Cell culture tank swinging device

Abstract

The utility model relates to a cell culture tank swing device, and relates to the field of cell culture, the cell culture tank swing device comprises a support frame, the support frame is rotatably provided with two oppositely arranged rotating shafts, the two rotating shafts are provided with clamping assemblies used for clamping and fixing a culture tank, the support frame is provided with a swing assembly with adjustable swing amplitude, and the swing assembly is provided with a plurality of clamping assemblies used for clamping and fixing the culture tank. The swing assembly is connected with the rotating shaft and used for driving the rotating shaft to swing. The swing device has the effect that the swing amplitude of the culture tank can be adjusted according to different cell types and culture conditions, so that the applicability of the swing device is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cell culture, in particular to a cell culture tank swinging device. BACKGROUND

[0002] Cell culture refers to a method of simulating the in-vivo environment (sterile, appropriate temperature, pH, and certain nutritional conditions, etc.) to make it survive, grow, reproduce and maintain the main structure and function in vitro.

[0003] In the process of cell culture, in order to promote the exchange of gas and liquid, and to disperse the cell group, it is necessary to swing the cell culture tank for sampling or harvesting cells.

[0004] A biological cell culture reactor is disclosed in a Chinese patent with the authorization announcement number CN215757421U, which installs the reaction tank on the fixed frame through the fixing sleeve, and then drives the rotating rod to rotate through the motor. The rotating rod drives the fixed frame to swing by using the principle of crank rocker mechanism, so as to realize the swinging of the reaction tank. However, the swinging amplitude of the reaction tank cannot be adjusted, so it cannot be adjusted according to different cell types and culture conditions, resulting in poor applicability. CONTENT OF THE UTILITY MODEL

[0005] In order to improve the problem that the swinging amplitude of the reaction tank cannot be adjusted, resulting in poor applicability of the swinging device, the present application provides a cell culture tank swinging device.

[0006] The cell culture tank swinging device provided by the present application adopts the following technical scheme:

[0007] A cell culture tank swinging device, comprising a support frame, two oppositely arranged rotating shafts are rotatably arranged on the support frame, a clamping assembly for clamping and fixing the culture tank is arranged on the two rotating shafts, a swinging amplitude adjustable swinging assembly is arranged on the support frame, the swinging assembly is connected with the rotating shafts and is used to drive the rotating shafts to swing.

[0008] By adopting the above technical scheme, when the culture tank is shaken, the culture tank is fixed on the rotating shaft by the clamping assembly, and then the swinging assembly drives the rotating shaft to reciprocatingly swing, the rotating shaft drives the culture tank to swing, the shaking of the culture is realized, the swinging amplitude of the culture tank is adjusted by adjusting the swinging amplitude of the swinging assembly, the shaking amplitude of the culture tank is adjusted, the swinging amplitude can be adjusted according to different cell types and culture conditions, thereby improving the applicability of the swinging device.

[0009] In a specific implementable scheme, the swinging assembly comprises a rotary cylinder, and the output shaft of the rotary cylinder is connected with the rotating shaft through a shaft coupling.

[0010] By adopting the technical scheme, the rotary cylinder drives the rotating shaft to swing, the swing of the culture tank is driven, the swing amplitude of the rotary cylinder is adjusted by adjusting the size of the air intake through the adjusting screw, and the convenience of the swing amplitude of the culture tank is improved.

[0011] In a specific embodiment, the swing assembly includes a rotating motor, a rotating disc, and a swing rod, the rotating motor is fixedly arranged on the support frame, the rotating disc is coaxially fixedly arranged on the output shaft of the rotating motor, the swing rod is fixedly arranged on the rotating shaft, the rotating disc is provided with an adjusting member, the adjusting member is connected with the swing rod, so that the rotating disc drives the swing rod to reciprocatingly swing around the rotating shaft, and the adjusting member can adjust the distance between the adjusting member and the axis of the rotating disc.

