Colloid osmotic pressure tester

Abstract

The utility model discloses a colloid osmotic pressure tester which comprises a shell, and a semi-permeable membrane replacement mechanism, a machine body auxiliary module and a controller which are arranged in the shell, the semi-permeable membrane replacement mechanism is detachably connected with a semi-permeable membrane fixing device and a reagent bag, and a semi-permeable membrane is arranged in the semi-permeable membrane fixing device; the controller is in communication connection with the semi-permeable membrane replacement mechanism and the machine body auxiliary module, and the machine body auxiliary module is used for inputting and outputting information, controlling the semi-permeable membrane replacement mechanism to drive the semi-permeable membrane fixing device and the reagent bag to automatically pop up, and adding a sample into the semi-permeable membrane fixing device for osmotic pressure measurement. The semi-permeable membrane replacing mechanism drives the semi-permeable membrane fixing device to turn over, so that the semi-permeable membrane fixing device is convenient to replace, the internal semi-permeable membrane is further replaced, the reagent bag is rapidly replaced, the mounting process is simplified, automatic control is realized, and the working efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of medical equipment, in particular to a colloid osmotic pressure measuring instrument. BACKGROUND

[0002] The colloid osmotic pressure measuring instrument is a kind of widely used medical instrument, is used for the osmotic pressure detection of colloid, carries out the immune situation inspection analysis to human body by detecting patient's plasma or whole blood, and the colloid osmotic pressure is generated by macromolecular solute such as protein in plasma, it regulates and controls the exchange and balance of water in and out of capillary, thus the determination of colloid osmotic pressure becomes an indispensable detection index in the monitoring, diagnosis, treatment and prognosis judgment of diseases such as pulmonary edema, cerebral edema and pregnancy-induced hypertension syndrome.

[0003] Among them, the semi-permeable membrane is an important component to realize the above functions, the protein in the sample cannot pass through the semi-permeable membrane, so in the process of measuring the colloid osmotic pressure value of the sample, due to the existence of colloid osmotic pressure, the sample will absorb ions and small molecules on the other side of the semi-permeable membrane to offset the colloid osmotic pressure value, so the semi-permeable membrane needs to be replaced when it reaches the service life.

[0004] In the prior art, the semi-permeable membrane replacement method is: first, immerse the semi-permeable membrane to completely wet, then manually unscrew the screw cap above the semi-permeable membrane, take out the sealing ring and old semi-permeable membrane, clean the cavity below the semi-permeable membrane, and inject reference liquid, then install the new semi-permeable membrane, install the sealing ring, and tighten the screw cap. The above semi-permeable membrane replacement method makes the semi-permeable membrane replacement process complex, has high failure rate caused by too much human operation, and takes long time to replace. Generally, the semi-permeable membrane is cleaned manually, which not only can easily damage the semi-permeable membrane, but also can cause the semi-permeable membrane to be not cleaned, and more importantly, cleaning liquid needs to be provided separately, and the waste liquid of measurement and cleaning also cannot be collected, so that the cleaning process is complex and the work efficiency is reduced.

[0005] Therefore, how to provide a colloid osmotic pressure measuring instrument capable of quickly and efficiently replacing the semi-permeable membrane is a technical problem to be solved by those skilled in the art at present. UTILITY MODEL CONTENTS

[0006] The utility model aims at providing a colloid osmotic pressure measuring instrument, which drives the semi-permeable membrane fixing device to overturn through the semi-permeable membrane replacement mechanism, facilitates the replacement of the semi-permeable membrane fixing device, further replaces the internal semi-permeable membrane, quickly replaces the reagent package, simplifies the installation process, realizes automatic control, and improves the work efficiency.

[0007] In order to solve the above technical problems, the utility model provides a kind of colloid osmotic pressure determination instrument, including shell and be installed in the semi-permeable membrane replacement mechanism of shell, body auxiliary module and controller, the semi-permeable membrane replacement mechanism detachably connects semi-permeable membrane fixing device and reagent package, semi-permeable membrane is provided in the semi-permeable membrane fixing device, the controller communication connection semi-permeable membrane replacement mechanism and the body auxiliary module, the body auxiliary module is used for information input and output, controls semi-permeable membrane replacement mechanism drive semi-permeable membrane fixing device and reagent package automatic pop, and sample is added semi-permeable membrane fixing device and carries out osmotic pressure determination.

[0008] Preferably, the semi-permeable membrane replacement mechanism includes a base plate and an installation platform mounted above the base plate, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, the installation platform is detachably mounted with the semi-permeable membrane fixing device, a conveying mechanism communicating with the inside of the semi-permeable membrane fixing device is provided below the installation platform, the reagent driving structure is connected to the conveying mechanism through the flow control mechanism, for inputting or discharging different reagents into the inside of the semi-permeable membrane fixing device, the replacement driving mechanism is connected to the installation platform through the transmission mechanism, for driving the installation platform to overturn forward to make the upper end of the semi-permeable membrane fixing device tilt forward, or for driving the installation platform to overturn backward to restore the semi-permeable membrane fixing device to the vertical state.

[0009] Preferably, the replacement driving mechanism is a vertical linear motor, the transmission mechanism includes a base, a transmission plate and a connecting rod, the installation platform is located at the front end of the base plate, the base is located at the rear end of the base plate, the installation platform is hinged to the base plate, the rear end of the transmission plate is hinged to the base, the lower surface of the middle part of the transmission plate is provided with a sliding groove, the upper end of the lead screw of the linear motor is connected with a transmission shaft, the transmission shaft is installed in the sliding groove, the upper end of the connecting rod is hinged to the front end of the transmission plate, and the lower end of the connecting rod is hinged to the rear end of the installation platform.

[0010] Preferably, the reagent package is detachably mounted below the base plate, a puncture needle is inserted into the reagent package below the base plate, the flow control mechanism is connected to the reagent package through the puncture needle, a movable buckle is provided below the base plate, the movable buckle is clamped with the upper end of the reagent package, the lower end of the lead screw of the linear motor can trigger the movable buckle to unlock to pop out the reagent package.

[0011] Preferably, the semi-permeable membrane fixing device comprises a reference chamber container and a measuring chamber container, the reference chamber container is provided with a reference cavity, the measuring chamber container is provided with a measuring cavity and a liquid pipeline connected to the measuring cavity, the reference chamber container is installed below the measuring chamber container, the upper end of the reference cavity is connected to the lower end of the measuring cavity, a support sieve plate is installed on the upper end of the reference cavity, a semi-permeable membrane is covered on the support sieve plate, and a connecting structure for detachably connecting a reference chamber working hole of a colloidal osmotic pressure measuring instrument is arranged on the outer periphery of the reference chamber container.

[0012] Preferably, the reagent bag comprises a box body and an upper cover detachably connected to the upper end opening of the box body, a plurality of reagent bags are installed in the box body, a plurality of delivery holes are arranged on the upper cover, a sealing rubber plug is installed in each delivery hole, a delivery tube is connected to the rear end of each sealing rubber plug, each delivery tube is connected to a plurality of reagent bags, respectively, a docking structure for detachably connecting a main body of the measuring instrument is arranged on the upper end surface of the upper cover, and a plurality of puncture needles below the main body of the measuring instrument are respectively inserted through each sealing rubber plug to connect each reagent bag.

