Wet granulation system with cleaning function

Abstract

The utility model discloses a wet granulation system with a cleaning function, which comprises a cleaning and inactivation component, an isolator communicated with the cleaning and inactivation component, and a detection component used for detecting the cleaning effect of each component in the isolator, a wet granulator, a fluidized bed, a granulator and a mixer assembly are arranged in the isolator; the cleaning and inactivating assembly comprises a buffer tank, a heat exchanger, and a first cleaning pipeline and a second cleaning pipeline which are respectively communicated with the upper end and the lower end of the buffer tank; the first cleaning pipeline communicates with the cleaning agent assembly and the inactivating agent assembly and is connected with a water inlet of the heat exchanger. And the second cleaning pipeline is connected with a water outlet pipeline of the heat exchanger and is also respectively communicated with corresponding cleaning pipelines of the wet granulator, the fluidized bed, the granulator and the mixer assembly. The utility model aims to realize the whole process of cleaning, purging and inactivating equipment by using one pipeline, so that the manufacturing cost can be saved while the cleaning efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of pharmacy technology, especially to a wet granulation system with cleaning function. BACKGROUND

[0002] The wet granulator is used to grind moist powder into the required granules, and can also crush blocky dry material into the required granules. When it is applied in the field of pharmacy, it is necessary to clean and sterilize the inside of the granulator in time. At present, most of the wet granulation systems for pharmaceuticals need to be removed from protection before manual disassembly and cleaning, which exposes the pharmaceuticals to a high risk, especially when used for anti-tumor drugs, which can harm the operator. In addition, the disassembly and cleaning steps of the wet granulation system for pharmaceuticals are complicated, inconvenient to operate, time-consuming, and low in work efficiency. Finally, manual cleaning also has unstable cleaning effect.

[0003] The existing patent with the patent number CN102698651A discloses a wet granulator with an in-situ cleaning system and an in-situ cleaning method, which realizes cleaning of the granulator, but only realizes cleaning of the granulator alone, and the cleaning equipment is single. The patent with the patent number CN215607703U discloses a small-batch high-activity solid preparation isolation production system, which uses a cleaning spray gun to flush the inside of the isolator transfer cabin, the inside of the isolator operation cabin, and the wet granulator. The fluidized bed uses a self-contained cleaning system for cleaning. The wastewater after cleaning in the cabin is uniformly collected and treated through a drain valve. After draining, the residual water in the cabin is blown dry using a cleaning spray gun. It can be seen that the system cleaning is relatively complex, and the cleaning effect needs to be considered. Therefore, it is urgent to provide a pharmaceutical production system with simple cleaning structure and high cleaning efficiency. UTILITY MODEL CONTENT

[0004] The main purpose of the utility model is to provide a wet granulation system with cleaning function, which aims to solve the technical problems of single cleaning, complex cleaning structure, and low cleaning efficiency of the existing granulator system.

[0005] To achieve the above purpose, the utility model provides a wet granulation system with cleaning function, which comprises a cleaning and inactivation assembly, an isolator in communication with the cleaning and inactivation assembly, and a wastewater detection assembly for detecting the cleaning effect of each component inside the isolator.

[0006] The isolator is internally provided with a wet granulator, a fluidized bed, a granulator, and a mixer assembly.

[0007] The cleaning and inactivation assembly comprises a buffer tank, a heat exchanger, and a first cleaning pipeline and a second cleaning pipeline in communication with the upper and lower ends of the buffer tank, respectively.

[0008] The first cleaning pipeline is in communication with the cleaning agent assembly and the inactivation agent assembly respectively, and is connected with the water inlet of the heat exchanger.

[0009] The second cleaning pipeline is connected with the water outlet pipeline of the heat exchanger, and is in communication with the corresponding cleaning pipelines of the wet granulation machine, the fluidized bed, the granulator and the mixing machine assembly respectively.

[0010] Optionally, the waste water after cleaning of the wet granulation machine, the granulator and the mixing machine assembly is discharged through the multiple isolator discharge pipelines and communicated with the waste water detection assembly.