[0012] By adopting the technical scheme, when the rotating shaft swings, the rotating motor drives the rotating disc to rotate, the rotating disc drives the adjusting member to rotate, the adjusting member drives the swing rod to reciprocatingly swing while rotating, the swing of the culture tank is driven, the swing amplitude of the swing rod is adjusted by adjusting the distance between the adjusting member and the axis of the rotating disc, and the swing amplitude of the culture tank is adjusted.

[0013] In a specific embodiment, the adjusting member includes an adjusting screw, the rotating disc is provided with an adjusting through hole arranged along the radial direction of the rotating disc, the adjusting screw is provided with a fixing ring, one end of the adjusting screw passes through the adjusting through hole, and a fixing nut is threadedly connected to the end, the fixing nut can pull the fixing ring to abut against and be fixed on the rotating disc, so as to fix the adjusting screw, and the adjusting screw is connected with the swing rod through a connecting structure.

[0014] By adopting the technical scheme, when the swing amplitude of the swing rod is adjusted, the fixing nut is loosened, the adjusting screw is driven to slide in the adjusting through hole, the distance between the adjusting screw and the rotating disc is adjusted, and then the fixing nut is screwed, so that the fixing ring is abutted against and fixed on the rotating disc, thereby adjusting the swing amplitude of the swing rod.

[0015] In a specific embodiment, the connecting structure includes a sliding groove and a roller, the sliding groove is arranged along the length direction of the swing rod, the adjusting screw is inserted into the sliding groove, and the roller is rotatably sleeved on one end of the adjusting screw inserted into the sliding groove, so as to slide along the sliding groove.

[0016] By adopting the technical scheme, the adjusting screw slides in the sliding groove while rotating with the rotating disc, thereby driving the swing rod to swing, and the roller slides in the sliding groove, thereby reducing the friction of the adjusting screw sliding in the sliding groove.

[0017] In one specific implementation, the clamping assembly includes clamping blocks fixed on the rotating shafts respectively, each of the clamping blocks is provided with a clamping groove for inserting the ear pipes of the culture tank, and the clamping blocks can support the culture tank and drive the culture tank to swing.

[0018] By using the above technical solution, when the culture tank is installed by swinging, the two ear pipes of the culture tank are inserted into the clamping grooves on the clamping blocks, the culture tank is connected with the clamping blocks by gravity, and the rotating shaft drives the culture tank to swing.

[0019] In one specific implementation, the driving assembly corresponds to one of the rotating shafts, and the other rotating shaft is sleeved with a telescopic spring and a rotating cylinder, the rotating cylinder is rotationally connected with the rotating shaft, one end of the telescopic spring is connected with the support frame, and the other end of the telescopic spring is connected with the rotating cylinder, so as to extrude the clamping blocks to move towards the other clamping block.

[0020] By using the above technical solution, when the cell culture tank is clamped, one rotating shaft is pulled to move laterally, so that the two clamping blocks are away from each other, then the cell culture tank is placed between the two clamping blocks, and then the rotating shaft is released, the telescopic spring pushes the clamping blocks to clamp the ear pipes on the cell culture tank, thereby improving the convenience of clamping and fixing the cell culture tank.

[0021] In one specific implementation, the clamping assembly includes clamping arc plates, a fixed sleeve and a mounting nut, the clamping arc plates are fixed on the fixed sleeve, the fixed sleeve is sleeved on the rotating shaft, and the mounting nut is screwed on the rotating shaft, so as to extrude the fixed sleeve and make the clamping arc plates clamp and fix the culture tank.

[0022] By using the above technical solution, when the culture tank is installed by swinging, the culture tank is placed between the two clamping arc plates, and then the mounting nut is rotated, the mounting nut pushes the clamping arc plates against the culture tank through the fixed sleeve, and the two clamping arc plates clamp and fix the culture tank, thereby completing the installation of the culture tank.

