Electrode wire and implantable electrical nerve stimulation system

Abstract

The utility model relates to the technical field of medical products, and discloses an electrode wire and an implantable electrical nerve stimulation system. Wherein the electrode wire comprises a stimulation assembly and a guide wire assembly, the stimulation assembly comprises a contact support, a printed circuit board and a plurality of stimulation pieces, and the printed circuit board is arranged on the contact support; the plurality of stimulation members are installed on the contact support, and the stimulation members are electrically connected to the printed circuit board. The guide wire assembly comprises a stimulation signal transmission guide wire and a communication signal transmission guide wire, and one end of the stimulation signal transmission guide wire is electrically connected to the printed circuit board; one end of the communication signal transmission guide wire is electrically connected to the printed circuit board. According to the application, the control of a plurality of stimulation pieces can be completed only by two guide wires, the number of the guide wires is reduced, the product structure is optimized, the production cost is reduced, and the guide wire assembly is changed into two strands from multiple strands, so that the pitch is reduced, and the tensile strength is increased.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical products, in particular to an electrode lead and an implantable nerve electrical stimulation system. BACKGROUND

[0002] At present, all electrode leads on the market are pulse generators that transmit stimulation signals to each stimulation point of the electrode lead through independent channels. For example, four stimulation points require four independent stimulation signal transmission channels, so four stimulation signal transmission guide wires are needed inside the lead to achieve signal transmission, and four connection points are also needed between the lead and the extension lead and between the extension lead and the IPG (Implantable Pulse Generator).

[0003] With the demand for directional electrodes, the number of stimulation points gradually increases, which means an increase in the number of connection channels on the IPG and the extension lead, one channel corresponding to one guide wire, which in turn leads to an increase in the number of guide wires in the electrode lead. The increase in the number of guide wires leads to an increase in the pitch of the spiral guide wire, which reduces the tensile and bending resistance of the guide wire, and also leads to a complex structure of the stimulation end of the electrode lead, increasing the production cost.

[0004] Therefore, there is an urgent need for an electrode lead and an implantable nerve electrical stimulation system to solve the above problems. CONTENT OF THE INVENTION

[0005] Based on the above, the purpose of the present application is to provide an electrode lead and an implantable nerve electrical stimulation system, which can control multiple stimulation components with only two guide wires, reduce the number of guide wires, optimize the product structure, reduce the production cost, and change the guide wire assembly from multiple strands to two strands, reduce the pitch and increase the tensile strength.

[0006] To achieve the above purpose, the present application adopts the following technical solutions:

[0007] On the one hand, an electrode lead is provided, comprising:

[0008] a stimulation component, which comprises a contact support, a printed circuit board and a plurality of stimulation components, the printed circuit board being arranged on the contact support; a plurality of stimulation components are mounted on the contact support, and the stimulation components are electrically connected to the printed circuit board;

[0009] a guide wire assembly, which comprises a stimulation signal transmission guide wire and a communication signal transmission guide wire, one end of the stimulation signal transmission guide wire being electrically connected to the printed circuit board; one end of the communication signal transmission guide wire being electrically connected to the printed circuit board.

[0010] As a preferred technical scheme of the electrode lead, the printed circuit board is provided with a chip, the chip is provided with a plurality of connection ports, each of the stimulating members is connected with one of the connection ports, and the stimulating signal transmission wire and the communication signal transmission wire are respectively connected with one of the connection ports.

[0011] As a preferred technical scheme of the electrode lead, the electrode lead further comprises an electrical connection assembly, the electrical connection assembly is arranged at one end of the electrode lead away from the stimulating assembly, and the wire assembly is connected with the stimulating assembly and the electrical connection assembly.

[0012] As a preferred technical scheme of the electrode lead, the electrical connection assembly comprises two connection rings arranged at an insulating interval, and the two connection rings are respectively electrically connected with the other end of the stimulating signal transmission wire and the other end of the communication signal transmission wire.

