Nitrogen charging device in injection preparation process

Abstract

The utility model relates to the technical field of injection nitrogen charging protection, in particular to a nitrogen charging device in an injection preparation process, which comprises a base, a tee joint, a flow equalizer, a top plate, a tensioning component, a lifting driving component and a one-way limiting mechanism. A support is arranged on the base, a movable plate is arranged on the support, and a plurality of piston cylinders are arranged on the movable plate. A port A of the tee joint is communicated with the interior of the piston cylinder, and a port B and a port C are communicated with a branch pipe with a one-way valve A and a needle pipe with a one-way valve B respectively. And the flow equalizer is communicated with the nitrogen supply pipeline and the branch pipe. The top plate is connected with the support and connected with a plurality of piston rods, and each piston rod is connected with a piston inserted into a piston cylinder. The tensioning assembly is connected with the support and the top plate. The lifting driving assembly drives the movable plate to lift. The one-way limiting mechanism is connected with the support, and the one-way limiting mechanism limits the top plate to slide on the support in the locking state. The quantitative nitrogen filling protection device can rapidly perform quantitative nitrogen filling protection on the injection, and is simple in structure and high in stability.

Description

Technical Field

[0001] This utility model relates to the field of nitrogen filling protection technology for injectable drugs, and in particular to a nitrogen filling device for the preparation process of injectable drugs. Background Technology

[0002] Injectable drugs are usually packaged in bottles or bags. During packaging, the drug is not fully loaded. In this case, the empty area needs to be filled with nitrogen to prevent the drug from oxidizing due to contact with air. However, existing nitrogen filling devices require multiple lifting drive mechanisms, which is inefficient.

[0003] The technical solution disclosed in Chinese Patent No. CN221235201U uses a hydraulic cylinder to push the baffle plate upwards, thereby moving the clamped air inlet pipe downwards into the ampoule. At the same time, the fixing frame pushes the extrusion rod upwards, thereby opening the air inlet and filling the ampoule with nitrogen. This facilitates the independent use of the protective gas injection structure, making it more flexible when injecting nitrogen into the ampoule and meeting the needs of injecting protective gas alone, thus improving the flexibility of the protective gas injection device for Reganoxon injection.

[0004] However, the device still has shortcomings: the device starts filling with nitrogen as soon as the air inlet pipe is inserted into the packaging bottle. Since the molecular mass of nitrogen is smaller than that of air, the nitrogen that enters the packaging bottle first is prone to overflow. In order to ensure that the air in the packaging bottle is completely removed, a large amount of nitrogen needs to be filled in, which is wasteful and the nitrogen filling efficiency is low. Utility Model Content

[0005] The purpose of this invention is to address the problems existing in the background art by proposing a nitrogen-filling device for the preparation process of injectable drugs.

[0006] The technical solution of this utility model is: a nitrogen filling device for the preparation process of an injection, including a base, a support on the base, a movable plate slidably connected to the support, and a plurality of piston cylinders on the movable plate.

[0007] The three-way valves each include port A, port B, and port C. Port A is connected to the interior of the piston cylinder on the corresponding side, while ports B and C are connected to the branch pipe with one-way valve A and the needle tube with one-way valve B, respectively.

[0008] The flow equalizer is connected to the movable plate. The input end of the flow equalizer is connected to the nitrogen supply pipeline, and each output end of the flow equalizer is connected to the branch pipe on the corresponding side.

[0009] The top plate is slidably connected to the support and located above the movable plate. The top plate is connected to several piston rods, each piston rod is connected to a piston, and each piston is inserted into the piston cylinder on the corresponding side and slidably connected to its inner wall.

[0010] The tensioning assembly is connected with the top end of the support and the top plate.

[0011] The lifting driving assembly is connected with the support and drives the movable plate to lift.

[0012] The one-way limiting mechanism is connected with the support, limits the sliding of the top plate on the support in the locked state, and is unlocked in the state that the movable plate inserts the needle tube into the medicine bottle, so that the top plate is pushed down by the tensioning assembly.

