Drug dissolution rate instrument

Abstract

The utility model belongs to the technical field of medical instruments, and particularly relates to a medicine dissolution rate instrument which comprises a water bath constant-temperature heating box body, a driving assembly is connected to the side portion of the constant-temperature heating box body, a stirring detection assembly is connected to the lower end of the driving assembly, and a containing frame is connected to the middle of the water bath constant-temperature heating box body. A dissolution cup is placed on the placement frame, and the stirring detection assembly is matched with the dissolution cup to complete drug dissolution rate detection. Firstly, the constant-temperature heating box body is started, liquid water is heated to the temperature of DEG C, then a simulated slow-release reagent is placed in the dissolution cup, after a certain period of time and the temperature of the simulated slow-release reagent is also increased to the temperature of DEG C, a medicine to be subjected to dissolution rate detection is added into the slow-release reagent, then the stirring detection assembly pair is started, and the dissolution rate of the medicine is detected. The slow-release reagent and the medicine are stirred, the dissolution rate of the medicine is detected, and the detection precision is high.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to a medicine dissolution instrument. BACKGROUND

[0002] The absorption speed of medicine in the body is often determined by the speed of dissolution, and the medicine in solid preparation must go through the process of disintegration and dissolution and then be converted into solution before being absorbed. In order to determine the rate and degree of dissolution of medicine components from tablets, capsules or granules and other preparations under specified conditions, an instrument for simulating the disintegration and dissolution of orally taken solid preparations in the gastrointestinal tract is needed. Patent No. CN213148894U discloses a new medicine dissolution instrument. The technology discloses a water bath box, a driving device arranged above the water bath box, a plurality of support columns connecting the water bath box and the driving device, a plurality of dissolution cups arranged in the water bath box, two liquid supplementing cups arranged in the water bath box, a dissolution cup cover arranged on the top of the dissolution cup, a stirring paddle arranged in the dissolution cup, a paddle blade arranged on the stirring paddle, and a top end of the stirring paddle penetrating through the dissolution cup cover and connected with the driving device. The above-mentioned prior art can reduce the temperature difference in the water bath box, but the dissolution instrument stirs the mixed liquid in the dissolution cup through the stirring paddle, the stirring effect is poor, and the device cannot prevent the evaporation of the solvent in the dissolution cup when the medicine is dissolved, thereby affecting the test results. SUMMARY

[0003] The utility model aims at providing a medicine dissolution instrument, which can realize up-down reciprocating and left-right reciprocating stirring while maintaining good sealing, thereby improving detection accuracy.

[0004] The technical scheme adopted by the utility model is as follows:

[0005] A medicine dissolution instrument comprises a water bath constant-temperature heating box body, a driving assembly is connected to the side of the constant-temperature heating box body, a stirring and detection assembly is connected to the lower end of the driving assembly, a placing rack is connected to the middle of the water bath constant-temperature heating box body, a dissolution cup is placed on the placing rack, the stirring and detection assembly and the dissolution cup are mutually adapted, and medicine dissolution detection is completed.

[0006] The driving assembly comprises a connecting rack arranged outside the constant-temperature heating box body, an electric telescopic rod is arranged at the end of the connecting rack, and a horizontal rod is connected to the output end below the electric telescopic rod.

[0007] The stirring detection assembly comprises a mounting block arranged on the cross rod, a stirring rod connected to the mounting block through a bearing, an installation groove arranged on the mounting block, a conductive slip ring arranged on the stirring rod, the conductive slip ring being arranged in the installation groove, and a detection sensor arranged on the stirring rod.

[0008] The stirring rod and the mounting block are provided with a skeleton oil seal, the stirring rod is arranged in the dissolution cup, the lower end surface of the air bag ring of the mounting block is tightly attached to the upper end surface of the dissolution cup when the mounting block moves up and down within a certain height range.

[0009] The upper portion of the mounting block is provided with a servo motor, the output end of the servo motor is connected to the upper end portion of the stirring rod, the constant-temperature heating box body is externally provided with a controller, and the controller is electrically connected with the servo motor and the electric telescopic rod.

[0010] The constant-temperature heating box body is provided with a water circulation assembly, the water circulation assembly comprises a first pipe arranged at the lower end of one side of the constant-temperature heating box body, a micro water pump and a first valve are arranged on the first pipe, the first pipe is through-connected with a second pipe at the end portion, the second pipe is connected with a second valve at one end portion, the other end of the second pipe is through-connected with the other side of the constant-temperature heating box body at the upper end, and the end portion of the first pipe is provided with a third valve.

