Polypeptide cracking reaction kettle with good stirring effect
By introducing multiple stirring blades and scraper structures into the peptide lysis reactor, multiple stirring in both horizontal and vertical directions is achieved, solving the problem of poor stirring effect in traditional reactors and improving the utilization rate of reactants and the quality of finished products.
Patent Information
- Application Number
- CN202520085496.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-14
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2035-01-14
AI Technical Summary
Traditional peptide lysis reactors have poor stirring performance, resulting in incomplete reactions and contamination of the filtrate with unreacted solution, which increases process costs and reduces the quality of the finished product.
It adopts a multi-blade stirring structure, including large and small triangular stirring blades, combined with inclined scrapers and wall scrapers, to achieve multi-stage stirring in both horizontal and vertical directions, enhancing the stirring effect. It also optimizes the distribution of reactants and removes adhering substances through baffles and guide plates.
It improves the saturation of reactants in the reactor, reduces the adhesion of unreacted substances, improves the quality of the finished product, and reduces process costs.
Smart Images
Figure CN223717132U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to polypeptide cleavage technical field, more specifically, the utility model relates to a polypeptide cleavage reaction kettle with good stirring effect. BACKGROUND
[0002] Polypeptide cleavage reaction refers to the process of breaking the amide bond or other chemical bonds in the polypeptide chain through specific chemical or biological methods, thereby obtaining shorter polypeptide fragments or individual amino acids. In the cleavage reactor, TFA solution is used to cleave the peptide chain from the peptide resin and remove the side chain.
[0003] However, there will be TFA solution and peptide resin in the reaction kettle, and the mixed solution needs to be stirred to make the reaction effect better. In the traditional device, only one stirring rod and several stirring blades are used for stirring, which cannot make the reaction more fully, resulting in that the filtrate is mixed with the solution that is not fully reacted, increasing the process cost in the later period and obtaining poor quality of finished products. Therefore, it is necessary to improve and optimize the polypeptide cleavage reactor. UTILITY MODEL CONTENT
[0004] In order to overcome the shortcomings of the prior art, the utility model provides a polypeptide cleavage reaction kettle with good stirring effect, which has the advantages of good stirring effect.
[0005] To achieve the above purpose, the utility model provides the following technical scheme: a polypeptide cleavage reaction kettle with good stirring effect, comprising a reaction kettle upper body, a reaction kettle lower body fixedly connected to the lower surface of the reaction kettle upper body, a partition plate fixedly connected to the inner part of the lower surface of the reaction kettle upper body, a motor assembly fixedly connected to the upper part of the reaction kettle upper body, a stirring rod fixedly connected to the output shaft of the motor assembly, a fixed block fixedly connected to the inner left and right surfaces of the reaction kettle lower body, a rotating shaft rotatably connected to the surface of one end of the fixed block close to the stirring rod, a small triangular stirring blade fixedly connected to the curved surface of the rotating shaft, a first bevel gear fixedly connected to the end of the rotating shaft close to the stirring rod, a second bevel gear fixedly connected to the curved surface of the lower part of the stirring rod, and a large triangular stirring blade fixedly connected to the lower surface of the second bevel gear.
[0006] As a preferred technical scheme of the utility model: a fixed shaft is fixedly connected to the curved surface of the middle part of the stirring rod, an inclined scraper is fixedly connected to the surface of the fixed shaft, a wall scraping plate is fixedly connected to the end of the fixed shaft away from the stirring rod, a layered hole is formed in the surface of the partition plate, and the acute angle between the inclined scraper and the partition plate is sixty degrees.
[0007] As a preferred technical scheme of the utility model: an insulation shell is fixedly connected to the lower surface of the partition plate, and the first bevel gear and the second bevel gear are located in the interior of the insulation shell.
[0008] As a preferred technical scheme of the utility model: the lower surface of the oblique scraper is attached to the upper surface of the partition, the height value of the oblique scraper is equal to the vertical wall height value of the upper body of the reaction kettle, and the outer side wall of the wall scraping plate is completely attached to the inner wall of the upper body of the reaction kettle.
