In-vitro prostate pathological tissue positioning identification and sampling device

Abstract

The utility model discloses an in-vitro prostate pathological tissue positioning identification and sampling device, which relates to the technical field of medical instruments and comprises a support component, a positioning guide component and a plurality of positioning needles. The support assembly comprises a supporting plate and a positioning column, and the positioning column is used for penetrating through the urethra of the prostate to fix the prostate; the positioning and guiding assembly is installed on the support assembly, and scales used for positioning the tumor position in the prostate body are arranged on the positioning and guiding assembly; and the plurality of positioning needles are used for positioning and identifying focuses in the prostate body. Through the arrangement, the preoperative mpMRI image of a patient and a 3D reconstructed digital model can be used as input, and the position of a tumor in a gland can be accurately positioned again under the condition that the prostate tissue is in vitro through the assistance of the in-vitro prostate pathological tissue positioning identifier and the sampling device; therefore, the target tumor tissue can be quickly and accurately taken out from the in-vitro prostate.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical equipment technical field, especially in vitro prostate pathological tissue positioning mark and material taking device. BACKGROUND

[0002] At present, the research on prostate cancer in the field of biological medicine is more and more in-depth, and the prostate cancer pathological tissue specimen is the cornerstone of the research on prostate cancer, but due to the characteristics of small organ, various lesion forms, and insignificant difference with the surrounding normal tissue, etc., the representative tumor lesions cannot be quickly and accurately obtained in the process of taking materials. At present, the methods for obtaining prostate cancer pathological tissue include transrectal ultrasound-guided prostate biopsy and transperineal ultrasound-guided prostate biopsy. However, these two techniques are limited to puncture and material taking of in vivo prostate tissue, because they can be guided by real-time ultrasound images or magnetic resonance imaging, and as long as strict operation training is carried out, satisfactory material taking effect can be basically achieved. For the material taking of in vitro prostate specimens after radical prostatectomy, the prostate has left the human body, and there is no auxiliary image positioning and anatomical relationship in vivo, so the depth and range of the target tumor tissue cannot be accurately positioned from the outside, so that the tumor specimen tissue that can meet the clinical research needs cannot be efficiently and accurately taken. Therefore, the in vitro re-coordinate positioning and efficient material taking of the specimen tissue has become a big problem for clinical researchers. The utility model utilizes the mature multi-parameter magnetic resonance (mpMRI) image 3D reconstruction technology, calibrates and measures the relative position relationship between the tumor center and range and the anatomical landmarks such as urethra, gland boundary, and seminal vesicle in the software, and under the assistance of the prostate pathological tissue positioning mark and material taking device provided by the utility model, the relative position relationship between the target tumor tissue and the gland can be quickly and accurately positioned, the positioning needle and the rotary cutter provided by the utility model are combined to realize efficient and accurate extraction of in vitro prostate tumor tissue, meet the technical requirements of specimen effectiveness and accuracy for clinical research, greatly improve the material taking efficiency, and ensure the scientificity and accuracy of tumor specimen detection, analysis, diagnosis and other activities.

[0003] Therefore, how to quickly and accurately position and mark the position of the actual in vitro tissue in the physical space according to the lesion position information obtained by imaging, and accurately take as much pathological tissue as possible, is a technical problem to be solved by those skilled in the art. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a prostate pathological tissue positioning mark device and material taking device, which can accurately position and mark the lesion position according to the mpMRI and image 3D reconstruction model of the patient before operation, and then quickly and accurately take out the tumor pathological tissue inside the prostate.

[0005] To achieve the above object, the utility model provides the following technical scheme:

[0006] A kind of ex vivo prostate pathological tissue positioning mark, comprising:

[0007] Support assembly, including supporting plate and positioning column, positioning column is configured as positioning reference, for being equipped with prostate urethra to fix prostate;

[0008] Positioning and guiding assembly is installed on support assembly, and scale for positioning prostate lesion is provided on positioning and guiding assembly;

[0009] Several positioning needles are equipped with prostate positioned on positioning column by positioning and guiding assembly, and the lesion in prostate is positioned and marked.

[0010] As preferred, positioning column is vertically arranged on supporting plate, and scale-equipped puncture through-hole square array is arranged in square with positioning column as center on supporting plate, and puncture through-hole is used for the entry of positioning needle;

[0011] Support assembly further includes:

[0012] Two first guide rods are vertically installed on supporting plate, and the top of the two first guide rods is provided with a first connecting piece;

[0013] First threaded rod is vertically installed on supporting plate, and located between the two first guide rods, and the top of the first threaded rod penetrates the first connecting piece and is provided with a first rotating handle;

[0014] Two second guide rods are equipped in first connecting piece and the second guide rods are parallel to supporting plate, and the end of the two second guide rods close to positioning column is provided with a second connecting piece;

[0015] Second threaded rod is equipped in first connecting piece and connected to second connecting piece and parallel to second guide rod, and the end away from second connecting piece is provided with a second rotating handle.