[0011] Optionally, the waste water detection assembly is arranged on the detection pipeline, and different regions of the detection pipeline are connected with the corresponding isolator discharge pipelines.

[0012] Optionally, the waste water after cleaning of the fluidized bed is connected with the detection pipeline through the fluidized bed discharge pipeline.

[0013] Optionally, the first cleaning pipeline is further connected with the flow monitoring assembly and the pressure boosting assembly.

[0014] Optionally, the water outlet pipeline of the heat exchanger is respectively provided with the temperature detection assembly and the pressure detection assembly.

[0015] Optionally, the second cleaning pipeline is further in communication with the compressed air assembly.

[0016] Optionally, the buffer tank is further provided with corresponding interfaces for the inlet of tap water and purified water.

[0017] Beneficial effects:

[0018] The wet granulation system with the cleaning function can avoid manual disassembly, cleaning and inactivation during system cleaning, realizes automatic cleaning, all production processes are completed in a closed environment, and the stability and reliability of the cleaning effect are improved, the personal health of the operator is fully ensured, the work efficiency is improved, and the labor cost is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained according to the structures shown in these drawings without creative labor.

[0020] Figure 1The utility model discloses a structure schematic drawing of one embodiment of wet granulation system with online cleaning function.

[0021] Figure 2 For Figure 1 The distribution schematic drawing of the isolator of the structure shown in the figure.

[0022] Figure 3 For Figure 1 The distribution schematic drawing of the cleaning and inactivation assembly of the structure shown in the figure.

[0023] Explanation of the reference signs:

[0024] Reference Name Reference Name 1 Buffer tank 2 Liquid level meter 3 Respirator 4 Cleaning agent assembly 5 Inactivator assembly 6 Flow monitoring assembly 7 Pressurization assembly 8 Heat exchanger 9 Temperature detection assembly 10 Pressure detection assembly 11 First cleaning line 12 Compressed air assembly 13 Second cleaning line 20 Isolator 21 Isolator cleaning line 22 Wet granulator 23 Fluid bed 24 Granulator 25 Mixer assembly 26 Isolator discharge line 30 Waste water detection assembly 31 Waste water detection line 2201 Wet granulator cleaning line 2301 Fluid bed cleaning line 2401 Granulator cleaning line 2501 Mixer assembly cleaning line

[0025] The utility model discloses the realization, functional characteristics and advantages will be combined with the embodiment, and further explanation is made with reference to the drawings. Specific implementation

[0026] The technical scheme in the embodiment of the utility model will be described clearly and completely in combination with the drawings in the embodiment of the utility model, and obviously, the described embodiment is only a part of the embodiment of the utility model, not all the embodiment. Based on the embodiment in the utility model, all other embodiments obtained by the person skilled in the art without making creative labor belong to the range of protection of the utility model.

[0027] It should be noted that all directional indications (such as up, down, …) in the embodiment of the utility model are only used to explain the relative position relationship, movement condition and the like between components in a certain specific posture (such as shown in the drawings), if the specific posture changes, then the directional indication also changes accordingly.

[0028] In addition, the description such as "first", "second" and the like in the utility model is only for the purpose of description, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second" can explicitly or implicitly include at least one feature.

[0029] And, the technical scheme of each embodiment of the utility model can be combined with each other, but it must be based on that the person skilled in the art can realize, when the combination of technical scheme appears contradictory or unachievable, it should be considered that the combination of technical scheme does not exist, also not in the protection range required by the utility model.

[0030] Reference Figures 1-3The utility model provides a wet granulation system with cleaning function, the system includes cleaning and inactivation component, and the isolator 20 who communicates with cleaning and inactivation component and the waste water detection component 30 for detecting the cleaning effect of each component inside the isolator 20.

