Multi-drug-loading microneedle mold

Abstract

The utility model relates to a multi-drug-loading microneedle mold which comprises a plurality of first molds (A) and a plurality of second molds (B), the first mold (A) comprises a first microneedle mold (11) and a first solid mold (12) which are arranged at an interval; the second mold (B) comprises second solid molds (21) and second microneedle molds (22) which are arranged at intervals; the first microneedle mold (11) and the second solid mold (21) are arranged in parallel, and the first solid mold (12) and the second microneedle mold (22) are arranged in parallel, so that the first mold (A) and the second mold (B) are arranged in a staggered manner. According to the transdermal drug delivery device, drug loading can be carried out according to actual requirements, corresponding molds can be flexibly drawn out to achieve transdermal administration of various drugs, and the transdermal drug delivery device has good market application prospects.

Description

Technical Field

[0001] This utility model belongs to the field of microneedle technology, and specifically relates to a multi-drug-loaded microneedle mold. Background Technology

[0002] Microneedling for painless percutaneous drug delivery is a novel drug delivery technology. Its mechanism of action involves painlessly creating micron-sized drug delivery channels on the skin, enabling effective absorption of the drug by subcutaneous tissue. It offers advantages such as being painless, safe, and easy to operate. Based on their structure, microneedles can be classified into hollow microneedles, soluble microneedles, coated microneedles, and solid microneedles. Soluble microneedles, in particular, are prepared using biodegradable materials as a matrix and by mixing the drug into a microneedle mother solution, such as hyaluronic acid and polylactic acid. After being inserted into the skin, soluble microneedles dissolve in the body, releasing the drug.

[0003] In addition to possessing the advantages of conventional microneedles, soluble microneedles overcome the challenge of microneedle breakage within the skin due to their biodegradability. This also increases the drug loading capacity of microneedles, expanding their application range. Therefore, soluble microneedles hold promise as an ideal carrier for transdermal drug delivery systems and possess significant application value.

[0004] However, current soluble microneedles can only deliver a single drug and cannot deliver multiple drugs transdermally, which affects their further application and expansion. Summary of the Invention

[0005] The technical problem to be solved by this utility model is to provide a variety of drug-loaded microneedle molds. The molds can be loaded with drugs according to actual needs, and the corresponding molds can be flexibly extracted to realize transdermal drug delivery of a variety of drugs, which has good market application prospects.

[0006] This utility model provides a variety of drug-loaded microneedle molds, including several first molds and second molds. The first mold includes a first microneedle mold and a first solid mold arranged at intervals; the second mold includes a second solid mold and a second microneedle mold arranged at intervals; the first microneedle mold and the second solid mold are arranged side by side, and the first solid mold and the second microneedle mold are arranged side by side to realize the staggered arrangement of the first mold and the second mold.

[0007] Preferably, the first mold is loaded with a drug or material, and the second mold is loaded with another drug or material.

[0008] Preferably, the material in the first solid mold or the second solid mold is extracted to form a hollow mold.

[0009] Preferably, the material in the first or second solid mold is silicone, PCL, or PLA.

[0010] Preferably, the number of the first mold and the second mold is two or more.

[0011] Preferably, the bottom of the first mold and the second mold are provided with a base.

[0012] Beneficial effects

[0013] This invention can be drug-loaded according to actual needs, and can flexibly extract the corresponding mold to achieve transdermal drug delivery of various drugs, which has good market application prospects, such as:

[0014] (1) After skin injury (especially diabetic wounds), the use of multi-drug loaded microneedles can prevent or fight infection in the early stage of skin injury, avoiding problems such as suppuration and difficulty in tissue regeneration caused by infection; the anti-inflammatory component can provide a good microenvironment for tissue regeneration, avoiding pathological regeneration caused by inflammatory granulation tissue; and the angiogenic component can accelerate tissue regeneration and repair.

[0015] (2) In the treatment of tumors and post-tumor tissue regeneration: anti-tumor components can effectively kill tumor cells; growth factor (bFGF, VEGF, etc.) components can promote tissue regeneration after tumor necrosis and damage;

[0016] (3) Tracheal injury: Similar to skin injury. Since the trachea also contains cartilage tissue, cartilage regeneration-promoting components (such as icariin) can be added to avoid cartilage damage caused by injury. Attached Figure Description

[0017] Figure 1 This is a top view of the present invention.

[0018] Figure 2 This is a side view of the present invention. Detailed Implementation

[0019] The present invention will be further illustrated below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that after reading the teachings of this invention, those skilled in the art can make various alterations or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims.

[0020] Example 1

[0021] like Figure 1As shown, this embodiment provides a variety of drug-loaded microneedle molds, including several first molds A and second molds B; the first mold A includes a first microneedle mold 11 and a first solid mold 12 arranged at intervals; the second mold B includes a second solid mold 21 and a second microneedle mold 22 arranged at intervals; the first microneedle mold 11 and the second solid mold 21 are arranged side by side, and the first solid mold 12 and the second microneedle mold 22 are arranged side by side, realizing the staggered arrangement of the first mold A and the second mold B.

[0022] Preferably, the first mold A is loaded with a drug or material, and the second mold B is loaded with another drug or material.

[0023] Preferably, the material in the first solid mold 12 or the second solid mold 21 is extracted to form a hollow mold.

[0024] Preferably, the material in the first solid mold 12 or the second solid mold 21 is silicone, PCL or PLA.

[0025] Preferably, the number of the first mold A and the second mold B is two or more.

[0026] like Figure 2 As shown, the bottom of the first mold A and the second mold B are provided with a base 3.

Claims

1. A multi-drug-loaded microneedle mold, characterized in that: It includes several first molds (A) and second molds (B); the first mold (A) includes a first microneedle mold (11) and a first solid mold (12) arranged at intervals; the second mold (B) includes a second solid mold (21) and a second microneedle mold (22) arranged at intervals; the first microneedle mold (11) and the second solid mold (21) are arranged side by side, and the first solid mold (12) and the second microneedle mold (22) are arranged side by side, so as to realize the staggered arrangement of the first mold (A) and the second mold (B).

2. The various drug-loaded microneedle molds according to claim 1, characterized in that: The first mold (A) is loaded with a drug or material, and the second mold (B) is loaded with another drug or material.

3. The various drug-loaded microneedle molds according to claim 1, characterized in that: The material in the first solid mold (12) or the second solid mold (21) is extracted to form a hollow mold.

4. The various drug-loaded microneedle molds according to claim 1 or 3, characterized in that: The material in the first solid mold (12) or the second solid mold (21) is silicone, PCL or PLA.

5. The various drug-loaded microneedle molds according to claim 1, characterized in that: The number of the first mold (A) and the second mold (B) is two or more.

6. The various drug-loaded microneedle molds according to claim 1, characterized in that: The bottom of the first mold (A) and the second mold (B) is provided with a base (3).

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