[0011] The technical effects achieved by the utility model are as follows:

[0012] In the utility model, firstly, the constant-temperature heating box body is started, liquid water is heated to ℃, then the simulated sustained-release reagent is placed in the dissolution cup, after a certain time, the simulated sustained-release reagent is also heated to ℃, then the medicine to be detected for the dissolution degree is added into the sustained-release reagent, then the stirring detection assembly is started to stir the sustained-release reagent and the medicine, and the dissolution degree of the medicine is detected, so that the detection result is more accurate.

[0013] In the utility model, the conductive slip ring is arranged, so that the detection sensor can be arranged on the stirring rod, the detection sensor can slide up and down or rotate left and right along with the stirring rod during the up-and-down sliding and left-and-right rotating of the stirring rod, the detection sensor does not continuously detect the dissolution degree of the medicine at a fixed point, the detection sensor can detect the dissolution degree of the medicine in any area of the solution, and the final detection result is more accurate.

[0014] The utility model discloses a kind of medical dissolution apparatus, including constant temperature heating box, driving assembly, stirring detection assembly, placing rack, dissolution cup, controller, water circulation assembly, connecting frame, electric telescopic rod, crossbar, installation block, stirring rod, conductive slip ring, detection sensor, skeleton oil seal, air bag ring and servo motor, wherein, constant temperature heating box is connected with driving assembly, stirring detection assembly is connected with constant temperature heating box, placing rack is connected with constant temperature heating box, dissolution cup is connected with placing rack, controller is connected with constant temperature heating box, water circulation assembly is connected with constant temperature heating box, connecting frame is connected with constant temperature heating box, electric telescopic rod is connected with connecting frame, crossbar is connected with electric telescopic rod, installation block is connected with crossbar, stirring rod is connected with installation block, conductive slip ring is connected with stirring rod, detection sensor is connected with stirring rod, skeleton oil seal is connected with installation block, air bag ring is connected with installation block, and servo motor is connected with installation block. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 It is a kind of medical dissolution apparatus whole structure schematic diagram of the utility model;

[0016] Figure 2 It is a kind of medical dissolution apparatus isometric structure schematic diagram of the utility model;

[0017] Figure 3 It is a kind of medical dissolution apparatus overhead structure schematic diagram of the utility model;

[0018] Figure 4 It is a kind of medical dissolution apparatus Figure 3 A-A section view of the utility model in;

[0019] Figure 5 It is the utility model Figure 4 B enlarged view in.

[0020] In the drawings, the component list represented by each sign is as follows:

[0021] 1, constant temperature heating box;2, driving assembly;3, stirring detection assembly;4, placing rack;5, dissolution cup;6, controller;7, water circulation assembly;201, connecting frame;202, electric telescopic rod;203, crossbar;301, installation block;302, stirring rod;303, conductive slip ring;304, detection sensor;305, skeleton oil seal;306, air bag ring;307, servo motor;701, first pipe;702, micro water pump;703, first valve;704, second pipe;705, second valve;706, third valve. DETAILED DESCRIPTION

[0022] In order to make the purpose and the advantage of the utility model more clearly, the utility model is specifically explained below with examples. It should be understood that the following text is only used to describe one or several specific embodiments of the utility model, and does not strictly limit the protection scope of the utility model specifically requested.

[0023] For example, Figures 1-5As shown, a drug dissolution tester, including water bath constant temperature heating box 1, constant temperature heating box 1 side is connected with drive assembly 2, drive assembly 2 lower end is connected with stirring detection assembly 3, water bath constant temperature heating box 1 middle part is connected with placing rack 4, placing rack 4 is placed with dissolution cup 5, stirring detection assembly 3 and dissolution cup 5 are mutually adapted, complete drug dissolution detection.

[0024] In the utility model, first start constant temperature heating box 1, heat liquid water to 37 DEG C, then place simulated sustained-release reagent in dissolution cup 5 inside, after a certain time, simulated sustained-release reagent also warms to 37 DEG C, then add the drug to be carried out dissolution detection to sustained-release reagent inside, then start stirring detection assembly 3, and the sustained-release reagent and drug are stirred, and the dissolution of the detected drug is completed.

[0025] Drive assembly 2 includes the connecting frame 201 being arranged outside constant temperature heating box 1, the electric telescopic rod 202 being equipped with in the end of connecting frame 201, the horizontal rod 203 being connected to the output end below electric telescopic rod 202.

[0026] In the utility model, the temperature of water bath heating in constant temperature heating box 1 can be adjusted, and constant temperature heating box 1 is prior art, which will not be described here, and the electric telescopic rod 202 drives stirring detection assembly 3 to slide up and down through the horizontal rod 203, so that stirring detection assembly 3 can slide into dissolution cup 5 or slide out of dissolution cup 5.

