Donor faeces sample low-oxygen collection box and device

Abstract

The utility model discloses a low-oxygen collection box and device for a donor excrement sample, and relates to the technical field of biomedicine. The box body is internally provided with a sample collecting cavity, the box cover is connected with the box body, the side, close to the box body, of the box cover is connected with a containing groove, and a deoxidizing agent bag capable of reducing the oxygen content in the sample collecting cavity is placed in a containing cavity of the containing groove. A vent hole communicated with the accommodating cavity and the sample collecting cavity is formed in the accommodating groove. According to the utility model, the excrement sample can be in a low-oxygen environment, so that the survival rate of anaerobic bacteria in the excrement sample is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of biomedical technology, specifically to a donor fecal sample low oxygen collection box and device. BACKGROUND

[0002] Fecal microbiota transplantation (FMT) is a technology that transplants the fecal flora of a healthy donor into the intestinal tract of a patient after processing, reestablishes flora balance and realizes the treatment of intestinal and extra-intestinal diseases; as an innovative treatment method, it has been officially included in the "Notice on Issuing National Medical Service Project Technical Specifications" issued by the National Health Commission in 2023.

[0003] Before the implementation of the intestinal microbiota transplantation technology (FMT), the flora diversity and relative abundance of intestinal beneficial bacteria in the fecal sample need to be maintained as much as possible to improve the treatment effect of the intestinal microbiota transplantation technology (FMT).

[0004] After research and analysis, it is found that most of the intestinal beneficial bacteria are anaerobes, and although the existing fecal sample collector can conveniently collect fecal samples, its effect on maintaining the flora diversity and relative abundance of anaerobes in the fecal sample is poor, and it will result in a low survival rate of anaerobes in the fecal sample, therefore, it is necessary to improve it. UTILITY MODEL CONTENT

[0005] The utility model aims at overcoming the defects of the prior art, and provides a donor fecal sample low oxygen collection box and device to improve the survival rate of anaerobes in the fecal sample.

[0006] To achieve the above-mentioned purpose, the technical scheme designed by the utility model is as follows:

[0007] In the first aspect, the utility model provides a donor fecal sample low oxygen collection box, which comprises a box body provided with a sample collection cavity inside and a box cover connected with the box body, a receiving groove is connected to the side of the box cover close to the box body, a deoxidizer bag capable of reducing the oxygen content in the sample collection cavity is placed in the receiving cavity of the receiving groove, and a ventilation hole communicating the receiving cavity and the sample collection cavity is arranged on the receiving groove.

[0008] In the above technical scheme, a plurality of supporting feet are arranged at the lower end of the box body.

[0009] In the above technical scheme, a supporting foot groove corresponding to the supporting feet is arranged on the box cover.

[0010] In the above technical scheme, the plurality of supporting legs comprises first supporting legs located at two sides of the box body and second supporting legs located at the middle part of the box body, the cross section of the first supporting legs along the horizontal direction is in the shape of 7, and the cross section of the second supporting legs along the horizontal direction is in the shape of a single line.

[0011] In the above technical scheme, the box cover is connected with a pull ring.

[0012] In the above technical scheme, the pull ring and the box cover are in an integrated structure, and the pull ring is located at the middle part of the arc-shaped arch edge of the box cover.

[0013] In the above technical scheme, the top edge of the box body is connected with an outer lip, and the edge of the box cover is provided with an inner groove corresponding to the outer lip.

[0014] In the above technical scheme, the box body and / or the box cover are provided with a label for realizing the traceability function of the sample.

[0015] In the above technical scheme, the box body is made of hard transparent material, and the box cover is made of soft material.

[0016] In the above technical scheme, the box body is made of hard material, and the box cover is made of soft material; and / or, the cross section of the box body and the box cover along the horizontal direction is in the shape of a half ellipse.

[0017] In the above technical scheme, the outer wall of the box body is connected with a plurality of reinforcing ribs; and / or, the receiving groove is further provided with a desiccant bag for removing the fog in the box body.