[0023] In one specific implementation, the fixed sleeve is provided with a support rod, one end of the support rod extends to the bottom of the culture tank, so as to support the culture tank, and two fastening nuts are threadedly sleeved on the support rod, and the two fastening nuts are located on the two sides of the fixed sleeve respectively, so as to fix the support rod.

[0024] By adopting the technical scheme, when the clamping arc plates clamp and fix the culture tank, the support rods support the bottom of the culture tank, thereby improving the stability of the culture tank when swinging; the position of the support rods can be adjusted by screwing the fastening nuts, so as to adapt to the support of different types of culture tanks.

[0025] In summary, the present application has at least one of the following beneficial technical effects:

[0026] 1. When the culture tank is shaken, the culture tank is fixed on the rotating shaft by the clamping assembly, then the swinging assembly drives the rotating shaft to swing back and forth, the rotating shaft drives the culture tank to swing, the shaking of the culture is realized, the swinging amplitude of the culture tank is adjusted by adjusting the swinging amplitude of the swinging assembly, the shaking amplitude of the culture tank is adjusted, the swinging amplitude can be adjusted according to different cell types and culture conditions, thereby improving the applicability of the swinging device;

[0027] 2. When the culture tank is installed to swing, the culture tank is placed between the two clamping arc plates, then the installation nut is turned, the installation nut pushes the clamping arc plates against the culture tank through the fixing sleeve, the two clamping arc plates clamp and fix the culture tank, the support rods support the bottom of the culture tank, thereby improving the stability of the culture tank when swinging; the position of the support rods can be adjusted by screwing the fastening nuts, so as to adapt to the support of different types of culture tanks. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 is a structure schematic view of a cell culture tank swinging device according to Embodiment 1 of the present application.

[0029] Figure 2 is Figure 1 an enlarged view of A part in

[0030] Figure 3 is a structure schematic view of a cell culture tank swinging device according to Embodiment 2 of the present application.

[0031] Figure 4 is Figure 3 an enlarged view of B part in

[0032] Figure 5 is a structure schematic view of a cell culture tank swinging device according to Embodiment 3 of the present application.

[0033] Figure 6 is Figure 5 an enlarged view of C part in

[0034] Figure 7 is an explosion view for showing a rectangular block.

[0035] Explanation of reference numerals in the attached drawings: 1. Support frame; 11. Support platform; 12. Rotating bracket; 13. Telescopic spring; 14. Rotating cylinder; 15. Bearing; 16. Baffle; 2. Rotating shaft; 3. Clamping assembly; 311. Clamping block; 312. Clamping groove; 321. Clamping arc plate; 322. Fixing sleeve; 323. Mounting nut; 324. Rectangular block; 325. Support part; 326. Support rod; 327. Fastening nut; 4. Swing assembly; 41. Rotary cylinder; 42. Coupling; 43. Rotating motor; 44. Rotating disk; 45. Swing rod; 46. Adjusting component; 461. Adjusting screw; 462. Fixing ring; 463. Adjusting through hole; 464. Fixing nut; 47. Connecting structure; 471. Sliding groove; 472. Roller; 5. Culture tank; 51. Ear tube. Detailed Implementation

[0036] The following is in conjunction with the appendix Figures 1-7 This application will be described in further detail.

[0037] This application discloses a cell culture tank swinging device.

[0038] Example 1

[0039] Reference Figure 1 , Figure 2 A cell culture jar swinging device includes a support frame 1, which includes a bottom support platform 11 and two rotating brackets 12. The two rotating brackets 12 are fixedly mounted on the support platform 11 and arranged opposite to each other. Each rotating bracket 12 is rotatably connected to a rotating shaft 2, and the two rotating shafts 2 are coaxially arranged. Clamping components 3 are provided on opposite sides of the two rotating shafts 2 to clamp and fix the culture jar 5. One of the rotating brackets 12 is provided with a swinging component 4 with adjustable swing amplitude. The other rotating shaft 2 can slide along its own axis and has a telescopic spring 13 and a rotating cylinder 14 sleeved on it. The rotating cylinder 14 is connected to the rotating shaft 2 through a bearing 15. One end of the telescopic spring 13 is fixedly connected to the rotating cylinder 14, and the other end is fixedly connected to the rotating bracket 12. A baffle 16 is fixedly provided on the end of the rotating shaft 2 facing away from the other rotating shaft 2. Initially, the telescopic spring 13 applies a thrust to the rotating shaft 2 toward the other rotating shaft 2. The swinging component 4 is connected to the rotating shaft 2 and is used to drive the rotating shaft 2 to swing.