[0027] Stirring detection assembly 3 includes the mounting block 301 being arranged on the horizontal rod 203, the stirring rod 302 being connected to the mounting block 301 through a bearing, the mounting groove being formed in the mounting block 301, the conductive slip ring 303 being installed on the stirring rod 302, the conductive slip ring 303 being located in the mounting groove, and the detection sensor 304 being installed on the stirring rod 302.

[0028] The utility model needs to explain that the detection sensor 304 adopts the solubility sensor, is used for real-time detection drug dissolution, and the specific structure and principle of the detection sensor 304 are the public knowledge of the people in the art, which will not be described here, the conductive slip ring 303 is arranged, so that the detection sensor 304 can be installed on the stirring rod 302, so that the detection sensor 304 can slide up and down or rotate left and right with the stirring rod 302 in the process of sliding up and down and rotating left and right, so that the detection sensor 304 does not continuously detect the drug dissolution of the fixed point, the detection sensor 304 can detect the drug dissolution of any area in the solution, so that the final detection result is more accurate, and the data line of the specific detection sensor 304 is connected with the inner ring wiring port of the conductive slip ring 303 from the inside of the stirring rod 302, the outer ring of the conductive slip ring 303 is fixedly connected with the mounting block 301, and the outer ring lead wire of the conductive slip ring 303 is directly connected with the controller 6, so as to realize data transmission.

[0029] It should be noted that the specific results and working principle of the controller 6 are well known to those skilled in the art, and will not be described here.

[0030] The stirring rod 302 is provided with a skeleton oil seal 305 between the mounting block 301, the stirring rod 302 is located in the dissolution cup 5, and the mounting block 301 is provided with an air bag ring 306 on the lower end face. When the mounting block 301 moves up and down within a certain height range, the lower end face of the air bag ring 306 is tightly attached to the upper end face of the dissolution cup 5.

[0031] In the utility model, the skeleton oil seal 305 is set, the skeleton oil seal 305 adopts the skeleton oil seal 305 that meets the medical health level, the sealing between the stirring rod 302 and the mounting block 301 is better through the setting of the skeleton oil seal 305, the air bag ring 306 is set, the air bag ring 306 has certain toughness, when the mounting block 301 moves up and down within a certain height range, the lower end face of the air bag ring 306 is tightly attached to the upper end face of the dissolution cup 5, and the dissolution cup 5 can keep good sealing when the stirring rod 302 stirs up and down and left and right.

[0032] The mounting block 301 is provided with a servo motor 307 on the upper portion, the output end of the servo motor 307 is connected with the upper end portion of the stirring rod 302, the constant-temperature heating box body 1 is provided with a controller 6 outside, and the controller 6 is electrically connected with the servo motor 307 and the electric telescopic rod 202.

[0033] In actual use, the servo motor 307 is controlled under the controller 6, realizes driving the stirring rod 302 to reciprocate left and right, realizes reciprocating stirring simulation of slow-release reagent, and the electric telescopic rod 202 drives the whole stirring detection assembly 3 to slide up and down, so that the stirring rod 302 reciprocates up and down and left and right, more accurately simulates the drug dissolution in the real environment, and the measured drug dissolution is more accurate.

[0034] The constant-temperature heating box body 1 is provided with a water circulation assembly 7, the water circulation assembly 7 includes a first pipe 701 arranged at the lower end of one side of the constant-temperature heating box body 1, the first pipe 701 is provided with a micro water pump 702 and a first valve 703, the first pipe 701 is connected with a second pipe 704 penetratingly, one end of the second pipe 704 is connected with a second valve 705, the other end of the second pipe 704 is connected with the other side of the constant-temperature heating box body 1 penetratingly, and the first pipe 701 is provided with a third valve 706.

[0035] In practical use, during the dissolution measurement process, the first valve 703 is opened, the second valve 705 and the third valve 706 are closed, and the micro water pump 702 is started simultaneously. Liquid water flows out from the first pipe 701, then flows back to the constant temperature heating chamber 1 through the second pipe 704. Under the action of water circulation, the liquid water flows, keeping all the water at a constant temperature, resulting in better temperature control. After the dissolution test is completed, the dissolution cup 5 is removed, and the electric telescopic rod 202 continues to drive the stirring and detection component 3 vertically downward. At this time, the stirring and detection component 3 is located in liquid water, and the flowing water can clean the stirring and detection component 3 from all directions. After cleaning, the second valve 705 is closed, the third valve 706 is opened, and the liquid water is discharged from the first pipe 701. New liquid water is then added back to the constant temperature heating chamber 1. By setting up the water circulation component 7, better temperature control can be ensured during water bath heating, and it is also more convenient to clean the stirring and detection component 3 from all directions.