[0031] Specifically, as Figure 2 The isolator 20 is internally provided with a wet granulator 22, a fluidized bed 23, a granulator 24 and a mixer assembly 25, and the waste water discharged from the wet granulator 22, the granulator 24 and the mixer assembly 25 after cleaning is communicated with the waste water detection component 30 through a plurality of isolator discharge pipelines 26, the waste water detection component 30 is arranged on a detection pipeline 31, different regions of the detection pipeline 31 are connected with corresponding isolator discharge pipelines 26, thereby realizing real-time monitoring of the waste water discharged from the wet granulator 22, the granulator 24 and the mixer assembly 25 inside the isolator 20 through the waste water detection pipeline 31, and further determining the cleaning effect of the wet granulator 22, the granulator 24 and the mixer assembly 25. Preferably, the waste water detection component 30 is used for conducting conductivity detection on the waste liquid in the detection pipeline 31, that is, the cleaning effect is determined by the conductivity of the waste liquid.

[0032] Further, the waste water discharged from the fluidized bed 23 after cleaning is connected with the detection pipeline 31 through a fluidized bed discharge pipeline 2302, and the conductivity of the waste liquid in the detection pipeline 31 is detected by the waste water detection component 30, that is, the cleaning effect of the fluidized bed 23 is determined by the conductivity of the waste liquid.

[0033] Further, as Figure 3 The cleaning and inactivation component includes a buffer tank 1, a heat exchanger 8 and a first cleaning pipeline 11 and a second cleaning pipeline 13 respectively communicated with the upper and lower ends of the buffer tank 1, wherein the first cleaning pipeline 11 is communicated with the bottom of the buffer tank 1 through a corresponding valve, the second cleaning pipeline 13 is communicated with the top of the buffer tank 1 through a corresponding valve, the top of the buffer tank 1 is further provided with corresponding interfaces for the inlet of tap water and purified water, and a liquid level meter is further arranged in the buffer tank 1 to record the liquid level height in the buffer tank 1 in real time, thereby determining whether water needs to be added to the buffer tank 1, and the second cleaning pipeline 13 can also effectively flow the water discharged from the first cleaning pipeline 11 back to the buffer tank 1.

[0034] Further, the first cleaning pipeline 11 is communicated with the cleaning agent assembly 4 and the inactivation agent assembly 5 respectively, and is connected with the water inlet of the heat exchanger 8, wherein the cleaning agent assembly 4 is mainly loaded with cleaning agent inside, and a corresponding valve is arranged between the first cleaning pipeline 11 and the cleaning agent assembly 4, and the inactivation agent assembly 5 is loaded with inactivation agent inside, and a corresponding valve is also arranged between the first cleaning pipeline 11 and the inactivation agent assembly 5. When the components or pipelines in the system need to be cleaned, the valve between the first cleaning pipeline 11 and the cleaning agent assembly 4 is opened, so that the cleaning agent is injected into the first cleaning pipeline 11, and when the components or pipelines in the system need to be inactivated, the valve between the first cleaning pipeline 11 and the inactivation agent assembly 5 is opened, so that the inactivation agent is injected into the first cleaning pipeline 11, thereby facilitating subsequent cleaning or inactivation treatment.

[0035] Further, the second cleaning pipeline 13 is provided with a valve with multiple communication openings, so that the second cleaning pipeline 13 can be communicated with the buffer tank 1, the heat exchanger 8 and the isolator 20 respectively. Specifically, the second cleaning pipeline 13 is connected with the water outlet pipeline of the heat exchanger 8, and the heat exchanger 8 is provided with a corresponding heating member inside, which is controlled by a corresponding control member. When heating is needed, the control member is started to heat the heating member, so that the water with cleaning agent in the first cleaning pipeline 11 can be further heated by the heat exchanger 8, and then flows out from the water outlet pipeline of the heat exchanger 8 to the second cleaning pipeline 13. The second cleaning pipeline 13 is also communicated with the corresponding cleaning pipelines of the wet granulator 22, the fluidized bed 23, the granulator 24 and the mixing machine assembly 25 respectively. Therefore, in the cleaning stage, the water with cleaning agent can flow into the wet granulator 22, the fluidized bed 23, the granulator 24 and the mixing machine assembly 25 through the second cleaning pipeline 13, so as to clean the wet granulator 22, the fluidized bed 23, the granulator 24 and the mixing machine assembly 25. In the inactivation stage, the inactivation agent in the second cleaning pipeline 13 can flow into the wet granulator 22, the fluidized bed 23, the granulator 24 and the mixing machine assembly 25, thereby realizing inactivation treatment of the components inside the isolator 20.