[0013] As a preferred technical scheme of the electrode lead, the connection rings are respectively connected with insulating isolation rings at two ends in the length direction.

[0014] As a preferred technical scheme of the electrode lead, the stimulating signal transmission wire and the communication signal transmission wire extend in a double helix shape.

[0015] As a preferred technical scheme of the electrode lead, the side wall of the contact support is provided with a mounting groove, and the stimulating member is mounted in the mounting groove.

[0016] As a preferred technical scheme of the electrode lead, the stimulating member comprises a stimulating ring, the mounting groove is annular, and the stimulating ring is embedded in the mounting groove; and / or

[0017] The stimulating member further comprises at least three stimulating pieces, the at least three stimulating pieces are arranged at an insulating interval along the same circumferential direction of the electrode lead, the mounting groove is matched with the shape of the stimulating piece, and the stimulating piece is embedded in the mounting groove.

[0018] As a preferred technical scheme of the electrode lead, the side wall of the contact support is provided with a glue injection flow channel extending in the length direction, and the glue injection flow channel is used for flowing glue to bond the stimulating member to the outer wall of the contact support through the glue.

[0019] In another aspect, the application provides an implantable nerve electrical stimulation system, which comprises an implantable pulse generator and the electrode lead according to any one of the above schemes, one end of the electrode lead is used for implanting in the brain, and the other end is electrically connected with the implantable pulse generator.

[0020] As a preferred technical scheme of the implantable nerve electrical stimulation system, the implantable nerve electrical stimulation system further comprises an extension lead wire, and the implantable pulse generator is electrically connected with the electrode lead wire through the extension lead wire.

[0021] The application has the following beneficial effects:

[0022] The application provides an electrode lead wire and an implantable nerve electrical stimulation system, an implantable pulse generator is electrically connected to a printed circuit board through a stimulation signal transmission guide wire and a communication signal transmission guide wire, the stimulation signal transmission guide wire is responsible for transmitting a stimulation signal in the implantable pulse generator to the printed circuit board in a contact support; the communication signal transmission guide wire is responsible for transmitting an instruction set by programmed software to the printed circuit board, and the printed circuit board is responsible for controlling whether a stimulation signal needs to be transmitted to each stimulation piece and how much stimulation signal needs to be transmitted. The electrode lead wire only needs two guide wires to complete the control of multiple stimulation pieces, by reducing the number of guide wires, optimizing the product structure, reducing the production cost, and changing the guide wire assembly from multiple strands to two strands, the pitch is reduced, and the tensile strength is increased. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the application, the drawings needed to be used in the description of the embodiments of the application will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative labor on the basis of the contents of the embodiments of the application and these drawings.

[0024] Figure 1 is a structural schematic diagram of the electrode lead wire provided by the specific embodiment of the application;

[0025] Figure 2 is a partial structural exploded view of the electrode lead wire provided by the specific embodiment of the application;

[0026] Figure 3 is Figure 1 is an enlarged view at A.

[0027] The drawings are marked as follows:

[0028] 1, stimulation assembly; 11, contact support; 111, mounting groove; 112, glue pouring flow channel; 12, printed circuit board; 121, connection port; 13, stimulation piece; 131, stimulation sheet; 132, stimulation ring; 14, first guide head;

[0029] 2, guide wire assembly; 21, stimulation signal transmission guide wire; 22, communication signal transmission guide wire; 23, outer skin;

[0030] 3, electrical connection assembly; 31, connection ring; 32, insulation isolation ring; 33, locking ring. DETAILED DESCRIPTION

[0031] The application will be further described below in conjunction with the drawings and embodiments. It is to be understood that the specific embodiments described herein are intended to be illustrative only and not limiting of the application. In addition, it is to be understood that the drawings are diagrammatic and schematic and that therefore their dimensions are not necessarily to scale.