[0036] like Figures 1-5 As shown, the working principle of this utility model is as follows: First, the constant temperature heating chamber 1 is started to heat the liquid water to 37°C. Then, the simulated sustained-release reagent is placed inside the dissolution cup 5. After a certain period of time, the simulated sustained-release reagent also heats up to 37°C. Then, the drug to be tested for dissolution is added to the sustained-release reagent. Then, the stirring and detection component 3 is started to stir the sustained-release reagent and the drug, and the drug dissolution is tested. Specifically, while keeping the lower end face of the airbag ring 306 in close contact with the upper end face of the dissolution cup 5, the electric telescopic rod 202 drives the stirring and detection component 3 to slide up and down. At the same time, the servo motor 307 drives the stirring rod 302 to rotate back and forth left and right, so that the stirring rod 302 moves back and forth up and down and back and forth left and right, more accurately simulating the drug dissolution under real conditions, making the measured drug dissolution more accurate. During the dissolution measurement process, the first... Valve 703 is closed, the second valve 705 and the third valve 706 are closed, and the micro water pump 702 is started. Liquid water flows out from the first pipe 701, then flows back to the constant temperature heating chamber 1 through the second pipe 704. Under the action of water circulation, the liquid water flows, so that all the water maintains a constant temperature, making the temperature control effect better. After the dissolution test is completed, the dissolution cup 5 is taken out, and the electric telescopic rod 202 continues to drive the stirring and detection component 3 vertically downward. At this time, the stirring and detection component 3 is located in the liquid water. The flowing water can clean the stirring and detection component 3 from all directions. After cleaning, the second valve 705 is closed, the third valve 706 is opened, the liquid water is discharged from the first pipe 701, and new liquid water is added back to the constant temperature heating chamber 1. By setting the water circulation component 7, the temperature control effect during water bath heating can be better, and it is also more convenient to clean the stirring and detection component 3 from all directions.

[0037] The above merely describes preferred embodiments of the present application, and it should be noted that, for those skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, and these improvements and refinements should also be considered as the protection scope of the present application. Structures, devices and operation methods not specifically described and explained in the present application are implemented according to conventional means in the art, unless otherwise specified and limited.

Claims

1. A drug dissolution apparatus characterized in that: Including water bath constant temperature heating box (1), the constant temperature heating box (1) side is connected with drive assembly (2), the drive assembly (2) lower end is connected with stirring detection assembly (3), the water bath constant temperature heating box (1) middle part is connected with placing rack (4), the placing rack (4) is placed with dissolution cup (5), the stirring detection assembly (3) and the dissolution cup (5) are mutually adapted, complete medicine dissolution degree detection.

2. The drug dissolution apparatus of claim 1, wherein: The drive assembly (2) includes a connecting frame (201) disposed outside the constant temperature heating box (1), the connecting frame (201) is provided with an electric telescopic rod (202) at one end, and the electric telescopic rod (202) is connected with a horizontal rod (203) at the lower output end.

3. The drug dissolution apparatus of claim 2, wherein: The stirring detection assembly (3) includes an installation block (301) disposed on the horizontal rod (203), the installation block (301) is connected with a stirring rod (302) through a bearing, the installation block (301) is provided with an installation groove, the stirring rod (302) is provided with a conductive slip ring (303), the conductive slip ring (303) is located in the installation groove, and the stirring rod (302) is provided with a detection sensor (304).

4. The drug dissolution apparatus of claim 3, wherein: The stirring rod (302) and the installation block (301) are provided with a skeleton oil seal (305), the stirring rod (302) is located in the dissolution cup (5), the lower end surface of the installation block (301) is provided with an air bag ring (306), and when the installation block (301) moves up and down within a certain height range, the lower end surface of the air bag ring (306) is tightly attached to the upper end surface of the dissolution cup (5).

5. The drug dissolution apparatus of claim 4, wherein: The upper part of the installation block (301) is provided with a servo motor (307), the output end of the servo motor (307) is connected with the upper end of the stirring rod (302), the outside of the constant temperature heating box (1) is provided with a controller (6), and the controller (6) is electrically connected with the servo motor (307) and the electric telescopic rod (202).

6. The drug dissolution apparatus of claim 5, wherein: The constant temperature heating box (1) is provided with a water circulation assembly (7), the water circulation assembly (7) includes a first pipe (701) disposed at the lower end of one side of the constant temperature heating box (1), the first pipe (701) is provided with a micro water pump (702) and a first valve (703), the first pipe (701) is connected with a second pipe (704) at one end, the second pipe (704) is connected with a second valve (705) at one end, the second pipe (704) is connected with the other side of the constant temperature heating box (1) at the other end, and the first pipe (701) is provided with a third valve (706).

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