Liquid drainage sealing structure of synthesizer
By employing electromagnetic blocks and buffer components in the high-throughput synthesizer, the gap problem during pressurized drainage of the fixed disk was solved, ensuring complete drainage of the reaction solution, improving experimental accuracy and equipment stability, and realizing automated operation.
Patent Information
- Application Number
- CN202423275198.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-12-19
- Estimated Expiration
- 2034-12-30
AI Technical Summary
In high-throughput synthesizers, gaps can easily form when the fixed disk is pressurized to drain the liquid, resulting in incomplete drainage of the reaction solution and affecting the accuracy of subsequent experiments.
The pressure plate and the fixed plate are attached by using a pressure assembly and a sealing assembly. The magnetic attraction of electromagnetic block one and electromagnetic block two is used to make the pressure plate fit with the fixed plate. Combined with a buffer assembly and a reinforcement assembly, a stable connection between the pressure plate and the fixed plate is ensured and gaps are prevented.
This allows for the complete discharge of the reaction solution, improving the accuracy of subsequent reaction experiments, reducing the risk of air leakage during equipment operation, and enhancing the stability and automation of the equipment.
Smart Images
Figure CN223683520U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to the technical field of synthesis instruments, in particular to a synthesis instrument liquid discharge sealing structure. BACKGROUND
[0002] A high-throughput synthesis instrument is an experimental device that can efficiently and quickly synthesize a variety of compounds. It uses microfluidic technology and automation systems to simultaneously synthesize multiple compounds and process and analyze them within the same time.
[0003] In some DNA synthesis technologies, a high-throughput synthesis instrument is needed, which includes a rack, a fixing disc and a reaction disc. The fixing disc is fixed on the rack, and a plurality of reaction holes are formed in the fixing disc. Reaction solution is injected into the reaction holes. The reaction disc is provided with a plurality of reaction columns, and the reaction columns are coated with a reaction material. The reaction columns are inserted into the corresponding reaction holes to react. After the reaction, the reaction disc is moved away from the fixing disc, and the reaction solution in the reaction hole is discharged.
[0004] When discharging the reaction solution in the reaction hole, the fixing disc needs to be pressurized. However, when the fixing disc is pressurized by a pressurizing device, due to the pressure of the gas pressure itself, gaps are easily generated, which leads to incomplete discharge of the reaction solution, thereby affecting the accuracy of subsequent experiments. Invention content
[0005] In order to improve the problem that gaps are easily generated when the fixing disc is pressurized and discharged, thereby leading to incomplete discharge of the reaction solution, the application provides a synthesis instrument liquid discharge sealing structure.
[0006] The synthesis instrument liquid discharge sealing structure provided by the application adopts the following technical scheme:
[0007] A synthesis instrument liquid discharge sealing structure includes a rack and a fixing disc. The fixing disc is arranged on the rack. Reaction holes are formed in the fixing disc. The reaction holes are used to hold reaction solution. The structure further includes a pressurizing assembly and a sealing assembly. The pressurizing assembly includes a pressurizing plate and a pressurizing pipe. The pressurizing pipe is connected to and communicates with the pressurizing plate. The pressurizing plate is arranged on the fixing disc. The pressurizing pipe introduces positive pressure into the reaction hole. The sealing assembly includes a power supply, an electromagnetic block one and an electromagnetic block two. The power supply is arranged on the rack. The electromagnetic block one is arranged on the rack. The electromagnetic block two is arranged on the pressurizing plate. The electromagnetic block one and the electromagnetic block two are magnetically attracted and attached.
[0008] By adopting the technical scheme, after the reaction is completed, when the reaction hole is subjected to pressure discharge, the pressing plate is moved to the fixed disc to make the two adhere, that is, the electromagnetic block one and the electromagnetic block two adhere, then the power supply is energized to make the electromagnetic block one and the electromagnetic block two generate magnetic attraction force, magnetic attraction adhesion is realized, and the adhesion between the pressing plate and the fixed disc is more stable by the magnetic attraction force, that is, even if the pressing is performed later, no gap exists between the two, the liquid is completely discharged, and the reaction hole is as free as possible from residual liquid, which is beneficial to improve the accuracy of subsequent reaction tests.
[0009] Preferably, the pressing plate is provided with a containing groove for containing the electromagnetic block two.
[0010] By adopting the technical scheme, the connection between the electromagnetic block two and the pressing plate is more stable, and the electromagnetic block two can stably move with the movement of the pressing plate.
