Novel chromatographic column temperature control equipment

Abstract

The utility model relates to the technical field of chromatographic columns, in particular to novel chromatographic column temperature control equipment, which comprises a chromatographic column body, plug sealing barrels and a heating piece, the chromatographic column body comprises a glass column tube, the upper end and the lower end of the glass column tube are opened, and the plug sealing barrels are hermetically filled at the upper end and the lower end of the glass column tube; a heating piece is vertically arranged at the bottom end of the sealing plug barrel at the upper end of the glass column tube, the heating piece comprises an oil shell barrel, the top end of the oil shell barrel is fixed on the bottom end face of the sealing plug barrel at the upper end of the glass column tube, the oil shell barrel is filled with heat conduction oil, a plurality of meshes are horizontally fixed in the oil shell barrel in the vertical direction, and a plurality of heating rods are fixed on the meshes in a penetrating manner. According to the utility model, the glass column tube is effectively and uniformly heated, and the temperature control uniformity of the chromatographic column is ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of chromatography column, especially to a novel chromatography column temperature control equipment. BACKGROUND

[0002] The chromatography column is the main body in the column chromatography separation technology, and generally adopts a glass tube or an organic glass tube. In the chemical, chemical and pharmaceutical fields, some substances are sensitive to temperature. For example, glycyrrhizin, a triterpenoid saponin component in natural products, is easily soluble in hot water, and column chromatography under heating conditions is beneficial to the separation of such components.

[0003] The existing announcement No. CN213665706U, named a control column temperature sandwich chromatography column, is provided with a feed inlet on the upper end of the chromatography column body, an internal sand core, a discharge pipe on the lower end, a discharge control valve on the discharge pipe, a diameter of the discharge pipe being smaller than that of the chromatography column body, a jacket layer on the outer periphery of the chromatography column body, the outer periphery of the chromatography column body being entirely surrounded by the jacket layer, a cavity being formed between the jacket layer and the chromatography column body, an inlet and an outlet of the carrier being provided on the jacket layer, which can better control the column separation column temperature in the chemical, chemical and pharmaceutical experimental fields, and realize the very warm separation of temperature-sensitive special components. The separation efficiency of the easily soluble components in the hot solvent can be improved.

[0004] However, the above-mentioned method of increasing a circulating heating system around the chromatography column, heating the chromatography column tube, and then transferring mass to the materials and fillers in the chromatography column through the chromatography column tube, has the problems of low mass transfer efficiency and uneven mass transfer due to the need to conduct heat through the outer wall of the chromatography column during heat transfer, and part of the heat is consumed during heat transfer. UTILITY MODEL CONTENTS

[0005] The utility model solves the problems in the related art and provides a novel chromatography column temperature control equipment.

[0006] To solve the above technical problems, the utility model is realized by the following technical scheme: a novel chromatography column temperature control equipment, comprising a chromatography column body, a plug-in cylinder and a heating element, the chromatography column body comprising a glass column tube, the upper and lower ends of the glass column tube being provided with openings, and the upper and lower ends of the glass column tube being sealed and plugged with plug-in cylinders, the bottom end of the upper plug-in cylinder of the glass column tube being vertically provided with a heating element, the heating element comprising an oil shell cylinder, the top end of the oil shell cylinder being fixed on the bottom end surface of the upper plug-in cylinder of the glass column tube, the inside of the oil shell cylinder being filled with heat-conducting oil, a plurality of mesh sheets being fixed horizontally in the inside of the oil shell cylinder along the vertical direction, and a plurality of heating rods being fixed through the mesh sheets.

[0007] As a preferred scheme, a plurality of oil guide rings are horizontally provided on the outside of the oil shell cylinder along the vertical direction, a plurality of communication cylinders are horizontally provided between the oil guide rings and the oil shell cylinder, and the two ends of the plurality of communication cylinders are respectively communicated and fixed on the oil guide rings and the oil shell cylinder.

[0008] As a preferred scheme, the inside of the sealing cylinder is hollow, and a plurality of through holes are arranged through the horizontal end face of the glass column pipe.