[0013] Preferably, a sliding groove is arranged on the support, a plurality of sliding rods are arranged in the sliding groove along the height direction of the sliding groove, and a fixed plate is arranged in the sliding groove. One end of the movable plate is inserted into the sliding groove and is in sliding connection with the inner wall of the sliding groove, and the movable plate is above the fixed plate. One end of the top plate is inserted into the sliding groove and is in sliding connection with the sliding groove. The sliding rods pass through the movable plate and the top plate and are in sliding connection with the movable plate and the top plate.

[0014] Preferably, the tensioning assembly comprises a spring. A limiting groove in communication with the sliding groove is arranged on the support above the top plate. The top end of the sliding rod is inserted into the limiting groove and is connected with the upper wall of the limiting groove. The spring is sleeved on the sliding rod, and the spring is located in the limiting groove. The two ends of the spring are respectively in abutment with the upper wall of the limiting groove and the upper surface of the top plate.

[0015] Preferably, the one-way limiting mechanism comprises a straight plate and a spring rod. Two side grooves are symmetrically arranged on the support with respect to the center of the sliding groove. The straight plate is arranged in the side groove and is in sliding connection with the inner wall of the side groove. One wedge-shaped clamping block A and one wedge-shaped clamping block B are respectively arranged on the two straight plates. In the state that the top plate is in the high position, the wedge-shaped clamping block A is located between the fixed plate and the movable plate, the inclined surface of the wedge-shaped clamping block A faces upward, and at this time, the wedge-shaped clamping block B is located between the movable plate and the top plate, the inclined surface of the wedge-shaped clamping block B faces downward, the upper end of the straight surface of the wedge-shaped clamping block B is in abutment with the bottom surface of the top plate, and the spring rod connects the inner wall of the side groove and the straight plate.

[0016] Preferably, the nitrogen supply pipeline comprises an inner tube and an outer tube. The inner tube is connected with the movable plate, and the output end of the inner tube is in communication with the input end of the current distributor. The outer tube is connected with the support, the top end of the inner tube is inserted into the outer tube and is in sliding connection with the inner wall of the outer tube, and the input end of the outer tube is in communication with the soft tube.

[0017] Preferably, the base is provided with a clamping mechanism for positioning the medicine bottle.

[0018] Preferably, the clamping mechanism comprises a clamping frame and a driving assembly. The clamping frame is symmetrically arranged on the base and is in sliding connection with the base. The driving assembly is connected with the base and drives the two clamping frames to move close to or away from each other.

[0019] Compared with the prior art, the utility model has the beneficial technical effects that:

[0020] By setting the activity board, top plate, tensioning assembly and one-way limiting mechanism, and setting the three-way on the piston cylinder which communicates with the inside, the other two ports of the three-way respectively communicate with the branch pipe and the needle tube, and the one-way valve A and the one-way valve B are respectively arranged on the branch pipe and the needle tube, the conduction direction of the one-way valve A and the one-way valve B is opposite, so that the piston keeps the height unchanged in the process of reducing the height of the activity board, and the purpose of automatically completing the inflation of the piston cylinder is achieved, and when the activity board reaches the low position, the needle tube is inserted into the bottom of the packaging cavity, and the one-way limiting mechanism releases the activity restriction of the top plate, the top plate slides down under the action of the tensioning assembly and pushes the piston, the nitrogen in the piston is inflated from the bottom of the packaging container cavity, the nitrogen is injected from the bottom, effectively expelling the air in the packaging bottle, and the nitrogen amount does not need to be too much, avoiding waste, the structure is high in nitrogen injection efficiency; Meanwhile, the clamping mechanism is also arranged, and the clamping mechanism ensures that the packaging container is always aligned with the needle tube. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 It is a structural schematic view of an embodiment in the utility model;

[0022] Figure 2 It is a connection structure schematic view of each component on the base;

[0023] Figure 3 It is a connection structure schematic view of each component on the activity board;

[0024] Figure 4 It is a structure schematic view of the clamping mechanism.