[0011] Preferably, the sealing assembly further comprises a sealing surrounding plate, the sealing surrounding plate is arranged on the fixed disc and located outside the reaction hole, and the pressing plate is provided with a sealing groove for placing the sealing surrounding plate.
[0012] By adopting the technical scheme, the sealing surrounding plate extends into the sealing groove, the connection between the pressing plate and the fixed disc is more close, and when the pressing plate and the reaction hole are subjected to aeration and pressurization through the pressing pipe later, the risk of air leakage can be greatly reduced, and the equipment operation stability is improved.
[0013] Preferably, the moving assembly comprises a moving driving source, a mechanical arm and a connecting plate, the moving driving source is arranged in the rack, the moving driving source is used to drive the mechanical arm to operate, the connecting plate is connected to the end of the mechanical arm, and the side, away from the mechanical arm, of the connecting plate is connected with the pressing plate.
[0014] By adopting the technical scheme, the connecting plate is connected with the pressing plate, the moving driving source drives the mechanical arm to move the connecting plate and the pressing plate according to the PLC program setting, the pressing plate is covered on the fixed disc to facilitate subsequent pressurization and liquid discharge, or the pressing plate is moved away from the fixed disc, which is beneficial to realize automation.
[0015] Preferably, the pressing plate is provided with an aeration pipeline, the pressing pipe is connected to the aeration pipeline, and the connecting plate is connected to the end, away from the pressing plate, of the aeration pipeline.
[0016] By adopting the technical scheme, the pressing pipe is connected to the aeration pipeline, the aeration pipeline is communicated with the pressing plate, and when the pressing plate is covered on the fixed disc, the positive pressure airflow moves into the fixed disc through the aeration pipeline.
[0017] Preferably, the buffer assembly further comprises a buffer bolt and a buffer spring, the connecting plate is provided with a through hole for the buffer bolt, the pressing plate is provided with a connecting hole for the buffer bolt, and the buffer spring is sleeved on the buffer bolt and abuts against one side of the connecting plate away from the pressing plate.
[0018] By adopting the technical scheme, when the pressing plate is connected to the fixed disc and the power is turned on, a large electromagnetic attraction is generated at the moment when the electromagnetic block one is powered on, so that the electromagnetic block one and the electromagnetic block two are tightly attached and adsorbed, and if the magnetic attraction is too large, the pressing plate will continue to move close to the fixed disc, thereby compressing the sealing coaming, the buffer bolt connects the pressing plate and the connecting plate, and when the pressing plate moves, the connecting plate presses the buffer spring, the buffer spring is used to realize buffering by using the elastic force of the buffer spring, and the possibility of damage to the device itself is reduced.
[0019] Preferably, the buffer assembly further comprises a guide sleeve, and the guide sleeve is installed in the through hole and the buffer bolt is arranged in the guide sleeve.
[0020] By adopting the technical scheme, the buffer bolt moves relative to the connecting plate under the driving of the pressing plate, and the guide sleeve realizes self-lubrication of the buffer bolt.
[0021] Preferably, the device further comprises a plurality of reinforcing assemblies, each of the reinforcing assemblies comprises a reinforcing bolt and a reinforcing clamp, the reinforcing bolt is threadedly connected to the connecting plate, the reinforcing clamp is sleeved on the reinforcing bolt, the reinforcing clamp abuts against the surface of the connecting plate, and the reinforcing clamp abuts against one side surface of the guide sleeve.
[0022] By adopting the technical scheme, the reinforcing bolt and the reinforcing clamp cooperate to limit the guide sleeve, a plurality of reinforcing assemblies cooperate to clamp and limit the guide sleeve from both sides, and the stability of the relative position between the guide sleeve and the connecting plate is improved.
[0023] In summary, the present application has at least one of the following beneficial technical effects:
[0024] 1. By arranging the electromagnetic block one and the electromagnetic block two, when the reaction is completed and the reaction hole is pressurized and drained, the pressing plate is moved to the fixed disc to make the two plates adhere to each other, that is, the electromagnetic block one and the electromagnetic block two adhere to each other, and then the power is turned on, the electromagnetic block one and the electromagnetic block two are magnetically attracted and adhered to each other, the magnetic attraction is used to make the pressing plate and the fixed disc adhere to each other more stably, and even if the pressing is performed later, no gap will be generated between the two, so that the liquid is completely drained and no residue is left in the reaction hole, which is beneficial to improve the accuracy of subsequent reaction tests.
