Reaction kettle for synthesizing 5-fluoro-3-Boc aminopiperidine

Abstract

The utility model discloses a synthetic reaction kettle for 5-fluoro-3-Boc aminopiperidine, which relates to the technical field of reaction kettles and comprises a mounting bottom frame, a plurality of groups of rare gas storage tanks are arranged in an inner cavity of the mounting bottom frame, a propelling component is mounted on one side of the top wall of the mounting bottom frame, a reaction kettle outer shell is mounted at the end of the propelling component, and a reaction kettle is mounted in the reaction kettle outer shell. A plurality of groups of cushion blocks are uniformly mounted on the bottom wall of the inner cavity of the reaction kettle outer shell, and a reaction kettle inner shell is mounted on the top walls of the plurality of groups of cushion blocks. Synthetic raw materials are poured into the inner cavity of the inner shell of the reaction kettle, the control valve on the rare gas storage tank is opened, so that rare gas in the inner cavity of the rare gas storage tank is sprayed out through the ventilation assembly, and the sprayed airflow enables the synthetic raw materials in the inner cavity of the inner shell of the reaction kettle to continuously roll and stir; the propelling assembly is started to drive the synthetic raw materials in the reaction kettle outer shell, the reaction kettle inner shell and the inner cavity of the reaction kettle outer shell to move synchronously, so that the synthetic raw materials can be fully stirred, and the air tightness can be ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of reaction kettle, especially to a kind of for 5-fluoro-3-Boc amido piperidine synthetic reaction kettle. BACKGROUND

[0002] 5-fluoro-3-Boc amido piperidine is an organic compound, wherein Boc represents tert-butoxy carbonyl, it is a commonly used amino protecting group. A fluorine atom is introduced on the 5th position of piperidine ring, the physical and chemical properties of the compound are changed, tert-butoxy carbonyl is the protecting group of amino group, can react with amino group under alkaline condition, generate stable amide compound, so as to protect amino group from being affected by other reaction conditions, while piperidine ring is a six-membered ring, contains a nitrogen atom, has wide application in medicinal chemistry and organic synthesis, 5-fluoro-3-Boc amido piperidine needs certain gas pressure protection environment when synthesizing.

[0003] The utility model discloses a synthetic reaction kettle, including kettle body, the kettle body is formed by inner layer kettle wall and outer layer kettle wall, and the inner layer kettle wall and the outer layer kettle wall form the jacket layer between, the kettle body upper portion is provided with feed pipe, exhaust pipe, and the kettle body bottom is provided with discharge pipe, and the kettle body top is provided with speed reducer, and the speed reducer top is provided with motor, and the motor output shaft is connected with the speed reducer input shaft, and the speed reducer output shaft is connected with the rotating shaft, and at least one group of stirring blades is arranged on the rotating shaft.

[0004] The above-mentioned synthetic reaction kettle is extended to the inside of reaction kettle body due to the arrangement of speed reducer, motor and rotating shaft and other components, which is easy to cause insufficient airtightness to lead to the synthesis failure of 5-fluoro-3-Boc amido piperidine, therefore, the utility model provides a synthetic reaction kettle for 5-fluoro-3-Boc amido piperidine to solve the above-mentioned technical problem. UTILITY MODEL CONTENTS

[0005] In order to improve the above-mentioned problem that insufficient airtightness is easy to lead to the synthesis failure of 5-fluoro-3-Boc amido piperidine, the utility model provides a synthetic reaction kettle for 5-fluoro-3-Boc amido piperidine.

[0006] The utility model provides a synthetic reaction kettle for 5-fluoro-3-Boc amido piperidine, adopts the following technical scheme:

[0007] The utility model provides a kind of reaction kettle for 5-fluoro-3-Boc aminopiperidine synthesis, including installation bottom frame, the inner cavity of installation bottom frame is provided with multiple groups of noble gas storage tank, the one side of the top wall of installation bottom frame is equipped with propelling assembly, the end of propelling assembly is equipped with reaction kettle outer shell, the inner cavity bottom wall position of reaction kettle outer shell is uniformly equipped with multiple groups of cushion block, the top wall of multiple groups of cushion block is equipped with reaction kettle inner shell, the top wall of reaction kettle outer shell is embedded with ventilation assembly extending into the inner cavity of reaction kettle inner shell, the top end of ventilation assembly is equipped with collapsible hose, another end of collapsible hose is interconnected with noble gas storage tank.

