Mixer for foaming experiment and microbubble generator

Abstract

The utility model relates to a mixer for foaming experiment and a microbubble generator, which comprise a body, a fluid channel arranged in the body, and a surfactant coating arranged on the inner wall of the fluid channel; the body is provided with connectors corresponding to the two ends of the fluid channel respectively, the fluid channel comprises a first straight section, a first contraction section and a second straight section, the diameter of the first straight section is larger than that of the second straight section, the first contraction section is arranged between the first straight section and the second straight section, and the second contraction section is arranged between the first straight section and the second straight section. The surface active agent coating is arranged on the inner wall of the mixer, a surface active agent can be conveniently dissolved in foaming liquid in the foaming experiment, the stability of bubbles in the liquid is improved, the dosage of the surface active agent can be prepared in advance through the design of the mixer, the efficiency of the foaming experiment is improved, and the use convenience is improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to a mixer for foaming experiment and microbubble generator. BACKGROUND

[0002] PFO (patent foramen ovale) is a kind of congenital heart disease, which refers to that the foramen ovale between left and right atrium fails to close completely during the development of infants, resulting in abnormal channel between left and right atrium. PFO exists in 1 / 4 of ordinary people, and is related to various diseases, especially closely related to the occurrence of migraine and cryptogenic stroke. At present, the patent foramen ovale is usually diagnosed by transthoracic echocardiography or transcranial Doppler ultrasound contrast. The ultrasound contrast agent is injected into the body through the vein and circulates to the right atrium with the blood. When PFO exists, the ultrasound contrast agent (microbubbles) will enter the left atrium, left ventricle, aorta and intracranial artery through the unclosed foramen ovale. These microbubbles will strongly reflect the ultrasonic wave, so as to be detected by the probe of echocardiography or transcranial Doppler, so as to prove the existence and size of PFO.

[0003] At present, the ultrasound contrast agent for diagnosing PFO is mainly a mixture of air and physiological saline, and the microbubbles are generated by manual oscillation method. The stability of the bubbles is poor, and a surfactant is usually added to the mixture to reduce the merging rate of the microbubbles in the liquid and increase the stability during use. The surfactants used include polysorbate, propylene glycol, polyethylene glycol, lecithin, poloxamer, glycerol, hypertonic saline and the like. The amount of the above surfactants injected into the human blood is strictly limited, and too much injection often causes other adverse reactions. Too little addition of the surfactant will not produce effective bubbles. The on-site proportioning by the operator will be cumbersome and have great error, and finally cause poor mixing effect of the contrast agent or cause new complications.

[0004] Therefore, in view of the problems in the prior art, there is an urgent need for a mixer for foaming experiment and a microbubble generating device. INVENTION CONTENTS

[0005] Therefore, the utility model provides a mixer for foaming experiment, through setting surfactant coating on the inner wall of the mixer, can be convenient for dissolving surfactant to foaming liquid in foaming experiment, increase the stability of bubble in liquid, and through the design of mixer, can prepare the dosage of surfactant in advance, improved the efficiency of foaming experiment, increased the convenience of use.

[0006] The technical scheme adopted by the utility model is:

[0007] The utility model discloses a foaming experiment mixer, including: the body is arranged with fluid passage in, and the inner wall of fluid passage is arranged with surfactant coating, the body is provided with the connecting head respectively in corresponding both ends of fluid passage.

[0008] Further optimization of the technical scheme of the utility model, the fluid passage includes first straight section, first contraction section and second straight section, the diameter of first straight section is greater than the diameter of second straight section, and the first contraction section is arranged between the first straight section and the second straight section.

[0009] Further optimization of the technical scheme of the utility model, the surfactant coating is arranged on the inner wall of the contraction section and / or the inner wall of the second straight section.

[0010] Further optimization of the technical scheme of the utility model, the fluid passage further includes third straight section and second contraction section, one end of the third straight section is connected with the first straight section through the first contraction section, the other end is connected with the second straight section through the second contraction section, and the diameter of the third straight section is less than the diameter of the second straight section.

[0011] Further optimization of the technical scheme of the utility model, the surfactant coating is arranged on the inner wall of the third straight section, or a surfactant placement cavity is arranged in the third straight section.

[0012] Further optimization of the technical scheme of the utility model, the body includes first connector and second connector, the first connector and the second connector are connected through screw threads or clamping, and a bubble splitting film is arranged on the corresponding fluid passage at the connection.

[0013] Further optimization of the technical scheme of the utility model, the inner wall of the fluid passage is frosted or is provided with a groove for facilitating surfactant adhesion.

[0014] Further optimization of the technical scheme of the utility model, a microporous structure is arranged in the third straight section.

