Hydroxypropyl cyclodextrin reaction kettle

Abstract

The utility model belongs to the technical field of mixing equipment, and particularly relates to a hydroxypropyl cyclodextrin reaction kettle which comprises a kettle body, a stirring mechanism and a temperature control system, the stirring mechanism comprises a stirring shaft, an upper-layer stirring paddle and a lower-layer stirring paddle are fixedly arranged on the stirring shaft, and the tail end width of a paddle blade of the upper-layer stirring paddle is larger than that of a paddle blade of the lower-layer stirring paddle. The inner wall of the kettle body is connected with a plurality of baffle plates through a plurality of supporting rods extending in the radial direction, one end of each supporting rod is detachably connected with the corresponding baffle plate, the other end of each supporting rod is fixedly connected with the kettle body, and a gap channel is formed between each baffle plate and the inner wall of the kettle body. The device can realize high-efficiency mixing and mass transfer of materials, ensures uniform and stable reaction temperature, and fundamentally eliminates sanitary dead angles.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of mixing equipment, and specifically relates to a hydroxypropyl cyclodextrin reaction kettle. BACKGROUND

[0002] Hydroxypropyl cyclodextrin is an important cyclodextrin derivative, which is made by introducing a hydroxypropyl group into the cyclodextrin molecular skeleton. The synthesis process mainly involves ring-opening etherification reaction of cyclodextrin and propylene oxide in the presence of an alkaline catalyst. The reaction is essentially a heterogeneous reaction in a high-viscosity system, and its success is highly dependent on efficient contact and mass transfer between reactant molecules. However, when the existing conventional reaction kettle is used for the synthesis process, there are still several technical bottlenecks: first, the traditional stirring paddle cannot achieve efficient contact between cyclodextrin and reagents at the molecular level, resulting in uneven reaction, poor product substitution uniformity, and serious impact on product yield and quality; second, uneven mixing leads to uneven temperature field distribution in the reaction kettle, which exacerbates the risk of side reactions, and the product substitution uniformity and batch stability are difficult to control; third, the traditional welded baffle plate is prone to cleaning dead angles, resulting in high risk of cross-contamination between batches, and cannot meet the stringent requirements of pharmaceutical-grade products for equipment cleanliness.

[0003] Chinese patent CN221015623U discloses a modified cyclodextrin preparation device, which comprises a tank body, a feed inlet and a discharge outlet are arranged on the tank body, a stirring assembly is arranged in the tank body, the stirring assembly comprises outer stirring shafts and inner stirring shafts with opposite rotating directions, the outer stirring shafts are hollow, a stirring frame is connected to the outer stirring shafts, outer stirring blades are connected to the stirring frame, the inner stirring shafts are coaxially arranged in the outer stirring shafts, inner stirring blades are connected to the inner stirring shafts, and the outer stirring shafts and the inner stirring shafts are connected with a driving mechanism and a reciprocating lifting mechanism. The patent eliminates stirring dead angles and improves mixing efficiency through bidirectional stirring and axial lifting. However, the stirring paddle of the patent is a simple single-layer flat paddle, which mainly produces radial flow, and this flow pattern is poor for breaking the contact barrier of cyclodextrin molecules and achieving axial large circulation mixing. At the same time, the patent does not specially design the baffle structure, and the traditional baffle installation method has cleaning dead angles, which cannot meet the stringent requirements of pharmaceutical-grade production for equipment cleanliness. UTILITY MODEL CONTENTS

[0004] The utility model aims to provide a hydroxypropyl cyclodextrin reaction kettle, which can realize efficient mixing and mass transfer of materials, ensure uniform and stable reaction temperature, and fundamentally eliminate sanitary dead angles.

[0005] To achieve the above-mentioned purpose, the technical scheme of the utility model is as follows:

[0006] The utility model relates to a kind of hydroxypropyl cyclodextrin reaction kettle, including kettle body, stirring mechanism and temperature control system, stirring mechanism includes stirring shaft, and upper layer stirring paddle and lower layer stirring paddle are fixedly arranged on stirring shaft, the width of paddle tip of upper layer stirring paddle is greater than the width of paddle tip of lower layer stirring paddle, and upper layer stirring paddle and lower layer stirring paddle are staggered in circumferential direction, and the inner wall of kettle body is connected with several baffles by multiple radially extending support rods, one end of support rod is detachably connected with baffle, the other end of support rod is fixedly connected with kettle body, and clearance passage is formed between baffle and the inner wall of kettle body.