[0008] By using the above technical scheme, the synthesis raw materials are poured into the inner cavity of the reaction kettle inner shell, the control valve on the noble gas storage tank is opened to make the noble gas in the inner cavity of the noble gas storage tank spray out through the ventilation assembly, the sprayed gas flow makes the synthesis raw materials in the inner cavity of the reaction kettle inner shell constantly roll and stir, the propelling assembly is started to drive the reaction kettle outer shell, the reaction kettle inner shell and the synthesis raw materials in the inner cavity thereof to move synchronously, so that the synthesis raw materials can be fully stirred, and the air tightness can be guaranteed.

[0009] Optionally, the propelling assembly includes a mounting vertical plate fixed to the top wall of the installation bottom frame, and a plurality of air cylinders are mounted on the outer wall of the mounting vertical plate at the top and bottom ends thereof, and the end of the horizontal output shaft of each air cylinder is fixed to the outer wall of the reaction kettle outer shell.

[0010] Optionally, the ventilation assembly includes a vertical ventilation pipe connected to the end of the collapsible hose, the vertical ventilation pipe penetrates through the top wall of the reaction kettle outer shell and the reaction kettle inner shell and extends to the lower end of the inner cavity of the reaction kettle inner shell, a plurality of horizontal ventilation pipes are connected to the outer wall of the vertical ventilation pipe, and a plurality of ventilation holes are uniformly formed in the outer wall of each horizontal ventilation pipe.

[0011] By using the above technical scheme, the control valve on the noble gas storage tank is opened to make the noble gas in the inner cavity of the noble gas storage tank spray into the vertical ventilation pipe and the horizontal ventilation pipe through the collapsible hose and spray out through the plurality of ventilation holes, the sprayed gas flow makes the synthesis raw materials in the inner cavity of the reaction kettle inner shell constantly roll and stir, and the plurality of air cylinders are synchronously started to drive the reaction kettle outer shell to move synchronously on the top wall of the installation bottom frame through the plurality of moving wheels, and the reaction kettle inner shell and the synthesis raw materials in the inner cavity thereof can be driven to move synchronously under the action of the reaction kettle outer shell.

[0012] Optionally, a liquid injection pipe penetrating through the top wall of the reaction kettle outer shell is mounted on the top wall of the reaction kettle inner shell, and a liquid discharge pipe penetrating through the outer wall of the reaction kettle outer shell is mounted on the bottom end of the outer wall of the reaction kettle inner shell.

[0013] By adopting the technical scheme, the control valve on the water injection pipe is opened to add the synthetic raw material, and the control valve on the water discharge pipe is opened to discharge the synthetic product.

[0014] Optionally, a water injection pipe is installed at one end of the top wall of the reaction kettle outer shell, a water discharge pipe is installed at one end of the bottom wall of the reaction kettle outer shell, and an electric heating pipe is installed at the bottom end of the side outer wall of the reaction kettle outer shell.

[0015] Optionally, a waterproof temperature sensor extending to the bottom of the inner cavity of the reaction kettle inner shell is installed at the lower end of the side outer wall of the reaction kettle outer shell, an open hole is formed at the lower end of the outer wall of the installation vertical plate, a PLC controller is installed at the upper end of the outer wall of the installation vertical plate, and the PLC controller is electrically connected with the air cylinder, the waterproof temperature sensor and the electric heating pipe.

[0016] By adopting the technical scheme, the control valve on the water injection pipe is opened to add the synthetic raw material, and the control valve on the water discharge pipe is opened to discharge the synthetic product.

[0017] Optionally, a gas pressure gauge extending to the upper end of the inner cavity of the reaction kettle inner shell is installed at one end of the top wall of the reaction kettle outer shell.

[0018] By adopting the technical scheme, the gas pressure value of the inner cavity of the reaction kettle inner shell can be conveniently checked by the staff in real time under the action of the gas pressure gauge.

[0019] Optionally, a plurality of sets of moving wheels in contact with the top wall position of the installation bottom frame are installed on the bottom wall of the reaction kettle outer shell.

[0020] By adopting the technical scheme, the stability of the reaction kettle outer shell and the reaction kettle inner shell can be improved and the frictional resistance of movement can be reduced under the auxiliary support action of the plurality of sets of moving wheels.

[0021] Optionally, a plurality of sets of the noble gas storage tanks are provided with a stop block fixed with the bottom wall position of the installation bottom frame.

[0022] By adopting the technical scheme, the position of the noble gas storage tank can be limited under the action of the plurality of sets of stop blocks, so that the noble gas storage tank is not easy to shake and move left and right.