[0032] In the description of the present application, unless otherwise clearly specified and limited, the terms "connected", "connected", "fixed" should be understood broadly, for example, can be fixedly connected, can be detachably connected, or integrated; can be mechanically connected, can be electrically connected; can be directly connected, can be indirectly connected through an intermediate medium, can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0033] In the present application, unless otherwise clearly specified and limited, the first feature "on" or "under" the second feature can include that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, the first feature "on", "above" and "above" the second feature includes that the first feature is directly above and obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature "under", "below" and "below" the second feature includes that the first feature is directly below and obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0034] In the description of the present embodiment, the terms "up", "down", "left", "right" and other orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of description and simplification of operation, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second" are only used to distinguish in the description, and have no special meaning.

[0035] The technical field and related terms of the embodiments of the present application are briefly described below.

[0036] Implantable medical systems include implantable neurostimulation systems, implantable cardiac electrical stimulation systems (also known as cardiac pacemakers), implantable drug delivery systems (IDDS), lead extension systems, and the like. Implantable neurostimulation systems include, for example, deep brain stimulation systems (DBS), cortical nerve stimulation systems (CNS), spinal cord stimulation systems (SCS), sacral nerve stimulation systems (SNS), vagus nerve stimulation systems (VNS), and the like.

[0037] An implantable neurostimulation system includes a neurostimulator implanted in a patient (i.e., an implantable neurostimulator) and a programming device disposed outside the patient. That is, the neurostimulator is a medical device, or in other words, a medical device includes the neurostimulator. The relevant neuromodulation technology is mainly through stereotactic surgery to implant electrodes (electrodes are in the form of electrode leads, for example) at specific locations (i.e., target points) of the patient's tissues, and deliver electrical pulses to the target points through the electrodes to modulate the electrical activity and function of the corresponding neural structures and networks, thereby improving symptoms and relieving pain.

[0038] As an example, a DBS includes an IPG (Implantable Pulse Generator), an extension lead, and an electrode lead, with the IPG connected to the extension lead and the electrode lead. The IPG is implanted in the patient, for example, in the front of the patient's chest or other body part.

[0039] As another example, a DBS includes an IPG and an electrode lead, with the IPG directly connected to the electrode lead. The IPG is implanted in the patient's head, for example, by slotting the patient's skull and then installing the IPG in the slot of the skull, in which case the IPG can or can not partially protrude from the outer surface of the skull.

[0040] The IPG provides controllable electrical stimulation therapy (or electrical stimulation energy) to the tissues in the body by means of a sealed battery and circuitry in response to programming instructions sent by the programming device. The IPG delivers one or more controllable specific electrical stimulations to specific areas of the tissues in the body through the electrode lead.

[0041] In some embodiments, the extension lead is used in conjunction with the IPG as a transmission medium for electrical stimulation, delivering electrical stimulation generated by the IPG to the electrode lead.

[0042] In some embodiments, the electrical stimulation can be delivered in the form of a pulsed signal or in the form of a non-pulsed signal. For example, the electrical stimulation can be delivered as a signal having various waveform shapes, frequencies, and amplitudes. Thus, the electrical stimulation in the form of a non-pulsed signal can be a continuous signal, which can have a sinusoidal waveform or other continuous waveform.

[0043] The electrode lead delivers the electrical stimulation received from the IPG or the extension lead to a specific region of the in-vivo tissue through a plurality of electrode contacts. The stimulator is provided with one or more electrode leads, which are unilateral or bilateral, and the electrode leads are provided with a plurality of electrode contacts, which can be arranged uniformly or non-uniformly in the circumferential direction of the electrode lead. As an example, the electrode contacts can be arranged in a 4-row-by-3-column array (totally 12 electrode contacts) in the circumferential direction of the electrode lead. The electrode contacts can include stimulation electrode contacts and / or acquisition electrode contacts. The electrode contacts can have a sheet shape, a ring shape, a dot shape, etc.

