Spherical stent for large bone defect
By designing a spherical scaffold that combines support, cushioning, adhesion, and antibacterial functions, the problem of repairing large bone defects has been solved, achieving effective repair of bone defects and functional recovery.
Patent Information
- Application Number
- CN202422796826.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Priority Date
- 2024-11-08
- Filing Date
- 2024-11-18
- Publication Date
- 2025-12-02
- Estimated Expiration
- 2034-11-18
AI Technical Summary
Existing technologies for treating large bone defects suffer from high failure rates, heavy economic burdens, and difficulty in achieving effective bone healing and functional recovery.
Design a spherical scaffold that includes an internal support and cushioning structure, a built-in adhesive function, and an antibacterial and biodegradable structure. Utilize components such as cushioning springs, dampers, collagen, and an antibacterial adhesive coating to achieve support, cushioning, adhesion, and antibacterial effects.
It provides effective support and cushioning, promotes osteoblast growth, reduces the risk of adhesion and infection, and enables the repair of bone defects and functional recovery.
Smart Images
Figure CN223614980U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of spherical scaffold technology, and in particular to a spherical scaffold for large bone defects. Background Technology
[0002] Bone defect repair is a persistent international medical challenge. With societal modernization and an aging population, bone defects caused by severe trauma, infection, tumors, and severe osteoporotic fractures are increasingly common, becoming one of the most common disabling injuries worldwide. Statistics show that 5%-10% of bone injuries globally eventually lead to bone defects, seriously threatening patients' quality of life and even their lives. In the United States and Europe, more than 500,000 patients undergo bone defect repair surgery annually, with total costs exceeding $3 billion. Meanwhile, the failure rate of bone defect treatment is as high as 40%, and the subsequent secondary surgeries and hospitalizations further increase the economic burden of bone defects. Therefore, bone defect repair and reconstruction is a significant challenge currently facing orthopedic surgeons.
[0003] When bone defects exceed a critical threshold in size, clinical intervention is necessary to achieve defect healing and functional recovery. In recent years, bone tissue engineering grafts have shown great potential in the field of bone regeneration, and the design of specially structured bone tissue engineering scaffolds for bone defect repair is a novel treatment strategy. Therefore, we propose a spherical scaffold for large bone defects to address the aforementioned issues. Utility Model Content
[0004] The purpose of this invention is to provide a spherical scaffold for large bone defects, in order to solve the problems mentioned in the background art.
[0005] This utility model discloses a spherical scaffold for large bone defects, comprising a spherical scaffold body, a connecting seat provided on the inner wall of the spherical scaffold body, a support frame inserted inside the connecting seat, a damper connected to the inner side of the support frame, a buffer spring sleeved on the outside of the damper, and a central shaft connecting seat connected to one end of the buffer spring.
[0006] This utility model discloses a spherical support for large bone defects, wherein the central axis connecting seat is connected to a damper on the inner side of the support frame via a buffer spring, and multiple sets of support frame, damper and buffer spring are provided.
[0007] This invention relates to a spherical scaffold for large bone defects, wherein the support frame is connected to the interior of the spherical scaffold body via a connecting seat, and the central connecting seat, damper, and support frame support the interior of the spherical scaffold body.
[0008] This utility model discloses a spherical scaffold for large bone defects, wherein the spherical scaffold body has a groove on its exterior and an internal connecting scaffold is inserted inside the spherical scaffold body.
[0009] This invention relates to a spherical scaffold for large bone defects, wherein the interior of the spherical scaffold is filled with a sac, the sac contains collagen, the inner layer of the collagen is connected to a solvent diaphragm, and the interior of the solvent diaphragm is filled with a solvent.
[0010] This invention relates to a spherical scaffold for large bone defects, wherein the sac is provided in multiple sets, and the solvent is separated from the collagen by a solvent diaphragm and filled inside the sac.
[0011] This invention relates to a spherical scaffold for large bone defects, wherein the exterior of the spherical scaffold is coated with an antibacterial adhesion coating, and the interior of the spherical scaffold contains bidirectional calcium phosphate, PLGA, and PLA.
[0012] This invention relates to a spherical scaffold for large bone defects, wherein the main body of the spherical scaffold is composed of biaxial calcium phosphate, PLA and PLGA, and the inner and outer surfaces of the spherical scaffold are coated with an antibacterial adhesion coating.
[0013] The spherical scaffold for large bone defects of this invention differs from the prior art in that it not only achieves internal support and buffering functions and internal adhesion functions, but also antibacterial and biodegradable functions.
[0014] This invention relates to a spherical scaffold for large bone defects. Through the design of an internal support and buffer structure, the advantages of this invention are as follows: During use, a central axis connecting seat, a buffer spring, and a support frame connected to the outside of a damper are installed inside the spherical scaffold. The support frame connects to the connecting seat inside the spherical scaffold, allowing the central axis connecting seat and support frame inside the spherical scaffold to form a support within the spherical scaffold. When the spherical scaffold fills the bone, and multiple sets of spherical scaffolds are subjected to compression and collision, the support frame inside the spherical scaffold buffers the force through the damper, buffer spring, and central axis connecting seat, thus achieving the internal support and buffer function. The surface of the spherical scaffold has 600μm diameter grooves, and the interior of the spherical scaffold has multiple through-through internal connecting supports and support frames, which not only mimics the structure of bone trabeculae but also facilitates osteoblast crawling and replacement growth.