[0025] The drawing comprises: 1, base; 101, guide groove; 2, support; 201, sliding groove; 202, limiting groove; 203, side groove; 3, fixed plate; 4, sliding rod; 5, activity board; 6, cylinder A; 7, piston cylinder; 8, three-way; 9, branch pipe; 91, one-way valve A; 10, flow equalizer; 11, needle tube; 111, one-way valve B; 12, inner tube; 13, outer tube; 14, hose; 15, piston rod; 16, piston; 17, top plate; 18, spring; 19, straight plate; 20, wedge-shaped block A; 21, wedge-shaped block B; 22, spring rod; 23, sliding block; 24, clamping frame; 25, rack; 26, gear; 27, cylinder B. DETAILED DESCRIPTION

[0026] Example one

[0027] As Figures 1-3The utility model provides a nitrogen filling device for injection preparation process, including base 1, three way 8, current equalizer 10, top plate 17, tensioning assembly, lifting drive assembly and one -way limiting mechanism. The support 2 is set up on base 1, the movable plate 5 of sliding connection is set up on the support 2, and a plurality of piston cylinders 7 are set up on the movable plate 5. Each three way 8 includes port A, port B and port C, wherein port A communicates with the inside of corresponding side piston cylinder 7, port B and port C communicate branch pipe 9 with one -way valve A 91 and needle tube 11 with one -way valve B 111 respectively. Current equalizer 10 is connected with movable plate 5, and the input end of current equalizer 10 communicates with the nitrogen supply pipeline, and the nitrogen supply pipeline includes inner tube 12 and outer tube 13, wherein the inner tube 12 is connected with movable plate 5, the output end of inner tube 12 communicates with the input end of current equalizer 10, the outer tube 13 is connected with the support 2, the top end of inner tube 12 is inserted into outer tube 13 and is connected with the inner wall slidingly, the input end of outer tube 13 communicates with hose 14, and hose 14 communicates with nitrogen gas tank. Each output end of current equalizer 10 communicates with corresponding side branch pipe 9. Top plate 17 is connected with the support 2 slidingly and is located above movable plate 5, and top plate 17 is connected with a plurality of piston rods 15, each piston rod 15 is connected with one piston 16, and each piston 16 is inserted into corresponding side piston cylinder 7 and is connected with the inner wall slidingly. The support 2 is provided with a sliding groove 201, a plurality of slide rods 4 are arranged in the height direction in the sliding groove 201, and a fixed plate 3 is arranged in the sliding groove 201. One end of movable plate 5 is inserted into the sliding groove 201 and is connected with the inner wall slidingly, and movable plate 5 is located above fixed plate 3, one end of top plate 17 is inserted into the sliding groove 201 and is connected with the sliding groove 201, and slide rod 4 penetrates movable plate 5 and top plate 17 and is connected with the sliding groove 201. Tensioning assembly includes spring 18. The support 2 is provided with the limiting groove 202 that communicates with the sliding groove 201 above top plate 17, the top end of slide rod 4 is inserted into the limiting groove 202 and is connected with the upper wall, spring 18 is sleeved on slide rod 4, spring 18 is located in the limiting groove 202, and the both ends of spring 18 are respectively abutted with the upper wall of limiting groove 202 and the upper surface of top plate 17. Lifting drive assembly is connected with the support 2 and drives movable plate 5 to lift. One -way limiting mechanism includes straight plate 19 and spring rod 22.Two side slots 203 are symmetrically arranged on the bracket 2 relative to the center of the chute 201, the straight plate 19 is arranged in the side slot 203 and is in sliding connection with the inner wall thereof, one wedge-shaped clamping block A 20 and one wedge-shaped clamping block B 21 are respectively arranged on the two straight plates 19, the wedge-shaped clamping block A 20 is located between the fixed plate 3 and the movable plate 5 in the state that the top plate 17 is at a high position, the inclined surface of the wedge-shaped clamping block A 20 faces upward, and at this time, the wedge-shaped clamping block B 21 is located between the movable plate 5 and the top plate 17, the inclined surface of the wedge-shaped clamping block B 21 faces downward, the upper end of the straight surface of the wedge-shaped clamping block B 21 is in abutment with the bottom surface of the top plate 17, the spring rod 22 connects the inner wall of the side slot 203 and the straight plate 19, the one-way limiting mechanism limits the sliding of the top plate 17 on the bracket 2 in the locked state, and the one-way limiting mechanism is unlocked in the state that the movable plate 5 inserts the needle tube 11 into the medicine bottle, so as to push down the top plate 17 through the tensioning assembly.