[0009] As a preferred technical scheme of the utility model: the inner wall of the lower body of the reaction kettle is fixedly connected with a flow guide plate, the bottom of the lower body of the reaction kettle is fixedly connected with a filter plate, and the lower curved surface of the stirring rod is fixedly connected with a small stirring plate.
[0010] As a preferred technical scheme of the utility model: the stirring rod is rotatably connected inside the partition, the upper portion of the second bevel gear fixedly connected to the surface of the stirring rod is rotatably connected to the lower portion of the insulation shell, and the lower end of the stirring rod is rotatably connected inside the filter plate.
[0011] As a preferred technical scheme of the utility model: the outer surface of the upper body of the reaction kettle is fixedly connected with a fixing frame, the upper surface of the upper body of the reaction kettle is fixedly connected with a plurality of feeding ports, and the lower portion of the lower body of the reaction kettle is fixedly provided with a discharging pump.
[0012] Compared with the prior art, the utility model has the beneficial effects as follows:
[0013] 1、 the utility model discloses a stirring rod drives the rotation of the large triangular stirring blade, so that the reaction in the vertical direction is stirred, the upper surface of the large triangular stirring blade is fixedly connected with the second bevel gear, and the second bevel gear is meshed with the first bevel gear, so as to drive the rotation of the small triangular stirring blade fixedly connected to the surface of the rotating shaft, compared with the traditional device, the stirring rod can only realize the stirring in the vertical direction, and due to the limited space inside the upper body of the reaction kettle, the stirring effect inside the reaction kettle cannot be better, the device not only realizes the segmented stirring through the partition, but also realizes the multiple stirring in the horizontal and vertical directions, so that the stirring effect is better.
[0014] 2、 the utility model discloses that the stirring rod drives the rotation of the oblique scraper, and the reaction inside the upper body of the reaction kettle is preliminarily stirred, and the reaction on the upper surface of the partition can be hung and removed by the oblique scraper, and the outer surface of the wall scraping plate is in conformity with the inner surface of the upper body of the reaction kettle, so that the reaction attached to the inner surface of the upper body of the reaction kettle is scraped off by the wall scraping plate, the reaction is more fully utilized, and the stirring effect is improved, compared with the traditional device, the reaction inside the reaction kettle is mostly attached to the inner wall, so that the reaction is not fully utilized, the device has the advantages of simple structure and strong practicability. BRIEF DESCRIPTION OF DRAWINGS
[0015] Figure 1 The utility model structure schematic diagram is shown in the figure.
[0016] Figure 2The utility model discloses a guide plate structure schematic diagram shows that the utility model discloses a stirring rod section structure schematic diagram shows.
[0017] Figure 3 The utility model discloses a stirring rod section structure schematic diagram shows.
[0018] Figure 4 The utility model discloses a isolation shell structure schematic diagram shows.
[0019] Figure 5 The utility model discloses an inclined scraper structure schematic diagram shows.
[0020] Figure 6 The utility model discloses a first bevel gear structure schematic diagram shows.
[0021] In the drawing: 1, reation kettle upper body;2, reation kettle lower body;3, partition;4, motor assembly;5, stirring rod;6, fixed block;7, rotating shaft;8, small triangle stirring blade;9, first bevel gear;10, second bevel gear;11, big triangle stirring blade;12, fixed shaft;13, inclined scraper;14, wall adhering scraper;15, layered hole;16, isolation shell;17, guide plate;18, filter plate;19, small stirring plate;20, fixed frame;21, feed inlet;22, discharge pump. DETAILED DESCRIPTION
[0022] The technical scheme in the embodiments of the utility model will be described clearly and completely below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model and not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the utility model.
