Microsphere generating device

Abstract

The utility model provides a microsphere generating device. The microsphere generating device comprises a spraying device, a liquid storage device for storing a hydrogel raw material and a curing device for curing the hydrogel raw material, a containing cavity is formed in the curing device, and a bearing plate, a filtering piece and a collecting box which are sequentially arranged from top to bottom are arranged in the containing cavity; the side wall of the curing device is provided with an opening for the bearing plate, the filtering piece and the collecting box to enter and exit from the accommodating cavity; the curing device is provided with an injection port for communicating the accommodating cavity with the outside; the spraying device is communicated with the output end of the liquid storage device, faces the injection opening and is used for spraying the hydrogel raw materials to the bearing plate in the containing cavity, so that the hydrogel raw materials are solidified on the bearing plate to form hydrogel microspheres. The microsphere generating device disclosed by the utility model has the advantages of simple structure, high space utilization rate and the like, integrates the functions of preparing, filtering and collecting hydrogel microspheres, and is convenient to use and good in experience feeling.

Description

Technical Field

[0001] This utility model relates to the field of microsphere preparation technology, and specifically to a microsphere generation device. Background Technology

[0002] Hydrogel microspheres refer to hydrogels or composite hydrogels with diameters ranging from nanometers to micrometers and shapes that are spherical, near-spherical, or other geometrically shaped. Common morphologies include solid, hollow, porous, and onion-shaped. Hydrogel microspheres have broad application prospects in numerous fields such as drug release, cell culture, microreactors, molecular detection, and cell labeling.

[0003] Current research on microsphere generation devices is limited, and existing devices often have several drawbacks. For example, in existing devices for preparing hydrogel microspheres using the condensation method, the condensation and collection devices are mostly designed as separate units, resulting in large space requirements and a bulky structure. Some generation devices also lack filtration and collection functions, failing to screen the hydrogel microspheres and leading to inconsistent quality, inconvenience, and a poor user experience.

[0004] Based on this, the present invention aims to provide a solution to address at least one of the problems existing in the prior art. Utility Model Content

[0005] To overcome the shortcomings of the prior art, this utility model provides a microsphere generating device, the specific technical solution of which is as follows:

[0006] The present invention provides a microsphere generating device, comprising: a spraying device, a liquid storage device for storing hydrogel raw materials, and a curing device for curing the hydrogel raw materials;

[0007] The curing device has an internal cavity containing a support plate, a filter element, and a collection box arranged from top to bottom. The side wall of the curing device has openings for the support plate, the filter element, and the collection box to enter and exit the cavity.

[0008] The curing device is provided with an injection port that connects the receiving cavity to the outside; the spraying device is connected to the output end of the liquid storage device and faces the injection port, and is used to spray the hydrogel raw material onto the support plate in the receiving cavity, so that the hydrogel raw material is cured on the support plate to form hydrogel microspheres.

[0009] In one specific embodiment, the liquid storage device is equipped with a controller, and the liquid storage device is internally equipped with a temperature sensor and a heater, and the controller is communicatively connected to the temperature sensor and the heater respectively.

[0010] In one specific embodiment, the input end of the liquid storage device is connected to an external raw material supply device through a valve, and a liquid level sensor is also installed inside the liquid storage device. The controller is communicatively connected to the valve and the liquid level sensor respectively.

[0011] In one specific embodiment, the curing device includes a cavity and a condenser and / or an irradiator disposed in the cavity; the injection port and the notch are both formed on the cavity, and the receiving cavity is located in the cavity.

[0012] In one specific embodiment, the thickness of the support plate is less than the width of its corresponding notch.

[0013] In one specific embodiment, both the support plate and the filter element have a sealing plate on one side, the sealing plate being used to seal the opening;

[0014] And / or, the support plate includes a hydrophobic layer.

[0015] In one specific embodiment, the carrier plate, the filter element, and the collection box are all provided with handles, and the handles are located outside the receiving cavity.

[0016] In one specific embodiment, the spraying device includes a manual nozzle or an automatic nozzle connected to the liquid storage device;

[0017] And / or, the liquid storage device is provided with a liquid inlet, and the liquid inlet is detachably covered.

