Biological nano magnetic bead kit

Abstract

The utility model relates to a biological nano magnetic bead kit which comprises a kit body, the upper cover plate and the lower cover plate are arranged in the box body and used for placing the magnetic beads, the magnetic beads are placed in an arc-shaped groove in the top of the lower cover plate, four guide rods at the bottom of the upper cover plate are inserted into guide grooves, the upper cover plate is close to the lower cover plate to limit and protect the magnetic beads, meanwhile, two pressing plates are pressed to slide on long rods, and springs are stretched; when the box body is collided, the lower cover plate shakes to drive the push rod at the bottom to swing, the push rod pushes the sliding seat to slide on the sliding rod, the pressing plate is inserted into the clamping groove in the lower cover plate, the convex part on one side of the pressing plate is placed into the groove in the groove body, and clamping and fixing are carried out under the action of the spring, so that the upper cover plate and the lower cover plate are fixed; and when the box body is collided, the lower cover plate shakes to drive the push rod at the bottom to swing, and the push rod pushes the sliding seat to slide on the sliding rod. The sliding seat can drive the piston rod to push the sealing piston to move in the pipe body, and the sealing pipe is filled with gas, so that the sealing piston is difficult to move, damping force is formed, and impact force is absorbed.

Description

Technical Field

[0001] This utility model relates to the field of biological equipment technology, specifically a biological nanomagnetic bead reagent kit. Background Technology

[0002] Magnetic bead separation technology is simple to operate and can achieve efficient and rapid separation results. This technology requires minimal manual operation and is well-suited for automated instrument operation. Microbially synthesized biomagnetic nanobeads are excellent natural biomagnetic nanomaterials with advantages unmatched by artificially synthesized magnetic beads. Using genetic engineering or chemical modification techniques, peptides or biofunctional molecules with specific functions, as well as silylated coatings, can be directionally displayed on the surface of biomagnetic nanobeads. This allows biomagnetic nanobeads to be used for the purification and extraction of common nucleic acids and specific nucleic acid molecules. In current technologies, biomagnetic nanobead reagent tubes are often stored and transported within reagent kits. Existing reagent kits do not provide adequate shock absorption during transport, leading to shaking and potential leakage of the biomagnetic nanobeads.

[0003] For example, a near-infrared fluorescent encoded bio-magnetic nanobead reagent kit disclosed in the authorized patent document with application number CN201820173090.8 includes a base and a box body connected to the top of the base; the box body has a plurality of reagent bottle slots inside; the bottom of the reagent bottle slots has a cavity; the bottom of the cavity has a through hole; the base has a negative pressure chamber inside; the top of the negative pressure chamber has a negative pressure hole corresponding to the through hole; one end of the negative pressure chamber has an exhaust hole; a turbine fan is installed inside the exhaust hole; the bottom of the base has a battery box electrically connected to the turbine fan; and the box body has a switch electrically connected to the turbine fan.

[0004] The aforementioned patents have the drawback of not being convenient for shock absorption and protection of the reagent tubes, causing them to shake during transportation. Therefore, we need to provide a biological nanomagnetic bead reagent kit. Utility Model Content

[0005] The purpose of this invention is to provide a biological nanomagnetic bead reagent kit. The magnetic beads are placed in an arc-shaped groove at the top of the lower cover plate, and four guide rods at the bottom of the upper cover plate are inserted into guide grooves. The upper cover plate, close to the lower cover plate, limits and protects the magnetic beads. Simultaneously, two push plates are pressed and slid along a long rod, stretching a spring. The push plates are inserted into slots within the lower cover plate, and the protrusions on one side of the push plates are placed into grooves within the slots. Under the action of the spring, they are locked in place, thus securing the upper and lower cover plates. When the kit is impacted, the lower cover plate shakes, causing the bottom push rod to swing. The push rod pushes the sliding seat to slide along the slide rod, and the sliding seat drives the piston rod to move the sealing piston within the tube. Because the sealed tube is filled with gas, the movement of the sealing piston is difficult, thus creating a damping force that absorbs the impact force, solving the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a bio-nanomagnetic bead reagent kit, comprising:

[0007] Box body;

[0008] And the upper and lower cover plates set inside the box for placing the magnetic beads;

[0009] A protective component installed inside the housing for energy absorption by the lower cover.

[0010] The protective component includes two slide rods fixedly installed inside the housing. Slide seats are slidably installed on both sides of the surface of the two slide rods. Two push rods are hinged to the top of the two slide seats. The tops of the four push rods are hinged to the bottom of the lower cover plate. An energy-absorbing component is provided on one side of the slide seat.

[0011] Preferably, the energy-absorbing component includes two piston rods fixedly installed on one side of the sliding seat. A sealing piston is fixedly installed at one end of each of the two piston rods. A sealing tube is provided on the surface of the sealing piston. One end of the sealing tube is fixedly installed inside the box body. A sealing ring is fixedly installed on the surface of the sealing piston.