[0044] In some embodiments, the in-vivo tissue to be stimulated can be the brain tissue of the patient, and the site to be stimulated can be a specific site of the brain tissue. When the patient has different types of diseases, the site to be stimulated is generally different, and the number of stimulation contacts (single source or multiple sources) used, the application of one or more specific electrical stimulations (single channel or multiple channels), and the stimulation parameters (values) are also different.

[0045] The embodiments of the present application are not limited to the applicable disease types, which can be the disease types applicable to deep brain stimulation (DBS), spinal cord stimulation (SCS), sacral nerve stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. Among them, the disease types that can be treated or managed by DBS include but are not limited to: convulsive diseases (e.g., epilepsy), pain, migraine, mental diseases (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety disorder, post-traumatic stress disorder, mild depression, obsessive-compulsive disorder (OCD), behavioral disorder, emotional disorder, memory disorder, mental state disorder, movement disorder (e.g., essential tremor or Parkinson's disease), Huntington's disease, Alzheimer's disease, drug addiction, autism, or other neurological or psychiatric diseases and impairments.

[0046] In the embodiments of the present application, when the programming device and the stimulator establish a programming connection, the programming device can adjust one or more stimulation parameters of the stimulator (or one or more stimulation parameters of the pulse generator, different stimulation parameters correspond to different electrical stimulation), or the stimulator can sense the electrical physiological activity of the patient to acquire an electrical physiological signal, and the stimulation parameters of the stimulator can be continuously adjusted based on the acquired electrical physiological signal to realize closed-loop control (or adaptive adjustment) of the stimulation parameters.

[0047] Stimulation parameters may include at least one of the following: electrode contact identification for delivering electrical stimulation (e.g., electrode contact #2 and electrode contact #3), frequency (e.g., the number of electrical stimulation pulse signals per second, in Hz), pulse width (duration of each pulse, in μs), amplitude (generally expressed as voltage, i.e., the intensity of each pulse, in V), timing (e.g., continuous or bursty, bursty refers to discontinuous timing behavior composed of multiple processes), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode, and cyclic stimulation mode), physician control upper and lower limits (the range that the physician can adjust), and patient control upper and lower limits (the range that the patient can adjust independently).

[0048] In some embodiments, the stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.

[0049] Programmable devices can include physician-controlled devices (i.e., devices used by physicians) and / or patient-controlled devices (i.e., devices used by patients). Physician-controlled devices are, for example, smart terminal devices such as tablets, laptops, desktop computers, and mobile phones equipped with programming software. Patient-controlled devices are, for example, smart terminal devices such as tablets, laptops, desktop computers, and mobile phones equipped with programming software; patient-controlled devices can also be other electronic devices with programming functions (e.g., chargers with programming functions, electrophysiological acquisition devices, etc.).

[0050] like Figure 1 and Figure 2 As shown, this embodiment provides an implantable neurostimulation system, which includes an implantable pulse generator and electrode leads. One end of the electrode leads is implanted in the brain, and the other end is electrically connected to the implantable pulse generator. Preferably, the implantable neurostimulation system further includes an extension lead, through which the implantable pulse generator is electrically connected to the electrode leads.

[0051] Furthermore, the electrode wire includes a stimulation assembly 1 and a guide wire assembly 2. Specifically, the stimulation assembly 1 includes a contact support 11, a printed circuit board 12, and multiple stimulation elements 13. The printed circuit board 12 is disposed on the contact support 11; the multiple stimulation elements 13 are mounted on the contact support 11 and electrically connected to the printed circuit board 12; the guide wire assembly 2 includes a stimulation signal transmission guide wire 21 and a communication signal transmission guide wire 22. One end of the stimulation signal transmission guide wire 21 is electrically connected to the printed circuit board 12; one end of the communication signal transmission guide wire 22 is electrically connected to the printed circuit board 12.