[0016] As preferred, positioning and guiding assembly includes:

[0017] First guide plate is in U-shaped structure, and is movably sleeved on the outer periphery of first guide rod and first threaded rod, the bottom plate of first guide plate is provided with through hole for passing through first guide rod and threaded hole for passing through first threaded rod, and the two side plates of first guide plate are provided with scale-equipped puncture through-hole square array.

[0018] As preferred, scale-equipped puncture through-hole square array is arranged in concentric circle with positioning column as center on supporting plate, and puncture through-hole is used for the entry of positioning needle;

[0019] Support assembly further includes:

[0020] a bottom plate, the supporting plate is arranged on the bottom plate at an angle;

[0021] a bracket body, the bracket body is arranged on the bottom plate at an angle, and the bracket body is connected to the supporting plate perpendicularly;

[0022] two second guide rods, the two second guide rods are arranged at the end of the bracket body away from the supporting plate, and the second guide rods are parallel to the supporting plate, and the end of the second guide rods is provided with a second connecting piece;

[0023] a second threaded rod, the second threaded rod is arranged through the top end of the bracket body and connected to the second connecting piece and parallel to the second guide rods, and the end of the second threaded rod away from the second connecting piece is provided with a second rotating handle.

[0024] Preferably, the positioning and guiding assembly comprises a second guide plate, the second guide plate is movably sleeved on the outer periphery of the second guide rods and the second threaded rod, the second guide plate comprises a front plate for abutting the prostate positioned on the positioning column, the front plate is provided with a square array of puncture through holes with scales, and the bottom end of the front plate is attached to the supporting plate.

[0025] Preferably, the positioning and guiding assembly comprises:

[0026] a first guide plate, the first guide plate is in a cuboid structure and is fixedly installed on the supporting plate perpendicularly, the side surface of the first guide plate is provided with a square array of puncture through holes with scales, and the positioning column is fixedly installed on the first guide plate and perpendicular to the first guide plate;

[0027] a second guide plate, the second guide plate is movably installed on the supporting plate and perpendicular to the first guide plate and the supporting plate, the second guide plate comprises a fixed plate and a movable plate embedded in the fixed plate, and a puncture through hole with scales for the positioning needle to pass through is vertically arranged between the fixed plate and the movable plate.

[0028] Preferably, the positioning column is arranged on the supporting plate perpendicularly;

[0029] The support assembly further comprises:

[0030] a bracket body, the bracket body is in a square frame structure and arranged on one side of the supporting plate;

[0031] two first guide rods, the two first guide rods are arranged in the bracket body perpendicularly to the supporting plate;

[0032] a first threaded rod, the first threaded rod is arranged between the two first guide rods perpendicularly to the supporting plate, the top end of the first threaded rod passes through the bracket body, and the top end of the first threaded rod is provided with a first rotating handle;

[0033] The lifting plate body is in T-shaped structure, and comprises a mounting portion, a circular table portion, and a connecting plate connecting the mounting portion and the circular table portion. The mounting portion is movably sleeved on the outer circumferences of the first guide rod and the first threaded rod, and is provided with a through hole for passing through the first guide rod and a threaded hole for passing through the first threaded rod. The circular table portion is arranged at the end of the connecting plate away from the mounting portion, and is in circular structure and provided with a scale on the outer circumference thereof.

[0034] As preferred, the positioning and guiding assembly comprises:

[0035] The rotating ruler body is rotatably installed at the center of the lower side of the circular table portion through the boss fixing piece. The rotating ruler body is in square structure, and is provided with a scale and a moving groove on two sides thereof.

[0036] The needle seat is movably connected to the rotating ruler body. The top of the needle seat is provided with an assembly groove matched with the moving groove, and a first pointer for reading the scale on the rotating ruler body.

[0037] As preferred, the bottom of the needle seat is provided with a square array of puncture through holes arranged in concentric circles.

[0038] The tail end of the positioning needle is connected with a hose for injecting the marking liquid.

[0039] The circular table portion is provided with a first locking piece for locking the rotation of the rotating ruler body, and the top of the needle seat is provided with a second locking piece for locking the movement of the needle seat.

[0040] The positioning and guiding assembly further comprises a first guide plate vertically arranged on the supporting plate. The first guide plate is located on the side away from the bracket body, and is provided with a square array of puncture through holes with scales for the positioning needle to pass through.

[0041] An in-vitro prostate pathological tissue sampling device comprises the positioning and marking device described above, and further comprises:

[0042] A spoon-shaped cutter is rotatably installed at the bottom end of the needle seat.

[0043] A scale vertically extends on the outer side of the bracket body.

[0044] An optical axis is vertically installed at the lower side of the mounting portion. A second pointer is movably arranged on the optical axis, and is used for indicating the scale on the outer side of the bracket body.

[0045] With respect to the above background art, the utility model provides a kind of prostate pathological tissue positioning mark in vitro, comprising: support assembly, positioning guide component and several positioning needles;Support assembly, including supporting plate and positioning column, the positioning column is used to pass through prostate urethra to fix prostate;Positioning guide component is installed on the support assembly, the positioning guide component is provided with scale for positioning the prostate lesion;Several positioning needles, by the positioning guide component, pass through the prostate positioned on the positioning column, and the lesion in the prostate is positioned and identified.