[0009] As a preferred scheme, a liquid guide pipe is fixedly connected to the other horizontal end face of the sealing cylinder, and a one-way valve is fixedly connected to the liquid guide pipe.

[0010] As a preferred scheme, a sealing groove is arranged on the outer wall of the sealing cylinder, and a sealing ring is fixed in the sealing groove of the sealing cylinder.

[0011] As a preferred scheme, an electric heating film is fixedly sleeved on the outer wall of the glass column pipe.

[0012] As a preferred scheme, a heating controller is fixed on the upper end sealing cylinder of the glass column pipe, an input end of the heating controller is electrically connected with the cable, and an output end of the heating controller is electrically connected with the electric connection end of the plurality of heating rods.

[0013] Compared with the prior art, the beneficial effects of the utility model are as follows: in use, the upper and lower ends of the glass column pipe are respectively filled with the sealing cylinders, the heating member is inserted into the glass column pipe through the upper sealing cylinder of the glass column pipe, the liquid to be treated is guided into the glass column pipe, then according to the actual chromatographic treatment temperature requirement, the heating rod is started to heat the heat conducting oil in the oil shell cylinder, the heat conducting oil carries the heat to the oil shell cylinder and is transmitted to the liquid to be treated in the glass column pipe for heating treatment, at the same time, the electric heating film fixedly sleeved on the outer wall of the glass column pipe is started to heat the outer wall of the glass column pipe, the heat is transmitted to the liquid to be treated in the glass column pipe, the glass column pipe is effectively and uniformly heated, and the uniformity of the chromatographic column temperature control is ensured. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 is the overall structure schematic view of the utility model;

[0015] Figure 2 is the exploded structure schematic view of the utility model;

[0016] Figure 3 is the structure schematic view of the chromatographic column in the exploded state in the embodiment of the utility model;

[0017] Figure 4 is the structure schematic view of the sealing cylinder in the exploded state in the embodiment of the utility model;

[0018] Figure 5 is the structure schematic view of the heating member in the exploded state in the embodiment of the utility model.

[0019] In the figure: 1, chromatography column body; 11, glass column tube; 12, electric heating film; 2, sealing cylinder; 21, through hole; 211, sealing ring; 22, liquid guide pipe; 23, one-way valve; 24, heating controller; 3, heating part; 31, oil shell cylinder; 32, oil guide ring; 33, communication cylinder; 34, mesh; 35, heating rod. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. The description of the at least one exemplary embodiment is actually only illustrative, but not as any limitation on the present application and its application or use. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the present application.

[0021] It should be noted that the terms used herein are only intended to describe specific embodiments, and are not intended to limit the exemplary embodiments according to the present application. As used herein, the singular form is intended to include the plural form unless the context clearly indicates otherwise, and it should also be understood that when the terms "comprise" and / or "include" are used in the specification, there is a feature, step, operation, device, component and / or combination thereof.

[0022] Unless specifically stated otherwise, the relative arrangement of components and steps, numerical expressions, and numerical values set forth in the various embodiments described herein are not meant to limit the scope of the present application. At the same time, it should be understood that the sizes of the various parts shown in the drawings are not drawn in proportion. The techniques, methods and devices known to those skilled in the relevant art can not be discussed in detail, but should be considered as part of the authorized description. In all examples shown and discussed herein, any specific value should be interpreted as merely exemplary, and not as a limitation. Therefore, other examples of exemplary embodiments can have different values. It should be noted that similar reference numerals and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

[0023] In the description of the utility model, it is understood that the orientation words such as '' front, back, up, down, left, right '' '' horizontal, vertical, perpendicular, horizontal '' and '' top, bottom '' and the like indicated orientation or positional relationship is usually based on the orientation or positional relationship shown in the drawing, only for the convenience of describing the utility model and simplifying the description, in the absence of the opposite statement, these orientation words do not indicate and imply the device or element indicated must have a particular orientation or be constructed and operated in a particular orientation, therefore can not be understood as the restriction of the protection scope of the utility model;The orientation words '' inside, outside '' refer to the inside and outside relative to the contour of each component.