[0040] Reference Figure 1 In this embodiment, the swing component 4 is a rotary cylinder 41, which is fixedly mounted on the rotating bracket 12. The output shaft of the rotary cylinder 41 is connected to the rotating shaft 2 via a coupling 42. The swing amplitude of the rotary cylinder 41 is adjusted by adjusting the air intake by adjusting the adjusting screw on the rotary cylinder 41, thereby improving the convenience of swing amplitude of the culture tank 5.

[0041] With reference to Figure 1 The clamping assembly 3 in the embodiment comprises clamping blocks 311 fixedly arranged on the rotating shafts 2, the ends of the clamping blocks 311 away from the corresponding rotating shafts 2 are inclined upward, and the clamping slots 312 are arranged on the inclined ends, the two ear tubes 51 are fixedly arranged on the side wall of the culture tank 5, the two ear tubes 51 correspond to the clamping blocks 311 one by one, and the two ear tubes 51 are inserted into the clamping slots 312, so that the clamping blocks 311 support the culture tank 5 and drive the culture tank 5 to shake.

[0042] When the culture tank 5 is clamped, one rotating shaft 2 is pulled to move laterally, so that the two clamping blocks 311 are away from each other, then the culture tank 5 is placed between the two clamping blocks 311, and then the rotating shaft 2 is released, the extension spring 13 pushes the clamping blocks to clamp the ear tubes 51 on the culture tank 5, thereby improving the convenience of clamping and fixing the culture tank 5.

[0043] The implementation principle of the embodiment 1 is that when the culture tank 5 is shaken, the two ear tubes 51 of the culture tank 5 are inserted into the clamping slots 312 on the clamping blocks 311, then the rotating shaft 2 is driven by the rotary cylinder 41 to reciprocate, the rotating shaft 2 drives the culture tank 5 to swing, the shaking of the culture tank 5 is realized, the swinging amplitude of the rotary cylinder 41 is adjusted by adjusting the adjusting screw on the rotary cylinder 41, and the swinging amplitude of the culture tank 5 is adjusted, the shaking amplitude of the culture tank 5 is adjusted, the swinging amplitude can be adjusted according to different cell types and culture conditions, thereby improving the applicability of the shaking device.

[0044] Embodiment 2

[0045] With reference to Figure 3 , Figure 4 The difference between the embodiment and the embodiment 1 is that the swinging assembly 4 in the embodiment comprises a rotating motor 43, a rotating disc 44 and a swinging rod 45, the rotating motor 43 is a servo motor, the rotating motor 43 is fixedly arranged on one support table 11, the axis of the output shaft of the rotating motor 43 is parallel to the axis of the rotating shaft 2, the rotating disc 44 is coaxially and fixedly arranged on the output shaft of the rotating motor 43, the swinging rod 45 is fixedly arranged on the rotating shaft 2, the adjusting member 46 in the embodiment comprises an adjusting screw 461, the middle part of the adjusting screw 461 is protruded to form a fixing ring 462, the adjusting through hole 463 is arranged along the radial direction of the rotating disc 44, one end of the adjusting screw 461 penetrates through the adjusting through hole 463, and the fixed nut 464 is threadedly arranged on the end penetrating through the adjusting through hole 463, the fixed nut 464 is rotated, the fixed nut 464 pulls the fixing ring 462 and is tightly fixed on the rotating disc 44, and the fixing of the adjusting screw 461 is completed.