[0018] In one specific embodiment, the filter element has a plurality of filter holes, the diameter of which is between 90 micrometers and 110 micrometers.

[0019] In one specific embodiment, the liquid storage device is provided with a touch screen display, which is communicatively connected to the controller.

[0020] This utility model has at least the following beneficial effects:

[0021] This invention provides a microsphere generation device, which integrates the functions of preparing, filtering, and collecting hydrogel microspheres by sequentially arranging a support plate, a filter element, and a collection box within a curing device. The cooperation of these three components enhances the device's functionality. Furthermore, the support plate, filter element, and collection box can enter and exit the curing device's receiving cavity through openings, forming a drawer-like structure. This facilitates easy access to components during preparation, providing a convenient and user-friendly experience. After preparation, the components can be stored in the receiving cavity, significantly improving the device's space utilization and reducing its structural complexity. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a perspective view of the overall structure of one embodiment of the present utility model;

[0024] Figure 2 This is a perspective view of the overall structure of another embodiment of the present invention;

[0025] Figure 3 A schematic diagram of the structure when the support plate, filter element and collection box are housed in the receiving cavity;

[0026] Figure 4 This is a schematic diagram showing the structure with the support plate, filter element, and collection box partially exposed in the receiving cavity.

[0027] Figure 5 for Figure 4 Detailed diagram A.

[0028] Figure label:

[0029] 1-Spraying device; 2-Liquid storage device; 21-Liquid inlet; 3-Curing device; 31-Cavity; 32-Condenser; 33-Irradiator; 4-Receiving cavity; 5-Support plate; 6-Filter element; 7-Collection box; 8-Notch; 9-Injection port; 10-Temperature sensor; 11-Heater; 12-Valve; 13-Level sensor; 14-Sealing plate; 15-Handle; 16-Touch display screen. Detailed Implementation

[0030] Various embodiments of the present invention will be described more fully below. The present invention may have various embodiments, and adjustments and changes may be made therein. However, it should be understood that there is no intention to limit the various embodiments of the present invention to the specific embodiments disclosed herein, but rather the present invention should be understood to cover all adjustments, equivalents, and / or alternatives falling within the spirit and scope of the various embodiments of the present invention.

[0031] In the following, the terms “comprising” or “may include”, which may be used in various embodiments of the present invention, indicate the presence of the disclosed functions, operations, or elements, and do not limit the addition of one or more functions, operations, or elements. Furthermore, as used in various embodiments of the present invention, the terms “comprising,” “having,” and their cognates are intended only to indicate a specific feature, number, step, operation, element, component, or combination of the foregoing, and should not be construed as primarily excluding the presence of one or more other features, numbers, steps, operations, elements, components, or combinations of the foregoing, or the possibility of adding one or more combinations of features, numbers, steps, operations, elements, components, or combinations of the foregoing.

[0032] In various embodiments of this utility model, the expression "or" or "at least one of A and / or B" includes any combination or all combinations of the words listed simultaneously. For example, the expression "A or B" or "at least one of A and / or B" may include A, may include B, or may include both A and B.

[0033] The terms used in the various embodiments of this utility model (such as "first," "second," etc.) may modify various constituent elements in the various embodiments, but do not limit the corresponding constituent elements. For example, the above terms do not limit the order and / or importance of the elements. The above terms are only used for the purpose of distinguishing one element from other elements. For example, a first user device and a second user device refer to different user devices, although both are user devices. For example, without departing from the scope of the various embodiments of this utility model, a first element may be referred to as a second element, and similarly, a second element may be referred to as a first element.

[0034] It should be noted that, in this utility model, unless otherwise explicitly specified and defined, terms such as "installation," "connection," and "fixation" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0035] Please refer to Figures 1 to 5 The present invention provides a microsphere generating device, comprising: a spraying device 1, a liquid storage device 2 for storing hydrogel raw materials, and a curing device 3 for curing hydrogel raw materials.