[0028] In the embodiment, the packaging bottles are neatly arranged on the base 1 and correspond to the corresponding needle tubes 11 respectively, the hose 14 is communicated with the nitrogen tank, the air cylinder A 6 is communicated with the air pump, the air cylinder A 6 is started, the push rod of the air cylinder A 6 pulls down the movable plate 5, so that each needle tube 11 gradually inserts into the corresponding packaging bottle, at this time, the top plate 17 cannot slide downward due to the blocking and limiting of the wedge-shaped clamping block B 21, that is, the piston 16 remains the original height, the piston cylinder 7 descends, at this time, the one-way valve A 91 is open, the one-way valve B 111 is closed, the nitrogen is uniformly dispersed into the corresponding piston cylinder 7 along the flow equalizer 10 and the branch pipe, when the movable plate 5 is lowered to the low position, the needle tube 11 is just inserted into the packaging bottle and the opening thereof is at the low position, at the same time, the movable plate 5 extrudes the wedge-shaped clamping block A 20 to push the paper plate 19 and the wedge-shaped clamping block B 21 to retract into the side slot 203, at this time, the top plate 17 is not resisted, and starts to descend under the action of the gravity and the tension of the spring 18, and pushes down the piston 16, at this time, the one-way valve A 91 is closed, the one-way valve 111 is open, the nitrogen enters the packaging bottle along the needle tube 11, and the nitrogen stops when the pressure is complete, then the air cylinder A 6 pushes up the movable plate 5 to reset, the top plate 17 rises and resets, and the wedge-shaped clamping block B 21 resets automatically and limits the downward sliding of the top plate 17 again.

[0029] Embodiment two

[0030] As Figure 1 , Figure 2 and Figure 4The utility model discloses a kind of nitrogen filling devices for injection preparation process, compared with embodiment one, clamping mechanism for positioning medicament bottle is arranged on base 1. Clamping mechanism includes card frame 24 and driving assembly, driving assembly includes rack 25, gear 26 and cylinder B 27 card frame 24 is symmetrically arranged on base 1 and is slidably connected with it, two guide grooves 101 are arranged on base 1, sliding block 23 is slidably connected in guide groove 101, two sides sliding block 23 are respectively connected with the card frame 24 of corresponding side;Rack 25 is arranged in base 1 and is slidably connected with it, two racks are interval arrangement and are respectively connected with the sliding block 23 of corresponding side, gear 26 is arranged in base 1 and is rotatably connected with it, gear 26 is located between two sides rack 25 and is all engaged connection with two sides rack 25, the body of cylinder B 27 is arranged on base 1, the output end of cylinder B 27 is connected with one of card frame 24.

[0031] In the embodiment, the gas inlet end of the cylinder B 27 is communicated with the gas pump, the packaging bottle is placed on the base 1 and between the two card frames 24, the cylinder B 27 is started, the cylinder B 27 drives the card frame 24 on one side to move, the card frame 24 on the other side is synchronously close to under the meshing transmission action of the gear 26 and the rack 25, so as to clamp and position the packaging bottle by using the two card frames 24 close to each other, to avoid the misplacement of the packaging bottle when the needle tube 11 probes down.

[0032] The embodiments of the utility model are described in detail above in combination with the drawings, but the utility model is not limited to this, within the knowledge range possessed by the person skilled in the art, various changes can be made without departing from the purpose of the utility model.