[0052] The implantable pulse generator is electrically connected to the printed circuit board 12 through the stimulation signal transmission wire 21 and the communication signal transmission wire 22. The stimulation signal transmission wire 21 is responsible for transmitting the stimulation signal in the implantable pulse generator to the printed circuit board 12 in the contact support 11. The communication signal transmission wire 22 is responsible for transmitting the instructions set by the programmed software to the printed circuit board 12. The printed circuit board 12 is responsible for controlling whether the stimulation signal needs to be transmitted to each stimulation piece 13 and how much stimulation signal needs to be transmitted. The electrode lead wire only needs two wires to complete the control of multiple stimulation pieces 13. By reducing the number of wires, the product structure is optimized, the production cost is reduced, and the wire assembly 2 is changed from multiple strands to two strands, the pitch is reduced, and the tensile strength is increased.

[0053] The printed circuit board 12 is provided with a chip. The chip is provided with a plurality of connection ports 121. Each stimulation piece 13 is connected to a connection port 121. The stimulation signal transmission wire 21 and the communication signal transmission wire 22 are respectively connected to a connection port 121. Specifically, the printed circuit board 12 is composed of a chip and an integrated circuit board. The printed circuit board 12 is wrapped by a biocompatible material that can be implanted for a long time. The communication signal transmission wire 22 is responsible for transmitting the instructions set by the programmed software to the chip in the printed circuit board 12. The chip is responsible for controlling whether the stimulation signal needs to be transmitted to each stimulation piece 13. The printed circuit board 12 is provided with two connection ports 121 at one end close to the wire assembly 2. The two connection ports 121 are respectively welded and connected to the stimulation signal transmission wire 21 and the communication signal transmission wire 22 to realize electrical connection.

[0054] In this embodiment, the stimulation signal transmission wire 21 and the communication signal transmission wire 22 extend in a double helix shape, the pitch is reduced, and the tensile strength is increased. The wire assembly 2 further includes an outer skin 23 that covers the stimulation signal transmission wire 21 and the communication signal transmission wire 22.

[0055] In this embodiment, the side wall of the contact support 11 is provided with a mounting groove 111. The stimulation piece 13 is mounted in the mounting groove 111 to make the outer wall of the stimulation assembly 1 flat, so that the stimulation assembly 1 can be easily arranged in the human body.

[0056] Further, the stimulating member 13 comprises stimulating rings 132, the mounting grooves 111 are annular, and the stimulating rings 132 are embedded in the mounting grooves 111; and / or the stimulating member 13 comprises at least three stimulating pieces 131, the at least three stimulating pieces 131 are arranged in the same circumferential direction and are insulated, the mounting grooves 111 are matched with the shapes of the stimulating pieces 131, and the stimulating pieces 131 are embedded in the mounting grooves 111. In the embodiment, the stimulating member 13 comprises two stimulating rings 132 and two stimulating piece groups, each stimulating piece group comprises three stimulating pieces 131 arranged in the circumferential direction, so as to realize the stimulation of the brain tissue in a specific direction, and the contact support 11 is sequentially and spacedly provided with one stimulating ring 132, one stimulating piece group, another stimulating piece group and another stimulating ring 132 in the length direction. In the embodiment, the stimulating pieces 131 are platinum-iridium pieces, and the stimulating rings 132 are platinum-iridium rings.

[0057] In the embodiment, the mounting grooves 111 are provided with the connecting ports 121 of the printed circuit board 12, and the stimulating pieces 131 and / or the stimulating rings 132 are welded to the connecting ports 121, so as to realize the electrical connection between the stimulating pieces 131 and / or the stimulating rings 132 and the printed circuit board 12.

[0058] Further, the side wall of the contact support 11 is provided with a glue injection channel 112 extending in the length direction, and the glue injection channel 112 is used for the flow of glue, so that the stimulating member 13 is bonded to the outer wall of the contact support 11 by the glue. In the embodiment, the side wall of the contact support 11 is provided with three glue injection channels 112 spaced in the circumferential direction, the glue injection channels 112 flow through the groove bottoms of the mounting grooves 111 corresponding to the stimulating pieces 131 and the stimulating rings 132, and the stimulating pieces 131 and the stimulating rings 132 are firmly bonded to the mounting grooves 111 by the glue in the glue injection channels 112.