[0015] This invention relates to a spherical scaffold for large bone defects. By incorporating an internal adhesion structure, the advantages of this invention are as follows: During use, multiple sets of spherical scaffolds are filled inside the spherical scaffold. Before use, the spherical scaffold is vigorously shaken to rupture the spherical spherical scaffolds and solvent diaphragms inside the scaffold, allowing the solvent and collagen inside the spherical spherical scaffolds to mix and create viscosity. This allows the spherical scaffolds containing the solvent and collagen to adhere to each other and fill into the bone body, thus achieving the internal adhesion function. Point contact is formed between the spherical scaffolds in the bone defect area, maximizing the preservation of the extracellular matrix.
[0016] This utility model discloses a spherical scaffold for large bone defects. By setting an antibacterial and biodegradable structure, the advantages of this utility model are as follows: When in use, the spherical scaffold body is made of a mixture of bidirectional calcium phosphate, PLGA and PLA, which makes the spherical scaffold body elastic and biodegradable. Both the inside and outside of the spherical scaffold body are coated with an antibacterial adhesion coating, which can increase the antibacterial and anti-adhesion properties of the spherical scaffold body, thereby realizing the antibacterial and biodegradable functions.
[0017] The following description, in conjunction with the accompanying drawings, further illustrates a spherical scaffold for large bone defects according to this invention. Attached Figure Description
[0018] Figure 1 This is a schematic diagram of the spherical scaffold for large bone defects according to the present invention;
[0019] Figure 2 This is a side view sectional view of a spherical scaffold for large bone defects according to the present invention.
[0020] Figure 3 This is a schematic diagram of the structure of a buffer spring in a spherical scaffold for large bone defects according to the present invention;
[0021] Figure 4 This is a cross-sectional enlarged structural diagram of the spherical scaffold for large bone defects according to the present invention;
[0022] Figure 5 This is a partial enlarged cross-sectional schematic diagram of the spherical scaffold body in a spherical scaffold for large bone defects according to the present invention;
[0023] The markings in the diagram are as follows: 1-Spherical support body; 2-Groove; 3-Internal connecting support; 4-Support frame; 5-Bag; 6-Connecting seat; 7-Central axis connecting seat; 8-Damper; 9-Buffer spring; 10-Soluble; 11-Collagen; 12-Solvent diaphragm; 13-Bipolar calcium phosphate; 14-Antibacterial adhesion coating; 15-PLA; 16-PLGA. Detailed Implementation
[0024] The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of the present invention.
[0025] Example
[0026] like Figures 1-5 As shown, the present invention provides a spherical support for large bone defects, comprising a spherical support body 1, a connecting seat 6 provided on the inner wall of the spherical support body 1, a support frame 4 inserted inside the connecting seat 6, a damper 8 connected to the inner side of the support frame 4, a buffer spring 9 sleeved on the outside of the damper 8, and a central shaft connecting seat 7 connected to one end of the buffer spring 9.
[0027] The central shaft connecting seat 7 is connected to the damper 8 inside the support frame 4 through the buffer spring 9. There are multiple sets of support frame 4, damper 8 and buffer spring 9. The support frame 4 is connected to the inside of the spherical support body 1 through the connecting seat 6. The central shaft connecting seat 7, damper 8 and support frame 4 support the inside of the spherical support body 1.
[0028] like Figure 1 , Figure 2 and Figure 3 As shown, by setting an internal support and buffer structure, during use, a central axis connecting seat 7, a buffer spring 9, and a support frame 4 connected to the outside of the damper 8 are installed inside the spherical support body 1. The support frame 4 is connected to the connecting seat 6 inside the spherical support body 1, so that the central axis connecting seat 7 and the support frame 4 inside the spherical support body 1 form a support inside the spherical support body 1. When the spherical support body 1 is filled inside the bone, when multiple sets of spherical support bodies 1 are squeezed and collided, the support frame 4 inside the spherical support body 1 will buffer the force through the damper 8 and the buffer spring 9 and the central axis connecting seat 7, thereby realizing the internal support and buffer function.
[0029] The spherical support 1 is filled with a sac 5, the sac 5 is filled with collagen 11, the inner layer of the collagen 11 is connected to a solvent diaphragm 12, and the solvent diaphragm 12 is filled with a solvent 10.
[0030] Multiple sets of capsules 5 are provided, and the solvent 10 is separated from the collagen 11 by the solvent diaphragm 12 and filled inside the capsules 5;
[0031] like Figure 1 , Figure 2 and Figure 4As shown, by setting an internal adhesion structure, multiple sets of spherical scaffold 1 are filled inside during use. Before use, the multiple sets of spherical scaffold 1 are shaken vigorously to rupture the spherical scaffold 5 and solvent diaphragm 12 inside the spherical scaffold 1, allowing the solvent 10 and collagen 11 inside the spherical scaffold 5 to mix and generate viscosity, thus adhering the spherical scaffold 1 containing solvent 10 and collagen 11 to each other and filling them into the bone body, thereby realizing the internal adhesion function.
