705 is arranged to the right of the third platinum-cured silicone tube 704.

[0023] like Figures 1-4 As shown, the reservoir bag body 7 is placed inside the device body 1 for use. Both the sterile bottle 2 and the disposable reservoir bag 701 are used to store stem cell preparations. The sterile bottle 2 is used to provide stem cell preparations to the disposable reservoir bag 701. When the peristaltic pump 4 is running, it can extract and transport the stem cell preparations inside the disposable reservoir bag 701, and finally deliver them to the inside of the vial 6 by the filling needle 5 for filling.

[0024] Example 2

[0025] Reference Figure 2 and 3For the second embodiment of the utility model, the embodiment is based on the previous embodiment.

[0026] In the embodiment, the appliance body 1 comprises a bag-shaking appliance 101, and the front and back surfaces of the bag-shaking appliance 101 are both provided with positioning grooves 102, and the number of the positioning grooves 102 is eight.

[0027] The two sides of the top of the bag-shaking appliance 101 are both provided with limiting frames 103, the limiting frames 103 are detachably connected with the inner cavities of the positioning grooves 102, and the front end and the rear end of the bottom of the limiting frame 103 are both fixedly connected with pressing clamps 104.

[0028] As shown in Figure 2 and 3 , the right side first platinum sulfuration silica gel pipe 702 of the liquid storage bag body 7 is connected and fixed with the pump head of the peristaltic pump 4, the filling needle 5 is fixed on the needle rack of the filling machine, finally, the disposable liquid storage bag 701 is placed in the bag-shaking appliance 101 and fixed by using the pressing clamp 104, the peristaltic pump 4 is started, and when the peristaltic pump 4 is running, the stem cell preparation can be filled from the disposable liquid storage bag 701 into the westlin bottle 6 through the right side first platinum sulfuration silica gel pipe 702, the third platinum sulfuration silica gel pipe 704, the fourth platinum sulfuration silica gel pipe 705 and the filling needle 5.

[0029] Embodiment 3

[0030] Referring to Figure 3 , the third embodiment of the utility model is based on the previous two embodiments.

[0031] In the embodiment, the sterile bottle 2 is connected with the second platinum sulfuration silica gel pipe 703 through the quick connection mechanism 3, and the quick connection mechanism 3 comprises a quick mounting adapter, a quick mounting gasket, a quick mounting cover and a quick mounting clamp.

[0032] The left side first platinum sulfuration silica gel pipe 702 and the second platinum sulfuration silica gel pipe 703 are provided with a, and a comprises a male luer adapter and a female luer adapter.

[0033] The two sides of the third platinum sulfuration silica gel pipe 704 are both provided with b, the peristaltic pump 4 is connected with the right side first platinum sulfuration silica gel pipe 702, the third platinum sulfuration silica gel pipe 704 and the fourth platinum sulfuration silica gel pipe 705 through b, and the surface of the first platinum sulfuration silica gel pipe 702 is provided with c.

[0034] As shown in Figure 3As shown, the model of the quick-mount adapter, the quick-mount gasket, the quick-mount cover and the quick-mount clamp are TC50-1 / 4"HB, 1-1 / 2"(TC50), TC50 respectively, the model of the male luer adapter and the female luer adapter are 1 / 4"HB, 1 / 8"HB respectively, the model of b is 3 / 32"HB-3 / 32"HB-3 / 32"HB respectively, and the model of c is OD3 / 16"-OD5 / 16" respectively.

[0035] In use, the disposable storage bag 701 is placed inside the shaking bag device 101 for use, and is clamped and fixed by the clamp 104, the sterile bottle 2 and the disposable storage bag 701 are both used for storing stem cell preparations, the sterile bottle 2 is used for providing stem cell preparations for the disposable storage bag 701, and the peristaltic pump 4 can draw out and deliver the stem cell preparations in the disposable storage bag 701 when running, and finally deliver the stem cell preparations to the inside of the vial 6 through the filling needle 5, so as to perform filling work, and the weight error of the stem cell preparation product filled in each vial 6 is ≤±0.1g.

[0036] The standard parts used in the present application can be purchased from the market, and can be ordered according to the description and the drawings, and the specific connection mode of each part adopts the conventional means such as bolts, rivets and welding in the prior art, the mechanical parts and equipment adopt conventional types in the prior art, the control mode is automatically controlled through a controller, the control circuit of the controller can be realized by simple programming of a person skilled in the art, and the control mode and the circuit connection are common knowledge in the art, and the present application is mainly used for protecting mechanical devices, so the control mode and the circuit connection will not be explained in detail.

[0037] Although the present application has been disclosed with the preferred embodiments, it is not intended to limit the present application. Those skilled in the art can make various modifications and decorations without departing from the spirit and scope of the present application. Therefore, the protection scope of the present application is defined by the claims.

Claims

1. A uniform filling device for stem cell preparations, comprising an instrument body (1), a sterile vial (2), a quick-connect mechanism (3), a peristaltic pump (4), a filling needle (5), a vial (6), and a reservoir bag body (7), characterized in that: The liquid storage bag body (7) includes a disposable liquid storage bag (701). Both sides of the bottom of the disposable liquid storage bag (701) are connected to a first platinum vulcanized silicone tube (702). A second platinum vulcanized silicone tube (703) is provided on the left side of the first platinum vulcanized silicone tube (702), a third platinum vulcanized silicone tube (704) is provided on the right side of the first platinum vulcanized silicone tube (702), and a fourth platinum vulcanized silicone tube (705) is provided on the right side of the third platinum vulcanized silicone tube (704).

2. The uniform filling device for stem cell preparations as described in claim 1, characterized in that: The device body (1) includes a bag-shaking device (101), and the front and back of the bag-shaking device (101) are provided with positioning grooves (102), and the number of positioning grooves (102) is eight.

3. The uniform filling device for stem cell preparations as described in claim 2, characterized in that: The top of the bag-shaking device (101) is provided with a limit frame (103) on both sides. The limit frame (103) is detachably connected to the inner cavity of the positioning groove (102). The front end and rear end of the bottom of the limit frame (103) are fixedly connected with a clip (104).

4. The uniform filling device for stem cell preparations as described in claim 1, characterized in that: The sterile bottle (2) is connected to the second platinum vulcanized silicone tube (703) via a quick-connect mechanism (3), which includes a quick-connect adapter, a quick-connect gasket, a quick-connect cap, and a quick-connect clamp.

5. The uniform filling device for stem cell preparations as described in claim 1, characterized in that: An a is provided between the first platinum vulcanized silicone tube (702) and the second platinum vulcanized silicone tube (703) on the left side, wherein the a includes a male Luer adapter and a female Luer adapter.

6. The uniform filling device for stem cell preparations as described in claim 1, characterized in that: Both sides of the third platinum-cured silicone tube (704) are provided with b. The peristaltic pump (4) is connected to the first platinum-cured silicone tube (702) on the right side, the third platinum-cured silicone tube (704) and the fourth platinum-cured silicone tube (705) through b. The surface of the first platinum-cured silicone tube (702) is provided with c.

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