[0013] Preferably, the docking structure comprises a buckle groove arranged in the middle of the upper end surface of the upper cover and a guide groove arranged at both ends of the upper end surface of the upper cover in the length direction, and a guide rail groove is arranged on the lower end surface of the box body, and the buckle groove, the guide groove and the guide rail groove all extend in the width direction.

[0014] Preferably, the body auxiliary module comprises a first diaphragm pump, a second diaphragm pump and a gas-liquid separation bottle, the first diaphragm pump is connected to the inside of the semi-permeable membrane fixing device and the upper end of the gas-liquid separation bottle, respectively, the second diaphragm pump is connected to the lower end of the gas-liquid separation bottle and the reagent bag, respectively.

[0015] Preferably, the body auxiliary module further comprises a filter, a network extension line, a code scanner, a thermal printer and a screen, the filter is used to filter out interference frequencies and provide stable voltage, the code scanner is used for information input, and the screen is used for operating software and displaying measurement results.

[0016] Preferably, the screen is arranged above the shell, the code scanner and the thermal printer are arranged on the front face of the shell, a window is arranged on the front face of the shell, a door is installed at the window, and the semi-permeable membrane fixing device can be stretched out of the window.

[0017] The utility model provides a kind of colloidal osmotic pressure determination appearance, including shell and be installed in the semi-permeable membrane replacement mechanism of shell, body auxiliary module and controller, semi-permeable membrane replacement mechanism detachably connects semi-permeable membrane fixing device and reagent package, semi-permeable membrane fixing device is provided with semi-permeable membrane, controller communication connection semi-permeable membrane replacement mechanism and body auxiliary module, body auxiliary module is used for information input and output, control semi-permeable membrane replacement mechanism drives semi-permeable membrane fixing device and reagent package automatic pop-up, and sample is added semi-permeable membrane fixing device and carries out osmotic pressure determination.

[0018] When semi-permeable membrane needs to be replaced, semi-permeable membrane replacement mechanism drives semi-permeable membrane fixing device to automatically pop up, extends installation position, conveniently takes out old semi-permeable membrane fixing device, then installs new semi-permeable membrane fixing device, semi-permeable membrane replacement mechanism drives semi-permeable membrane fixing device to reset, and semi-permeable membrane fixing device restores to vertical state, when reagent package needs to be replaced, semi-permeable membrane replacement mechanism drives old reagent package, then installs new reagent package.

[0019] Semi-permeable membrane replacement mechanism drives semi-permeable membrane fixing device to overturn, conveniently replaces semi-permeable membrane fixing device, further replaces internal semi-permeable membrane, and quickly replaces reagent package, simplifies installation process, realizes automatic control, and improves work efficiency. DRAWINGS

[0020] Figure 1 It is a structure schematic view of one specific embodiment of the colloidal osmotic pressure determination appearance provided by the utility model;

[0021] Figure 2 It is the structure schematic view of semi-permeable membrane replacement mechanism in one specific embodiment of the colloidal osmotic pressure determination appearance provided by the utility model;

[0022] Figure 3 It is the section schematic view of semi-permeable membrane replacement mechanism in one specific embodiment of the colloidal osmotic pressure determination appearance provided by the utility model;

[0023] Figure 4 It is the bottom view schematic view of semi-permeable membrane replacement mechanism in one specific embodiment of the colloidal osmotic pressure determination appearance provided by the utility model;

[0024] Figure 5 It is the internal structure schematic view of semi-permeable membrane fixing device in one specific embodiment of the colloidal osmotic pressure determination appearance provided by the utility model;

[0025] Figure 6 It is the external structure schematic view of semi-permeable membrane fixing device in one specific embodiment of the colloidal osmotic pressure determination appearance provided by the utility model;

[0026] Figure 7A cross section schematic view of the reference chamber container of the semi-permeable membrane fixing device in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0027] Figure 8 A cross section schematic view of the measuring chamber container of the semi-permeable membrane fixing device in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0028] Figure 9 A top view schematic view of the support sieve plate of the semi-permeable membrane fixing device in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0029] Figure 10 A structure schematic view of the reagent bag in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0030] Figure 11 A decomposition schematic view of the reagent bag in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0031] Figure 12 A bottom view schematic view of the upper cover of the reagent bag in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0032] Figure 13 A side view cross section view of the upper cover of the reagent bag in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0033] Figure 14 An installation schematic view of the support plate of the reagent bag in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0034] Figure 15 A bottom view schematic view of the support plate of the reagent bag in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0035] Figure 16 An internal structure schematic view of one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model;

[0036] Figure 17 A structure schematic view of the controller in one specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model.

[0037] Among them, the shell 1, the semi-permeable membrane replacement mechanism 2, the machine body auxiliary module 3, the controller 4, the semi-permeable membrane fixing device 5, the reagent bag 6;

[0038] Base plate 2-1, mounting platform 2-2, linear motor 2-4, base 2-5, transmission plate 2-6, connecting rod 2-7, sliding groove 2-8, lead screw 2-9, transmission shaft 2-10, sealing column 2-11, peristaltic pump 2-12, pinch valve 2-13, sample adding handle 2-14, movable buckle 2-15, puncture needle 2-16, guide hook 2-17;

[0039] Reference chamber container 5-1, upper sealing section 5-11, sieve plate mounting section 5-12, upper conical transition section 5-13, middle section 5-14, lower conical transition section 5-15, lower sealing section 5-16, annular groove 5-17, limiting step 5-18, measuring chamber container 5-2, measuring cavity 5-21, mounting hole 5-22, process hole 5-23, boss 5-24, support sieve plate 5-3, sieve hole 5-31, semi-permeable membrane 5-4, upper sealing ring 5-5, plug 5-6, lower sealing ring, connecting plate 5-7, conduit 5-8, silica gel tube 5-9;

[0040] Box body 6-1, upper cover 6-2, reagent bag 6-3, conveying hole 6-4, sealing rubber plug 6-5, conveying pipe 6-6, one-way valve 6-7, mounting seat 6-8, clamping jaw 6-9, buckle groove 6-10, guide groove 6-11, guide rail groove 6-12, buckle structure 6-13, support plate 6-14. DETAILED DESCRIPTION

[0041] The core of the utility model discloses a kind of colloidal osmotic pressure determination instruments, by semi-permeable membrane replacement mechanism drive semi-permeable membrane fixing device overturn, it is convenient to replace semi-permeable membrane fixing device, to replace internal semi-permeable membrane further, and reagent package is quickly replaced, simplify installation process, realize automatic control, improve work efficiency.

[0042] In order to enable the personnel in the technical field to better understand the utility model scheme, the utility model is further explained in detail below with the specific embodiments and the accompanying drawings.

[0043] Please refer to Figure 1 , Figure 1 It is a specific embodiment structure diagram of the colloidal osmotic pressure determination instrument provided by the utility model.

[0044] A kind of colloidal osmotic pressure determination instrument, it is characterized in that, including shell 1 and the semi-permeable membrane replacement mechanism 2, machine body auxiliary module 3 and controller 4 installed in shell 1, semi-permeable membrane replacement mechanism 2 detachably connect semi-permeable membrane fixing device 5 and reagent package 6, semi-permeable membrane fixing device 5 is provided with semi-permeable membrane 5-4 in, controller 4 is connected with semi-permeable membrane replacement mechanism 2 and machine body auxiliary module 3, machine body auxiliary module 3 is used for information input and output, control semi-permeable membrane replacement mechanism 2 drive semi-permeable membrane fixing device 5 and reagent package 6 automatic pop out, and sample is added semi-permeable membrane fixing device 5 and carries out osmotic pressure determination.