[0015] The utility model further provides a kind of microbubble generator, including syringe, injection needle, microbubble generating assembly and the foaming experiment mixer described above, and the foaming experiment mixer and the microbubble generator are both arranged between the syringe and the injection needle.

[0016] The utility model further provides a kind of microbubble generator, including syringe, injection needle, microbubble generating assembly and the foaming experiment mixer described above, and the foaming experiment mixer and the microbubble generator are both arranged between the syringe and the injection needle.

[0017] The utility model has the beneficial effects that:

[0018] Through the mixer structure, the surfactant can be quantitatively arranged on the inner surface of the fluid channel before the foaming experiment, so that the preparation time of the operator can be saved during the foaming experiment, and through the structural design of the mixer, the injection needle and the syringe can be directly connected through the connecting head, so that the clinical operation is convenient and fast.

[0019] By designing the fluid channel of the relaxation period into flow sections with different diameters, the liquid flow rate difference in the fluid channel can increase the dissolution rate of the surfactant, especially using the Venturi structure; in addition, in order to accelerate the dissolution rate of the surfactant and the liquid, the middle part of the fluid channel is designed into a microporous structure to increase the contact area of the liquid and the surfactant; similarly, the design of the microporous structure can also cut the bubbles in the liquid, so that the number of bubbles is more and the volume is smaller, and the detection effect of the contrast agent is improved. BRIEF DESCRIPTION OF DRAWINGS

[0020] The above and other objects, features and advantages of the present application will become more apparent from the following description of the embodiments of the present application with reference to the accompanying drawings, in which:

[0021] Figure 1 is a cross-sectional structure schematic view of the foaming experiment mixer embodiment 1 of the present application;

[0022] Figure 2 is a cross-sectional structure schematic view of the foaming experiment mixer embodiment 2 of the present application;

[0023] Figure 3 is a cross-sectional structure schematic view of the foaming experiment mixer embodiment 3 of the present application;

[0024] Figure 4 is Figure 3 is a local enlarged structure schematic view of part B;

[0025] Figure 5 is a cross-sectional structure schematic view of the foaming experiment mixer embodiment 4 of the present application;

[0026] Figure 6 is Figure 5 is a local enlarged structure schematic view of part A;

[0027] Figure 7 is a structure schematic view of the foaming experiment mixer embodiment 5 of the present application.

[0028] In the drawings: 1, first syringe; 2, second syringe; 3, injection needle; 4, three-way valve; 5, mixer; 6, bubble cutting film;

[0029] 51, connector; 52, first straight section; 53, first tapered section; 54, second straight section; 55, third straight section; 56, second tapered section; 57, first connecting body; 58, second connecting body; 59, microporous structure. DETAILED DESCRIPTION

[0030] The utility model is described below based on examples, but the utility model is not limited to these examples. In the following detailed description of the utility model, some specific details are described in detail in order to avoid confusion of the essence of the utility model, and well-known methods, processes, procedures, elements are not described in detail.

[0031] In addition, those skilled in the art should understand that the drawings provided herein are for illustrative purposes only, and the drawings are not necessarily drawn to scale.

[0032] Unless the context clearly requires otherwise, throughout the description and the claims, the words "comprise", "comprising", and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in the sense of "including, but not limited to".

[0033] In the description of the utility model, it is to be understood that the terms "first", "second" and the like are used only for the purpose of description, and cannot be understood as indicating or implying relative importance. In addition, in the description of the utility model, unless otherwise stated, the meaning of "multiple" is two or more.

[0034] The following is combined Figures 1-7 The technical scheme of the present application is described in detail.

[0035] <Example 1>

[0036] During the process of the foaming experiment, the bubbles in the solution will collide and automatically merge with the flow of the liquid in the natural state, thereby changing the volume and quantity of the bubbles in the solution, which affects the detection effect of patent foramen ovale in the process of contrast, in order to solve the problem, the utility model provides a kind of mixer 5 for foaming experiment, by setting surfactant in mixer 5, the stability of bubble in liquid can be improved, the collision rate of bubble is reduced, so that the microbubble manufactured in liquid can smoothly enter the detection area of patent foramen ovale, increase the detection effect of contrast, specific mixer 5 includes body, fluid channel is set in the body, can be supplied for the liquid in syringe to flow smoothly, and the inner wall of the fluid channel is provided with surfactant coating, when fluid flows, liquid contacts with surfactant, thereby dissolving surfactant into liquid, specific surfactant is polysorbate, glucose, propylene glycol, polyethylene glycol, lecithin, poloxamer, glycerol, hypertonic saline etc.;The body is provided with connecting head 51 at both ends corresponding the fluid channel, so that mixer 5 and injection needle 3 and syringe are connected respectively, medical staff can directly take mixer 5 when using, after connecting, it can be used, two connecting heads 51 can be provided with inner luer connector and outer luer connector respectively;At the same time, by controlling the amount of surfactant attached to the inner wall of mixer 5, the time for preparing surfactant and foaming liquid according to a certain proportion is also saved, and the use is more efficient and convenient.