[0023] In summary, the utility model has at least one of the following beneficial effects:

[0024] The control valve on the rare gas storage tank is opened, so that the rare gas in the inner cavity of the rare gas storage tank is sprayed out through the foldable hose, the vertical vent pipe, the horizontal vent pipe and the vent hole, the gas flow sprayed out continuously stirs the synthetic raw materials in the inner cavity of the reaction kettle shell, a plurality of groups of air cylinders are started synchronously, so that the reaction kettle shell, the reaction kettle inner shell and the synthetic raw materials in the inner cavity of the reaction kettle inner shell can be synchronously moved, so that the synthetic raw materials can be fully stirred, and the air tightness of the device can be guaranteed. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 It is a front view of the sectional structure of the utility model;

[0026] Figure 2 It is a front view of the structure of the utility model;

[0027] Figure 3 It is a front view of the sectional structure of the installation bottom frame of the utility model.

[0028] In the drawing: 1, PLC controller; 2, open hole; 3, waterproof temperature sensor; 4, rare gas storage tank; 5, installation bottom frame; 6, moving wheel; 7, cushion block; 8, electric heating pipe; 9, stop block; 10, drain pipe; 11, liquid discharge pipe; 12, horizontal vent pipe; 13, vent hole; 14, air pressure gauge; 15, reaction kettle shell; 16, reaction kettle inner shell; 17, vertical vent pipe; 18, foldable hose; 19, liquid injection pipe; 20, water injection pipe; 21, installation vertical plate; 22, air cylinder. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings Figures 1-3 The utility model is further explained in detail.

[0030] Please refer to the drawings in the specification Figure 1 、 2 and 3, one embodiment provided by the utility model: a kind of for 5-fluoro-3-Boc aminopiperidine synthesis reaction kettle, including installation bottom frame 5, the front and rear ends of installation bottom frame 5 are set to open, the inner cavity of installation bottom frame 5 is provided with multiple groups of rare gas storage tank 4, control valve is installed on the outside of rare gas storage tank 4, propelling assembly is installed on the side of installation bottom frame 5 top wall, propelling assembly includes installation vertical plate 21, installation vertical plate 21 is fixed on the top wall of installation bottom frame 5, air cylinder 22 is installed on the outer wall of installation vertical plate 21 both ends, the end of the horizontal output shaft of multiple groups of air cylinder 22 is installed with reaction kettle shell 15, multiple groups of moving wheel 6 are installed on the bottom wall of reaction kettle shell 15 and contact with the top wall position of installation bottom frame 5, multiple groups of cushion block 7 are evenly installed on the inner cavity bottom wall position of reaction kettle shell 15, reaction kettle inner shell 16 is installed on the top wall of multiple groups of cushion block 7, reaction kettle inner shell 16 is arranged in the inner cavity of reaction kettle shell 15.

[0031] Please refer to the drawings in the specification Figure 1 and 2 The top wall of the reactor outer shell 15 is inlaid with a vent assembly, which includes a vertical vent pipe 17 fixedly inlaid on the top wall of the reactor outer shell 15 and the reactor inner shell 16, the bottom end of the vertical vent pipe 17 extends to the lower end position of the inner cavity of the reactor inner shell 16, the outer wall of the vertical vent pipe 17 is connected with multiple groups of horizontal vent pipes 12, the outer wall of the multiple groups of horizontal vent pipes 12 is uniformly provided with multiple groups of vent holes 13, and the top end of the vertical vent pipe 17 is installed with a foldable hose 18, the other end of the foldable hose 18 is in communication with the noble gas storage tank 4.

[0032] The synthetic raw materials are poured into the inner cavity of the reactor inner shell 16, the control valve on the noble gas storage tank 4 is opened, so that the noble gas in the inner cavity of the noble gas storage tank 4 is injected into the vertical vent pipe 17 and the horizontal vent pipe 12 through the foldable hose 18 and sprayed out through the multiple groups of vent holes 13, the sprayed gas flow continuously stirs the synthetic raw materials in the inner cavity of the reactor inner shell 16, multiple groups of air cylinders 22 are started synchronously, so that the reactor outer shell 15 can be driven to move synchronously on the top wall of the mounting bottom frame 5 through the multiple groups of moving wheels 6, the reactor inner shell 16 and the synthetic raw materials in the inner cavity thereof can be driven to move synchronously under the action of the reactor outer shell 15, so that the synthetic raw materials can be fully stirred, and the air tightness can be ensured.

[0033] Please refer to the drawings in the specification Figure 1 and 2 The top wall of the reactor inner shell 16 is installed with a liquid injection pipe 19 penetrating through the top wall of the reactor outer shell 15, the bottom end of the outer wall of one side of the reactor inner shell 16 is installed with a liquid discharge pipe 11 penetrating through the outer wall of the reactor outer shell 15, and the outer portions of the liquid injection pipe 19 and the liquid discharge pipe 11 are installed with manual valves. The control valve on the liquid injection pipe 19 is opened to facilitate pouring of the synthetic raw materials into the inner cavity of the reactor inner shell 16, and after the synthesis is completed, the control valve on the liquid discharge pipe 11 is opened to discharge the synthetic product.