[0045] When the semipermeable membrane needs to be replaced, the semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to pop out automatically and extend from the installation position, making it easy to remove the old semipermeable membrane fixing device. Then, the new semipermeable membrane fixing device is installed. The semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to reset and return to the vertical position. When the reagent pack needs to be replaced, the semipermeable membrane replacement mechanism drives the old reagent pack and then installs the new reagent pack.

[0046] The semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to rotate, facilitating the replacement of the semipermeable membrane fixing device, thereby replacing the internal semipermeable membrane and quickly replacing the reagent pack. This simplifies the installation process, enables automated control, and improves work efficiency.

[0047] Please refer to Figures 2 to 4 , Figure 2 This is a schematic diagram of the semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by this utility model. Figure 3 This is a cross-sectional schematic diagram of the semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by this utility model. Figure 4 This is a bottom view of the semipermeable membrane replacement mechanism in one specific embodiment of the colloid osmotic pressure measuring instrument provided by this utility model.

[0048] The semipermeable membrane replacement mechanism 2-2 includes a horizontally positioned base plate 2-1, an installation platform 2-2 mounted above the base plate 2-1, a reagent driving structure, a flow control mechanism, a replacement driving mechanism, and a transmission mechanism. A semipermeable membrane fixing device is detachably mounted on the installation platform 2-2. This device contains the semipermeable membrane and is a key component for osmotic pressure testing. A conveying mechanism connected to the interior of the semipermeable membrane fixing device is located below the installation platform 2-2, used to deliver reagents into or out of the device. Furthermore, the reagent driving structure is connected to the conveying mechanism via the flow control mechanism, allowing different reagents to enter or exit the semipermeable membrane fixing device. The reagent driving structure provides power for the reagent flow, while the flow control mechanism controls the direction of reagent flow, i.e., the specific flow pattern.

[0049] The replacement drive mechanism is connected to the installation platform 2-2 via the transmission mechanism. When the semi-permeable membrane needs to be replaced, the replacement drive mechanism and transmission mechanism drive the installation platform 2-2 to flip forward, causing the upper end of the semi-permeable membrane fixing device to tilt forward and extend out of the installation position, making it easy to remove the old semi-permeable membrane fixing device. Then, the new semi-permeable membrane fixing device is installed. The replacement drive mechanism and transmission mechanism drive the installation platform 2-2 to flip backward, causing the upper end of the semi-permeable membrane fixing device to flip backward, and the semi-permeable membrane fixing device returns to the vertical position, and the corresponding work continues.

[0050] By replacing the driving mechanism and the transmission mechanism, the semi-permeable membrane fixing device is flipped over, the semi-permeable membrane fixing device is replaced, and the semi-permeable membrane inside the semi-permeable membrane fixing device is replaced, thereby simplifying the installation process, realizing automatic control, and improving work efficiency.

[0051] Specifically, the replacement driving mechanism is a vertically arranged linear motor 2-4, the transmission mechanism includes a base 2-5, a transmission plate 2-6, and a connecting rod 2-7, the front end and the rear end are defined according to the position of the installation platform 2-2, the installation platform 2-2 is located at the front end of the bottom plate 2-1, the base 2-5 is located at the rear end of the bottom plate 2-1, the front end of the installation platform 2-2 is hinged to the bottom plate 2-1, the rear end of the transmission plate 2-6 is hinged to the base 2-5, the lower surface of the middle part of the transmission plate 2-6 is provided with a connecting structure, the connecting structure is provided with a sliding groove 2-8, the upper end of a screw rod 2-9 of the linear motor 2-4 is connected with a transmission shaft 2-10, the transmission shaft 2-10 is installed in the sliding groove 2-8, the upper end of the connecting rod 2-7 is hinged to the front end of the transmission plate 2-6, and the lower end of the connecting rod 2-7 is hinged to the rear end of the installation platform 2-2. The extension direction of the sliding groove 2-8 is parallel to the transmission plate 2-6, the connecting rod 2-7 is a bending piece, and the lower end of the connecting rod 2-7 is bent forward.

[0052] When the semi-permeable membrane inside the semi-permeable membrane fixing device reaches the service life, the semi-permeable membrane needs to be replaced. At this time, the linear motor 2-4 drives the screw rod 2-9 to move upward, drives the transmission shaft 2-10 to move upward, drives the transmission plate 2-6 to move upward while the transmission shaft 2-10 slides in the sliding groove 2-8, and drives the connecting rod 2-7 to move upward, so that the installation platform 2-2 and the semi-permeable membrane fixing device realize flipping motion under the power transmission of the connecting rod 2-7, and swing forward. When it is flipped to the corresponding angle, it will stop moving. At this time, the semi-permeable membrane fixing device that reaches the service life is taken out, and a new semi-permeable membrane fixing device is replaced. At this time, the semi-permeable membrane fixing device is flipped back to the original position to complete the replacement of the semi-permeable membrane fixing device. When the sound of the ball head plunger and the prompt of the touch switch under the semi-permeable membrane fixing device 2-4 are heard during the replacement process, it indicates that the replacement is completed.

[0053] Preferably, the front end of the transmission plate 2-6 is provided with a sealing column 2-11 extending downward. When the semi-permeable membrane needs to be replaced, the replacement driving mechanism and the transmission mechanism drive the installation platform 2-2 to flip forward, and drive the upper end of the semi-permeable membrane fixing device to tilt forward, at the same time, the front end of the installation platform 2-2 drives the sealing column 2-11 to move upward, so that the sealing column 2-11 is separated from the upper end opening of the semi-permeable membrane fixing device. When the replacement is completed, the replacement driving mechanism and the transmission mechanism drive the installation platform 2-2 to flip backward, and drive the upper end of the semi-permeable membrane fixing device to flip backward, so that the semi-permeable membrane fixing device returns to the vertical state, at the same time, the front end of the installation platform 2-2 drives the sealing column 2-11 to move downward, so that the sealing column 2-11 is inserted into the upper end opening of the semi-permeable membrane fixing device, and the corresponding work is continued.

[0054] In the semi-permeable membrane replacement mechanism provided in the specific embodiment of the utility model, the reagent driving structure is a peristaltic pump 2-12. The peristaltic pump 2-12 is composed of a stepping motor and a peristaltic pump head, mainly realizes injection of samples and cleaning liquid into the measuring chamber in the semi-permeable membrane fixing device, the speed of the peristaltic pump 2-12 is adjustable and the precision is high, and the semi-permeable membrane replacement mechanism has the advantages of high precision and low cross contamination.

[0055] Specifically, the flow control mechanism includes a pinch valve 2-13 and a sample adding handle 2-14, the sample adding handle 2-14 is provided with a sample adding needle, the pinch valve 2-13 is a two-position three-way valve, three interfaces of the pinch valve 2-13 are connected with the inside of the semi-permeable membrane fixing device, a reagent bag and an external environment respectively, and the sample adding handle 2-14 manually controls the working state of the peristaltic pump 2-12 and the pinch valve 2-13. The pinch valve 2-13 cooperates with a Y-shaped connector to realize the function of the two-position three-way valve, one pipeline of the pinch valve 2-13 is connected with the inside of the semi-permeable membrane fixing device 2-4, and the other two pipelines are connected with the puncture needle 2-16 and air respectively. When connected with the puncture needle 2-16, the cleaning liquid in the reagent bag can be sucked out to clean the measuring chamber of the semi-permeable membrane fixing device; when connected with air, the sample in the sample adding needle can be sucked into the measuring chamber of the semi-permeable membrane fixing device 2-4 to realize the sample adding function.