[0059] Preferably, the gap between the stimulating member 13 and the side wall of the mounting groove 111 is filled with epoxy resin. In the embodiment, the stimulating assembly 1 is provided with a first guide head 14 at the end away from the guide wire assembly 2, and the first guide head 14 is spherical. The spherical first guide head 14 facilitates the embedding of the stimulating assembly 1 in the human body, plays a guiding role, and prevents the stimulating assembly 1 from damaging the human tissue. In the embodiment, the first guide head 14 is also made of epoxy resin.

[0060] In the prior art, as the number of stimulation points increases, more connection contacts are needed, and the connection end of the electrode lead wire needs to be provided with a connection ring in the same number as the number of guide wires. When the number of guide wires increases, the number of connection contacts also increases. For example, 8 stimulation points have 8 connection rings for connecting and conducting between two products, and at the same time, there are 8 or 7 isolation rings, thereby increasing the length of the connection end of the electrode lead wire, the length of the extension lead wire at both ends, and the length of the channel of the IPG, resulting in an increase in the plugging force of the electrode lead wire and the extension lead wire, and an increase in the plugging force of the extension lead wire and the IPG. At the same time, the increase in the number of connection contacts and the length of the connection end of the electrode lead wire and the extension lead wire increases the length of the connection end and the poor rigidity of the connection end, resulting in difficulty in inserting the electrode lead wire into the extension lead wire channel and inserting the extension lead wire into the IPG.

[0061] To solve the above problems, as shown in Figure 1 and Figure 3 The electrode lead wire further comprises an electrical connection assembly 3, which is provided at one end of the electrode lead wire away from the stimulation assembly 1, and the guide wire assembly 2 connects the stimulation assembly 1 and the electrical connection assembly 3. Further, the electrical connection assembly 3 comprises two connection rings 31 which are insulatively spaced apart, and the two connection rings 31 are respectively electrically connected to the other end of the stimulation signal transmission guide wire 21 and the other end of the communication signal transmission guide wire 22. Since only two guide wires are provided in the guide wire assembly 2, the electrical connection assembly 3 only needs to be provided with two connection rings 31, and the two connection rings 31 are respectively electrically connected to the stimulation signal transmission guide wire 21 and the communication signal transmission guide wire 22, thereby reducing the number of connection rings 31 and further reducing the length of the electrical connection assembly 3.

[0062] In this embodiment, the two ends of the connection ring 31 along the length direction are connected with insulating isolation rings 32. Among them, the connection ring 31 is two, so three insulating isolation rings 32 need to be provided to achieve the insulation between the two connection rings 31. Among them, the insulating isolation ring 32 at one end of the electrical connection assembly 3 away from the stimulation assembly 1 can be used as a second guide head. In this embodiment, the electrical connection assembly 3 is provided with a locking ring 33 at one end close to the stimulation assembly 1. Therefore, in this embodiment, the electrical connection assembly 3 serves as the connection end of the electrode lead wire, and the connection end of the electrode lead wire only needs the structure of two connection rings 31, three insulating isolation rings 32 and one locking ring 33. In the case of a large number of stimulation pieces 13, the length of the connection end is greatly reduced, the contact friction of the connection end inserted into the counterpiece channel is reduced, the plugging and unplugging force is reduced, and at the same time, the length of the connection end is reduced to improve the rigidity of the connection end, and the connection end is not easy to deform during the insertion into the counterpiece channel, thereby reducing the difficulty of insertion.

[0063] In other embodiments, the connection end of the electrode lead wire only needs two connection rings 31 and three insulating isolation rings 32, and the connection ring 31 close to one end of the stimulation assembly 1 can be used as a locking ring 33 to further reduce the length of the connection end of the electrode lead wire.