[0007] Further, the inclination of the paddle of the upper layer stirring paddle relative to the stirring shaft is less than the inclination of the paddle of the lower layer stirring paddle relative to the stirring shaft. The center line of the paddle is a straight line connecting the center point of the root of the paddle and the center point of the tip of the paddle. The angle between the center line of the paddle of the upper layer stirring paddle and the axis of the stirring shaft is 60-80°, and the angle between the center line of the paddle of the lower layer stirring paddle and the axis of the stirring shaft is 85-90°.

[0008] Further, the number of baffles is 4-6, and the baffles are evenly arranged along the inner wall of the kettle body in the circumferential direction.

[0009] Further, each baffle is fixedly connected with the inner wall of the kettle body by 3-4 support rods.

[0010] Further, one end of the support rod is provided with a connecting lug in cooperation with the baffle.

[0011] Further, the width of the clearance passage is 5-7% of the inner diameter of the kettle body.

[0012] Further, the distance between the lower layer stirring paddle and the bottom of the kettle body is 5-10% of the inner diameter of the kettle body.

[0013] Further, the temperature control system includes a jacket provided outside the kettle body.

[0014] Further, a driving motor is provided at the top of the kettle body, and the driving motor is in transmission connection with the stirring shaft.

[0015] Further, the material of the kettle body, the material of the stirring shaft, the material of the support rod and the material of the baffle are all stainless steel.

[0016] The utility model has the advantages that:

[0017] The utility model discloses a synergic design of stirring mechanism and baffle, which significantly improves the mixing efficiency and reaction uniformity of the hydroxypropyl cyclodextrin synthesis process. The upper stirring paddle can generate strong axial flow, effectively preventing the material from being layered up and down; the lower stirring paddle generates high-shear radial flow, which can fully break and disperse the cyclodextrin particles at the bottom, thereby realizing efficient contact and mass transfer of the reactants. In addition, the baffle is connected with the inner wall of the kettle body through the support rod, and the gap channel formed between the two allows fluid to pass through, not only breaking the main vortex, but also creating intense micro-turbulence locally, further strengthening the mass transfer process. The detachable connection between the support rod and the baffle eliminates the sanitary dead angle at the back of the traditional welded baffle, enabling the reaction kettle to be thoroughly cleaned and sterilized in place, greatly reducing the risk of cross-contamination between batches, and meeting the cleanliness requirements of pharmaceutical-grade production. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of the utility model;

[0019] Figure 2 It is a partial structural schematic diagram of the stirring shaft, upper stirring paddle and lower stirring paddle in the utility model;

[0020] Figure 3 It is a partial structural schematic diagram of the kettle body, support rod, baffle, connecting lug, jacket, stirring shaft, upper stirring paddle and lower stirring paddle in the utility model;

[0021] Figure 4 It is a structural schematic diagram of the upper stirring paddle in the utility model;

[0022] Figure 5 It is a structural schematic diagram of the lower stirring paddle in the utility model;

[0023] Figure 6 It is a top view of the stirring shaft, upper stirring paddle and lower stirring paddle in the utility model;

[0024] Figure 7 It is a front view of the stirring shaft, upper stirring paddle and lower stirring paddle in the utility model;

[0025] In the figure:

[0026] 1, kettle body; 2, stirring shaft; 3, upper stirring paddle; 4, lower stirring paddle; 5, support rod; 6, baffle; 7, connecting lug; 8, jacket; 9, driving motor. DETAILED DESCRIPTION

[0027] The utility model will be specifically described and explained in combination with examples.

[0028] Example 1

[0029] AsFigures 1-7 As shown, the hydroxypropyl cyclodextrin reaction kettle comprises a kettle body 1, a stirring mechanism and a temperature control system. The stirring mechanism comprises a stirring shaft 2, and an upper stirring paddle 3 and a lower stirring paddle 4 are fixedly arranged on the stirring shaft 2. The width of the blade end of the upper stirring paddle 3 is greater than that of the lower stirring paddle 4, and the upper stirring paddle 3 and the lower stirring paddle 4 are arranged in a circumferential staggered manner. A plurality of baffle plates 6 are connected to the inner wall of the kettle body 1 through a plurality of radially extending support rods 5. One end of the support rod 5 is detachably connected with the baffle plate 6, and the other end of the support rod 5 is fixedly connected with the kettle body 1. The gap passage is formed between the baffle plate 6 and the inner wall of the kettle body 1.