[0046] Specifically, support assembly includes supporting plate and positioning column, supporting plate is used to carry remaining parts or prostate to be positioned, and positioning column is used to pass through prostate urethra, and prostate is positioned based on prostate urethra, and scale is arranged on positioning guide component in each direction, so as to find out lesion position by scale by using positioning needle under the assistance of positioning guide component, and then positioning needle is inserted, and then identification fluid is injected into positioning needle, and lesion position is identified, so that lesion position can be easily found when sampling lesion subsequently, and too much time is not wasted for finding lesion position so as to damage prostate specimen. BRIEF DESCRIPTION OF DRAWINGS

[0047] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or prior art, the drawings needed to be used in the embodiment or prior art description will be briefly introduced as follows, and obviously, the drawings in the following description are only the embodiments of the utility model, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative labor.

[0048] Figure 1 The structural schematic diagram of embodiment one provided by the utility model is shown in the drawing;

[0049] Figure 2 The structural schematic diagram of support assembly in embodiment one is shown in the drawing;

[0050] Figure 3 The structural schematic diagram of first guide plate in embodiment one is shown in the drawing;

[0051] Figure 4 The structural schematic diagram of embodiment two provided by the utility model is shown in the drawing;

[0052] Figure 5 The structural schematic diagram of another angle is shown in the drawing; Figure 4 The structural schematic diagram of another angle is shown in the drawing;

[0053] Figure 6 The structural schematic diagram of second guide plate in embodiment one and embodiment two is shown in the drawing;

[0054] Figure 7 Structure schematic view of embodiment three provided by the utility model;

[0055] Figure 8 Exploded view of embodiment three structure;

[0056] Figure 9 Part structure schematic view of embodiment three;

[0057] Figure 10 For Figure 9 Another angle structure schematic view;

[0058] Figure 11 Structure schematic view of second guide plate in embodiment three;

[0059] Figure 12 Structure schematic view of embodiment four provided by the utility model;

[0060] Figure 13 For Figure 12 Another angle structure schematic view;

[0061] Figure 14 Structure schematic view of support assembly in embodiment four;

[0062] Figure 15 For Figure 14 Enlarged view of round table part structure;

[0063] Figure 16 Structure schematic view of rotating ruler main body in embodiment four;

[0064] Figure 17 Structure schematic view of needle holder in embodiment four;

[0065] Figure 18 Enlarged view of needle holder bottom structure in embodiment four;

[0066] Figure 19 Structure schematic view of positioning needle with hose in embodiment four;

[0067] Figure 20 Structure schematic view of embodiment five provided by the utility model;

[0068] Figure 21 For Figure 20 Another angle structure schematic view;

[0069] Figure 22 For Figure 20 Another angle structure schematic view;

[0070] Figure 23 Structure schematic view of lifting plate main body in embodiment five;

[0071] Figure 24 is a second pointer part structure enlarged view in the embodiment five;

[0072] Figure 25 is a structure schematic view of the needle seat in the embodiment five;

[0073] Figure 26 is a structure schematic view of the spoon-shaped cutter in the embodiment five.

[0074] Wherein:

[0075] 1-plate, 2-positioning column, 3-positioning needle, 4-puncture through hole, 5-first guide rod, 6-first connecting piece, 7-first threaded rod, 8-first rotating handle, 9-second guide rod, 10-second connecting piece, 11-second threaded rod, 12-second rotating handle, 13-first guide plate, 14-through hole, 15-threaded hole, 16-bottom plate, 17-carriage main body, 18-second guide plate, 19-front plate, 20-lifting plate main body, 21-mounting portion, 22-circular table portion, 23-connecting plate, 24-rotary ruler main body, 25-tower fixing piece, 26-moving groove, 27-needle seat, 28-assembly groove, 29-first pointer, 30-hose, 31-first locking piece, 32-second locking piece, 33-spoon-shaped cutter, 34-optical axis, 35-second pointer, 36-fixing plate, 37-moving plate. DETAILED DESCRIPTION

[0076] The technical solutions in the embodiments of the present application will be described clearly and completely in the following with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0077] In order to make the person skilled in the art better understand the present application, the present application will be further described in detail below with reference to the drawings and specific embodiments.

[0078] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left" and "right" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the indicated position or element must have a specific orientation, constitute and operate in a specific orientation, therefore it cannot be understood as a limitation of the present application.

[0079] The utility model aims at providing a kind of ex vivo prostate pathological tissue positioning mark and material taking device, can be positioned and marked according to the data obtained by mpMRI and 3D model to the lesion position, and then accurately take out prostate pathological tissue quickly.

[0080] To achieve the above object, the utility model provides the following technical scheme:

[0081] Please refer to Figures 1 to 26 The utility model provides a kind of ex vivo prostate pathological tissue positioning mark, comprising: support assembly, positioning guide component and several positioning needles 3;Support assembly, including supporting plate 1 and positioning column 2, positioning column 2 is used to be arranged in prostate urethra to fix prostate;Positioning guide component is installed on support assembly, and scale for positioning prostate lesion is provided on positioning guide component;Several positioning needles 3 are arranged in prostate on positioning column 2 by positioning guide component, and the lesion in prostate is positioned and marked.