[0023] As Figures 1 to 6 The utility model discloses a polypeptide cleavage reaction kettle with good stirring effect, which comprises a reaction kettle upper body 1, a reaction kettle lower body 2 fixedly connected to the lower surface of the reaction kettle upper body 1, a partition 3 fixedly connected to the inner lower surface of the reaction kettle upper body 1, a motor assembly 4 fixedly connected to the upper part of the reaction kettle upper body 1, a stirring rod 5 fixedly connected to the output shaft of the motor assembly 4, fixed blocks 6 fixedly connected to the inner left and right surfaces of the reaction kettle lower body 2, a rotating shaft 7 rotatably connected to the surface of one end of the fixed block 6 close to the stirring rod 5, small triangle stirring blades 8 fixedly connected to the curved surface of the rotating shaft 7, a first bevel gear 9 fixedly connected to one end of the rotating shaft 7 close to the stirring rod 5, a second bevel gear 10 fixedly connected to the curved surface of the lower part of the stirring rod 5, and big triangle stirring blades 11 fixedly connected to the lower surface of the second bevel gear 10.
[0024] The reactants needed for the reaction are injected into the cracking reactor from the feed port 21, before the reactants are injected, the motor assembly 4 will first reach the inside of the upper body 1 of the reactor, the reactants are preliminarily stirred by the stirring structure, and then enter the lower body 2 of the reactor through the layered hole 15. The stirring rod 5 fixedly connected to the surface of the stirring rod 5 extending into the inside of the lower body 2 of the reactor drives the second bevel gear 10 to rotate, thereby realizing the stirring of the reactants in the vertical direction. Since the second bevel gear 10 is meshed with the first bevel gear 9, and the shaft 7 with the small triangular stirring blade 8 is rotatably connected in the fixed block 6, the reactants in the horizontal direction inside the upper body 1 of the reactor are stirred.
[0025] The middle part of the stirring rod 5 is fixedly connected to the surface of the fixed shaft 12, the surface of the fixed shaft 12 is fixedly connected to the inclined scraper 13, one end of the fixed shaft 12 away from the stirring rod 5 is fixedly connected to the wall scraping plate 14, the surface of the partition plate 3 is provided with the layered hole 15, and the acute angle between the inclined scraper 13 and the partition plate 3 is sixty degrees.
[0026] When the reactants enter the inside of the upper body 1 of the reactor, the motor assembly 4 is started to drive the stirring rod 5 to rotate. Since the stirring rod 5 is fixedly connected to the surface of the fixed shaft 12, and the surface of the fixed shaft 12 is fixedly connected to the inclined scraper 13, the stirring rod 5 rotates counterclockwise from the perspective of the top view due to the angle setting of the inclined scraper 13. Thus, the reactants on the lower surface of the inclined scraper 13 have a downward pressure, and the reactants in the upper body 1 of the reactor can be stirred, and the reactants stuck in the layered hole 15 can be hung and removed into the lower body 2 of the reactor for stirring. The wall scraping plate 14 can scrape off the reactants attached to the vertical wall surface inside the upper body 1 of the reactor.
[0027] The lower surface of the partition plate 3 is fixedly connected to the isolation shell 16, and the first bevel gear 9 and the second bevel gear 10 are located inside the isolation shell 16.
[0028] The first bevel gear 9 and the second bevel gear 10 are protected by the isolation shell 16. Since the reactor is filled with liquid, the working failure of the first bevel gear 9 and the second bevel gear 10 is prevented.
[0029] The lower surface of the inclined scraper 13 is attached to the upper surface of the partition plate 3, the height of the inclined scraper 13 is equal to the vertical wall height of the upper body 1 of the reactor, and the outer wall of the wall scraping plate 14 is completely attached to the inner wall of the upper body 1 of the reactor.
[0030] The reactants in the layered hole 15 are hung and removed by the fixed shaft 12 and the lower surface, and the reactants attached to the inner wall of the upper body 1 of the reactor are scraped off by the wall scraping plate 14.
[0031] The inner wall of the lower body 2 of the reaction kettle is fixedly connected with a flow guide plate 17, and the bottom of the lower body 2 of the reaction kettle is fixedly connected with a filter plate 18.