[0036] Specifically, the curing device 3 has an internal cavity 4, in which a support plate 5, a filter element 6, and a collection box 7 are arranged sequentially from top to bottom. The side wall of the curing device 3 has a notch 8 for the support plate 5, filter element 6, and collection box 7 to enter and exit the cavity 4. The support plate 5, filter element 6, and collection box 7 can be completely inserted into and housed in the cavity 4 through the notch 8, or completely pulled out of the cavity 4 through the notch 8, or partially located in and partially outside the cavity 4, thus forming a drawer-type structure.

[0037] In some cases, a slide rail may be provided on the inner wall of the curing device 3 to assist the movement of the support plate 5, filter element 6 and collection box 7, and to provide a certain degree of support.

[0038] The curing device 3 is provided with an injection port 9 that connects the receiving cavity 4 to the outside. The spraying device 1 is connected to the output end of the liquid storage device 2 and faces the injection port 9. It is used to spray the hydrogel material in the liquid storage device 2 onto the support plate 5 in the receiving cavity 4, so that the hydrogel material is cured on the support plate 5 by the action of the curing device 3 to form hydrogel microspheres.

[0039] For example, injection port 9 can be as follows Figure 1 As shown, the injection port 9 is located on the side wall of the curing device 3, and its vertical height is higher than that of the support plate 5. In other cases, the injection port 9 may also be located at the top of the curing device 3.

[0040] For example, the spray device 1 can be connected to the output end of the liquid storage device 2 via a pipe. Optionally, the spray device 1 can be directed vertically toward the injection port 9 or tilted toward the injection port 9.

[0041] Please refer to Figure 3 and Figure 4 The following is an exemplary description of one method of using this utility model. Specifically, before the preparation begins, the support plate 5, filter element 6, and collection box 7 are pushed into the receiving cavity 4. The spray device 1 is turned on, spraying the hydrogel material in the liquid storage device 2 onto the support plate 5 in the receiving cavity 4. The hydrogel material initially appears as droplets, and under the action of the solidification device 3, it solidifies from a liquid state to form hydrogel microspheres. Next, the support plate 5 is removed from the receiving cavity 4, and the filter element 6 and collection box 7 are partially or completely removed. The hydrogel microspheres are poured onto the filter element 6. Under the filtration effect of the filter element 6, the hydrogel microspheres that meet the size and shape requirements fall into the collection box 7 and are collected, thus completing one round of preparation operations.

[0042] Preferably, the support plate 5 may include a hydrophobic layer that contacts the hydrogel raw material, thereby maintaining the spherical shape of the hydrogel microspheres as much as possible. Optionally, the hydrophobic layer may be a layer of hydrophobic material disposed on the support plate 5, or it may be a coating of hydrophobic material applied to the support plate 5, or the entire support plate 5 may be made of a hydrophobic material plate.

[0043] In one specific embodiment, the liquid storage device 2 is equipped with a controller, such as a control circuit board, please refer to... Figure 1 The liquid storage device 2 is equipped with a temperature sensor 10 and a heater 11, and the controller is communicatively connected to the temperature sensor 10 and the heater 11. In actual use, the temperature of the hydrogel material inside the liquid storage device 2 can be detected by the temperature sensor 10. When the detected temperature is lower than the preset value, the controller controls the heater 11 to heat the hydrogel material, thereby improving the fineness of the hydrogel material when it is sprayed by increasing the temperature of the hydrogel material.

[0044] For example, heater 11 may be an electric heating wire.

[0045] Further, please refer to Figure 2 The input end of the liquid storage device 2 can be connected to an external raw material supply device (not shown in the figure) through a valve 12. A liquid level sensor 13 can also be installed inside the liquid storage device 2. The controller is communicatively connected to the valve 12 and the liquid level sensor 13. In actual use, the liquid level sensor 13 can detect the storage amount of hydrogel raw material inside the liquid storage device 2. When the detected storage amount is lower than a preset value, the controller controls the valve 12 to open, so that the external raw material supply device can input hydrogel raw material into the liquid storage device 2.

[0046] In this embodiment, the spraying device 1 preferably includes an automatic nozzle connected to the liquid storage device 2. The automatic nozzle is communicatively connected to a controller for operation or shutdown under the control of the controller. In this case, the controller can be configured to control the heater 11 to heat the hydrogel material before controlling the automatic nozzle to operate.