[0024] For the convenience of description, spatial relative terms can be used here, such as '' above'', '' above'', '' upper surface'', '' upper '' and the like, to describe the spatial position relationship of one device or feature with other devices or features as shown in the drawing. It should be understood that the spatial relative terms are intended to include different orientations in use or operation in addition to the orientation of the device described in the drawing. For example, if the device in the drawing is inverted, the device described as '' above '' or '' above '' other devices or structures will be positioned '' below '' or '' below '' other devices or structures. Thus, the exemplary term '' above '' can include both '' above '' and '' below '' orientations. The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative description used here is interpreted accordingly.

[0025] In addition, it should be noted that the use of '' first'', '' second '' and the like to limit parts is only for the convenience of distinguishing the corresponding parts, and the above words have no special meaning unless otherwise stated, therefore can not be understood as the restriction of the protection scope of the utility model.

[0026] As Figures 1 to 5As shown, a new type of chromatography column temperature control equipment, including chromatography column body 1, plug cylinder 2 and heating element 3, chromatography column body 1 includes glass column 11, the upper and lower ends of glass column 11 are provided with opening, and the upper and lower ends of glass column 11 are sealed and filled with plug cylinder 2, the bottom end of plug cylinder 2 on the upper end of glass column 11 is vertically provided with heating element 3, heating element 3 includes oil shell cylinder 31, the top end of oil shell cylinder 31 is fixed on the bottom end surface of plug cylinder 2 on the upper end of glass column 11, and the inside of oil shell cylinder 31 is filled with heat conducting oil, a plurality of mesh 34 are fixed horizontally in the inside of oil shell cylinder 31 along the vertical direction, and a plurality of heating rods 35 are fixed through the plurality of mesh 34, and the outer wall of glass column 11 is sleeved and fixed with electric heating film 12, in use, plug cylinder 2 is filled in the upper and lower ends of glass column 11 respectively, heating element 3 is inserted into glass column 11 through plug cylinder 2 on the top of glass column 11, the liquid needing chromatography treatment is guided into glass column 11, then according to the actual chromatography treatment temperature requirement, the heat conducting oil in the inside of oil shell cylinder 31 is heated by starting heating rod 35, the heat conducting oil carries heat to contact oil shell cylinder 31 and is transmitted to the liquid for chromatography treatment to heat treatment, at the same time, the outer wall of glass column 11 is heated by starting electric heating film 12 sleeved and fixed on the outer wall of glass column 11, the heat is transmitted to the liquid for chromatography treatment in the inside of glass column 11, effectively heating the glass column 11 uniformly, ensuring the uniformity of chromatography column temperature control.

[0027] In one embodiment, as shown in Figure 2 and 5 As shown, a plurality of oil guiding rings 32 are horizontally provided on the outside of oil shell cylinder 31 along the vertical direction, and a plurality of communication cylinders 33 are horizontally provided between the plurality of oil guiding rings 32 and oil shell cylinder 31, and the two ends of the plurality of communication cylinders 33 are respectively communicated and fixed on the oil guiding ring 32 and the oil shell cylinder 31, in use, the plurality of oil guiding rings 32 provided on the outside of oil shell cylinder 31 are communicated through the plurality of communication cylinders 33, the heat conducting oil is guided into the plurality of oil guiding rings 32, the contact area with the liquid for chromatography treatment is increased, and the heating uniformity of the liquid for chromatography treatment is improved.

[0028] In one embodiment, as shown in Figure 3 and 4 As shown, the inside of plug cylinder 2 is hollow, a plurality of through holes 21 are provided through the horizontal end surface of plug cylinder 2 inserted into glass column 11, a liquid guiding pipe 22 is communicated and fixed on the other horizontal end surface of plug cylinder 2, a one-way valve 23 is communicated and fixed on the liquid guiding pipe 22, a sealing groove is formed on the outer wall of plug cylinder 2, and a sealing ring 211 is fixed in the sealing groove of plug cylinder 2, in use, the one-way valve 23 of liquid guiding pipe 22 on plug cylinder 2 is rotated, the liquid for chromatography is guided into and out of glass column 11 by liquid guiding pipe 22, and in order to improve the sealing of plug cylinder 2 sealing the opening of glass column 11, the gap between plug cylinder 2 and glass column 11 is sealed by sealing ring 211.