[0018] In the above technical scheme, the receiving groove and the box cover are connected together through a buckle structure, and the opening direction of the receiving cavity in the receiving groove faces the box cover.

[0019] In the above technical scheme, the receiving groove and the box cover are in an integrated structure, and the receiving groove is provided with a deoxidizing opening for taking and placing the deoxidizing agent bag.

[0020] In the second aspect, the utility model also provides a kind of donor fecal sample low oxygen collection device, including toilet and the donor fecal sample low oxygen collection box, and the toilet is provided with the seat groove for placing the donor fecal sample low oxygen collection box.

[0021] In the above technical scheme, the toilet has a handrail; and / or, the shape of the inner wall of the rear end of the seat groove matches the shape of the outer wall of the box body, and the cavity is formed between the front end of the seat groove and the outer wall of the box body.

[0022] The utility model has the advantages that:

[0023] 1. The box body and lid can be sealed together. The box body can be made of a rigid transparent material (such as PEP plastic), and the lid can be made of a soft material (such as latex). The fecal sample can be placed inside the sample collection chamber. After the box body and lid are connected, the desiccant pack absorbs oxygen in the sample collection chamber through the vent, thereby reducing the oxygen content in the sample collection chamber and improving the survival rate of anaerobic bacteria in the fecal sample, thus better protecting the fecal sample. The desiccant pack can remove fog from the box body, allowing people to directly view the fecal sample inside the box, making this application more convenient to use.

[0024] 2. The support feet and support foot grooves not only make it easier to place the donor fecal sample hypoxia collection box on the ground, toilet, table or test bench, making the use of this application more convenient, but also allow multiple donor fecal sample hypoxia collection boxes to be stacked together more firmly, thereby improving the structural stability of this application.

[0025] 3. The pull ring can be used to separate the box body and the lid, making this application more convenient to use; at the same time, this application provides two ways to connect the storage tank and the lid together, so that people can easily place the deoxygenating agent pack in the storage tank, thereby keeping the fecal sample in a low-oxygen environment and thus improving the survival rate of anaerobic bacteria in the fecal sample.

[0026] 4. With the combined effect of the toilet and the donor fecal sample low-oxygen collection box, people can collect fecal samples more conveniently; at the same time, this application can store fecal samples for a long time. When long-term storage of fecal samples is required, this application only needs to put them in the freezer (-20℃) of a refrigerator.

[0027] 5. The outer lip and inner groove can further enhance the sealing performance between the box body and the lid, so that the sample collection chamber described in this application can maintain a low oxygen state for a longer time, which can not only further improve the survival rate of anaerobic bacteria in feces, but also extend the storage time of fecal samples in the freezer.

[0028] 6. The fecal sample hypoxia collection device can assist people in collecting fecal samples. The handrail makes it easier for people to stand up or sit on the toilet. The cavity formed between the inner wall of the front end of the toilet bowl and the outer wall of the box can separate urine and feces, so that the fecal sample is drier. This makes it easier to preserve and transport the donor fecal sample hypoxia collection box (containing the fecal sample), thus making the use of this application more convenient. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the donor fecal sample hypoxia collection box described in this application from a first-view perspective.

[0030] Figure 2Structure diagram of the donor fecal sample hypoxia collection box along a second visual angle;

[0031] Figure 3 For Figure 1 Structure diagram without the box cover;

[0032] Figure 4 Structure diagram of the connection between the box cover and the receiving groove;

[0033] Figure 5 Structure diagram of the toilet.

[0034] In the figure: 1, box body; 11, sample collection cavity; 12, outer lip; 2, box cover; 3, receiving groove; 31, receiving cavity; 32, air hole; 4, deoxidizer package; 5, supporting leg; 51, first supporting leg; 52, second supporting leg; 6, supporting leg groove; 71, pull ring; 72, reinforcing rib; 8, buckle structure; 9, toilet; 91, toilet bowl; 92, handrail. DETAILED DESCRIPTION

[0035] The utility model will be described in further detail below in combination with specific embodiments, so that those skilled in the art can understand.