[0047] In other embodiments, the spraying device 1 may also include a manually operated nozzle connected to the liquid storage device 2, for example... Figure 1 As shown, the liquid storage device 2 may have a liquid inlet 21, and a detachable cover 22 is provided on the liquid inlet 21. In use, hydrogel raw materials can be manually injected into the liquid storage device 2 by opening the cover 22. Different components of hydrogel raw materials can be injected according to actual conditions and needs to obtain different hydrogel microspheres, which has good flexibility.

[0048] In one specific embodiment, the curing device 3 includes a cavity 31 and a condenser 32 and / or an irradiator 33 disposed within the cavity 31. The condenser 32 is used to condense and cure the hydrogel material sprayed onto the support plate 5 by condensation, while the irradiator 33 is used to photocur the hydrogel material sprayed onto the support plate 5 by light irradiation. It should be noted that, when photocuring is performed, a photoinitiator is mixed into the hydrogel material.

[0049] Optionally, the cavity 31 may contain only a condenser 32, or only an irradiator 33, or both a condenser 32 and an irradiator 33.

[0050] For example, please refer to Figure 1 When a condenser 32 is provided in the cavity 31, the condenser 32 has an air outlet (refer to reference 32 in the diagram). The air outlet is located on the inner wall of the cavity 31, and preferably the air outlet is distributed in a circumferential manner, surrounding the support plate 5, for directly supplying cold air to the support plate 5, thereby enabling rapid condensation and solidification of the hydrogel raw material droplets sprayed onto the support plate 5. Other components of the condenser 32 are not shown, but can be configured according to existing technology.

[0051] For example, please refer to Figure 2 When an irradiator 33 is provided in the cavity 31, the irradiator 33 can be provided on the inner top wall and inner side wall of the cavity 31. The irradiator 33 can be, for example, an ultraviolet lamp.

[0052] In this embodiment, both the injection port 9 and the notch 8 are formed on the cavity 31, and the receiving cavity 4 is located in the cavity 31.

[0053] In one specific embodiment, please refer to Figure 4 and Figure 5 The thickness of the support plate 5 is less than the width of its corresponding notch 8. Therefore, when the support plate 5 is removed after preparation, the hydrogel microspheres on it are less likely to collide with or be squeezed by the curing device 3, thus making the morphology of the hydrogel microspheres less likely to be damaged, which can improve the yield and quality of hydrogel microspheres.

[0054] Furthermore, both the support plate 5 and the filter element 6 have a sealing plate 14 on one side, the sealing plate 14 being sized to fit the notch 8, for sealing the notch 8 when the support plate 5 and the filter element 6 are fully inserted into the receiving cavity 4. Preferably, the sealing plate 14 can be sealed to the inner wall of the notch 8 by means of a sealing ring.

[0055] In one specific embodiment, handles 15 are provided on the support plate 5, the filter element 6, and the collection box 7, and the handles 15 are located outside the receiving cavity 4. Understandably, the provision of handles 15 facilitates the movement and handling of the support plate 5, the filter element 6, and the collection box 7 by the operator, thereby improving the user experience of the device.

[0056] In one specific embodiment, refer to Figure 4 The filter element 6 may be plate-shaped and has a plurality of filter pores, the diameter of which may be between 90 micrometers and 110 micrometers. Preferably, the diameter of the filter pores is 100 micrometers, thereby enabling the screening of hydrogel microspheres with a diameter of approximately 100 micrometers. In other embodiments, the filter element 6 may also be a filter screen, the mesh size of which may also be between 90 micrometers and 110 micrometers, preferably 100 micrometers.

[0057] In one specific embodiment, the liquid storage device 2 is also provided with a touch display screen 16, which is communicatively connected to the controller. In an embodiment including a valve 12, an automatic nozzle, and a heater 11, the touch display screen 16 is exemplarily configured to send control signals to the controller to control the opening and closing of the valve 12, the automatic nozzle, and the heater 11.