[0056] Preferably, the peristaltic pump 2-12, the pinch valve 2-13 and the sample adding handle 2-14 are located on the same side of the linear motor 2-4, and the pinch valve 2-13 and the sample adding handle 2-14 are located in front of the peristaltic pump 2-12. The installation positions and connection modes of the components can also be adjusted according to the situation, which are all within the protection scope of the utility model.

[0057] On the basis of the semi-permeable membrane replacement mechanism provided in the above specific embodiments, a reagent bag is detachably installed below the bottom plate 2-1, the puncture needle 2-16 below the bottom plate 2-1 is inserted into the reagent bag, and the flow control mechanism is connected with the reagent bag through the puncture needle 2-16. The puncture needle 2-16 is fixed below the bottom plate 2-1, mainly realizes the puncture function of the sealing plug of the reagent bag, and after successful puncture, the puncture needle 2-16 can be connected with the reagent bag inside the reagent bag to realize cleaning of the measuring chamber of the semi-permeable membrane fixing device 2-4 and recovery of the measurement waste liquid.

[0058] Preferably, the bottom plate 2-1 is provided with a movable buckle 2-15 below, the movable buckle 2-15 is clamped with the upper end of the reagent bag, the lower end of the lead screw 2-9 of the linear motor 2-4 can trigger the movable buckle 2-15 to be unlocked to pop up the reagent bag. The linear motor 2-4 is a through type linear motor, the upper end of the linear motor 2-4 is connected with the transmission shaft 2-10, when the linear motor 2-4 moves upwards, the lead screw 2-9 drives the transmission shaft 2-10 to move upwards, when the linear motor 2-4 moves downwards, the lower end of the lead screw 2-9 contacts with the elastic rod of the movable buckle 2-15, the corresponding buckle of the reagent bag is linked with the elastic rod and is lifted to realize the pop-up of the reagent bag. The buckle torsional spring is matched with the buckle through the buckle rotating shaft, so that the buckle is pressed tightly downwards to realize the fixation of the reagent bag. The bottom plate 2-1 is provided with a guide hook 2-17 matched with the upper end sliding way of the reagent bag to play a guiding role in the process of replacing the reagent bag and prevent the problem of position deviation when the reagent bag is replaced.

[0059] When the reagent bag is replaced, the two-dimensional code on the reagent bag is aligned with the code scanning gun on the colloidal osmotic pressure measuring instrument, the information of the new reagent bag is input into the colloidal osmotic pressure measuring instrument, the new reagent bag can be installed into the colloidal osmotic pressure measuring instrument, the reagent bag is placed at the corresponding position in the colloidal osmotic pressure measuring instrument, and the reagent bag is pushed into the colloidal osmotic pressure measuring instrument with force, at this time the linear motor 2-4 moves upwards, the movable buckle 2-15 is clamped under the action of the buckle torsional spring, and downward pressure is applied to clamp the reagent bag, and the fixation of the reagent bag is completed.

[0060] When the sample needs to be added, the sample adding handle 2-14 is lifted, at this time the sample is sucked under the power of the peristaltic pump 2-12, and the sample exists in the sample adding needle and the pipeline. After the sample adding handle 2-14 is put down, the pinch valve 2-13 is connected with the air, so that the sample in the sample adding needle and the pipeline can be injected into the measuring chamber in the semi-permeable membrane fixing device; after the measurement is completed, the pinch valve 2-13 is switched to be connected with the reagent bag in the reagent bag of the reagent bag, so that the measuring chamber in the semi-permeable membrane fixing device can be cleaned; after the cleaning is completed, the waste liquid in the measuring chamber of the semi-permeable membrane fixing device is injected into the vacuum reagent belt in the reagent bag, and the waste liquid is recycled.

[0061] Through the above-mentioned mode, automatic sample adding and cleaning are realized, the sample adding amount is accurate, and the control accuracy is improved.

[0062] Please refer to Figures 5 to 9 , Figure 5 It is an internal structure diagram of the semi-permeable membrane fixing device in a specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model; Figure 6 It is an external structure diagram of the semi-permeable membrane fixing device in a specific embodiment of the colloidal osmotic pressure measuring instrument provided by the utility model; Figure 7The utility model provides a kind of cross section schematic diagram of reference chamber container of semi-permeable membrane fixing device in the specific embodiment of osmometer provided by the utility model; Figure 8 The utility model provides a kind of cross section schematic diagram of measuring chamber container of semi-permeable membrane fixing device in the specific embodiment of osmometer provided by the utility model; Figure 9 The utility model provides a kind of cross section schematic diagram of reference chamber container of semi-permeable membrane fixing device in the specific embodiment of osmometer provided by the utility model;

[0063] The utility model specific implementation provides a kind of semi-permeable membrane fixing device, including reference chamber container 5-1 and measuring chamber container 5-2, reference chamber container 5-1 is provided with reference cavity, measuring chamber container 5-2 is provided with measuring cavity 5-21 and the liquid pipeline that communicates measuring cavity 5-21, reference chamber container 5-1 is installed in measuring chamber container 5-2 below, and reference cavity upper end communicates measuring cavity 5-21 lower end, reference cavity upper end is equipped with support screen plate 5-3, support screen plate 5-3 is covered with semi-permeable membrane 5-4, i.e. reference chamber container 5-1 and measuring chamber container 5-2 combination form fixing device, and reference chamber container 5-1 and measuring chamber container 5-2 inside are provided with cavity for detecting work, semi-permeable membrane 5-4 is installed in cavity, reference chamber container 5-1 and measuring chamber container 5-2 are regarded as one whole component with semi-permeable membrane 5-4, when semi-permeable membrane 5-4 needs to be replaced, integral replacement fixing device, since semi-permeable membrane 5-4 is in the state of preparation in fixing device, need not artificially prepare work, greatly reduce human interference, reduce failure rate.

[0064] Preferably, cylindrical convex structure can also be provided on both sides of the lower end of the measuring chamber container 5-2, and the cylindrical convex structure is inserted into the corresponding positioning hole during installation to realize the guidance and positioning of installation.

[0065] The preparation before operation: first, the liquid inside the measuring cavity 5-21 is drained, the semi-permeable membrane fixing device is inclined through the colloid osmotic pressure measuring instrument, and the semi-permeable membrane fixing device inside the colloid osmotic pressure measuring instrument reaching the service life is pulled out. The next operation is to replace the new semi-permeable membrane fixing device. The film below the reference chamber container 5-1 of the new semi-permeable membrane fixing device is torn off, the two side cylindrical protruding structures below the semi-permeable membrane fixing device are aligned with the corresponding reference chamber working hole positions on the colloid osmotic pressure measuring instrument, and are pressed down. When pressed to the bottom, the lower sealing ring below the reference chamber container 5-1 and the sensor fixing part inside the colloid osmotic pressure measuring instrument are sealed, the lower sealing ring below the reference chamber container 5-1 will squeeze the switch inside the colloid osmotic pressure measuring instrument, so as to determine whether the new semi-permeable membrane fixing device is installed in place. After the new semi-permeable membrane fixing device is installed in place, it is adjusted to be horizontal, and the replacement of the new semi-permeable membrane fixing device is completed, and the new test can be carried out.