[0046] With reference to Figure 3 ,Figure 4 The adjusting screw 461 is connected with the swing rod 45 through the connecting structure 47, and the connecting structure 47 in the embodiment includes a sliding groove 471 and a roller 472. The sliding groove 471 is arranged along the length direction of the swing rod 45, one end of the adjusting screw 461 is inserted into the sliding groove 471, and the roller 472 is rotatably sleeved on the one end of the adjusting screw 461 inserted into the sliding groove 471, so that the roller 472 can roll along the groove wall of the sliding groove 471, and the friction between the adjusting screw 461 and the swing rod 45 is reduced.

[0047] The principle of the embodiment of the embodiment 2 is that when the rotating shaft 2 swings, the rotating motor 43 drives the rotating disc 44 to rotate, the rotating disc 44 drives the adjusting screw 461 to rotate, the adjusting screw 461 drives the roller 472 to reciprocatingly slide in the sliding groove 471 while rotating, and drives the swing rod 45 to reciprocatingly swing, so as to drive the swing of the culture tank 5. When the swing amplitude of the swing rod 45 is adjusted, the fixed nut 464 is loosened, then the adjusting screw 461 is driven to slide in the adjusting through hole 463, the distance between the adjusting screw 461 and the rotating disc 44 is adjusted, then the fixed nut 464 is screwed, the fixed ring 462 is tightly fixed against the rotating disc 44, and the swing amplitude of the swing rod 45 is adjusted.

[0048] Embodiment 3

[0049] With reference to Figure 5 , Figure 6 and Figure 7 , the difference between the embodiment and the embodiment 2 is that the clamping assembly 3 in the embodiment includes a clamping arc plate 321, a fixed sleeve 322 and a mounting nut 323. The clamping arc plate 321 is matched with the circumferential wall of the culture tank 5, and the clamping arc plate 321 is fixedly arranged on the fixed sleeve 322. Rectangular blocks 324 are fixedly arranged on opposite ends of the rotating shaft 2. The fixed sleeve 322 is a rectangular sleeve matched with the rectangular blocks 324. The rectangular blocks 324 are inserted into the fixed sleeve 322 to limit the rotation of the fixed sleeve 322. The fixed sleeve 322 is sleeved on the rotating shaft 2 in a sliding manner. The mounting nut 323 is screwed on the rotating shaft 2 to press the fixed sleeve 322, so that the clamping arc plate 321 clamps and fixes the culture tank 5.

[0050] With reference to Figure 5 , Figure 6 and Figure 7 , a support portion 325 is formed on the side of the fixed sleeve 322. A support rod 326 is arranged through the support portion 325. The support rod 326 is an L-shaped rod. One end of the support rod 326 extends to the bottom of the culture tank 5 to support the culture tank 5. Two fastening nuts 327 are threadedly sleeved on the support rod 326 and are located on the two sides of the support portion 325 to fix the support rod 326.

[0051] The principle of the embodiment of the example 3 is that when the culture tank 5 is swing-mounted, the culture tank 5 is placed between the two clamping arc plates 321, then the mounting nut 323 is rotated, the mounting nut 323 pushes the clamping arc plates 321 to tightly contact on the culture tank 5 through the fixing sleeve 322, the two clamping arc plates 321 clamp and fix the culture tank 5, and the installation of the culture tank 5 is completed.

[0052] When the clamping arc plates 321 clamp and fix the culture tank 5, the support rod 326 supports the bottom of the culture tank 5, thereby improving the stability of the culture tank 5 when swinging; the position of the support rod 326 can be adjusted by screwing the fastening nut 327, so as to adapt to the support of different types of culture tanks 5.

[0053] The above are preferred embodiments of the present application, which do not limit the protection scope of the present application, therefore: any equivalent changes made on the structure, shape and principle of the present application should be covered within the protection scope of the present application.