[0029] In one embodiment, as shown in Figure 2 and 4 The heating controller 24 is fixed on the upper end of the glass column 11, and the input end of the heating controller 24 is electrically connected with the cable, and the output end of the heating controller 24 is electrically connected with the multiple heating rods 35. In use, the temperature of the heat conducting oil is controlled by the heating controller 24, so as to control the heat storage effect of the heat conducting oil.

[0030] In this embodiment, the upper and lower ends of the glass column 11 are respectively filled with the sealing cylinder 2. The heating element 3 is inserted into the glass column 11 through the upper sealing cylinder 2 of the glass column 11. The liquid to be treated is introduced into the glass column 11. Then, according to the actual temperature requirement of the chromatographic treatment, the heating rod 35 is started to heat the heat conducting oil in the oil shell cylinder 31. The heat conducting oil carries the heat to the oil shell cylinder 31 and is transmitted to the liquid to be treated for heating treatment. At the same time, the electric heating film 12 is sleeved and fixed on the outer wall of the glass column 11, and the outer wall of the glass column 11 is heated, so that the heat is transmitted to the liquid to be treated in the glass column 11.

[0031] The above is the preferred embodiment of the present application. The skilled in the art can also change and modify the above embodiment. Therefore, the present application is not limited to the above specific embodiments. Any obvious improvement, replacement or modification made by the skilled in the art on the basis of the present application belongs to the protection scope of the present application.

Claims

1. A novel temperature control apparatus for chromatography columns, characterized in that, Including chromatographic column body (1), plug cylinder (2) and heating element (3), the chromatographic column body (1) includes glass column tube (11), the upper and lower ends of the glass column tube (11) are provided with openings, and the upper and lower ends of the glass column tube (11) are sealed and plugged with the plug cylinder (2), the bottom end of the upper end plug cylinder (2) of the glass column tube (11) is vertically provided with the heating element (3), the heating element (3) includes oil shell cylinder (31), the top end of the oil shell cylinder (31) is fixed on the bottom end surface of the upper end plug cylinder (2) of the glass column tube (11), and the inside of the oil shell cylinder (31) is filled with heat conducting oil, a plurality of mesh sheets (34) are fixed horizontally in the inside of the oil shell cylinder (31) along the vertical direction, and a plurality of heating rods (35) are fixed through the plurality of mesh sheets (34).

2. The temperature control device for chromatography column according to claim 1, wherein: A plurality of oil guiding rings (32) are horizontally arranged outside the oil shell cylinder (31) along the vertical direction, a plurality of communication cylinders (33) are horizontally arranged between the plurality of oil guiding rings (32) and the oil shell cylinder (31), and the two ends of the plurality of communication cylinders (33) are respectively communicated and fixed on the oil guiding ring (32) and the oil shell cylinder (31).

3. The temperature control device for chromatography column according to claim 1, wherein: The inside of the plug cylinder (2) is hollow, and a plurality of through holes (21) are arranged through the horizontal end surface of the plug cylinder (2) inserted into the glass column tube (11).

4. The temperature control device for chromatography column according to claim 3, characterized in that: A liquid guiding pipe (22) is communicated and fixed on the other horizontal end surface of the plug cylinder (2), and a one-way valve (23) is communicated and fixed on the liquid guiding pipe (22).

5. The novel temperature control device for chromatography column according to claim 4, characterized in that: A sealing groove is formed on the outer wall of the plug cylinder (2), and a sealing ring (211) is fixed in the sealing groove of the plug cylinder (2).

6. The novel temperature control device for chromatography column according to claim 1, characterized in that: An electrothermal film (12) is fixed on the outer wall of the glass column tube (11).

7. The novel temperature control device for chromatography column according to claim 6, characterized in that: A heating controller (24) is fixed on the upper end plug cylinder (2) of the glass column tube (11), the input end of the heating controller (24) is electrically connected with the cable, and the output end of the heating controller (24) is electrically connected with the electrically connected end of the plurality of heating rods (35).

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