Mobile phase mixer applied to liquid chromatograph

Abstract

The utility model discloses a mobile phase mixer applied to a liquid chromatograph, which comprises a shell, two ends of the shell are respectively provided with an inlet and an outlet, and a mixing turbulent flow component and a shunting diffusion component are arranged in the shell; the mixed turbulent flow assembly comprises a turbulent flow column and a turbulent flow ring which are arranged at the inlet position of the shell, the turbulent flow column is matched with the turbulent flow ring, so that a mobile phase passes through a gap between the turbulent flow column and the turbulent flow ring, and a plurality of sections of spirals with opposite rotation directions are arranged on the outer wall of the turbulent flow column; the shunting diffusion assembly is arranged at the rear stage of the mixed turbulent flow assembly and comprises a sleeve filled with shunting balls, and sieve plates are arranged at the two ends of the sleeve. According to the utility model, two or more mobile phases can be effectively mixed, so that liquid is effectively mixed in the mixing cavity, and the full mixing effect is achieved through the continuous change of the states of convergence, diffusion, spiral vortex, diffusion and the like.

Description

TECHNICAL FIELD

[0001] The utility model relates to a kind of liquid chromatography technology, in particular to a kind of flow phase mixers applied to liquid chromatograph. BACKGROUND

[0002] In the present liquid chromatography analysis method, in order to high-efficiency analysis effect, two, multiple flow phase mixed elution is required, whether gradient or isocratic, basically multiple solutions output by infusion pump are fully mixed and then enter sample valve and chromatographic column, through the mixing solvent ratio of different content, the best separation effect is achieved. The conventional static mixer includes diffusion separation by shunt ball or sieve plate, sometimes the effect is often not ideal, dynamic mixer is realized by motor-driven blade rotation stirring, there is certain limitation in high pressure small volume. SUMMARY

[0003] In order to solve the above-mentioned deficiencies in the prior art, the purpose of the utility model is to provide a flow phase mixer applied to liquid chromatograph, which can effectively mix the liquid in the mixing cavity, and continuously change the states of convergence, diffusion, spiral vortex and diffusion to achieve the effect of full mixing.

[0004] The utility model solves the technical scheme that the technical problem thereof adopts: a flow phase mixer applied to liquid chromatograph, including shell, the both ends of the shell are equipped with import and export respectively, the mixing turbulence component and the shunt diffusion component are installed in the shell;

[0005] The mixing turbulence component includes turbulence column and turbulence ring arranged at the import position of the shell, the turbulence column is matched with the turbulence ring, so that the flow phase passes through the gap between the turbulence column and the turbulence ring, and a plurality of helices with opposite rotation directions are arranged on the outer wall of the turbulence column.

[0006] The shunt diffusion component is arranged at the rear stage of the mixing turbulence component, and the shunt diffusion component includes a sleeve filled with shunt balls, and the sleeve is provided with sieve plates at both ends.

[0007] Optionally, the import and export of the shell are in the shape of a horn.

[0008] Optionally, the turbulence ring and the sieve plate are sealed by a peek ring.

[0009] Optionally, the shunt diffusion component is provided with two groups, and the two groups of shunt diffusion components are separated by a partition plate, and the partition plate is provided with a through hole in the middle.

[0010] Adopting the technical scheme, the two or more than two mobile phases can be effectively mixed, liquid is effectively mixed in the mixing cavity, and the liquid experiences continuous change of convergence, diffusion, spiral vortex and diffusion, so that the effect of full mixing is achieved. BRIEF DESCRIPTION OF DRAWINGS

[0011] Figure 1 It is a structural schematic view of the utility model. DETAILED DESCRIPTION

[0012] The application will be further described in detail below with reference to the drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the related utility model, and not to limit the utility model. In addition, it should be noted that, for the convenience of description, only the parts related to the utility model are shown in the drawings.

[0013] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The present application will be described in detail below with reference to the drawings and embodiments.

[0014] As Figure 1 shown, the utility model discloses a mobile phase mixer for liquid chromatograph, it includes shell 100, is equipped with import 110 and outlet 120 respectively at both ends of shell 100, and import 110 and outlet 120 are all horn shape, installs mixed turbulence subassembly and shunt diffusion subassembly in shell 100, and shunt diffusion subassembly is located mixed turbulence subassembly after stage, through the effect of mixed turbulence subassembly and shunt diffusion subassembly, multiple mobile phases can be mixed fully.