Claims

1. A nitrogen filling device for an injection preparation process, characterized by The utility model relates to a kind of nitrogen injection device, including Base (1), support (2) is provided on base (1), movable plate (5) is provided in sliding connection with it on support (2), and several piston cylinders (7) are provided on movable plate (5); Three-way (8), each three-way (8) includes port A, port B and port C, wherein port A is communicated with the inside of corresponding side piston cylinder (7), port B and port C are communicated with branch pipe (9) with one-way valve A (91) and needle tube (11) with one-way valve B (111) respectively; Flow equalizer (10), flow equalizer (10) is connected with movable plate (5), the input end of flow equalizer (10) is communicated with nitrogen supply pipeline, and each output end of flow equalizer (10) is communicated with corresponding side branch pipe (9); Top plate (17), top plate (17) is in sliding connection with support (2) and is located above movable plate (5), top plate (17) is connected with several piston rods (15), each piston rod (15) is connected with one piston (16) respectively, and each piston (16) is inserted into corresponding side piston cylinder (7) and is in sliding connection with its inner wall; Tensioning assembly, tensioning assembly connects the top end of support (2) and top plate (17); Lifting drive assembly, lifting drive assembly is connected with support (2) and drives movable plate (5) to lift; And one-way limiting mechanism, one-way limiting mechanism is connected with support (2), one-way limiting mechanism limits top plate (17) to slide on support (2) in locked state, and one-way limiting mechanism is unlocked in the state that movable plate (5) inserts needle tube (11) into medicament bottle, to push top plate (17) down by tensioning assembly.

2. The nitrogen charging device for a process of preparing an injection preparation according to claim 1, characterized in that Support (2) is provided with sliding groove (201), and several slide rods (4) are provided in the height direction of sliding groove (201) in it, and fixed plate (3) is provided in sliding groove (201);One end of movable plate (5) is inserted into sliding groove (201) and is in sliding connection with its inner wall, and movable plate (5) is located above fixed plate (3), and one end of top plate (17) is inserted into sliding groove (201) and is in sliding connection with it, and slide rod (4) penetrates movable plate (5) and top plate (17) and is in sliding connection with it.

3. The nitrogen charging device for a process of preparing an injection preparation according to claim 2, characterized in that Tensioning assembly includes spring (18);Support (2) is provided with limiting groove (202) in communication with sliding groove (201) above top plate (17), the top end of slide rod (4) is inserted into limiting groove (202) and is connected with its upper wall, spring (18) is sleeved on slide rod (4), spring (18) is located in limiting groove (202), and the two ends of spring (18) are respectively abutted with the upper wall of limiting groove (202) and the upper surface of top plate (17).

4. The nitrogen charging device for a process of preparing an injection preparation according to claim 2, characterized by The one-way limiting mechanism comprises straight plates (19) and spring rods (22); two side slots (203) are symmetrically arranged on the bracket (2) relative to the center of the sliding slot (201), the straight plates (19) are arranged in the side slots (203) and are in sliding connection with the inner walls of the side slots (203), one wedge-shaped clamping block A (20) and one wedge-shaped clamping block B (21) are respectively arranged on the two straight plates (19), when the top plate (17) is in the high position, the wedge-shaped clamping block A (20) is located between the fixed plate (3) and the movable plate (5), the inclined surface of the wedge-shaped clamping block A (20) faces upward, at this time, the wedge-shaped clamping block B (21) is located between the movable plate (5) and the top plate (17), the inclined surface of the wedge-shaped clamping block B (21) faces downward, the upper end straight surface of the wedge-shaped clamping block B (21) is in abutment with the bottom surface of the top plate (17), and the spring rods (22) are connected between the inner walls of the side slots (203) and the straight plates (19).

5. The nitrogen charging device for a process of preparing an injection preparation according to claim 1, wherein The nitrogen supply pipeline comprises an inner tube (12) and an outer tube (13), the inner tube (12) is connected with the movable plate (5), the output end of the inner tube (12) is in communication with the input end of the current distributor (10), the outer tube (13) is connected with the bracket (2), the top end of the inner tube (12) is inserted into the outer tube (13) and is in sliding connection with the inner wall of the outer tube (13), and the input end of the outer tube (13) is in communication with the soft tube (14).

6. The nitrogen charging device for a process of preparing an injection preparation according to claim 1, characterized by The base (1) is provided with a clamping mechanism for positioning a medicament bottle.

7. A nitrogen charging device for a process of preparing an injection formulation according to claim 6, characterized in that The clamping mechanism comprises clamping frames (24) and a driving assembly, the clamping frames (24) are symmetrically arranged on the base (1) and are in sliding connection with the base (1), and the driving assembly is connected with the base (1) and drives the two clamping frames (24) to move close to or away from each other.

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