[0082] Specifically, support assembly includes supporting plate 1 and positioning column 2, supporting plate 1 is used to carry remaining parts or the prostate to be positioned, and positioning column 2 is used to pass through prostate urethra, and prostate urethra is used as the reference to position prostate, and scale is provided on positioning guide component in each direction, so that the lesion position related data is read out by mpMRI and 3D model, then positioning needle 3 is inserted into the lesion position by using scale under the assistance of positioning guide component, and then identification fluid is injected into positioning needle 3, and the lesion position is marked, so that the lesion position can be easily found when sampling the lesion subsequently, and too much time is not wasted to find the lesion position so as to damage prostate specimen.

[0083] This paper provides embodiment one, as shown in Figure 1 、 Figure 2 、 Figure 3 And Figure 6 In embodiment one, supporting plate 1 is used as the basis of the whole device to carry remaining parts and the prostate to be positioned, and the supporting plate 1 in embodiment one is square plate structure;Positioning column 2 is vertically installed on supporting plate 1, and 13x13 square matrix composed of puncture through hole 144 is arranged on the upper side of supporting plate 1 with positioning column 2 as center, and the spacing between every two puncture through holes 144 is 5mm, and in order to facilitate positioning needle 3 to be accurately inserted according to the data of lesion position, scale is further arranged at the edge of puncture through hole 144 square matrix, so that the position of prostate can be accurately judged by prostate urethra as reference in the embodiment.

[0084] The support assembly in the embodiment one further comprises two first guide rods 5, a first threaded rod, two second guide rods 9 and a second threaded rod 11, as shown in detail in Figure 2 two first guide rods 5 are vertically installed on one side of the supporting plate 1, and the top of the two first guide rods 5 are connected by a first connecting piece 6; at the same time, the first threaded rod is also vertically installed on the supporting plate 1 and located between the two first guide rods 5, the top of the first threaded rod penetrates the first connecting piece 6, and the penetrated part is provided with a first rotating handle 8, which can rotate the first threaded rod; the two second guide rods 9 are arranged in the first connecting piece 6 and parallel to the supporting plate 1, that is, the second guide rods 9 are perpendicular to the first guide rods 5, and the second guide rods 9 extend towards the puncture hole 144 square array; similarly, the end of the two second guide rods 9 close to the positioning column 2 is provided with a second connecting piece 10, the second threaded rod 11 is located between the two second guide rods 9 and penetrates the first connecting piece 6, and the end of the second threaded rod 11 penetrating the first connecting piece 6 is provided with a second rotating handle 12, which can also rotate the second threaded rod 11.

[0085] Further, the positioning and guiding assembly comprises a first guide plate 13 and a second guide plate 18; the first guide plate 13 is in a U-shaped structure as a whole, the bottom of the U-shaped part is movably sleeved on the outer periphery of the first guide rod 5 and the first threaded rod, that is, the first guide plate 13 is provided with a through hole 14 for the first guide rod 5 to pass through and a threaded hole 15 for the first threaded rod to pass through on the bottom of the U-shaped part, at the same time, the first guide plate 13 is also provided with a 13x13 puncture hole 144 square array with scales on the two side plates of the U-shaped part, wherein the first guide plate 13 can move up and down under the driving of the first threaded rod when the first rotating handle 8 is rotated.

[0086] At the same time, the second guide plate 18 is also movably sleeved on the outer periphery of the second guide rod 9 and the second threaded rod 11, wherein the second guide plate 18 comprises a front plate 19 for abutting the prostate positioned on the positioning column 2, the front plate 19 is provided with a puncture hole 144 square array with scales, and the bottom end of the front plate 19 is attached to the supporting plate 1; wherein the second guide plate 18 can move left and right under the driving of the second threaded rod 11 when the second rotating handle 12 is rotated.

[0087] That is, in embodiment one, first rotate the first rotating handle 8 to move the first guide plate 13 to the top, then fix the prostate on the positioning column 2, and then lower the first guide plate 13 to the upper surface of the supporting plate 1, and then rotate the second rotating handle 12 to make the front plate 19 of the second guide plate 18 close to the prostate, so that the front plate 19 with the square array of puncture through holes 144 abuts against the prostate, and finally according to the lesion position read by mpMRI and 3D model, the positioning needle 3 is quickly positioned and inserted into the prostate lesion around the puncture through hole 144, and the marking solution is injected for marking; when the marking is completed, the positioning needle 3 is removed, the first guide plate 13 and the second guide plate 18 are removed, and the prostate is removed.