[0036] Further, in order to improve the cleaning effect, the first cleaning pipeline 11 is also provided with a flow monitoring assembly 6 and a pressure boosting assembly 7. The flow monitoring assembly 6 is used to monitor the flow of water or inactivation agent in the first cleaning pipeline 11, and the pressure boosting assembly 7 is used to pressurize the water or inactivation agent in the first cleaning pipeline 11, so as to enhance the subsequent cleaning or inactivation effect. In addition, in the inactivation state, the heat exchanger 8 is not heated inside, and only serves as a component for inactivation agent to flow through.

[0037] Further, the temperature detection assembly 9 is arranged on the outlet pipeline of the heat exchanger 8 to monitor the outlet water temperature of the heat exchanger 8 in real time, and the pressure detection assembly 10 is arranged on the outlet pipeline of the heat exchanger 8 to monitor the outlet water pressure of the heat exchanger 8 in real time, so that the temperature and pressure of the heat exchanger 8 and the booster assembly 7 can be adjusted according to the water temperature and the outlet water pressure monitored by the temperature detection assembly 9 and the pressure detection assembly 10.

[0038] Further, the second cleaning pipeline 13 is also communicated with the compressed air assembly 12, so that the corresponding valve on the second cleaning pipeline 13 is opened, and the pipelines and equipment inside the system are blown by the compressed air assembly 12 to remove water vapor residues.

[0039] Further, in order to better illustrate the structure of the system, the following will be described in detail through specific use methods:

[0040] Step 1 - program start, the tap water in the buffer tank 1 is filled to the target liquid level, the cleaning agent assembly 4 is opened to inject the cleaning agent into the first cleaning pipeline 11, the water flow is detected by the flow monitoring assembly 6, the pressure is increased to the set pressure by the booster assembly 7, the pressure in the pipeline is monitored in real time by the pressure detection assembly 10, and the water temperature is heated to the set temperature by the heat exchanger 8 and the temperature detection assembly 9.

[0041] Step 2 - isolator cleaning, the cleaning pipe valves of the wet granulator 22, the fluidized bed 23, the granulator 24, the mixing machine assembly 25 and the isolator 2 are opened in sequence, so that the cleaning water with heating, pressurization and cleaning agent is introduced for cleaning, and the waste water after cleaning flows into the waste water detection pipeline 31 in sequence, and the waste liquid in the detection pipeline 31 is detected by the waste water detection assembly 30.

[0042] Specifically, the wet granulator cleaning: on the basis of step 1, further open all the valves of the wet granulator 22 cleaning pipeline, and control the wet granulator 22 to rotate at low speed to clean the wet granulator 22, the cleaning effect is monitored by the conductivity, and the cleaning time and the cleaning sequence are set according to the cleaning formula.

[0043] Fluidized bed cleaning: on the basis of step 1, further open all the valves of the fluidized bed 23 cleaning pipeline and the fluidized bed discharge pipeline 2302, wet the equipment, take off the filter bag through the glove, seal, and RTP transmits, clean the fluidized bed 23 again, the cleaning effect is monitored by the conductivity, and the cleaning time and the cleaning sequence are set according to the cleaning formula.

[0044] Whole granulator cleaning: on the basis of step 1, open all valves of the cleaning pipeline of the whole granulator 24, clean the whole granulator 24, and the cleaning effect is monitored by conductivity, and the cleaning time and sequence are set according to the cleaning formula.

[0045] Mixer assembly cleaning: on the basis of step 1, open all valves of the cleaning pipeline of the mixer assembly 25, clean the mixer assembly 25, and the cleaning effect is monitored by conductivity, and the cleaning time and sequence are set according to the cleaning formula.