[0032] The flow guide plate 17 guides the flow, prevents the reactants from falling too fast, has a certain impact force on the upper surface of the filter plate 18, and causes damage to the filter plate 18, and the small stirring plate 19 is used for stirring the reactants in the lower cylindrical part of the lower body 2 of the reaction kettle.
[0033] The stirring rod 5 is rotatably connected in the partition plate 3, the upper part of the second bevel gear 10 fixedly connected to the surface of the stirring rod 5 is rotatably connected to the lower part of the insulation shell 16, and the lower end of the stirring rod 5 is rotatably connected in the filter plate 18.
[0034] The stirring rod 5 works to drive the devices between the upper and lower surfaces of the partition plate 3, and passes through the insulation shell 16 and has good sealing performance.
[0035] The outer surface of the upper body 1 of the reaction kettle is fixedly connected with a fixing frame 20, the upper surface of the upper body 1 of the reaction kettle is fixedly connected with a plurality of feeding ports 21, and the lower part of the lower body 2 of the reaction kettle is fixedly connected with a discharge pump 22.
[0036] The fixing frame 20 is used for fixing the upper body 1 of the reaction kettle, the feeding port 21 is used for feeding, and the discharge pump 22 is used for pumping the filtrate after reaction to the next process.
[0037] The working principle and use process of the utility model are as follows:
[0038] The reactant to be reacted is injected into the cracking reaction kettle from the feeding port 21, before the reactant is injected, the motor assembly 4 is first arranged in the upper body 1 of the reaction kettle, the reactant is preliminarily stirred by the stirring structure, and then enters the lower body 2 of the reaction kettle through the layered hole 15. The surface of the stirring rod 5 extending into the lower body 2 of the reaction kettle is fixedly connected with the second bevel gear 10, so as to drive the large triangular stirring blade 11 fixedly connected to the lower surface of the second bevel gear 10 to rotate, thereby realizing stirring of the reactant in the vertical direction. Since the second bevel gear 10 is meshed with the first bevel gear 9, and the rotating shaft 7 containing the small triangular stirring blade 8 is rotatably connected in the fixed block 6, the reactant in the horizontal direction in the upper body 1 of the reaction kettle is stirred.
[0039] When the reactants enter the inside of the upper body 1 of the reactor, the motor assembly 4 is started to drive the rotation of the stirring rod 5, the fixed shaft 12 is fixedly connected to the surface of the stirring rod 5, and the inclined scraper 13 is fixedly connected to the surface of the fixed shaft 12, the stirring rod 5 rotates counterclockwise from the perspective of the top view due to the angle of the inclined scraper 13, so that the reactants on the lower surface of the inclined scraper 13 have a downward pressure, and the reactants in the layered hole 15 can be stirred and removed to the lower body 2 of the reactor, and the wall scraping plate 14 can scrape the reactants attached to the vertical wall surface in the inside of the upper body 1 of the reactor.
[0040] The first bevel gear 9 and the second bevel gear 10 are protected by the isolation shell 16, and the first bevel gear 9 and the second bevel gear 10 are prevented from malfunctioning due to the liquid in the inside of the reactor.
[0041] The reactants in the inside of the layered hole 15 are removed by the fixed shaft 12 and the lower surface, and the reactants attached to the inner wall of the upper body 1 of the reactor are scraped by the wall scraping plate 14.
[0042] The flow guide plate 17 guides the flow to prevent the reactants from falling too fast, and has a certain impact force on the upper surface of the filter plate 18, which can cause damage to the filter plate 18, and the small stirring plate 19 is used for the final stirring of the reactants in the lower cylindrical part of the lower body 2 of the reactor.
[0043] The stirring rod 5 works to drive the devices between the upper and lower surfaces of the partition plate 3, and passes through the isolation shell 16 with good sealing performance.