[0088] Embodiment two is provided herein, which is similar in structure to embodiment one, as shown in Figure 4 、 Figure 5 and Figure 6 , the supporting plate 1 in embodiment two is not horizontally arranged, but is arranged at an angle on the bottom plate 16 in the support assembly in this embodiment, and the positioning column 2 in embodiment two is also arranged vertically to the supporting plate 1, but the supporting plate 1 in embodiment two is arranged in a concentric circle structure with the positioning column 2 as the center, that is, a polar coordinate formed by a plurality of circularly divided small holes, and similarly, the square array of puncture through holes 144 in each circle has the same distance, and each puncture through hole 144 can read the accurate position through the scale on the supporting plate 1.

[0089] The support assembly in embodiment two further comprises a bottom plate 16, a bracket body 17, two second guide rods 9 and a second threaded rod 11; the bottom plate 16 in embodiment two is the basis of the entire device, and is used to bear the remaining parts, and the supporting plate 1 is arranged at an angle on the bottom plate 16, and at the same time, the bracket body 17 is also arranged at an angle on the bottom plate 16, but the bracket body 17 is connected vertically to the supporting plate 1; the two second guide rods 9 are arranged through the end of the bracket body 17 away from the supporting plate 1, and are parallel to the supporting plate 1, and extend towards the positioning column 2, and the end of the second guide rod 9 is provided with a second connecting piece 10; similarly, the second threaded rod 11 passes through the top end of the bracket body 17 and is connected to the second connecting piece 10 and is parallel to the second guide rod 9, and the end of the second threaded rod 11 passing through the top end of the bracket body 17 is provided with a second rotating handle 12, and the second rotating handle 12 can drive the second threaded rod 11 to rotate. The positioning and guiding assembly in embodiment two comprises a second guide plate 18, which is the same as the second guide plate 18 in embodiment one.

[0090] The second embodiment adopts polar coordinates to locate the position of the prostate lesion. In addition, the second embodiment is inclined to the supporting plate 1, so that the prostate positioned on the positioning column 2 does not block the polar coordinates arranged on the supporting plate 1, so that the positioning needle 3 cannot accurately penetrate the prostate. Because the supporting plate 1 and the bottom plate 16 are arranged at an angle, the positioning column 3 is also inclined, so that the prostate can block the operator's view, and the operator can more conveniently puncture the prostate from the bottom to the top, thereby improving the accuracy of puncture.

[0091] Provided herein is the third embodiment, as shown in Figures 7 to 11 The third embodiment, the supporting plate 1 is the basis of the whole, carrying the rest of the components; the positioning and guiding assembly includes a first guiding plate 13 and a second guiding plate 18; the first guiding plate 13 is a square structure, vertically fixedly installed on one side of the supporting plate 1, and a square array of puncture through holes 144 with scales is arranged on the plate body of the first guiding plate 13, wherein the positioning column 2 is fixedly installed on the first guiding plate 13. It should be noted that the positioning column 2 is arranged parallel to the supporting plate 1, and the scale on the first guiding plate 13 at the position where the positioning column 2 is installed is 0; and the second guiding plate 18 is movably installed on the supporting plate 1, wherein the second guiding plate 18 is perpendicular to the first guiding plate 13 and the supporting plate 1; specifically, a corresponding notch is arranged on the supporting plate 1, a side groove is arranged at the bottom of the notch, and a boss that can exactly fit the side groove is arranged at the bottom of the second guiding plate 18, so that the installation position of the second guiding plate 18 on the supporting plate 1 can be changed. In addition, screw holes are arranged on both sides of the notch on the supporting plate 1, and corresponding screw holes are arranged on the bottom boss of the second guiding plate 18, so that the second guiding plate 18 can be fixed by screws after assembly. In addition, in the third embodiment, the second guiding plate 18 includes a fixed plate 36 and a movable plate 37 embedded in the fixed plate 36. When the movable plate 37 and the fixed plate 36 are assembled, a puncture through hole 144 is arranged between the gap of the two plates. In this way, when the second guiding plate 18 is in a complete state, the second guiding plate 18 can guide the positioning needle 3 to pass through the puncture through hole 144. Similarly, the puncture through hole 144 on the second guiding plate 18 is also provided with scales.

[0092] After the third embodiment marks the position of the prostate pathological puncture, the movable plate 37 can be removed, the positioning needle 3 penetrating the center of the lesion can be removed together with the prostate from the fixed plate 36, so that the subsequent scalpel can cut along the positioning needle 3 in the center of the lesion.

[0093] Provided herein is the fourth embodiment, as shown in Figures 12 to 19 The positioning column 2 in the fourth embodiment is also vertically arranged on the supporting plate 1, and can be positioned based on the urethra of the prostate. The support assembly in the fourth embodiment includes a bracket main body 17, two first guide rods 5, a first threaded rod, and a lifting main body.