[0012] Preferably, the sealing ring is a rubber ring, and the surface of the sealing ring is in close contact with the inner wall of the sealing tube.

[0013] Preferably, guide rods are installed at the four corners of the bottom of the upper cover plate, and guide grooves for inserting the four guide rods are provided inside the lower cover plate.

[0014] Preferably, it also includes a mounting component for fixing the upper cover plate and the lower cover plate. The mounting component includes two slots with grooves formed in the lower cover plate. The upper cover plate has a groove inside. Both sides of the inner wall of the groove are spring-loaded with push plates. The surface of the push plates is integrally machined with protrusions that are adapted to the grooves.

[0015] Preferably, a long rod is fixedly installed inside the groove, the surface of the long rod is movably connected to the inside of the two push plates, and the surface of the long rod is movably connected to the inside of the spring.

[0016] Preferably, the two opposite sides of the pressing plates are integrally machined with corrugated grooves.

[0017] Compared with the prior art, the beneficial effects of this utility model are:

[0018] This invention uses a protective component to buffer and protect the magnetic beads between the upper and lower cover plates, thus buffering the impact force on the box and providing energy absorption protection for the magnetic beads. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural schematic diagram of the present invention;

[0020] Figure 2 This is a perspective view of the protective component of this utility model;

[0021] Figure 3 This utility model has a three-dimensional energy-absorbing component;

[0022] Figure 4 This is a partial three-dimensional structural view of the present invention;

[0023] Figure 5 This is a perspective view of the long rod of this utility model.

[0024] In the diagram: 1. Box body; 2. Upper cover plate; 3. Lower cover plate; 4. Protective component; 41. Sliding rod; 42. Sliding seat; 43. Push rod; 40. Energy-absorbing component; 401. Piston rod; 402. Sealing piston; 403. Sealing tube; 404. Sealing ring; 5. Guide rod; 6. Guide groove; 7. Mounting component; 71. Slot; 72. Groove body; 73. Press plate; 74. Spring; 8. Long rod; 9. Wave groove. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Please see Figure 1-5 This utility model provides a technical solution: a bio-nanomagnetic bead reagent kit, comprising:

[0027] Box 1;

[0028] And an upper cover plate 2 and a lower cover plate 3 set inside the box 1 for placing magnetic beads;

[0029] A protective component 4 is installed inside the housing 1 to absorb energy from the lower cover plate 3;

[0030] The protective component 4 includes two slide rods 41 fixedly installed inside the housing 1. Slide seats 42 are slidably installed on both sides of the surface of the two slide rods 41. Two push rods 43 are hinged to the top of the two slide seats 42. The tops of the four push rods 43 are hinged to the bottom of the lower cover plate 3. An energy-absorbing component 40 is provided on one side of the slide seat 42.

[0031] The energy-absorbing component 40 includes two piston rods 401 fixedly installed on one side of the sliding seat 42. A sealing piston 402 is fixedly installed at one end of each of the two piston rods 401. A sealing tube 403 is provided on the surface of the sealing piston 402. One end of the sealing tube 403 is fixedly installed inside the box body 1. A sealing ring 404 is fixedly installed on the surface of the sealing piston 402.

[0032] In this embodiment, the magnetic bead is placed in the arc-shaped groove at the top of the lower cover plate 3, and the four guide rods 5 at the bottom of the upper cover plate 2 are inserted into the guide groove 6. The upper cover plate 2 is close to the lower cover plate 3 to limit and protect the magnetic bead. At the same time, the two push plates 73 are pressed and slid on the long rod 8, and the spring 74 is stretched. The push plate 73 is inserted into the slot 71 in the lower cover plate 3, and the protrusion on one side of the push plate 73 is placed into the groove in the slot 72. Under the action of the spring 74, it is locked and fixed, thereby fixing the upper cover plate 2 and the lower cover plate 3. When the box 1 is hit, the lower cover plate 3 shakes and drives the bottom push rod 43 to swing. The push rod 43 pushes the sliding seat 42 to slide on the sliding rod 41, and the sliding seat 42 will drive the piston rod 401 to push the sealing piston 402 to move in the tube. Since the sealing tube 403 is filled with gas, it is difficult for the sealing piston 402 to move, thereby forming a damping force to absorb the impact force.

[0033] A metal block is installed on one side of the box body 1, and a flip cover with a magnetic block is hinged to the top of the box body 1.

[0034] The sealing ring 404 is a rubber ring, and the surface of the sealing ring 404 is in close contact with the inner wall of the sealing tube 403;

[0035] Specifically, the surface of the sealing ring 404 is in close contact with the inner wall of the sealing tube 403, and as the sealing piston 402 moves, it creates damping for the compression of the gas inside the sealing tube 403.

[0036] Guide rods 5 are installed at the four corners of the bottom of the upper cover plate 2, and guide grooves 6 for the insertion of the four guide rods 5 are opened inside the lower cover plate 3;

[0037] Furthermore, the magnetic bead is placed into the arc-shaped groove at the top of the lower cover plate 3, and the four guide rods 5 at the bottom of the upper cover plate 2 are inserted into the guide groove 6 to guide the installation.