[0037] In order to increase the adhesion of surfactant in the fluid channel, the inner wall of the fluid channel is ground or provided with grooves for facilitating the adhesion of surfactant, so that the surfactant can be attached to the inner surface of the fluid channel by smearing and spraying. In addition, in order to ensure that the surfactant can be dissolved in the fluid channel, the fluid channel is provided with three parts including a first straight section 52, a first contraction section 53 and a second straight section 54. The diameter of the first straight section 52 is greater than that of the second straight section 54, and the first contraction section 53 is arranged between the first straight section 52 and the second straight section 54. The surfactant coating is arranged on the inner wall of the first contraction section 53 or / and the second straight section 54. Because the speed of the fluid in the first contraction section 53 changes and the friction with the inner wall of the first contraction section 53 is relatively large, the surfactant is more easily dissolved in the liquid. Similarly, the flow rate of the liquid in the second straight section 54 is the largest, and the surfactant on the inner wall is also dissolved quickly.

[0038] <Embodiment 2>

[0039] On the basis of the above embodiment 1, in a preferred embodiment, the fluid channel is further provided with a third straight section 55 and a second contraction section 56, one end of the third straight section 55 is connected with the first straight section 52 through the first contraction section 53, the other end is connected with the second straight section 54 through the second contraction section 56, and the diameter of the third straight section 55 is smaller than that of the second straight section 54. The first contraction section 53, the third straight section 55 and the second contraction section 56 in this embodiment form a Venturi structure, which can first increase the flow rate of the liquid and then decrease the flow rate, and in this process, a turbulent flow can be formed to shear the gas bubbles in the liquid, so that the number of gas bubbles in the foaming liquid is more and the volume is smaller, and the contrast detection effect is provided. In addition, in this technical solution, the diameters of the first straight section 52, the third straight section 55 and the second straight section 54 are staggered, that is, the overall diameter of the fluid channel first decreases and then increases appropriately. This design has two beneficial effects: first, when the liquid flows in the reverse direction of the mixer 5 (the liquid flows from the second straight section 54 to the first straight section 52), the flow rate of the liquid first increases from the initial speed and then decreases to less than the initial speed, so that the surfactant can be fully dissolved in the liquid by changing the differential speed, and the surfactant can be first washed off from the inner wall of the fluid channel, and then the differential speed "stirring" can achieve the effect of rapid dissolution. Second, when the liquid of the mixer 5 flows in the forward direction (the liquid flows from the first straight section 52 to the second straight section 54), the liquid first accelerates and then decelerates, and the initial flow rate is increased to the maximum. By using the Venturi structure, a good turbulent shear effect can be formed at the second contraction section 56 to cut the gas bubbles in the liquid into smaller and more bubbles. Thus, the experimental effect is increased. In this embodiment, preferably, the surfactant coating is provided on the inner wall of the third straight section 55, or the surfactant coating is provided in the third straight section 55, the second contraction section 56 and the second straight section 54.

[0040] On the basis of the Venturi structure, a surfactant placement cavity can be provided in the third straight section 55. Specifically, the third straight section 55 is divided into two parallel fluid channels by a partition, a dialysis membrane is provided at the inlet of one of the fluid channels, the dialysis membrane can allow small molecules such as normal saline to flow through, and large molecules such as surfactants are not easy to flow through. Powder or granular surfactant can be placed in the dialysis membrane. In this way, the liquid can be vertically sucked during use, so that the surfactant is dissolved in the liquid and backflow does not occur. Of course, the disadvantage of this embodiment is that the mixer 5 must be placed in the correct way before use, that is, the end close to the dialysis membrane should be kept at the bottom as much as possible.

[0041] <Embodiment 3>

[0042] Because the mixer 5 of the technical solution is used on the foaming experiment device, in order to further help the foaming effect, the body is arranged as a first connector 57 and a second connector 58 which are connected through threads or clamping, and a bubble splitting film 6 is arranged on the corresponding fluid passage at the connection position, so that when the liquid flows through the position of the bubble splitting film 6, the bubbles in the liquid can be further split into more smaller bubbles, the foaming efficiency is improved, and the diameter of the micropore on the bubble splitting film 6 is between 0.1 microns and 10 microns.