[0034] Please refer to the drawings in the specification Figure 1 and 2 One end of the top wall of the reactor outer shell 15 is installed with a water injection pipe 20, one end of the bottom wall of the reactor outer shell 15 is installed with a water discharge pipe 10, the water discharge pipe 10 and the multiple groups of cushion blocks 7 are staggered with each other, the bottom end of the outer wall of one side of the reactor outer shell 15 is installed with an electric heating pipe 8, and the outer portions of the water injection pipe 20 and the electric heating pipe 8 are installed with control valves.

[0035] Please refer to the drawings in the specification Figure 1 and 2The lower end of the outer wall of the reaction kettle outer shell 15 is provided with a waterproof temperature sensor 3 extending to the bottom of the inner cavity of the reaction kettle inner shell 16, the lower end of the outer wall of the installed vertical plate 21 is provided with an open hole 2, the upper end of the outer wall of the installed vertical plate 21 is provided with a PLC controller 1, and the PLC controller 1 is electrically connected with the air cylinder 22, the waterproof temperature sensor 3 and the electric heating tube 8.

[0036] Open the control valve on the water injection pipe 20 and inject a proper amount of pure water into the inner cavity of the reaction kettle outer shell 15. The temperature of the synthetic raw materials in the inner cavity of the reaction kettle inner shell 16 is automatically measured by the waterproof temperature sensor 3 and the information is transmitted to the PLC controller 1. When the temperature is too low, the PLC controller 1 automatically starts the electric heating tube 8 to generate heat, thereby heating the pure water. The temperature of the pure water is used to heat the synthetic raw materials in the inner cavity of the reaction kettle outer shell 15, which is convenient for controlling the synthesis temperature.

[0037] Please refer to the drawings in the specification Figure 1 and 2 The top wall of the reaction kettle outer shell 15 is provided with a pressure gauge 14 extending to the upper end of the inner cavity of the reaction kettle inner shell 16. Under the action of the pressure gauge 14, the worker can easily check the pressure value of the inner cavity of the reaction kettle inner shell 16 in real time, so that the synthetic raw materials in the inner cavity of the reaction kettle inner shell 16 can be synthesized in a rare gas environment, avoiding oxidation of the raw materials during synthesis, and facilitating control of the synthesis pressure.

[0038] Please refer to the drawings in the specification Figure 1 、 2 and 3, the outer walls of the plurality of groups of rare gas storage tanks 4 are provided with stop blocks 9 fixed to the bottom wall position of the inner cavity of the installed base frame 5. Under the action of the plurality of stop blocks 9, the position of the rare gas storage tank 4 can be limited, so that the rare gas storage tank 4 is not easy to shake and move left and right.

[0039] Working principle: when using the 5-fluoro-3-Boc amine piperidine synthesis reaction kettle, open the control valve on the liquid injection pipe 19 and pour the synthetic raw materials into the inner cavity of the reaction kettle inner shell 16, open the control valve on the rare gas storage tank 4 so that the rare gas in the inner cavity of the rare gas storage tank 4 is injected into the vertical air pipe 17 and the horizontal air pipe 12 through the foldable hose 18 and is sprayed out through the plurality of air holes 13. The gas flow sprayed out makes the synthetic raw materials in the inner cavity of the reaction kettle inner shell 16 constantly roll and stir, and at the same time, the plurality of air cylinders 22 are started to extend and retract, thereby driving the reaction kettle outer shell 15 to move on the top wall of the installed base frame 5 through the plurality of moving wheels 6, and under the action of the reaction kettle outer shell 15, the reaction kettle inner shell 16 and the synthetic raw materials in its inner cavity can be driven to move synchronously, thereby fully stirring the synthetic raw materials and ensuring the air tightness.

[0040] The gas pressure value of the inner cavity of the reactor inner shell 16 can be conveniently viewed by the staff in real time under the action of the gas pressure gauge 14, so that the synthesis raw materials in the inner cavity of the reactor inner shell 16 can be synthesized in the environment of rare gas, and the raw materials are prevented from being oxidized in the synthesis process. The control valve on the water injection pipe 20 is opened first in the synthesis process, and an appropriate amount of pure water is injected into the inner cavity of the reactor outer shell 15, and the position of the rare gas storage tank 4 can be limited under the action of the plurality of stop blocks 9, so that the rare gas storage tank 4 is not easy to shake and move left and right.