[0030] By arranging the upper stirring paddle 3 and the lower stirring paddle 4, axial circulation and radial shearing of the material are realized, and the mixing and mass transfer problems of high-viscosity materials are fundamentally solved. At the same time, the baffle plate 6 is connected to the inner wall of the kettle body 1 through the support rod 5 to form a gap passage, which strengthens the turbulent flow and completely eliminates the sanitary dead angle on the back of the traditional welded baffle plate.

[0031] The inclination angle of the blade of the upper stirring paddle 3 relative to the stirring shaft 2 is less than that of the blade of the lower stirring paddle 4 relative to the stirring shaft 2. The blade center line is a straight line connecting the center point of the blade root and the center point of the blade end. The angle between the blade center line of the upper stirring paddle 3 and the axis of the stirring shaft 2 is 80°, and the angle between the blade center line of the lower stirring paddle 4 and the axis of the stirring shaft 2 is 85°. The upper stirring paddle 3 can generate a strong axial flow to drive the material to circulate globally in the kettle body 1, and the lower stirring paddle 4 can generate a radial flow to realize the crushing and dispersion of cyclodextrin particles at the bottom of the kettle body 1.

[0032] The number of baffle plates 6 is 4, and the baffle plates 6 are arranged uniformly along the inner wall of the kettle body 1 in the circumferential direction. The baffle plate 6 can strengthen the mixing effect.

[0033] Each baffle plate 6 is fixedly connected to the inner wall of the kettle body 1 through four support rods 5.

[0034] One end of the support rod 5 is provided with a connecting lug 7 matched with the baffle plate 6. The connecting lug 7 makes the disassembly and installation of the baffle plate 6 more convenient, and facilitates the cleaning and maintenance of the kettle body 1.

[0035] The width of the gap passage is 5% of the inner diameter of the kettle body 1.

[0036] The distance between the lower stirring paddle 4 and the bottom of the kettle body 1 is 10% of the inner diameter of the kettle body 1.

[0037] The temperature control system comprises a jacket 8 arranged outside the kettle body 1. The jacket 8 surrounds the outside of the kettle body 1 and can uniformly heat the kettle body 1 as a whole to maintain the stability of the temperature field in the entire kettle body 1.

[0038] A driving motor 9 is arranged on the top of the kettle body 1 and is in transmission connection with the stirring shaft 2.

[0039] The kettle body 1, the stirring shaft 2, the supporting rod 5 and the baffle 6 are all made of stainless steel.

Claims

1. A hydroxypropyl cyclodextrin reactor comprising a reactor body (1), a stirring mechanism and a temperature control system, characterized in that, The stirring mechanism comprises a stirring shaft (2), an upper layer stirring paddle (3) and a lower layer stirring paddle (4) fixedly arranged on the stirring shaft (2), the paddle end width of the upper layer stirring paddle (3) is greater than the paddle end width of the lower layer stirring paddle (4), and the upper layer stirring paddle (3) and the lower layer stirring paddle (4) are arranged in a circumferential staggered manner, a plurality of baffles (6) are connected to the inner wall of the kettle body (1) through a plurality of radially extending support rods (5), one end of the support rod (5) is detachably connected with the baffle (6), the other end of the support rod (5) is fixedly connected with the kettle body (1), and a gap channel is formed between the baffle (6) and the inner wall of the kettle body (1).

2. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, The inclination angle of the paddle of the upper layer stirring paddle (3) relative to the stirring shaft (2) is less than the inclination angle of the paddle of the lower layer stirring paddle (4) relative to the stirring shaft (2).

3. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, The number of baffles (6) is 4-6, and the baffles (6) are uniformly arranged along the circumferential direction of the inner wall of the kettle body (1).

4. The hydroxypropylcyclo dextrin reactor of claim 3, wherein, Each baffle (6) is fixedly connected with the inner wall of the kettle body (1) through 3-4 support rods (5).

5. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, One end of the support rod (5) is provided with a connecting lug (7) matched with the baffle (6).

6. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, The width of the gap channel is 5-7% of the inner diameter of the kettle body (1).

7. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, The distance between the lower layer stirring paddle (4) and the bottom of the kettle body (1) is 5-10% of the inner diameter of the kettle body (1).

8. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, The temperature control system comprises a jacket (8) arranged outside the kettle body (1).

9. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, A driving motor (9) is arranged at the top of the kettle body (1) and is in transmission connection with the stirring shaft (2).

10. The hydroxypropylcyclo dextrin reactor of claim 1, wherein, The materials of the kettle body (1), the stirring shaft (2), the support rod (5) and the baffle (6) are all stainless steel.

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