[0036] Soon after the birth of a newborn, a large number of external microorganisms begin to adhere to its body surface and intestinal tract, most of which are compatible with the human body and ultimately form a symbiotic relationship with the human body throughout their lives. Among these symbiotic microorganisms, about 100 trillion intestinal microorganisms colonize the human intestinal tract, which includes bacteria, fungi, viruses and other microorganisms. The genome of intestinal microorganisms contains about 5 million genes, about 150 times the number of human genes. Due to its large number and rich species characteristics, intestinal microorganisms are referred to as the "second gene library" of the human body, and are the most complex and largest microecological system in the human body, known as the eighth organ of the human body.

[0037] Fecal microbiota transplantation (FMT) originated from the works "Elbow Post-First Aid" in the Eastern Jin Dynasty and "Suwen" in the Spring and Autumn Period, and Chinese medicine used human feces (recorded as Huanglong Decoction / Golden Juice) to treat intestinal diseases. In 1958, surgeon Eiseman used human feces to treat patients with pseudomembranous enteritis, and in 2013, the American Medical Guide announced that human feces could be used for the treatment of Clostridium difficile.

[0038] Currently, the fecal microbiota transplantation (FMT) shows significant efficacy in treating gastrointestinal diseases such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), recurrent Clostridium difficile infection (CDI), ulcerative colitis (UC), functional constipation (FC) and the like. With the deepening of research and the continuous updating of high-throughput sequencing, artificial intelligence big data analysis, intelligent production system and other technical levels, the clinical application cases are also increasing, showing a broad application prospect.

[0039] Before the implementation of the fecal microbiota transplantation (FMT), the intestinal microorganisms in the fecal donor need to be separated, collected and treated. Before that, people need to maintain the flora diversity and relative abundance of intestinal beneficial bacteria in the fecal sample as much as possible to improve the therapeutic effect of the fecal microbiota transplantation (FMT).

[0040] After research and analysis, it is found that most of the intestinal beneficial bacteria are anaerobes. Although the existing fecal sample collector can conveniently collect the fecal sample, it has poor effect on maintaining the flora diversity and relative abundance of anaerobes in the fecal sample, and the survival rate of anaerobes in the fecal sample is low. Therefore, it is necessary to improve it.

[0041] To solve the above problems, the utility model provides a donor fecal sample low oxygen collection box, as shown in the first aspect of the present application, Figure 1 The utility model discloses a donor fecal sample low oxygen collection box, which comprises a box body 1 provided with a sample collection cavity 11 and a box cover 2 connected with the box body 1, a receiving groove 3 is connected on one side of the box cover 2 close to the box body 1, a deoxidizing agent bag 4 capable of reducing the oxygen content in the sample collection cavity 11 is placed in the receiving cavity 31 of the receiving groove 3, and a vent hole 32 communicating the receiving cavity 31 and the sample collection cavity 11 is arranged on the receiving groove 3.

[0042] In actual work, the box body 1 and the box cover 2 can be sealingly connected together, the box body 1 can be made of hard transparent material (such as PEP plastic), and the box cover 2 can be made of soft material (such as latex), so that people can directly view the fecal sample in the box body, thereby making the application more convenient to use.

[0043] The fecal sample can be placed in the sample collection cavity 11, after the box body 1 and the box cover 2 are connected together, the deoxidizing agent bag 4 can absorb the oxygen in the sample collection cavity 11 through the vent hole 32 to reduce the oxygen content in the sample collection cavity 11, thereby improving the survival rate of anaerobes in the fecal sample and better protecting the sample.

[0044] As shown in the first aspect of the present application, Figure 2As shown, the lower end of the box body 1 is provided with a plurality of supporting feet 5. The above-mentioned supporting feet 5 can not only support the box body 1, but also make the bottom of the box body 1 not directly contact with the desktop or the ground, so that the application is more convenient and cleaner to use.

[0045] The plurality of supporting feet 5 includes first supporting feet 51 located on both sides of the box body 1 and second supporting feet 52 located in the middle of the box body 1. The cross section of the first supporting feet 51 along the horizontal direction is in the shape of 7, and the cross section of the second supporting feet 52 along the horizontal direction is in the shape of a single character. In this way, under the joint action of the first supporting feet 51 and the second supporting feet 52, the structural stability of the application is higher.