Claims

1. A cell culture tank swing device, characterized by: The utility model provides a culture tank rotating device, including support frame (1), two opposite setting rotary shafts (2) are equipped on the support frame (1), and the rotary shaft (2) is equipped with the clamping assembly (3) for clamping and fixing culture tank (5), the swing component (4) with swing range adjustable is equipped on the support frame (1), and the swing component (4) is connected with the rotary shaft (2) and is used for driving the rotary shaft (2) swing.

2. The cell culture tank swing device according to claim 1, characterized by: The swing component (4) includes rotary cylinder (41), and the output shaft of rotary cylinder (41) is connected with the rotary shaft (2) through the shaft coupling (42).

3. The cell culture tank swing device according to claim 1, characterized by: The swing component (4) includes rotary motor (43), rotary disc (44) and swing lever (45), the rotary motor (43) is fixedly arranged on the support frame (1), the rotary disc (44) is coaxially fixedly arranged on the output shaft of rotary motor (43), the swing lever (45) is fixedly arranged on the rotary shaft (2), the rotary disc (44) is equipped with adjusting part (46), the adjusting part (46) is connected with the swing lever (45), so that the rotary disc (44) drives the swing lever (45) reciprocating swing around the rotary shaft (2), the adjusting part (46) can adjust the distance between the rotary disc (44) and the shaft center.

4. The cell culture tank swing device according to claim 3, characterized by: The adjusting part (46) includes adjusting screw (461), the rotary disc (44) is provided with adjusting through hole (463) along the radial direction, the adjusting screw (461) is provided with fixed ring (462), one end of the adjusting screw (461) passes through the adjusting screw (461), and the fixed nut (464) is threadedly connected on the end, the fixed nut (464) can pull the fixed ring (462) and be tightly fixed on the rotary disc (44), so as to fix the adjusting screw (461), and the adjusting screw (461) is connected with the swing lever (45) through the connecting structure (47).

5. The cell culture tank swing device according to claim 4, characterized by: The connecting structure (47) includes sliding groove (471) and roller (472), the sliding groove (471) is arranged along the length direction of the swing lever (45), the adjusting screw (461) is inserted into the sliding groove (471), and the roller (472) is rotatably arranged on the end of the adjusting screw (461) inserted into the sliding groove (471), so as to slide along the sliding groove (471).

6. The cell culture tank swing device according to claim 1, characterized by: The clamping assembly (3) includes clamping block (311) fixedly arranged on the rotary shaft (2) respectively, the clamping groove (312) for the ear pipe (51) of culture tank (5) is inserted is arranged on each clamping block (311), the clamping block (311) can support culture tank (5) and can drive the culture tank (5) swing.

7. The cell culture tank swing device according to claim 6, characterized by: The swing assembly (4) corresponds to one of the rotating shafts (2), and the other rotating shaft (2) is sleeved with an expansion spring (13) and a rotating cylinder (14). The rotating cylinder (14) is rotationally connected with the rotating shaft (2), one end of the expansion spring (13) is connected with the support frame (1), and the other end is connected with the rotating cylinder (14), so as to extrude the clamping block (311) to move towards the other clamping block (311).

8. The cell culture tank swing device according to claim 1, characterized by: The clamping assembly (3) comprises a clamping arc plate (321), a fixed sleeve (322) and a mounting nut (323). The clamping arc plate (321) is fixedly arranged on the fixed sleeve (322). The fixed sleeve (322) is sleeved on the rotating shaft (2) in a sliding manner. The mounting nut (323) is screwed on the rotating shaft (2), so as to extrude the fixed sleeve (322), so that the clamping arc plate (321) clamps and fixes the culture tank (5).

9. The cell culture tank swing device according to claim 8, characterized by: A support rod (326) is arranged on the fixed sleeve (322). One end of the support rod (326) extends to the bottom of the culture tank (5), so as to support the culture tank (5). Two fastening nuts (327) are threadedly sleeved on the support rod (326). The two fastening nuts (327) are respectively located on the two sides of the fixed sleeve (322), so as to fix the support rod (326).

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