[0094] Specifically, as shown in Figures 12 to 14 the bracket body 17 is a square frame structure, vertically arranged on one side of the supporting plate 1, and two first guide rods 5 are arranged in parallel in the bracket body 17 and vertically to the supporting plate 1, a first threaded rod is arranged between the two first guide rods 5, and the first threaded rod passes through the top end of the bracket body 17, and the top end through which the first threaded rod passes is provided with a first rotating handle 8, so that the rotation of the first threaded rod can be driven by rotating the first rotating handle 8; further, a lifting plate body 20 is sleeved on the first guide rod 5 and the first threaded rod, and the lifting plate body 20 can move up and down with the rotation of the first threaded rod; specifically, the lifting plate body 20 is in a T-shaped structure as a whole, and the lifting plate body 20 includes a mounting portion 21, a circular table portion 22, and a connecting plate 23 connecting the mounting portion 21 and the circular table portion 22, the mounting portion 21 is movably sleeved on the outer circumference of the first guide rod 5 and the first threaded rod, the mounting portion 21 is provided with a through hole 14 corresponding in position for passing through the first guide rod 5, and a threaded hole 15 for passing through the first threaded rod, the circular table portion 22 is arranged at the end of the connecting plate 23 away from the mounting portion 21, the circular table portion 22 is in a circular structure, and a scale is arranged on the outer circumference thereof, as shown in Figure 15 .

[0095] In addition, the positioning guide assembly in embodiment four includes a rotating ruler body 24 and a needle holder 27; the rotating ruler body 24 is rotatably mounted at the center of the lower side of the circular table portion 22 through a boss fixing piece 25, as shown in Figure 16 , the rotating ruler body 24 is in a rectangular structure, and scales and moving grooves 26 are arranged on the two sides thereof, the moving grooves 26 facilitate the movement of the needle holder 27 and the reading of the rotating angle of the rotating ruler body 24 from the circular table portion 22, and a straight line is arranged on the upper side of the rotating ruler body 24 above the rotating center; the needle holder 27 is in a frame structure, and the top thereof is movably connected to the rotating ruler body 24; specifically, the top of the needle holder 27 is connected to the rotating ruler body 24 through an assembly groove 28 which can cooperate with the moving groove 26, and a first pointer 29 for reading the scale on the rotating ruler body 24 is arranged on the top of the needle holder 27, and the first pointer 29 can confirm the sliding distance of the needle holder 27 in the moving groove 26 of the rotating ruler body 24.

[0096] And in the needle seat 27 bottom is provided with a square array of puncture through hole 144 arranged in concentric circles, namely, there is an equidistantly enlarged circle scale at the bottom of the needle seat 27, and there are equidistant puncture through holes 144 on each circle edge line, a positioning needle 3 with a hose 30 at the tail end is arranged in each puncture through hole 144, and the positioning needle 3 can be filled with marking liquid through the hose 30 nozzle; In addition, in order to be able to stably position and mark, a first locking member 31 for locking the rotation of the rotating ruler body 24 is arranged on the circular table part 22, and a second locking member 32 for locking the movement of the needle seat 27 is arranged on the top of the needle seat 27, wherein the first locking member 31 and the second locking member 32 are screw rods, the first locking member 31 is rotated downward until it abuts against the rotating ruler body 24, and the second locking member 32 is moved upward until it abuts against the lower side of the rotating ruler body 24, so as to prevent the rotation of the rotating ruler body 24 and the movement of the needle seat 27.

[0097] In addition, the positioning and guiding assembly in embodiment four further comprises a first guiding plate 13 vertically arranged on the supporting plate 1, the first guiding plate 13 is located on the side away from the bracket body 17, and a square array of puncture through holes 144 for the positioning needle 3 to pass through and with scales is arranged on the first guiding plate 13.

[0098] In embodiment four, the center of the circular table part 22 of the lifting plate body 20, the center hole of the bottom of the needle seat 27 and the positioning column 2 are the same axis when the zero scale, in use, the rotating ruler can be rotated according to the polar coordinate point of the lesion center and the needle seat 27 can be translated to make the center hole of the bottom of the needle seat 27 align with the lesion center, and the biopsy puncture needle is inserted into the needle seat 27 and the prostate according to the size of the lesion and the marking liquid is injected, this embodiment only needs to position the lesion center position, the operation is convenient, simple and intuitive, and a lot of time required for pathological removal is reduced.

[0099] The present application also provides an ex vivo prostate pathological tissue sampling device, as shown in Figures 20 to 26 The present application also provides an ex vivo prostate pathological tissue sampling device, as shown in

[0100] Specifically, the bottom of the needle seat 27 in embodiment five is different from that in embodiment four, the bottom of the needle seat 27 in embodiment five is provided with a through hole for mounting the spoon-shaped cutter 33, and a driving member is arranged on one side of the through hole. It should be noted that a bearing is arranged in the through hole, so that the spoon-shaped cutter 33 is more easily rotated under the action of the driving member. The spoon-shaped cutter 33 comprises a rod body and a cutter mounted at the bottom end of the rod body, the end of the rod body away from the cutter can be arranged in the through hole in the bottom of the needle seat 27, and a connecting member cooperating with the driving member is arranged on the rod body close to the end.