[0066] The semi-permeable membrane 5-4 and the installation container are combined into a whole to form a fixing device, which is disassembled and installed together with the fixing device when the semi-permeable membrane 5-4 needs to be replaced, thereby simplifying the installation process, reducing human operation, reducing the failure rate, and improving the work efficiency.

[0067] Specifically, the reference chamber container 5-1 is a vertically arranged cylindrical structure, and a stepped through hole is arranged in the middle of the reference chamber container 5-1 to form a reference cavity. Further, the stepped through hole comprises, from top to bottom, an upper sealing section 5-11, a sieve plate installation section 5-12, an upper conical transition section 5-13, an intermediate section 5-14, a lower conical transition section 5-15, and a lower sealing section 5-16. The diameters of the upper sealing section 5-11, the sieve plate installation section 5-12, the upper conical transition section 5-13, the intermediate section 5-14, and the lower conical transition section 5-15 decrease in turn, and the diameter of the lower sealing section 5-16 is greater than that of the intermediate section 5-14. Through the above size setting, the support sieve plate 5-3 is clamped into the sieve plate installation section 5-12, the upper sealing ring 5-5 is installed on the upper sealing section 5-11 and is pressed against the semi-permeable membrane 5-4 and the support sieve plate 5-3, and the lower sealing ring is installed in the lower sealing section 5-16 to seal the detection sensor.

[0068] The lower part of the reference chamber container 5-1 contacts the sensor to transmit the pressure change inside the measuring cavity 5-21, and the reference chamber inside stores a reference liquid. When there is a colloid osmotic pressure, ion and small molecule exchanges will occur with the sample. When the balance is reached, the reference cavity will have a certain pressure. The semi-permeable membrane 5-4 is a thin film with selectivity to different particles, which is a membrane structure that only allows ions and small molecules to pass freely. Biological macromolecules cannot pass through the semi-permeable membrane freely. The reason is that the pore size of the semi-permeable membrane is larger than that of ions and small molecules but smaller than that of biological macromolecules such as proteins and starch.

[0069] In order to ensure quick disassembly connection, the connecting structure is an annular groove 5-17 surrounding the outer periphery of the reference chamber container 5-1, and a matching annular protrusion is arranged on the inner wall of the working hole of the reference chamber. During installation, the two are clamped, and of course, other connection positioning modes can also be used, such as arranging an axially extending guide groove, which is within the protection scope of the utility model. A plurality of positioning recesses can also be arranged on the bottom surface of the reference chamber container 1, and the plurality of positioning recesses are arranged around the reference cavity to achieve radial limiting after installation, so that the sensor can be smoothly inserted into the lower end of the reference cavity.

[0070] Further, the lower end of the measuring chamber container 5-2 is provided with a mounting hole 5-22, the upper end of the reference chamber container 5-1 is inserted into the mounting hole 5-22, the middle part of the measuring chamber container 5-2 is provided with a straight hole penetrating upward and downward to form a measuring cavity 5-21, the measuring cavity 5-21 and the mounting hole 5-22 are coaxially arranged, and the lower part of the measuring chamber container 5-2 is provided with a connecting plate 5-7 for supporting the reference chamber container 5-1. Specifically, the middle part of the connecting plate 5-7 is provided with a hole for the lower end of the reference chamber container 5-1 to pass through, and at the same time, the corresponding position of the outer periphery of the reference chamber container 5-1 is provided with a limiting step 5-18. After the connecting plate 5-7 and the lower end of the measuring chamber container 5-2 are connected by bolts or other means, the inner ring of the connecting plate 5-7 abuts against the limiting step 5-18, thereby achieving the support and fixation of the reference chamber container 5-1. Of course, other connection modes can also be used, such as arranging a buckle or screwing the upper end of the reference chamber container 5-1 with the mounting hole 5-22, which are within the protection scope of the utility model.

[0071] In the semi-permeable membrane fixing device provided in the specific embodiment of the utility model, a plurality of process holes 5-23 surrounding the measuring cavity 5-21 are arranged in the measuring chamber container 5-2, the process holes 5-23 in multiple directions are communicated with each other to form a liquid pipeline, and the opening of the process hole 5-23 located at the position of the outer surface of the measuring chamber container 5-2 is plugged by a plug 5-6. After the process holes 5-23 are communicated, the upper end opening of the liquid pipeline is communicated with the measuring cavity 5-21, and the lower end opening of the liquid pipeline is located at the lower end surface of the lower end boss 5-24 of the measuring chamber container 5-2. Further, the lower end opening of the process hole 5-23 is provided with a guide pipe 5-8 and a silica gel pipe 5-9.

[0072] On the basis of the semi-permeable membrane fixing device provided in the above embodiments, the support sieve plate 5-3 is an upwardly arched circular arc plate, and a plurality of sieve holes 5-31 are arranged on the support sieve plate 5-3. Not only can the supporting force be increased, but also the contact area of the semi-permeable membrane 5-4 with the sample and the reference liquid can be increased; the semi-permeable membrane 5-4 is placed above the support sieve plate 5-3 and is used to block the protein in the sample to realize the measurement of the colloid osmotic pressure; the measurement cavity 5-21 is installed above the reference cavity, and through the shaft hole cooperation, the measurement cavity 5-21 and the reference cavity are ensured to be concentric, and a protruding structure exists below the measurement cavity 5-21 to extrude the upper sealing ring 5-5 to realize sealing. Two bosses 5-24 exist below the measurement chamber container 5-2, the conduit 5-8 and the silica gel tube 5-9 are arranged in the boss 5-24, the conduit 5-8 is connected with the liquid pipeline in the measurement chamber container 5-2, and the liquid inlet and outlet of the measurement cavity 5-21 body are realized.

[0073] Please refer to Figures 10 to 15 , Figure 10 It is a specific embodiment of the structure diagram of the reagent package of the colloid osmotic pressure measuring instrument provided by the utility model. Figure 11 It is a specific embodiment of the decomposition diagram of the reagent package of the colloid osmotic pressure measuring instrument provided by the utility model. Figure 12 It is a specific embodiment of the upper cover of the reagent package of the colloid osmotic pressure measuring instrument provided by the utility model. Figure 13 It is a specific embodiment of the upper cover of the reagent package of the colloid osmotic pressure measuring instrument provided by the utility model. Figure 14 It is a specific embodiment of the installation diagram of the support plate of the reagent package of the colloid osmotic pressure measuring instrument provided by the utility model. Figure 15 It is a specific embodiment of the installation diagram of the support plate of the reagent package of the colloid osmotic pressure measuring instrument provided by the utility model.

[0074] Please refer to Figure 16 and Figure 17 , Figure 16 It is a specific embodiment of the internal structure diagram of the colloid osmotic pressure measuring instrument provided by the utility model. Figure 17 It is a specific embodiment of the structure diagram of the controller of the colloid osmotic pressure measuring instrument provided by the utility model.