[0032] The spherical support body 1 is coated with an antibacterial adhesion coating 14 on the outside, and bidirectional calcium phosphate 13, PLGA 16 and PLA 15 are disposed inside the spherical support body 1;
[0033] The main body of the spherical support 1 is composed of biaxial calcium phosphate 13, PLA 15 and PLGA 16, and the inner and outer surfaces of the spherical support 1 are coated with an antibacterial adhesion coating 14.
[0034] like Figure 1 and Figure 5 As shown, by setting an antibacterial and biodegradable structure, the spherical scaffold 1 is made of a mixture of bidirectional calcium phosphate 13, PLGA 16 and PLA 15 during use, which makes the spherical scaffold 1 elastic and biodegradable. An antibacterial adhesion coating 14 is applied to both the inside and outside of the spherical scaffold 1, which can increase the antibacterial and anti-adhesion properties of the spherical scaffold 1, thereby realizing the antibacterial and biodegradable function.
[0035] Working Principle: In use, this invention fills the interior of the spherical scaffold 1 with multiple sets of pouches 5. Before use, the spherical scaffold 1 is vigorously shaken to rupture the pouches 5 and solvent diaphragms 12 inside, allowing the solvent 10 and collagen 11 inside the pouches 5 to mix and create viscosity. This allows the spherical scaffold 1 containing the solvent 10 and collagen 11 to adhere together and fill into the bone. Inside the spherical scaffold 1, a central axis connector 7, a buffer spring 9, and a support frame 4 connected to the outside of the damper 8 are installed. The support frame 4 connects to the connecting seat 6 inside the spherical scaffold 1, allowing the central axis connector 7 and support frame 4 to form a support within the spherical scaffold 1. When the spherical scaffold 1 is filled into the bone, the multiple sets of spherical supports... When the scaffold 1 is subjected to compression and collision, the support frame 4 inside the spherical scaffold 1 will buffer the force through the damper 8 and the buffer spring 9 and the central axis connecting seat 7. The spherical scaffold 1 forms point contact with each other in the bone defect area to preserve the extracellular matrix to the greatest extent. The surface of the spherical scaffold 1 has pores 2 with a diameter of 600μm. The spherical scaffold 1 has multiple through-through internal connecting scaffolds 3 and support frames 4, which not only mimic the structure of bone trabeculae, but also facilitate the crawling replacement growth of osteoblasts. The spherical scaffold 1 is made by mixing bidirectional calcium phosphate 13, PLGA 16 and PLA 15, which makes the spherical scaffold 1 elastic and biodegradable. The spherical scaffold 1 is coated with an antibacterial adhesion coating 14 on both the inside and outside, which can increase the antibacterial and anti-adhesion properties of the spherical scaffold 1.
[0036] Although the present invention has been described in detail above with general descriptions and specific embodiments, some modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.
Claims
1. A spherical scaffold for large-segment bone defects, comprising a spherical scaffold body, characterized in that: The spherical support body has a connecting seat on its inner wall. A support frame is inserted inside the connecting seat. A damper is connected to the inner side of the support frame. A buffer spring is sleeved on the outside of the damper. One end of the buffer spring is connected to a central shaft connecting seat.
2. A spherical scaffold for large bone defects according to claim 1, characterized in that: The central shaft connecting seat is connected to the damper inside the support frame via a buffer spring, and multiple sets of support frame, damper and buffer spring are provided.
3. A spherical scaffold for large bone defects according to claim 1, characterized in that: The support frame is connected to the interior of the spherical support body via a connecting seat, and the central axis connecting seat, damper, and support frame provide support for the interior of the spherical support body.
4. A spherical scaffold for large bone defects according to claim 1, characterized in that: The spherical support body has openings and slots on its exterior, and an internal connecting bracket is inserted inside the spherical support body.
5. A spherical scaffold for large bone defects according to claim 1, characterized in that: The spherical scaffold is internally filled with sacs containing collagen. The inner layer of the collagen is connected to a solvent diaphragm, which is filled with a solvent.
6. A spherical scaffold for large bone defects according to claim 5, characterized in that: The capsules are provided in multiple sets, and the solvent is separated from the collagen by a solvent diaphragm and filled inside the capsules.
7. A spherical scaffold for large bone defects according to claim 1, characterized in that: The exterior of the spherical scaffold is coated with an antibacterial adhesion coating, and the interior of the spherical scaffold contains bidirectional calcium phosphate, PLGA, and PLA.
8. A spherical scaffold for large bone defects according to claim 7, characterized in that: The main body of the spherical support is composed of biaxial calcium phosphate, PLA and PLGA, and the inner and outer surfaces of the spherical support are coated with an antibacterial adhesion coating.