[0101] In order to enable the spoon-shaped cutter 33 to be accurately inserted into the target lesion position in the present embodiment, the length of the rod body of the spoon-shaped cutter 33 and the rigidity of the cutter can be as long as possible, so that the spoon-shaped cutter 33 is not easy to deviate in position when being inserted downward into the lesion. In addition, the cutter at the bottom end of the spoon-shaped cutter 33 in the present embodiment is specifically in a spoon-shaped structure, so that when the spoon-shaped cutter 33 is rotated, the ice cover can be completely removed and the surrounding normal tissue will not be damaged. In addition, the cutter at the bottom end of the spoon-shaped cutter 33 can be designed and changed in size according to the size of the lesion, which is not limited herein.

[0102] In addition, in order to be able to judge the distance of each downward movement of the spoon-shaped cutter 33, a scale is arranged on the side of the bracket main body 17 in embodiment five, and a vertical optical axis 34 is arranged on the lower side of the mounting portion 21 of the lifting plate main body 20. A second pointer 35 is mounted on the optical axis 34, and the second pointer 35 can point to the scale on the bracket main body 17 in the mounted state. Of course, the embodiment five needs to be calibrated before use, that is, the spoon-shaped cutter 33 is first lowered so that the cutter tip touches the upper surface of the bracket, and then the second pointer 35 is moved to the zero scale line to complete the calibration.

[0103] In embodiment five, the center of the circular table portion 22 of the lifting plate main body 20, the through hole 14 in the bottom of the needle seat 27, the spoon-shaped cutter 33 and the positioning column 2 are the same axis at zero scale. In use, according to the lesion center position data provided by the mpMRI and the 3D model, that is, according to the distance between the lesion and the ground and the polar coordinate point of the lesion center, the rotating ruler is rotated and the needle seat 27 is translated to make the spoon-shaped cutter 33 align with the lesion center position, and then the spoon-shaped cutter 33 is lowered to the inside of the lesion to rotate and cut off, so that the spoon-shaped cutter 33 can cut off the complete lesion from the prostate. Embodiment five only needs to position the lesion center position and the bottom surface position, and the lesion positioning and lesion cutting are in the same step, without the need to inject a marking liquid and remove the prostate to perform the cutting step, which greatly reduces the operation steps of finding the lesion peripheral position, saves a lot of pathological removal time, and can better preserve the nucleic acid and other substances required for scientific research.

[0104] It should be noted that the relative terms, such as first and second, are used herein solely to distinguish one entity from another entity, and do not necessarily require or imply any actual relationship or order between such entities.

[0105] The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the difference from other embodiments, and the same or similar parts between the various embodiments can be referred to each other.

[0106] The above provides a detailed description of the embodiments of the present application. The principle and implementation of the present application are described by applying specific examples. The above description of the embodiments is only used to help understand the method and core idea of the present application. It should be pointed out that for ordinary skilled in the art, without departing from the principle of the present application, the present application can be improved and modified in several ways, and these improvements and modifications also fall within the protection scope of the claims of the present application.

Claims

1. An ex vivo prostate pathologic tissue localization marker, comprising, The utility model relates to a kind of prostate needle positioning device, including: Support assembly, including supporting plate (1) and positioning column (2), the positioning column (2) is configured as positioning reference, for the urethra of prostate is fixed prostate is passed through; Positioning guide assembly is installed on the support assembly, and the positioning guide assembly is provided with scale for positioning the position of the prostate tumor in vivo of the prostate; Several positioning needles (3) are passed through the prostate positioned on the positioning column (2) by the positioning guide assembly, and are used for positioning and identifying the lesion in vivo of the prostate.

2. The ex vivo prostate pathologic tissue localization marker of claim 1, wherein, The positioning column (2) is vertically arranged on the supporting plate (1), and the supporting plate (1) is centrally arranged with a square array of puncture through holes (4) with scales around the positioning column (2), and the puncture through holes (4) are used for the penetration of the positioning needle (3); The support assembly further includes: Two first guide rods (5) are vertically installed on the supporting plate (1), and the top of the two first guide rods (5) is provided with a first connecting piece (6); A first threaded rod (7) is vertically installed on the supporting plate (1) and located between the two first guide rods (5), and the top of the first threaded rod (7) penetrates the first connecting piece (6) and is provided with a first rotating handle (8); Two second guide rods (9) are penetrated in the first connecting piece (6), and the second guide rods (9) are parallel to the supporting plate (1), and the end of the two second guide rods (9) close to the positioning column (2) is provided with a second connecting piece (10); A second threaded rod (11) is penetrated in the first connecting piece (6) and connected to the second connecting piece (10) and parallel to the second guide rod (9), and the end away from the second connecting piece (10) is provided with a second rotating handle (12).

3. The ex vivo prostate pathologic tissue localization of claim 2, wherein, The positioning guide assembly includes: A first guide plate (13) in U-shaped structure is movably sleeved on the outer periphery of the first guide rod (5) and the first threaded rod (7), the bottom plate (16) of the first guide plate (13) is provided with a through hole (14) for penetrating the first guide rod (5) and a threaded hole (15) for penetrating the first threaded rod (7), and the two side plates of the first guide plate (13) are provided with a square array of puncture through holes (4) with scales.