[0025] 2. By setting the buffer assembly, the pressing plate is connected with the fixed disc. After opening the power supply, a large electromagnetic attraction is generated in the moment of opening the power supply of the electromagnetic block one, so that the electromagnetic block one and the electromagnetic block two are tightly attached and adsorbed. At this time, if the magnetic attraction is too large, it will drive the pressing plate to continuously move close to the fixed disc, thereby compressing the sealing fence. The buffer bolt connects the pressing plate and the connecting plate. When the pressing plate moves, it drives the connecting plate to press the buffer spring. The buffer spring itself realizes buffering by using its elastic force, reducing the possibility of damage to the device itself. BRIEF DESCRIPTION OF DRAWINGS
[0026] Figure 1 is the overall structure schematic diagram of the synthesis instrument in the embodiment of the present application.
[0027] Figure 2 is the position schematic diagram of the sealing fence in the embodiment of the present application.
[0028] Figure 3 is the structure schematic diagram of the position relationship between the electromagnetic block two and the pressing plate in the embodiment of the present application.
[0029] Figure 4 is the structure schematic diagram of the buffer assembly in the embodiment of the present application.
[0030] Figure 5 is Figure 4 is the local enlarged view of A part in FIG. 6.
[0031] Explanation of reference signs: 1, rack; 2, fixed disc; 21, reaction hole; 22, sealing fence; 3, pressing assembly; 31, pressing plate; 311, pressing through hole; 322, sealing groove; 323, accommodating groove; 324, connecting hole; 32, air duct; 33, pressing pipe; 4, sealing assembly; 41, power supply; 42, electromagnetic block one; 43, electromagnetic block two; 5, moving assembly; 51, mechanical arm; 52, connecting plate; 521, through hole; 6, buffer assembly; 61, buffer bolt; 611, buffer gasket; 62, buffer spring; 63, guide sleeve; 7, reinforcing assembly; 71, reinforcing bolt; 72, reinforcing clamping piece. DETAILED DESCRIPTION
[0032] In order to make the purpose, characteristics and advantages of the present application more obvious and easy to understand, the technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.
[0033] The following will be described in combination with the drawingsFigures 1-5 This application will be described in further detail.
[0034] This application discloses a synthesis instrument drainage sealing structure, such as... Figure 1 and 2 As shown, the apparatus includes a frame 1 and a fixed plate 2, which is fixedly connected to the frame 1. The fixed plate 2 has a reaction hole 21, which is used to hold the reaction solution. After the reaction experiment is completed, the reaction solution in the reaction hole 21 needs to be pressurized and drained to facilitate subsequent experiments.
[0035] like Figure 2 and 3 As shown, the synthesizer's drainage sealing structure also includes a pressurizing component 3. The pressurizing component 3 includes a pressurizing plate 31, a venting pipe 32, and a pressurizing tube 33. The pressurizing tube 33 is fixedly connected to the venting pipe 32. The pressurizing plate 31 has a pressurizing through-hole 311. The venting pipe 32 is fixedly connected to the pressurizing plate 31 and communicates with the pressurizing through-hole 311. The pressurizing tube 33 is connected to the venting pipe 32, which communicates with the pressurizing plate 31. When the pressurizing plate 31 covers the fixed plate 2, the positive pressure airflow passes through the pressurizing tube 33, the venting pipe 32, and the pressurizing through-hole 311 before moving into the fixed plate 2, pressurizing and draining the reaction hole 21.
[0036] like Figure 2 and 3 As shown, the synthesizer's drain sealing structure also includes a sealing assembly 4, which includes a sealing plate 22. The sealing plate 22 is mounted on the fixed plate 2 and located around the reaction hole 21. A sealing groove 322 is provided on the pressure plate 31 for the sealing plate 22 to be placed. The sealing plate 22 extends into the sealing groove 322, making the connection between the pressure plate 31 and the fixed plate 2 tighter. When the pressure plate 31 and the reaction hole 21 are pressurized by the pressure pipe 33, the risk of air leakage can be greatly reduced, and the stability of equipment operation can be improved.
[0037] like Figure 2 and 3As shown, the sealing assembly 4 further comprises a power supply, an electromagnetic block one 42 and an electromagnetic block two 43, the power supply (not shown in the figure) is fixedly connected to the rack 1, the electromagnetic block one 42 is fixedly connected to the rack 1, the pressing plate 31 is provided with a containing groove 323 containing the electromagnetic block two 43, the electromagnetic block two 43 is cast iron, the electromagnetic block one 42 is magnetized after being powered on, the electromagnetic block one 42 is attached to the electromagnetic block two 43, and the electromagnetic block two 43 is magnetized, so that the magnetic attraction force is generated between the electromagnetic block one 42 and the electromagnetic block two 43, thereby the magnetic attraction is attached. After the reaction is completed, before the reaction hole 21 is pressurized and drained, the pressing plate 31 is moved to the fixed disc 2 to attach the two, that is, the electromagnetic block one 42 and the electromagnetic block two 43 are attached, and then the power supply is powered on, the electromagnetic block one 42 and the electromagnetic block two 43 are tightly attached through the magnetic attraction force, the attachment between the pressing plate 31 and the fixed disc 2 is more stable by using the magnetic attraction force, even if the pressing is performed later, there will be no gap between the two, so that the drainage is complete, and the reaction hole 21 is as free as possible. Residual, conducive to improving the accuracy of subsequent reaction test.