[0041] The temperature of the synthesis raw materials in the inner cavity of the reactor inner shell 16 is automatically measured under the action of the waterproof temperature sensor 3 and information is transmitted to the PLC controller 1. When the temperature is too low, the PLC controller 1 automatically starts the electric heating pipe 8 to generate heat, so that the pure water can be heated. The temperature of the pure water is used to heat the synthesis raw materials in the inner cavity of the reactor outer shell 15. After the synthesis is completed, the control valve on the liquid discharge pipe 11 is opened, so that the synthesis product can be discharged. The control valve on the drain pipe 10 is opened, so that the pure water in the inner cavity of the reactor outer shell 15 can be discharged.

[0042] The standard parts used in the utility model document can be purchased from the market. According to the description and the drawings, each component in the utility model document can be ordered. The specific connection mode of each part adopts the conventional means such as bolt, rivet and welding in the prior art. The mechanical parts and equipment adopt conventional types in the prior art. The circuit connection adopts the conventional connection mode in the prior art, which will not be described in detail here.

[0043] The above are preferred embodiments of the utility model, which do not limit the protection scope of the utility model. Therefore, equivalent changes made according to the structure, shape and principle of the utility model should be covered in the protection scope of the utility model.

Claims

1. A reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine, comprising a mounting base frame (5), characterized in that: The inner cavity of the mounting base frame (5) is provided with multiple rare gas storage tanks (4). A propulsion assembly is installed on one side of the top wall of the mounting base frame (5). A reactor shell (15) is installed at the end of the propulsion assembly. Multiple sets of pads (7) are evenly installed on the bottom wall of the inner cavity of the reactor shell (15). A reactor inner shell (16) is installed on the top wall of the multiple sets of pads (7). A venting assembly extending into the inner cavity of the reactor inner shell (16) is embedded in the top wall of the reactor shell (15). A foldable hose (18) is installed at the top of the venting assembly. The other end of the foldable hose (18) is connected to the rare gas storage tank (4).

2. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: The propulsion assembly includes a mounting vertical plate (21), which is fixed on the top wall of the mounting base frame (5). Cylinders (22) are installed at both the upper and lower ends of the outer wall of the mounting vertical plate (21), and the ends of the horizontal output shafts of the multiple sets of cylinders (22) are fixed to the outer wall of the reactor shell (15).

3. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: The ventilation assembly includes a vertical ventilation pipe (17), which is connected to the end of a foldable hose (18). The vertical ventilation pipe (17) passes through the outer shell (15) and the top wall of the inner shell (16) of the reactor and extends to the lower end of the inner cavity of the inner shell (16). The outer wall of the vertical ventilation pipe (17) is connected to multiple sets of horizontal ventilation pipes (12), and multiple sets of ventilation holes (13) are evenly opened on the outer wall of the multiple sets of horizontal ventilation pipes (12).

4. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: The inner shell (16) of the reactor is equipped with a liquid injection pipe (19) that penetrates the top wall of the outer shell (15) of the reactor, and the bottom of one side of the outer wall of the inner shell (16) of the reactor is equipped with a liquid drain pipe (11) that penetrates the outer wall of the outer shell (15) of the reactor.

5. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: A water injection pipe (20) is installed at one end of the top wall of the reactor shell (15), a drain pipe (10) is installed at one end of the bottom wall of the reactor shell (15), and an electric heating pipe (8) is installed at the bottom of one side of the outer wall of the reactor shell (15).

6. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: A pressure gauge (14) is installed at one end of the top wall of the outer shell (15) of the reactor, extending to the upper end of the inner cavity of the inner shell (16) of the reactor.

7. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 2, characterized in that: A waterproof temperature sensor (3) extending to the bottom of the inner cavity of the reactor inner shell (16) is installed at the lower end of the outer wall of one side of the reactor outer shell (15). An open hole (2) is provided at the lower end of the outer wall of the mounting plate (21). A PLC controller (1) is installed at the upper end of the outer wall of the mounting plate (21). The PLC controller (1) is electrically connected to the cylinder (22), the waterproof temperature sensor (3), and the electric heating tube (8).

8. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: The bottom wall of the reactor shell (15) is equipped with multiple sets of movable wheels (6) that contact the top wall of the mounting frame (5).

9. The reactor for the synthesis of 5-fluoro-3-Boc aminopiperidine according to claim 1, characterized in that: The outer walls on both sides of the multiple rare gas storage tanks (4) are provided with blocks (9) that are fixed to the position of the bottom wall of the inner cavity of the mounting frame (5).

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