4. The ex vivo prostate pathologic tissue localization of claim 1, wherein, The supporting plate (1) is centrally arranged with a square array of puncture through holes (4) with scales in concentric circles around the positioning column (2), and the puncture through holes (4) are used for the penetration of the positioning needle (3); The support assembly further includes: The supporting plate (1) is angularly arranged on the bottom plate (16); A bracket body (17) is angularly arranged on the bottom plate (16), and the bracket body (17) is vertically connected with the supporting plate (1); Two second guide rods (9) are penetrated in the end of the bracket body (17) away from the supporting plate (1), and the second guide rods (9) are parallel to the supporting plate (1), and the end of the second guide rods (9) is provided with a second connecting piece (10). A second threaded rod (11) is connected to the second connecting piece (10) through the top end of the bracket body (17) and is parallel to the second guide rod (9), and the end of the second threaded rod (11) away from the second connecting piece (10) is provided with a second rotating handle (12).

5. The ex vivo prostate pathologic tissue localization marker of claim 3 or 4, wherein, The positioning guide assembly comprises a second guide plate (18) movably sleeved on the outer periphery of the second guide rod (9) and the second threaded rod (11), and the second guide plate (18) comprises a front plate (19) for abutting against the prostate positioned on the positioning column (2), wherein the front plate (19) is provided with a square array of puncture through holes (4) with scales, and the bottom end of the front plate (19) is attached to the supporting plate (1).

6. The ex vivo prostate pathologic tissue localization of claim 1, wherein, The positioning guide assembly comprises: A first guide plate (13) in a square structure is vertically fixedly installed on the supporting plate (1), the side surface of the first guide plate (13) is provided with a square array of puncture through holes (4) with scales, the positioning column (2) is fixedly installed on the first guide plate (13), and the positioning column (2) is perpendicular to the first guide plate (13); A second guide plate (18) is movably installed on the supporting plate (1), the second guide plate (18) is perpendicular to the first guide plate (13) and the supporting plate (1), the second guide plate (18) comprises a fixed plate (36) and a moving plate (37) embedded in the fixed plate (36), and the fixed plate (36) and the moving plate (37) are vertically provided with the puncture through holes (4) for the positioning needle (3) to pass through and with scales.

7. The ex vivo prostate pathologic tissue localization of claim 1, wherein, The positioning column (2) is vertically provided on the supporting plate (1); The bracket assembly further comprises: A bracket body (17) in a square frame structure is provided on one side of the supporting plate (1); Two first guide rods (5) are vertically provided in the bracket body (17); A first threaded rod (7) is vertically provided between the two first guide rods (5), the top end of the first threaded rod (7) penetrates through the bracket body (17), and the top end of the first threaded rod (7) is provided with a first rotating handle (8); An elevating plate body (20) in a T-shaped structure comprises an installation part (21), a circular table part (22), and a connecting plate (23) connecting the installation part (21) and the circular table part (22), the installation part (21) is movably sleeved on the outer periphery of the first guide rod (5) and the first threaded rod (7), the installation part (21) is provided with a through hole (14) for the first guide rod (5) to pass through and a threaded hole (15) for the first threaded rod (7) to pass through, the circular table part (22) is provided at the end of the connecting plate (23) away from the installation part (21), the circular table part (22) is in a circular structure, and the outer periphery thereof is provided with scales.

8. The ex vivo prostate pathologic tissue localization of claim 7, wherein, The positioning guide assembly comprises: A rotating ruler body (24) is rotatably installed at the center of the lower side of the circular table part (22) through a boss fixing part (25), the rotating ruler body (24) is a square structure, and two sides of the rotating ruler body (24) are provided with scales and a moving groove (26); A needle seat (27) is movably connected to the rotating ruler body (24), the top of the needle seat (27) is provided with a fitting groove (28) matched with the moving groove (26), and a first pointer (29) is arranged to facilitate reading the scales on the rotating ruler body (24).

9. The ex vivo prostate pathologic tissue localization of claim 8, wherein, The bottom of the needle seat (27) is provided with a square array of puncture through holes (4) arranged in concentric circles; The tail end of the positioning needle (3) is connected with a hose (30) for injection of identification liquid; The circular table part (22) is provided with a first locking part (31) for locking the rotation of the rotating ruler body (24), and the top of the needle seat (27) is provided with a second locking part (32) for locking the movement of the needle seat (27); The positioning and guiding assembly further comprises a first guiding plate (13) vertically arranged on the supporting plate (1), the first guiding plate (13) is located on the side away from the bracket body (17), and the first guiding plate (13) is provided with a square array of puncture through holes (4) for the positioning needle (3) to pass through and with scales.

10. A device for extracting pathological tissue from an ex vivo prostate, characterized in that, The positioning and identification device comprises the positioning and identification device according to claim 8, and further comprises: A spoon-shaped cutter (33) is rotatably installed at the bottom end of the needle seat (27); A scale vertically extends outside the bracket body (17); A light axis (34) is vertically installed at the lower side of the mounting part (21), and a second pointer (35) is movably arranged on the light axis (34), and the second pointer (35) is used to indicate the scale outside the bracket body (17).

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