[0043] <Embodiment 4>

[0044] With respect to the structure of the bubble splitting film 6 in the above-mentioned embodiment 3, an alternative embodiment is that the fluid passages of the third flat section 55 are all arranged as micropore structures 59, the diameter of the micropore is the same as that of the bubble splitting film 6, so that the contact area between the third flat section 55 and the liquid can be increased, and the bubbles in the liquid can be split when the liquid flows, to form smaller and more micro-bubbles.

[0045] <Embodiment 5>

[0046] The mixer 5 is matched with the above-mentioned foaming experiment device, and the utility model also provides a micro-bubble generating device, which comprises: a first syringe 1, a second syringe 2 and a needle 3 which are connected through a three-way valve 4, and the foaming experiment device is arranged on any branch of the three-way valve 4, preferably, the mixer 5 is arranged between the first syringe 1 and the three-way valve 4 or between the second syringe 2 and the three-way valve 4, so that the liquid can flow through the mixer every time in the process of bubble generation through repeated pulling of the syringe, so that the surfactant in the mixer is completely dissolved in the liquid. When in use, the first syringe 1 extracts the liquid, the second syringe 2 extracts the gas, and through the matching pulling of the first syringe 1 and the second syringe 2, the gas in the second syringe 2 can be dissolved into the liquid in the first syringe 1, and micro-bubbles are formed in the liquid. The structure of the foaming experiment device can be matched with the mixer 5, so that the surfactant in the mixer 5 can be dissolved into the liquid when the first syringe 1 extracts the liquid, so as to increase the stability of the bubbles in the liquid in the foaming process, and provide guarantee for subsequent contrast detection. In order to operate more conveniently, the first syringe 1 and the second syringe 2 can be provided with boost devices in the embodiment, so as to reduce the operation difficulty of the operator, and also can reduce the error of human operation.

[0047] <Embodiment 6>

[0048] Further, the utility model still provides a kind of microbubble generator, including syringe, injection needle 3, microbubble generator component and the mixer 5 described above for foaming experiment, the mixer 5 for foaming experiment and the microbubble generator are all arranged between the syringe and the injection needle 3.The microbubble generator component in this embodiment can use the microbubble generator device of patent publication No.CN 117241846 A, and the gas and liquid can be efficiently mixed by the microbubble generator component, and cooperate surfactant mixer 5, can make gas-liquid mixed phase more stable.

[0049] It should be understood that the above embodiments are only exemplary and not limiting, and various obvious or equivalent modifications or substitutions can be made by those skilled in the art without departing from the basic principles of the utility model, which shall be included in the scope of the claims of the utility model.

Claims

1. A mixer for foaming experiments, characterized in that The application relates to a foaming experiment mixer. The body is provided with a fluid channel, and the inner wall of the fluid channel is provided with a surfactant coating. The body is provided with a connecting head at each end corresponding to the fluid channel.

2. The foaming experiment mixer according to claim 1, wherein The fluid channel comprises a first straight section, a first contraction section and a second straight section, the diameter of the first straight section is larger than that of the second straight section, and the first contraction section is arranged between the first straight section and the second straight section.

3. The foaming experiment mixer according to claim 2, wherein The surfactant coating is arranged on the inner wall of the contraction section and / or the second straight section.

4. The foaming experiment mixer according to claim 2, wherein The fluid channel further comprises a third straight section and a second contraction section, one end of the third straight section is connected with the first straight section through the first contraction section, the other end of the third straight section is connected with the second straight section through the second contraction section, and the diameter of the third straight section is smaller than that of the second straight section.

5. The foaming experiment mixer according to claim 4, wherein The surfactant coating is arranged on the inner wall of the third straight section, or a surfactant placement cavity is arranged in the third straight section.

6. The foaming experiment mixer according to any one of claims 1 to 5, wherein The body comprises a first connecting body and a second connecting body, the first connecting body and the second connecting body are connected through threads or clamping, and a bubble splitting film is arranged on the corresponding fluid channel at the connecting position.

7. The foaming experiment mixer according to claim 6, wherein The inner wall of the fluid channel is a frosted surface or is provided with grooves for facilitating the adhesion of the surfactant.

8. The foaming experiment mixer according to claim 4 or 5, characterized in that, The third straight section is provided with a microporous structure.

9. A microbubble generator comprising: The first syringe, the second syringe and the injection needle are connected through a three-way valve, and the three-way valve is further provided with the foaming experiment mixer according to any one of claims 1-8.

10. A microbubble generator characterized by The injection syringe, the injection needle, the microbubble generating assembly and the foaming experiment mixer according to any one of claims 1-8 are connected, and the foaming experiment mixer and the microbubble generator are arranged between the injection syringe and the injection needle.

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