[0038] As shown in Figure 1 and 2 , the drainage sealing structure of the synthesizer further comprises a moving assembly 5, the moving assembly 5 comprises a moving drive source, a mechanical arm 51 and a connecting plate 52, the moving drive source (not shown in the figure) is arranged in the rack 1, the moving drive source is used to drive the mechanical arm 51 to operate, the connecting plate 52 is connected to the end of the mechanical arm 51, and the side of the connecting plate 52 away from the mechanical arm 51 is fixedly connected with the air duct 32. The connecting plate 52 is fixedly connected with the pressing plate 31, the moving drive source drives the mechanical arm 51 to move the connecting plate 52 and the pressing plate 31 according to the PLC program setting, so that the pressing plate 31 covers the fixed disc 2 to facilitate subsequent pressurization and drainage, or the pressing plate 31 moves away from the fixed disc 2, which is conducive to realizing automation.
[0039] As shown in Figure 4 and 5 , the drainage sealing structure of the synthesizer further comprises a buffer assembly 6, the buffer assembly 6 comprises a buffer bolt 61 and a buffer spring 62, the connecting plate 52 is provided with a through hole 521 for the buffer bolt 61 to pass through, a guide sleeve 63 is installed in the through hole 521, the buffer bolt 61 passes through the guide sleeve 63, the guide sleeve 63 has a self-lubricating function, and in the embodiment, the guide sleeve 63 can be made of POM material or PEEK material, etc. The pressing plate 31 is provided with a connecting hole 324 for the buffer bolt 61 to be threadedly connected. The buffer spring 62 is sleeved on the buffer bolt 61, the buffer bolt 61 is sleeved with a buffer gasket 611, one end of the buffer spring 62 abuts against the buffer gasket 611, and the other end abuts against the side of the connecting plate 52 away from the pressing plate 31.
[0040] After the pressing plate 31 is attached to the fixed disc 2, the power is turned on, and at the moment when the electromagnetic block one 42 is opened, a large electromagnetic attraction is generated, so that the electromagnetic block one 42 and the electromagnetic block two 43 are tightly attached and adsorbed. At this time, if the magnetic attraction is too large, it will drive the pressing plate 31 to continuously move close to the fixed disc 2, thereby compressing the sealing surrounding plate 22. The buffer bolt 61 connects the pressing plate 31 and the connecting plate 52, and when the pressing plate 31 moves, it drives the connecting plate 52 to press the buffer spring 62, so as to realize buffering by the elastic force of the buffer spring 62, thereby reducing the possibility of damage to the device itself.
[0041] As shown in Figure 5 The synthesis instrument liquid discharge sealing structure further comprises a plurality of reinforcing assemblies 7, each of which comprises a reinforcing bolt 71 and a reinforcing clamping piece 72. The reinforcing bolt 71 is threadedly connected to the connecting plate 52, and the reinforcing clamping piece 72 is sleeved on the reinforcing bolt 71. The same reinforcing clamping piece 72 abuts against the surface of the connecting plate 52, and the reinforcing clamping piece 72 abuts against one side surface of the guide sleeve 63. The plurality of reinforcing assemblies 7 are evenly arranged around the through hole 521, and the reinforcing clamping pieces 72 of the adjacent two reinforcing assemblies 7 abut against the opposite two side surfaces of the connecting plate 52, that is, the two reinforcing clamping pieces simultaneously abut against the opposite two side surfaces of the guide sleeve 63, thereby clamping and limiting the guide sleeve 63.