[0044] The fixed frame 20 is used for fixing the upper body 1 of the reactor, the feeding port 21 is helpful for feeding, and the discharge pump 22 can pump the filtered solution after the reaction to the next process.
[0045] It should be noted that, in the present text, relational terms such as first and second and the like are used merely to differentiate one entity or action from another, without necessarily requiring or implying any such actual relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variations thereof, are intended to cover non-exclusive inclusions, so that a process, method, article, or apparatus that comprises a list of elements does not only include those elements, but can also include other elements not expressly listed or inherent to such process, method, article, or apparatus.
[0046] Although the embodiments of the present application have been shown and described, it should be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present application, and the scope of the present application is defined by the appended claims and their equivalents.
Claims
1. A polypeptide cleavage reactor with good stirring effect, comprising a reactor upper body (1), characterized in that: The lower surface of the reactor upper body (1) is fixedly connected with a reactor lower body (2), the inner surface of the lower surface of the reactor upper body (1) is fixedly connected with a partition plate (3), the upper part of the reactor upper body (1) is fixedly connected with a motor assembly (4), the output shaft of the motor assembly (4) is fixedly connected with a stirring rod (5), the left and right inner surfaces of the reactor lower body (2) are fixedly connected with fixed blocks (6), the end surface of the fixed block (6) close to the stirring rod (5) is rotatably connected with a rotating shaft (7), the curved surface of the rotating shaft (7) is fixedly connected with a small triangular stirring blade (8), the end of the rotating shaft (7) close to the stirring rod (5) is fixedly connected with a first bevel gear (9), the curved surface of the lower part of the stirring rod (5) is fixedly connected with a second bevel gear (10), and the lower surface of the second bevel gear (10) is fixedly connected with a large triangular stirring blade (11).
2. The polypeptide cleavage reactor with good stirring effect according to claim 1, characterized in that: The curved surface of the middle part of the stirring rod (5) is fixedly connected with a fixed shaft (12), the surface of the fixed shaft (12) is fixedly connected with an inclined scraper (13), the end of the fixed shaft (12) away from the stirring rod (5) is fixedly connected with a wall scraping plate (14), the surface of the partition plate (3) is provided with a layered hole (15), and the acute angle between the inclined scraper (13) and the partition plate (3) is sixty degrees.
3. The polypeptide cleavage reactor with good stirring effect according to claim 1, characterized in that: The lower surface of the partition plate (3) is fixedly connected with an isolation shell (16), and the first bevel gear (9) and the second bevel gear (10) are located in the interior of the isolation shell (16).
4. The polypeptide cleavage reactor with good stirring effect according to claim 2, characterized in that: The lower surface of the inclined scraper (13) is attached to the upper surface of the partition plate (3), the height value of the inclined scraper (13) is equal to the vertical wall height value of the reactor upper body (1), and the outer side wall of the wall scraping plate (14) is completely attached to the inner wall of the reactor upper body (1).
5. The polypeptide cleavage reactor of claim 1, wherein: the reactor is a stirred tank reactor. The inner wall of the reactor lower body (2) is fixedly connected with a guide plate (17), the bottom of the reactor lower body (2) is fixedly connected with a filter plate (18), and the curved surface of the lower part of the stirring rod (5) is fixedly connected with a small stirring plate (19).
6. The polypeptide cleavage reactor of claim 1, wherein: The stirring rod (5) is rotatably connected in the partition plate (3), the upper part of the second bevel gear (10) fixedly connected to the surface of the stirring rod (5) is rotatably connected to the lower part of the isolation shell (16), and the lower end of the stirring rod (5) is rotatably connected in the filter plate (18).
7. The polypeptide cleavage reactor of claim 1, wherein the reactor is a stirred tank reactor. The outer surface of the reactor upper body (1) is fixedly connected with a fixed frame (20), the upper surface of the reactor upper body (1) is fixedly connected with a plurality of feeding ports (21), and the lower part of the reactor lower body (2) is fixedly connected with a discharging pump (22).