[0038] It also includes a mounting component 7 for fixing the upper cover plate 2 and the lower cover plate 3. The mounting component 7 includes two slots 71 with grooves in the lower cover plate 3. The upper cover plate 2 has a groove 72 inside. Both sides of the inner wall of the groove 72 are clamped with a pressing plate 73 by a spring 74. The surface of the pressing plate 73 has a protrusion that matches the groove.

[0039] The two pressing plates 73 slide on the long rod 8 and stretch the spring 74. The pressing plates 73 are inserted into the slots 71 in the lower cover plate 3. The protrusion on one side of the pressing plate 73 is placed into the groove in the slot 72. Under the action of the spring 74, they are locked and fixed, thereby fixing the upper cover plate 2 and the lower cover plate 3.

[0040] A long rod 8 is fixedly installed inside the groove 72. The surface of the long rod 8 is movably connected to the inside of the two push plates 73, and the surface of the long rod 8 is movably connected to the inside of the spring 74.

[0041] It is worth noting that setting the long rod 8 to move the two push plates 73 improves the stability.

[0042] To enhance the friction of pushing the push plate 73, the opposite sides of both push plates 73 are integrally machined with wave grooves 9.

[0043] This device places the magnetic bead into the arc-shaped groove at the top of the lower cover plate 3, and inserts the four guide rods 5 at the bottom of the upper cover plate 2 into the guide grooves 6. The upper cover plate 2 is close to the lower cover plate 3 to limit and protect the magnetic bead. At the same time, the two push plates 73 are pressed and slid on the long rod 8, and the spring 74 is stretched. The push plates 73 are inserted into the slots 71 in the lower cover plate 3, and the protrusion on one side of the push plate 73 is placed into the groove in the slot 72. Under the action of the spring 74, they are locked and fixed, thus fixing the upper cover plate 2 and the lower cover plate 3. When the box 1 is hit, the lower cover plate 3 shakes and drives the bottom push rod 43 to swing. The push rod 43 pushes the sliding seat 42 to slide on the sliding rod 41. The sliding seat 42 will drive the piston rod 401 to push the sealing piston 402 to move in the tube. Since the sealing tube 403 is filled with gas, it is difficult for the sealing piston 402 to move, thus forming a damping force to absorb the impact force.

[0044] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A biological nanomagnetic bead reagent kit, characterized in that, include: Box body (1); And an upper cover plate (2) and a lower cover plate (3) set inside the box (1) for placing magnetic beads; A protective component (4) is installed inside the box (1) for absorbing energy from the lower cover plate (3); The protective component (4) includes two slide rods (41) fixedly installed inside the box body (1). Slide seats (42) are slidably installed on both sides of the surface of the two slide rods (41). Two push rods (43) are hinged to the top of the two slide seats (42). The tops of the four push rods (43) are hinged to the bottom of the lower cover plate (3). An energy-absorbing component (40) is provided on one side of the slide seat (42).

2. The bio-magnetic nanobead reagent kit according to claim 1, characterized in that: The energy-absorbing component (40) includes two piston rods (401) fixedly installed on one side of the sliding seat (42). A sealing piston (402) is fixedly installed at one end of each of the two piston rods (401). A sealing tube (403) is provided on the surface of the sealing piston (402). One end of the sealing tube (403) is fixedly installed inside the box body (1). A sealing ring (404) is fixedly installed on the surface of the sealing piston (402).

3. The bio-magnetic nanobead reagent kit according to claim 2, characterized in that: The sealing ring (404) is a rubber ring, and the surface of the sealing ring (404) is in close contact with the inner wall of the sealing tube (403).

4. The bio-magnetic nanobead reagent kit according to claim 1, characterized in that: Guide rods (5) are installed at the four corners of the bottom of the upper cover plate (2), and guide grooves (6) for the insertion of the four guide rods (5) are provided inside the lower cover plate (3).

5. The bio-magnetic nanobead reagent kit according to claim 1, characterized in that: It also includes a mounting component (7) for fixing the upper cover plate (2) and the lower cover plate (3). The mounting component (7) includes two slots (71) with grooves on the lower cover plate (3). The upper cover plate (2) has a groove (72) inside. Both sides of the inner wall of the groove (72) are secured with a pressing plate (73) by a spring (74). The surface of the pressing plate (73) is integrally machined with a protrusion that matches the groove.

6. The bio-magnetic nanobead reagent kit according to claim 5, characterized in that: A long rod (8) is fixedly installed inside the groove (72). The surface of the long rod (8) is movably connected to the inside of the two push plates (73), and the surface of the long rod (8) is movably connected to the inside of the spring (74).

7. The bio-magnetic nanobead reagent kit according to claim 6, characterized in that: Both of the two pressing plates (73) have a corrugated groove (9) integrally machined on opposite sides.

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