[0058] In summary, the microsphere generation device provided by this utility model integrates the functions of preparing, filtering, and collecting hydrogel microspheres by sequentially arranging a support plate 5, a filter element 6, and a collection box 7 within a curing device 3, through their mutual cooperation. This results in a highly functional device. Furthermore, the support plate 5, filter element 6, and collection box 7 can enter and exit the receiving cavity 4 of the curing device 3 through a notch 8, forming a drawer-like structure. This facilitates the removal of components during the preparation process, providing convenience and a superior user experience. After preparation, the components can be stored in the receiving cavity 4, thereby significantly improving the space utilization of the device and reducing its structural complexity.

[0059] Those skilled in the art will understand that the accompanying drawings are merely schematic diagrams of a preferred embodiment, and the modules or processes shown in the drawings are not necessarily essential for implementing this utility model.

[0060] Those skilled in the art will understand that the modules in the apparatus of the implementation scenario can be distributed within the apparatus of the implementation scenario as described, or they can be located in one or more apparatuses different from this implementation scenario, with corresponding changes. The modules of the above-described implementation scenario can be combined into one module, or they can be further divided into multiple sub-modules.

[0061] The serial numbers of the above-mentioned utility models are for descriptive purposes only and do not represent the superiority or inferiority of the implementation scenarios.

[0062] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A microsphere generating device, characterized in that, include: A spraying device (1), a liquid storage device (2) for storing hydrogel raw materials, and a curing device (3) for curing the hydrogel raw materials; The curing device (3) has an internal cavity (4), in which a support plate (5), a filter element (6) and a collection box (7) are arranged from top to bottom; the side wall of the curing device (3) has an opening (8) for the support plate (5), the filter element (6) and the collection box (7) to enter and exit the cavity (4); The curing device (3) is provided with an injection port (9) that connects the receiving cavity (4) to the outside; the spraying device (1) is connected to the output end of the liquid storage device (2) and faces the injection port (9), and is used to spray the hydrogel material onto the support plate (5) in the receiving cavity (4) so ​​that the hydrogel material is cured on the support plate (5) to form hydrogel microspheres.

2. The microsphere generating device according to claim 1, characterized in that, The liquid storage device (2) is equipped with a controller. The liquid storage device (2) is equipped with a temperature sensor (10) and a heater (11). The controller is communicatively connected to the temperature sensor (10) and the heater (11).

3. The microsphere generating device according to claim 2, characterized in that, The input end of the liquid storage device (2) is connected to an external raw material supply device through a valve (12). The liquid storage device (2) is also equipped with a liquid level sensor (13). The controller is communicatively connected to the valve (12) and the liquid level sensor (13).

4. The microsphere generating device according to claim 1, characterized in that, The curing device (3) includes a cavity (31) and a condenser (32) and / or an irradiator (33) disposed in the cavity (31); the injection port (9) and the notch (8) are both opened on the cavity (31), and the receiving cavity (4) is located in the cavity (31).

5. The microsphere generating device according to claim 1, characterized in that, The thickness of the bearing plate (5) is less than the width of its corresponding notch (8).

6. A microsphere generating device according to claim 1 or 5, characterized in that, Both the support plate (5) and the filter element (6) have a sealing plate (14) on one side, which is used to seal the opening (8); And / or, the support plate (5) includes a hydrophobic layer.

7. The microsphere generating device according to claim 1, characterized in that, The support plate (5), the filter element (6) and the collection box (7) are all provided with handles (15), and the handles (15) are located outside the receiving cavity (4).

8. The microsphere generating device according to claim 1, characterized in that, The spraying device (1) includes a manual or automatic nozzle connected to the liquid storage device (2); And / or, the liquid storage device (2) is provided with a liquid inlet (21), and a cover (22) is detachably provided on the liquid inlet (21).

9. The microsphere generating device according to claim 1, characterized in that, The filter element (6) has a plurality of filter holes, the diameter of which is between 90 micrometers and 110 micrometers.

10. A microsphere generating device according to claim 2 or 3, characterized in that, The liquid storage device (2) is equipped with a touch screen (16), which is communicatively connected to the controller.

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