[0015] Specifically, the mixed turbulence subassembly includes turbulence column 200 and turbulence ring 300 arranged at the inlet position of the shell, the turbulence column 200 is distributed along the axis of the turbulence ring 300, and there is a gap between the turbulence column 200 and the turbulence ring 300, the gap forms a flow mixing channel for the mobile phase, so that the mobile phase passes through the gap between the turbulence column 200 and the turbulence ring 300. In order to improve the mixing effect of the mobile phase, a plurality of helices with opposite directions can be arranged on the outer wall of the turbulence column 200. In addition, a helix matched with the turbulence column 200 can be arranged on the inner wall of the turbulence ring 300 to form the flow mixing channel.

[0016] In the installation of the spoiler column 200, the end of the spoiler column 200 close to the inlet 110 is fixedly connected with the spoiler ring 300 through the radially distributed connecting rods, so that the main body of the spoiler column 200 is suspended in the internal space of the spoiler ring 300, and a gap is formed between the two to form a flow mixing channel, and the spoiler ring 300 can be directly assembled in the inside of the shell 100, for example, end covers 130 can be installed at both ends of the shell 100, and the inlet 110 and the outlet 120 are arranged in the end covers 130 at both ends of the shell 100, and the spoiler ring 300 and the flow splitting and diffusing assembly are pressed in the inside of the shell 100 through the end covers 130 at both ends.

[0017] The flow splitting and diffusing assembly comprises a sleeve 500 filled with flow splitting balls 400, and a sieve plate 600 is arranged at both ends of the sleeve 500, and the sieve plate 600 is a plate body with dense sieve holes and can filter the stationary phase in the mobile phase. When the mobile phase enters the sleeve 500, it is dispersed by the flow splitting balls in the sleeve 500, so that the mobile phase uniformly passes through the gaps between the flow splitting balls 400, and the mobile phase can be more fully mixed. In order to further improve the mixing effect of the mobile phase, two groups of flow splitting and diffusing assemblies can be arranged, and the two groups of flow splitting and diffusing assemblies are separated by a partition plate 700, and a through hole is arranged in the middle of the partition plate 700 to communicate the two groups of flow splitting and diffusing assemblies.

[0018] In the utility model, in order to guarantee the sealing performance of the mobile phase flow route, the spoiler ring 300 and the sieve plate 600 are sealed by a peek ring.

[0019] The above description is only the preferred embodiment of the application and the explanation of the applied technical principles. Those skilled in the art should understand that the utility model range involved in the present application is not limited to the technical solutions formed by the specific combination of the above technical features, and should also cover other technical solutions formed by the above technical features or their equivalent features in any combination without departing from the utility model concept. For example, the above features are replaced with the technical features disclosed in the present application (but not limited to) having similar functions to form technical solutions.

[0020] In addition to the technical features described in the specification, the remaining technical features are known to those skilled in the art, and in order to highlight the innovative features of the utility model, the remaining technical features will not be described here.

Claims

1. A mobile phase mixer for use in a liquid chromatograph, the mobile phase mixer comprising: The utility model relates to a kind of mixing and separating device, including shell, the two ends of the shell are equipped with inlet and outlet respectively, mixing and disturbing assembly and shunting diffusion assembly are installed in the shell; The mixing and disturbing assembly includes disturbing column and disturbing ring at the inlet position of shell, the disturbing column and disturbing ring are matched, so that flow phase passes through the gap between disturbing column and disturbing ring, the outer wall of disturbing column is equipped with multiple helixes with opposite rotation direction; The shunting diffusion assembly is arranged behind the mixing and disturbing assembly, and includes sleeve filled with shunting ball, both ends of the sleeve are equipped with sieve plate.

2. The mobile phase mixer for use in a liquid chromatograph according to claim 1, wherein, The inlet and outlet of the shell are both in the shape of a horn.

3. The mobile phase mixer for use in a liquid chromatograph according to claim 2, wherein, The disturbing ring and sieve plate are both sealed by peek ring.

4. The mobile phase mixer for use in a liquid chromatograph according to claim 3, wherein The shunting diffusion assembly is provided with two groups, and the two groups of shunting diffusion assemblies are separated by partition, and the middle part of the partition is provided with through hole.

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