[0075] The utility model discloses a kind of colloidal osmotic pressure determination reagent packs, including box 6-1 and upper cover 6-2, box 6-1 can be similar cuboid box structure, of course, other shapes can also be used according to circumstances, such as cylindrical box, box 6-1 lower end is closed, upper end is open and is provided with opening, upper cover 6-2 is buckled on the upper end opening of box 6-1, and closed cavity structure is formed in box 6-1. Multiple reagent bags 6-3 are installed in box 6-1, different reagents are loaded in reagent bag 6-3, such as different cleaning liquid etc., a vacant reagent bag 6-3 can also be provided, for collecting waste liquid. Multiple delivery holes 6-4 are provided on upper cover 6-2, sealing rubber plug 6-5 is installed in each delivery hole 6-4, sealing rubber plug 6-5 rear end is connected with delivery pipe 6-6, each delivery pipe 6-6 is connected with multiple reagent bags 6-3 respectively, and the upper end surface of upper cover 6-2 is provided with docking structure. Correspondingly, the lower portion of determination instrument main body 6-15 is provided with corresponding docking structure, and is detachably connected with upper cover 6-2, in use process, reagent pack is installed below determination instrument main body, after reagent is used up, new reagent pack can be replaced. At the same time, multiple puncture needles are arranged below determination instrument main body, when reagent pack is installed, multiple puncture needles respectively pass through each sealing rubber plug 6-5, and the corresponding each reagent bag 6-3 is connected with each delivery pipe 6-6 to realize the delivery of cleaning liquid and cost. When cleaning is needed, the cleaning liquid in the reagent bag 6-3 filled with cleaning liquid is sucked out, and the waste liquid generated after testing is discharged into the vacant reagent bag 6-3, so that the waste liquid generated during the testing process will not overflow, and will not contact the operator. The harm to the environment and air is avoided.

[0076] Multiple reagent bags 6-3 are integrated in a reagent pack, which can provide cleaning liquid and collect waste liquid simultaneously, simplify the cleaning process, make the replacement process simple, shorten the cleaning time, realize automatic cleaning and improve work efficiency.

[0077] Specifically, it comprises a cleaning liquid reagent bag and a vacuum reagent bag, the cleaning liquid reagent bag contains cleaning liquid, the vacuum reagent bag is a vacant reagent bag, two delivery holes 6-4 are arranged side by side on the upper cover 6-2, two sealing rubber plugs 6-5 and two delivery pipes 6-6 are connected with the cleaning liquid reagent bag and the vacuum reagent bag respectively. The delivery pipe 6-6 is a silica gel pipe, and other materials can also be used.

[0078] In order to prevent backflow, the rear end of the sealing rubber plug 6-5 is connected with a one-way valve 6-7, the rear end of the one-way valve 6-7 is connected with the front end of the delivery pipe 6-6, the rear end of the delivery pipe 6-6 is connected with the corresponding reagent bag 6-3, the flow direction of the one-way valve 6-7 at different positions is different, the one-way valve 6-7 connected with the cleaning liquid reagent bag allows the cleaning liquid to flow out of the cleaning liquid reagent bag, preventing backflow, and the one-way valve 6-7 connected with the vacuum reagent bag allows the waste liquid to flow back to the vacuum reagent bag, preventing leakage.

[0079] In order to stably install the one-way valve 6-7, mounting seats 6-8 are arranged at both ends of the lower end surface of the upper cover 6-2 in the length direction, the two one-way valves 6-7 are respectively installed in the two mounting seats 6-8, the sealing rubber plug 6-5 is installed at the front end of the one-way valve 6-7, the delivery hole 6-4 is arranged at the front side of the upper cover 6-2, the sealing rubber plug 6-5 extends forward and is embedded in the delivery hole 6-4. Further, the lower end surface of the upper cover 6-2 is provided with a plurality of clamping claws 6-9, the clamping claws 6-9 are arranged behind the mounting seats 6-8, the clamping claws 6-9 clamp the middle part of the corresponding delivery pipe 6-6, and the rear end of the delivery pipe 6-6 is bent downward to connect the cleaning liquid reagent bag and the vacuum reagent bag.

[0080] Specifically, the sealing rubber plug 6-5 is a cylindrical sleeve structure with a closed front end, that is, the rear end of the sealing rubber plug 6-5 is provided with a mounting hole, the front end of the one-way valve 6-7 extends into the mounting hole to realize sealing with the one-way valve 6-7, and the outer periphery of the sealing rubber plug 6-5 and the inner wall of the delivery hole 6-4 are clamped through a convex and a groove, so that the sealing rubber plug 6-5 is stably fixed with the delivery hole 6-4 and tightly contacts to ensure the sealing effect. Other fixing modes such as a clamping groove can also be used, which are all within the protection scope of the utility model.

[0081] In the colloid osmotic pressure determination reagent bag provided in the specific embodiment of the utility model, the butt joint structure includes a buckle groove 6-10 arranged at the middle part of the upper end surface of the upper cover 6-2 and a guide groove 6-11 arranged at both ends of the upper end surface of the upper cover 6-2 in the length direction, corresponding buckles and hooks are arranged below the main body of the tester, during installation, the buckles are matched with the buckle groove 6-10, the hooks are matched with the guide groove 6-11, detachable connection is realized, at the same time, the lower end surface of the box body 6-1 is provided with a guide rail groove 6-12, a supporting plate is arranged below the main body of the tester, a space for placing the reagent bag is arranged between the supporting plate and the main body of the tester, a guide rail is arranged on the supporting plate, during installation, the guide rail slides along the guide rail groove 6-12 to realize the guide and limiting functions, wherein the guide groove 6-11 and the guide rail groove 6-12 all extend along the width direction.

[0082] Preferably, the circumferential baffle of the upper cover 6-2 wraps the upper end of the box body 6-1, and the two are connected through the buckle structure 6-13. Other connection modes such as bolt connection or interference fit can also be used, which are all within the protection scope of the utility model.

[0083] On the basis of the colloidal osmotic pressure determination reagent package provided in each of the above embodiments, a support plate 6-14 is installed in the box body 6-1, the shape of the support plate 6-14 matches the cross-sectional shape inside the box body 6-1, and the support plate 6-14 can be a square plate. The four peripheral edges of the support plate 6-14 contact the inner side walls of the support box body 6-1, and a plurality of reinforcing ribs are arranged on the lower surface of the support plate 6-14 in a horizontal and vertical staggered manner to improve the support strength. Process holes are provided at both ends of the length direction of the support plate 6-14 for the conveying pipe 6-6 to pass through. The support plate 6-14 realizes the functions of supporting and protecting the box body 6-1, avoiding damage and local deformation of the box body 6-1 caused by transportation and collision, and preventing the reagent in the reagent package from spilling out and polluting the environment and air.

[0084] Preparation before operation:

[0085] First, it is necessary to determine whether the reagent package has reached the limit of use. When the limit is reached, the colloidal osmotic pressure determination instrument will prompt to replace the reagent package. At this time, the reagent package can be automatically or manually ejected, and then the ejected waste reagent package can be taken out. The next operation is to replace the new reagent package.

[0086] The two-dimensional code on the new reagent package is aligned with the code scanning gun on the colloidal osmotic pressure determination instrument, and the information of the new reagent package is input into the colloidal osmotic pressure determination instrument. The new reagent package can be installed in the colloidal osmotic pressure determination instrument. The guide rail groove 12 below the box body 1 is placed at the corresponding position inside the colloidal osmotic pressure determination instrument, and the reagent package is pushed into the colloidal osmotic pressure determination instrument with force. When the sound of the buckle being locked is heard, the reagent package is locked, and the colloidal osmotic pressure determination instrument prompts that the installation is complete. At this time, the replacement of the new reagent package is completed, and a new test can be performed. The present application greatly shortens the replacement time, and the replacement process is simple, has low failure rate, and greatly reduces human operation.