[0046] The box cover 2 is provided with a supporting foot groove 6 corresponding to the supporting feet 5. In this way, under the joint action of the supporting foot groove 6 and the supporting feet 5, a plurality of donor fecal sample low-oxygen collection boxes can be stacked together more firmly, and the structural stability is higher.

[0047] The box cover 2 is connected with a pull ring 71. In this way, people can separate the box body 1 and the box cover 2 through the pull ring 71, so that the application is more convenient to use.

[0048] The box body 1 and / or the box cover 2 are provided with a label (not shown in the figure) for realizing the traceability function of the sample. The label can be a two-dimensional code and / or a bar code, which can make the application more convenient to realize the donor traceability function. Preferably, each donor is configured with a label (such as a two-dimensional code), so as to facilitate the management of the donor fecal sample.

[0049] As shown in Figure 2 and Figure 4 The cross section of the box body 1 and the box cover 2 along the horizontal direction is semicircular. In this way, the box body 1 and the box cover 2 of the application can match the shape of the sitting groove 91 in the mainstream toilet 9 on the market, so that the application is more convenient to use.

[0050] In order to further increase the structural stability of the application, a plurality of reinforcing ribs 72 are connected to the outer wall of the box body 1.

[0051] The top edge of the box body 1 is connected with an outer lip 12, and the edge of the box cover 2 is provided with an inner groove corresponding to the outer lip 12. The above-mentioned outer lip 12 and inner groove can further strengthen the sealing performance between the box body 1 and the box cover 2, so that the sample collection cavity 11 of the application can maintain a low-oxygen state for a longer time, so as to improve the survival rate of anaerobic bacteria in feces.

[0052] Preferably, the length of the outer lip 12 is 2-4 mm (preferably 4 mm). A longer outer lip 12 can further enhance the sealing performance between the box body 1 and the lid 2, thereby further improving the survival rate of anaerobic bacteria in feces. Furthermore, the wall thickness of the box body 1 is 2-3 mm (preferably 2.5 mm), which makes the structure of this application more stable and extends its service life.

[0053] In actual operation, the storage slot 3 and the lid 2 can be connected together in various ways, as long as the storage slot 3 can accommodate the oxygen absorber pack 4, for example:

[0054] 1) such as Figure 4 The storage slot 3 and the lid 2 are connected together by a snap-fit ​​structure 8, and the opening of the storage cavity 31 in the storage slot 3 faces the lid 2. Preferably, the snap-fit ​​structure 8 includes a snap block on the lid 2, a flange on the top of the storage slot 3, and a snap groove corresponding to the flange in the snap block. The storage slot 3 and the lid 2 are detachably connected together by the snap block, flange, and snap groove.

[0055] This application realizes a first way of connecting the storage slot 3 and the lid 2 together. The snap-fit ​​structure 8 allows for a detachable connection between the storage slot 3 and the lid 2. When people remove the storage slot 3 from the lid 2, they can place the oxygen absorber pack 4 and the desiccant pack inside the storage slot 3.

[0056] 2) The storage slot 3 and the lid 2 are an integral structure. The storage slot 3 is provided with a deoxidation port (not shown in the figure) for taking out and putting in the deoxidizer pack 4. In this way, this application also realizes the second way of connecting the storage slot 3 and the lid 2 together, and the deoxidation port allows people to directly insert the deoxidizer pack 4 into the storage slot 3.

[0057] Secondly, this application also provides a donor fecal sample hypoxia collection device, including a toilet 9 and the donor fecal sample hypoxia collection box described above, wherein the toilet 9 is provided with a toilet bowl 91 for placing the donor fecal sample hypoxia collection box.

[0058] With the combined effect of the toilet 9 and the donor fecal sample hypoxia collection box, people can collect fecal samples more conveniently. For a detailed description of the fecal sample hypoxia collection device, please refer to the detailed description of the donor fecal sample hypoxia collection box. To avoid repetition, it will not be repeated here.