[0046] Step 3-inactivation treatment, close the cleaning agent assembly 4, start the inactivator assembly 5, and sequentially open the cleaning pipe valves corresponding to the wet granulator 22, the fluidized bed 23, the whole granulator 24, the mixer assembly 25 and the isolator 2, so that the inactivator performs corresponding inactivation.

[0047] Step 4-pure water cleaning, pure water is introduced into the buffer tank 1, and the cleaning pipe valves corresponding to the wet granulator 22, the fluidized bed 23, the whole granulator 24, the mixer assembly 25 and the isolator 2 are sequentially opened, so that the purified water is cleaned and the chlorine ion residue and the inactivator are eliminated.

[0048] Step 5-buffer tank cleaning, the buffer tank 1 is cleaned by the first cleaning pipeline 11 and the second cleaning pipeline 13 loop.

[0049] Step 6-pipeline and equipment purging, start the compressed air assembly 12 and discharge compressed air to the second cleaning pipeline 13, and sequentially open the cleaning pipe valves corresponding to the wet granulator 22, the fluidized bed 23, the whole granulator 24, the mixer assembly 25 and the isolator 2, so that the compressed air purges the pipeline and equipment inside the isolator.

[0050] The above is only the preferred embodiment of the present application, and does not limit the patent range of the present application, and any equivalent structural transformation made by utilizing the content of the present application specification and drawings, or directly / indirectly applied in other related technical fields under the utility model concept of the present application are included in the patent protection range of the present application.

Claims

1. A wet granulation system having a cleaning function, characterized by, The system comprises a cleaning and inactivation assembly, an isolator (20) in communication with the cleaning and inactivation assembly, and a waste water detection assembly (30) for detecting the cleaning effect of each component inside the isolator (20); The isolator (20) is internally provided with a wet granulator (22), a fluidized bed (23), a granulator (24) and a mixer assembly (25); The cleaning and inactivation assembly comprises a buffer tank (1), a heat exchanger (8) and a first cleaning pipeline (11) and a second cleaning pipeline (13) in communication with the upper and lower ends of the buffer tank (1) respectively; The first cleaning pipeline (11) is in communication with a cleaning agent assembly (4) and an inactivating agent assembly (5) respectively, and is connected with the water inlet of the heat exchanger (8); The second cleaning pipeline (13) is connected with the water outlet pipeline of the heat exchanger (8), and is also in communication with the corresponding cleaning pipelines of the wet granulator (22), the fluidized bed (23), the granulator (24) and the mixer assembly (25) respectively.

2. The wet granulation system with a cleaning function according to claim 1, characterized in that, The waste water after cleaning of the wet granulator (22), the granulator (24) and the mixer assembly (25) is discharged through a plurality of isolator discharge pipelines (26) and communicated with the waste water detection assembly (30).

3. The wet granulation system with a cleaning function according to claim 2, characterized in that, The waste water detection assembly (30) is arranged on a detection pipeline (31), and different regions of the detection pipeline (31) are connected with the corresponding isolator discharge pipelines (26).

4. The wet granulation system with a cleaning function according to claim 3, characterized in that, The waste water after cleaning of the fluidized bed (23) is discharged through a fluidized bed discharge pipeline (2302) and connected with the detection pipeline (31).

5. The wet granulation system with a cleaning function according to any one of claims 1 to 4, characterized in that, The first cleaning pipeline (11) is also connected with a flow monitoring assembly (6) and a pressure boosting assembly (7).

6. The wet granulation system with a cleaning function according to claim 1, wherein, The water outlet pipeline of the heat exchanger (8) is respectively provided with a temperature detection assembly (9) and a pressure detection assembly (10).

7. The wet granulation system with a cleaning function according to claim 1, wherein The second cleaning pipeline (13) is also in communication with a compressed air assembly (12).

8. The wet granulation system with a cleaning function according to claim 1, wherein, The buffer tank (1) is also provided with corresponding interfaces for the inlet of tap water and purified water.

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