[0087] On the basis of the colloidal osmotic pressure determination instrument provided in each of the above embodiments, the machine body auxiliary module 3 includes a first diaphragm pump 3-1, a second diaphragm pump 3-2, and a gas-liquid separation bottle 3-3. The first diaphragm pump 3-1 is connected to the inside of the semi-permeable membrane fixing device 5 and the upper end of the gas-liquid separation bottle 3-3, respectively. The first diaphragm pump 3-1 mainly realizes the injection of the waste liquid in the measuring chamber inside the semi-permeable membrane fixing device 5 into the gas-liquid separation bottle 3-3, that is, the first step of waste liquid recovery is completed. The second diaphragm pump 3-2 is connected to the lower end of the gas-liquid separation bottle 3-3 and the reagent package 6, respectively. The second diaphragm pump 3-2 mainly realizes the injection of the separated waste liquid into the reagent bag 6-3 inside the reagent package 6.

[0088] The body auxiliary module 3 further comprises a filter for filtering out interference frequencies and providing stable voltage, a network cable extender, a code scanner 3-4, a thermal printer 3-5, and a screen 3-6 for operating software and displaying measurement results. The screen 3-6 is arranged above the housing 1, and the code scanner 3-4 and the thermal printer 3-5 are arranged in front of the housing 1. A window is arranged in front of the housing 1, and a cartridge door 3-7 is mounted at the window. The semi-permeable membrane fixing device 5 can be extended out of the window.

[0089] The gas-liquid separation bottle 3-3 is a colorless and transparent plastic bottle. Two connecting heads are arranged at the upper part of the bottle, which are used to connect the first diaphragm pump 3-1 and the filter, respectively. A connecting head is arranged at the lower part of the bottle, which is used to connect one end of the second diaphragm pump 3-2. A liquid level switch is arranged in the bottle, which can detect the liquid level in the bottle. The filter is mounted and fixed behind the reagent bag 6, which mainly realizes filtering out interference frequencies and providing stable voltage. The network cable extender is mounted and fixed above the filter, and the other end is connected to the circuit board of the controller 4, which mainly realizes the function of external network cable. The code scanner 3-4 is mounted and fixed on the side of the cartridge door 3-9, which mainly realizes the input of reagent bag 6, semi-permeable membrane 5-4 and patient information, etc. The thermal printer 3-5 is mounted and fixed below the code scanner 3-4, which mainly realizes the printing function. The cartridge door 3-9 includes an upper cartridge door and a lower cartridge door. The upper cartridge door is mounted above the lower cartridge door. When the semi-permeable membrane fixing device 5 realizes the turnover function, the upper cartridge door will move upward, which mainly realizes the opening and closing function when the semi-permeable membrane 5-4 needs to be replaced. The screen 3-6 is mounted above, which mainly realizes the operation of software and the display of measurement results. The circuit board is mounted and fixed below the screen 3-6, which mainly realizes the input and output of instructions of all elements. After detection, the detection results are analyzed, the final test results are evaluated, and the clinical diagnosis results are determined according to the actual experimental results.

[0090] When the sample adding handle 2-14 is rotated upward, the sample adding needle fixing guide pushes the torsional spring push piece to rotate. When the sample adding handle 2-14 returns to the original position, the torsional spring pushes the sample adding needle fixing guide to return to the original position. The sample adding needle is fixed in the sample adding needle fixing guide by buckling, which mainly realizes the fixation of the sample adding needle.

[0091] Preparation before operation:

[0092] First, turn on the full-automatic colloid osmotic pressure measuring instrument. After turning on, the full-automatic colloid osmotic pressure measuring instrument will initialize and drain the liquid, which mainly realizes the emptying of the liquid in the internal pipeline of the full-automatic colloid osmotic pressure measuring instrument, preparing for the next test.

[0093] Sample adding:

[0094] Click the start button, the automatic osmometer will remind the sample handle 2-14 to be lifted, and the sample needle can be inserted into the prepared sample according to the prompt. The automatic osmometer will automatically sample the sample through the peristaltic pump. After the sample is finished, the sample handle 2-14 is put down according to the prompt, and the sample adding process is completed.

[0095] The following actions are automatically completed by the automatic osmometer.

[0096] Sample injection:

[0097] Because the reagent in the pipeline is injected into the measuring chamber of the semi-permeable membrane fixing device during the above-mentioned sample suction process, the first diaphragm pump needs to be operated. The liquid in the measuring chamber of the semi-permeable membrane fixing device is injected into the gas-liquid separation bottle, and then the peristaltic pump injects part of the sample in the sample needle and pipeline into the measuring chamber of the semi-permeable membrane fixing device. At the same time, the pinch valve switches to inject the sample by sucking air. After the pressure stabilizes, the first diaphragm pump injects the sample in the measuring chamber of the semi-permeable membrane fixing device into the gas-liquid separation bottle. Then the peristaltic pump operates again to inject the remaining sample into the measuring chamber of the semi-permeable membrane fixing device for re-measurement. When the pressure stabilizes, the measurement of the osmotic pressure of the colloid is completed.

[0098] Cleaning the semi-permeable membrane:

[0099] After the measurement is completed, the semi-permeable membrane in the semi-permeable membrane fixing device needs to be cleaned. For the first time, the peristaltic pump is operated to inject the cleaning liquid in the reagent bag into the measuring chamber of the semi-permeable membrane fixing device. At this time, the pinch valve is connected to the reagent bag in the reagent bag through the puncture needle, and the first diaphragm pump injects the waste liquid in the measuring chamber of the semi-permeable membrane fixing device into the gas-liquid separation bottle. The above actions are completed three times, and after three times, the cleaning action is completed. At this time, the entire test process is completed. When the waste liquid in the gas-liquid separation bottle reaches the corresponding height, the second diaphragm pump is used to suck the waste liquid in the gas-liquid separation bottle into the reagent bag to complete the recovery of the waste liquid.

[0100] Result printing:

[0101] After the detection is completed, the detection results are analyzed, the final test results are evaluated, the actual measured experimental results are judged to determine the clinical diagnosis results, the clinical diagnosis results are transmitted to the thermal printer, and the paper version report is printed for clinical diagnosis.

[0102] Replace the reagent bag:

[0103] First click to replace reagent package button, linear motor moves downward, linear motor linear lead screw and buckle elastic rod contact, so that the reagent package buckle in the elastic rod under the action, move upwards, the reagent package buckle and reagent package cover buckle slot is separated, reagent package pops out. The new reagent package two-dimensional code aligns the code scanner to enter information, after successful input, the new reagent package is pushed into the body module in the corresponding position. That is, the replacement of reagent package is completed.

[0104] Replace the semi-permeable membrane:

[0105] First click to replace semi-permeable membrane button, linear motor moves upward, drives the rotary shaft and connecting rod to move, at the same time, the measuring chamber support upper plate is turned over upward, the measuring chamber support upper plate pushes the upper door to move upward, the other end of the connecting rod is hinged below the semi-permeable membrane fixing device. Under the linkage of the connecting rod, the semi-permeable membrane fixing device will realize the turnover function, drive the lower door to turn over downward, realize the opening of the upper and lower doors, so that the semi-permeable membrane fixing device can be replaced. Then manually pull out the semi-permeable membrane fixing device, and scan the new semi-permeable membrane fixing device to enter information and then insert it into the corresponding position, click the door, the replacement of the semi-permeable membrane is completed.