[0042] The implementation principle of the synthesis instrument liquid discharge sealing structure according to the embodiment of the present application is as follows:
[0043] Through the arrangement of the electromagnetic block one 42 and the electromagnetic block two 43, after the reaction is completed, before the reaction hole 21 is pressurized and discharged, the pressing plate 31 is moved to the fixed disc 2 to attach them, that is, the electromagnetic block one 42 and the electromagnetic block two 43 are attached, and then the power is turned on. The electromagnetic block one 42 and the electromagnetic block two 43 are magnetically attracted and attached, the magnetic attraction is used to make the pressing plate 31 and the fixed disc 2 more stably attached, and then the positive air pressure is introduced inward, and the liquid is discharged under the action of the air pressure. After the reaction solution is completely discharged, the air pressure in it returns to the standard atmospheric pressure, the power is turned off, the magnetic attraction between the electromagnetic block one 42 and the electromagnetic block two 43 disappears, and the pressing plate 31 is moved away by the mechanical arm 51.
[0044] The above are preferred embodiments of the present application, which do not limit the protection scope of the present application, so that: any equivalent changes made according to the structure, shape, principle of the present application should be covered within the protection scope of the present application.
Claims
1. A liquid discharge sealing structure for a synthesizer, comprising a frame (1) and a fixed plate (2), wherein the fixed plate (2) is disposed on the frame (1), and a reaction hole (21) is provided on the fixed plate (2), the reaction hole (21) being used to hold a reaction solution, characterized in that: The device further comprises a pressurizing assembly (3) and a sealing assembly (4), the pressurizing assembly (3) comprises a pressurizing plate (31) and a pressurizing pipe (33), the pressurizing pipe (33) is connected with and communicates with the pressurizing plate (31), the pressurizing plate (31) is arranged on the fixed disc (2), the pressurizing pipe (33) introduces positive pressure into the reaction hole (21), the sealing assembly (4) comprises a power supply (41), an electromagnetic block one (42) and an electromagnetic block two (43), the power supply (41) is arranged on the rack (1), the electromagnetic block one (42) is arranged on the rack (1), the electromagnetic block two (43) is arranged on the pressurizing plate (31), and the electromagnetic block one (42) and the electromagnetic block two (43) are magnetically attracted and attached.
2. The liquid discharge sealing structure of a synthesizer according to claim 1, characterized by: The pressurizing plate (31) is provided with a containing groove (323) for containing the electromagnetic block two (43).
3. The liquid discharge sealing structure of a synthesizer according to claim 1, characterized by: The sealing assembly (4) further comprises a sealing surrounding plate (22), the sealing surrounding plate (22) is arranged on the fixed disc (2) and located outside the reaction hole (21), and the pressurizing plate (31) is provided with a sealing groove (322) for placing the sealing surrounding plate (22).
4. The seal structure for liquid discharge of a synthesizer according to claim 1, wherein: The device further comprises a moving assembly (5), the moving assembly (5) comprises a moving driving source, a mechanical arm (51) and a connecting plate (52), the moving driving source is arranged in the rack (1), the moving driving source is used for driving the mechanical arm (51) to run, and the connecting plate (52) is connected to the end of the mechanical arm (51), and the side, away from the mechanical arm (51), of the connecting plate (52) is connected with the pressurizing plate (31).
5. The seal structure for liquid discharge of a synthesizer according to claim 4, wherein: The pressurizing plate (31) is provided with an air passage (32), the pressurizing pipe (33) is connected with the air passage (32), and the connecting plate (52) is connected with one end of the air passage (32), away from the pressurizing plate (31).
6. The seal structure for liquid discharge of a synthesizer according to claim 5, wherein: The device further comprises a buffer assembly (6), the buffer assembly (6) comprises a buffer bolt (61) and a buffer spring (62), the connecting plate (52) is provided with a through hole (521) for penetrating the buffer bolt (61), the pressurizing plate (31) is provided with a connecting hole (324) for threadedly connecting the buffer bolt (61), the buffer spring (62) is sleeved on the buffer bolt (61), and one end of the buffer spring (62), away from the buffer bolt (61), abuts against the side, away from the pressurizing plate (31), of the connecting plate (52).
7. The seal structure according to claim 6, wherein: The buffer assembly (6) further comprises a guide sleeve (63), the guide sleeve (63) is installed in the through hole (521), and the buffer bolt (61) penetrates the guide sleeve (63).
8. The seal structure according to claim 7, wherein: The device further comprises a plurality of reinforcing assemblies (7), each reinforcing assembly (7) comprises a reinforcing bolt (71) and a reinforcing clamping piece (72), the reinforcing bolt (71) is threadedly connected to the connecting plate (52), the reinforcing clamping piece (72) is sleeved on the reinforcing bolt (71), the reinforcing clamping piece (72) abuts against the plate surface of the connecting plate (52), and the reinforcing clamping piece (72) abuts against one side surface of the guide sleeve (63).