[0064] Note that the above merely describes preferred embodiments of the present application and the principles of the technology applied. Those skilled in the art will understand that the present application is not limited to the specific embodiments described herein, and that various obvious changes, modifications and substitutions can be made thereto without departing from the scope of the present application. Therefore, although the present application has been described in detail through the above embodiments, the present application is not limited to the above embodiments, and can include more other equivalent embodiments without departing from the concept of the present application, and the scope of the present application is determined by the scope of the claims.

Claims

1. An electrode lead, characterized by, The electrode lead wire comprises a stimulating assembly (1), a wire assembly (2) and an electrical connection assembly (3). The stimulating assembly (1) comprises a contact support (11), a printed circuit board (12) and a plurality of stimulating pieces (13), the printed circuit board (12) is arranged on the contact support (11), and the stimulating pieces (13) are mounted on the contact support (11) and electrically connected to the printed circuit board (12). The wire assembly (2) comprises a stimulating signal transmission wire (21) and a communication signal transmission wire (22), one end of the stimulating signal transmission wire (21) is electrically connected to the printed circuit board (12), and one end of the communication signal transmission wire (22) is electrically connected to the printed circuit board (12).

2. The electrode lead of claim 1, wherein The printed circuit board (12) is provided with a chip, the chip is provided with a plurality of connection ports (121), each stimulating piece (13) is connected to one connection port (121), and the stimulating signal transmission wire (21) and the communication signal transmission wire (22) are respectively connected to one connection port (121).

3. The electrode lead of claim 1, wherein, The electrode lead wire further comprises an electrical connection assembly (3), the electrical connection assembly (3) is arranged at one end of the electrode lead wire away from the stimulating assembly (1), and the wire assembly (2) is connected to the stimulating assembly (1) and the electrical connection assembly (3).

4. The electrode lead of claim 3, wherein, The electrical connection assembly (3) comprises two connection rings (31) arranged at an insulating interval, and the two connection rings (31) are respectively electrically connected to the other end of the stimulating signal transmission wire (21) and the other end of the communication signal transmission wire (22).

5. The electrode lead of claim 4, wherein, The connection ring (31) is connected with an insulating isolation ring (32) at both ends in the length direction.

6. The electrode lead of claim 1, wherein, The stimulating signal transmission wire (21) and the communication signal transmission wire (22) extend in a double helix shape.

7. The electrode lead of claim 1, wherein, The side wall of the contact support (11) is provided with a mounting groove (111), and the stimulating piece (13) is mounted in the mounting groove (111).

8. The electrode lead of claim 7, wherein, The stimulating piece (13) comprises a stimulating ring (132), the mounting groove (111) is annular, and the stimulating ring (132) is embedded in the mounting groove (111); and / or The stimulating piece (13) further comprises at least three stimulating pieces (131), the at least three stimulating pieces (131) are arranged at an insulating interval along the same circumferential direction of the electrode lead wire, the mounting groove (111) is matched with the shape of the stimulating piece (131), and the stimulating piece (131) is embedded in the mounting groove (111).

9. The electrode lead of claim 1, wherein, The side wall of the contact support (11) is provided with a glue injection flow channel (112) extending in the length direction, the glue injection flow channel (112) is used for glue flow, and the stimulating piece (13) is bonded to the outer wall of the contact support (11) through the glue.

10. An implantable neurostimulation system, characterized in that, The electrode lead wire comprises an implantable pulse generator and an electrode lead wire as claimed in any one of claims 1-9, one end of the electrode lead wire is used for implanting in the brain, and the other end is electrically connected to the implantable pulse generator.

11. The implantable neurostimulation system of claim 10, wherein the at least one electrode is configured to deliver electrical stimulation to the patient's vagus nerve. The implantable neuroelectric stimulation system further comprises an extension lead wire, and the implantable pulse generator is electrically connected to the electrode lead wire through the extension lead wire.

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