[0059] Further, the toilet 9 is provided with a handrail 92, the shape of the inner wall of the toilet bowl 91 matches the shape of the outer wall of the box body 1, and a cavity is formed between the front end inner wall of the toilet bowl 91 and the outer wall of the box body 1. The fecal sample low-oxygen collection device can assist people in collecting fecal samples, the handrail can make people more conveniently stand up or sit on the toilet, and the cavity formed between the front end inner wall of the toilet bowl 91 and the outer wall of the box body 1 can separate urine and feces, so that the fecal sample is drier, so that the fecal sample low-oxygen collection box (which is internally provided with a fecal sample) of the donor is easier to preserve and transport, and the use of the present application is more convenient.

[0060] Other parts not described in detail are prior art. Although the above embodiment describes the present application in detail, it is only a part of the embodiments of the present application, not all the embodiments, and other embodiments can be obtained under the premise of no creativity according to the present embodiment, and these embodiments all belong to the protection scope of the present application.

Claims

1. A donor fecal sample hypoxia collection kit, characterized in that: The device includes a box body (1) with a sample collection chamber (11) inside and a box cover (2) connected to the box body (1). The box cover (2) has a storage slot (3) connected to the side near the box body (1). The storage cavity (31) of the storage slot (3) contains an oxygen absorber pack (4) that can reduce the oxygen content in the sample collection chamber (11). The storage slot (3) has a vent (32) that connects the storage cavity (31) and the sample collection chamber (11).

2. The donor fecal sample hypoxia collection kit according to claim 1, characterized in that: The lower end of the box (1) is provided with multiple support feet (5).

3. The donor fecal sample hypoxia collection kit according to claim 2, characterized in that: The cover (2) is provided with a support groove (6) corresponding to the support foot (5).

4. The donor fecal sample hypoxia collection kit according to claim 3, characterized in that: The plurality of support feet (5) include a first support foot (51) located on both sides of the box body (1) and a second support foot (52) located in the middle of the box body (1). The first support foot (51) has a 7-shaped cross section in the horizontal direction, and the second support foot (52) has a straight cross section in the horizontal direction.

5. The donor fecal sample hypoxia collection kit according to any one of claims 1 to 4, characterized in that: A pull ring (71) is attached to the lid (2).

6. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The pull ring (71) and the box cover (2) are an integral structure, and the pull ring (71) is located in the middle of the arc-shaped arch edge of the box cover (2).

7. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The top edge of the box body (1) is connected to an outer lip (12), and the edge of the box cover (2) is provided with an inner groove corresponding to the outer lip (12).

8. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The box body (1) and / or the lid (2) are provided with labels for enabling sample traceability.

9. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The box body (1) is made of a rigid transparent material, and the box lid (2) is made of a soft material; and / or, the box body (1) and the box lid (2) have a semi-elliptical cross section in the horizontal direction.

10. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The outer wall of the box (1) is connected with a plurality of reinforcing ribs (72); and / or, the storage slot (3) is also provided with a desiccant pack for removing mist from the box (1).

11. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The storage slot (3) and the box cover (2) are an integral structure. The storage slot (3) is provided with a deoxygenation port for taking out and putting in the deoxygenator pack (4).

12. The donor fecal sample hypoxia collection kit according to claim 5, characterized in that: The storage slot (3) and the box cover (2) are connected together by a snap-fit ​​structure (8), and the opening of the storage cavity (31) in the storage slot (3) faces the box cover (2).

13. A device for collecting low-oxygen donor fecal samples, characterized in that: Includes a toilet (9) and a donor fecal sample hypoxia collection box as claimed in any one of claims 1 to 12, wherein the toilet (9) is provided with a toilet bowl (91) for placing the donor fecal sample hypoxia collection box.

14. The donor fecal sample hypoxia collection device according to claim 13, characterized in that: The toilet (9) has a handrail (92); and / or, the shape of the inner wall of the rear end of the toilet bowl (91) matches the shape of the outer wall of the box (1), and a cavity is formed between the inner wall of the front end of the toilet bowl (91) and the outer wall of the box (1).

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