[0106] The above describes the colloidal osmotic pressure measuring instrument provided by the present application in detail. In this paper, specific examples are applied to explain the principles and implementation modes of the present application. The above examples are only used to help understand the method and core idea of the present application. It should be pointed out that for ordinary skilled persons in the technical field, without departing from the principles of the present application, the present application can be improved and modified in several ways, and these improvements and modifications also fall within the protection scope of the present application.

Claims

1. A colloid osmotic pressure apparatus characterized by, The application relates to a semi-permeable membrane replacement mechanism, which comprises a shell (1), a semi-permeable membrane replacement mechanism (2), a machine body auxiliary module (3) and a controller (4) which are arranged in the shell (1), the semi-permeable membrane replacement mechanism (2) is detachably connected with a semi-permeable membrane fixing device (5) and a reagent bag (6), the semi-permeable membrane fixing device (5) is provided with a semi-permeable membrane (5-4), the controller (4) is in communication connection with the semi-permeable membrane replacement mechanism (2) and the machine body auxiliary module (3), the machine body auxiliary module (3) is used for information input and output, controls the semi-permeable membrane replacement mechanism (2) to drive the semi-permeable membrane fixing device (5) and the reagent bag (6) to automatically pop out, and samples are added into the semi-permeable membrane fixing device (5) to carry out osmotic pressure measurement.

2. The colloid osmotic pressure measuring apparatus according to claim 1, wherein The semi-permeable membrane replacement mechanism (2) comprises a bottom plate (2-1), a mounting platform (2-2) arranged above the bottom plate (2-1), a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, the semi-permeable membrane fixing device (5) is detachably mounted on the mounting platform (2-2), a conveying mechanism communicating with the inside of the semi-permeable membrane fixing device (5) is arranged below the mounting platform (2-2), the reagent driving structure is connected with the conveying mechanism through the flow control mechanism and is used for inputting or discharging different reagents into or out of the inside of the semi-permeable membrane fixing device (5), the replacement driving mechanism is connected with the mounting platform (2-2) through the transmission mechanism and is used for driving the mounting platform (2-2) to forwardly overturn so that the upper end of the semi-permeable membrane fixing device (5) is forwardly inclined or for driving the mounting platform (2-2) to backwardly overturn so that the semi-permeable membrane fixing device (5) returns to a vertical state.

3. The colloid osmotic pressure measuring apparatus according to claim 2, characterized by The replacement driving mechanism is a vertical linear motor (2-4), the transmission mechanism comprises a base (2-5), a transmission plate (2-6) and a connecting rod (2-7), the mounting platform (2-2) is located at the front end of the bottom plate (2-1), the base (2-5) is located at the rear end of the bottom plate (2-1), the mounting platform (2-2) is hinged to the bottom plate (2-1), the rear end of the transmission plate (2-6) is hinged to the base (2-5), the lower surface of the middle part of the transmission plate (2-6) is provided with a sliding groove (2-8), the upper end of a screw rod (2-9) of the linear motor (2-4) is connected with a transmission rotating shaft (2-10), the transmission rotating shaft (2-10) is mounted in the sliding groove (2-8), the upper end of the connecting rod (2-7) is hinged to the front end of the transmission plate (2-6), and the lower end of the connecting rod (2-7) is hinged to the rear end of the mounting platform (2-2).

4. The colloid osmotic pressure measuring apparatus according to claim 3, wherein The reagent bag (6) is detachably mounted below the bottom plate (2-1), a puncture needle (2-16) below the bottom plate (2-1) is inserted into the reagent bag, the flow control mechanism is connected with the reagent bag through the puncture needle (2-16), a movable buckle (2-15) is arranged below the bottom plate (2-1), the movable buckle (2-15) is clamped with the upper end of the reagent bag, and the lower end of the lead screw (2-9) of the linear motor (2-4) can trigger the movable buckle (2-15) to be unlocked to pop out the reagent bag (6).

5. The colloid osmotic pressure measuring apparatus according to claim 1, wherein The semi-permeable membrane fixing device (5) comprises a reference chamber container (5-1) and a measuring chamber container (5-2), the reference chamber container (5-1) is provided with a reference cavity, the measuring chamber container (5-2) is provided with a measuring cavity (5-21) and a liquid pipeline communicating with the measuring cavity (5-21), the reference chamber container (5-1) is installed below the measuring chamber container (5-2), and the upper end of the reference cavity is communicated with the lower end of the measuring cavity (5-21), the upper end of the reference cavity is provided with a support sieve plate (5-3), the support sieve plate (5-3) is covered with a semi-permeable membrane (5-4), and the outer periphery of the reference chamber container (5-1) is provided with a connecting structure for detachably connecting a reference chamber working hole of a colloid osmotic pressure detector.

6. The colloid osmotic pressure measuring apparatus according to claim 1, wherein The reagent bag (6) comprises a box body (6-1) and an upper cover (6-2) buckled on the upper end opening of the box body (6-1), a plurality of reagent bags (6-3) are installed in the box body (6-1), a plurality of delivery holes (6-4) are arranged on the upper cover (6-2), a sealing rubber plug (6-5) is installed in each delivery hole (6-4), a delivery pipe (6-6) is connected to the rear end of the sealing rubber plug (6-5), each delivery pipe (6-6) is connected to a plurality of reagent bags (6-3), and a docking structure for detachably connecting a detector main body is arranged on the upper end surface of the upper cover (6-2), when the detector main body is installed, a plurality of puncture needles below the detector main body respectively pass through each sealing rubber plug (6-5) to conduct each reagent bag (6-3).

7. The colloid osmotic pressure measuring apparatus according to claim 6, wherein The docking structure comprises a buckle groove (6-10) arranged in the middle of the upper end surface of the upper cover (6-2) and a guide groove (6-11) arranged at both ends of the length direction of the upper end surface of the upper cover (6-2), and the lower end surface of the box body (6-1) is provided with a guide rail groove (6-12), the buckle groove (6-10), the guide groove (6-11) and the guide rail groove (6-12) all extend along the width direction.

8. The colloid osmotic pressure measuring apparatus according to any one of claims 1 to 7, characterized by The body auxiliary module (3) comprises a first diaphragm pump (3-1), a second diaphragm pump (3-2) and a gas-liquid separation bottle (3-3), the first diaphragm pump (3-1) is connected to the inside of the semi-permeable membrane fixing device (5) and the upper end of the gas-liquid separation bottle (3-3) respectively, the second diaphragm pump (3-2) is connected to the lower end of the gas-liquid separation bottle (3-3) and the reagent bag (6) respectively.

9. The colloid osmotic pressure measuring apparatus according to claim 8, wherein The body auxiliary module further comprises a filter for filtering out interference frequencies and providing stable voltage, a network cable extension line, a code scanner (3-4) for information entry, a thermal printer (3-5) and a screen (3-6) for operating software and displaying measurement results.

10. The colloid osmotic pressure measuring apparatus according to claim 9, wherein The screen (3-6) is arranged above the shell (1), the code scanner (3-4) and the thermal printer (3-5) are arranged in front of the shell (1), a window is arranged in front of the shell (1), a warehouse door (3-7) is installed at the window, and the semi-permeable membrane fixing device (5) can be extended out of the window.

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