Sampler for biopharmacy

Abstract

The utility model provides a sampler for biopharmacy, which relates to the technical field of biopharmacy, and comprises a workbench, a preparation tank, a tank cover and a liquid outlet pipe, the liquid outlet pipe and the tank cover are respectively provided with a first sampling mechanism and a second sampling mechanism; the air cylinder can drive the piston to move towards the left side of the interior of the material collecting pipe, so that the interior of the material collecting pipe is in a negative pressure state, suction force is generated in the material collecting pipe under the action of air pressure difference to suck raw material liquid in the liquid outlet pipe, and the lifting pipe can be inserted into the bottom of the liquid outlet pipe. An input end of an air pump is communicated with the interior of the lifting pipe through a telescopic pipe and a discharging pipe and is used for extracting air in the lifting pipe, so that the interior of the lifting pipe is in a negative pressure state, and suction force is generated in the lifting pipe through the action of air pressure difference; the device is used for sucking solids in raw materials at the bottom of a liquid outlet pipe, so that the time for sampling biopharmaceutical raw materials is saved, and the sampling efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of biopharmacy, especially to a sampler for biopharmacy. BACKGROUND

[0002] Biological medicine refers to the research results of microbiology, biology, medicine, biochemistry, etc., from biological body, biological tissue, cell, organ, body fluid, etc., and comprehensively utilizes the principles and methods of microbiology, chemistry, biochemistry, biotechnology, pharmacy, etc. A kind of product for prevention, treatment and diagnosis, biological pharmaceutical raw materials are mainly natural biological materials, including microorganism, human body, animal, plant, marine organism etc., with the development of biotechnology, artificially prepared biological raw materials become the main source of current biological pharmaceutical raw materials;

[0003] In the pharmaceutical process, the raw materials often need to be sampled and inspected, and the sampler used for sampling is usually 1.6 meters long, which is very inconvenient to clean. To avoid cross contamination, a special sampler is needed for each kind of raw material, and the repeated sampling process consumes a lot of time, resulting in low sampling efficiency. Therefore, the utility model provides a sampler for biopharmacy to solve the above problems. UTILITY MODEL CONTENT

[0004] To solve the problem of low sampling efficiency with only one sampler in the prior art, the utility model provides a sampler for biopharmacy.

[0005] To achieve the purpose of the utility model, the utility model realizes the following technical scheme: a sampler for biopharmacy, comprising a workbench, a preparation tank, a tank cover and a liquid outlet pipe, the top of the workbench is provided with a preparation tank, the top of the preparation tank is provided with a tank cover, the bottom of the preparation tank is communicated with a liquid outlet pipe, the inside of the workbench is provided with a filter cartridge, the bottom of the workbench is provided with a rotating mechanism, and the liquid outlet pipe and the tank cover are respectively provided with a first and a second sampling mechanism.

[0006] Further improvement lies in that the first sampling mechanism comprises a material collecting pipe, a gas cylinder, a piston and a discharge pipe, one end of the liquid outlet pipe is communicated with a material collecting pipe, one end of the material collecting pipe is installed with a gas cylinder, one end of the gas cylinder penetrates into the inside of the material collecting pipe and is fixedly connected with a piston, and the bottom of the material collecting pipe is communicated with a discharge pipe.

[0007] Further improvement lies in that the second sampling mechanism comprises a lifting pipe, a filter core, a gas pump, a discharge pipe and a telescopic pipe, the top of the tank cover is provided with a lifting pipe, one side of the workbench is installed with a filter core, one side of the filter core is provided with a gas pump, the input end of the gas pump is communicated with one end of the filter core, the other end of the filter core is communicated with a discharge pipe, one end of the discharge pipe is communicated with the top end of the lifting pipe through a telescopic pipe, and an electromagnetic valve is also arranged on the telescopic pipe.

[0008] Further improvement lies in that the top of the collecting pipe is communicated with a one-way valve, the outer wall of the piston is connected with the inner wall of the collecting pipe, and the electromagnetic valves are arranged on the liquid outlet pipe and the discharge pipe.

[0009] Further improvement lies in that the inner part of the tank cover is provided with a sealing gasket, the inner wall of the sealing gasket is slidably connected with the outer wall of the lifting pipe, one side of the top end of the lifting pipe is fixedly connected with a clamping rod, the top of the tank cover is fixedly connected with a supporting rod, and the top end of the supporting rod is clampedly connected with one end of the clamping rod.

[0010] Further improvement lies in that the rotating mechanism comprises a rotating shaft, a motor, a belt wheel and a belt, the bottom end of the preparation tank is rotatably connected with the rotating shaft, one side of the workbench is fixedly installed with the motor, the bottom end of the rotating shaft penetrates through the bottom of the workbench, the output end of the motor and the bottom end of the rotating shaft are fixedly connected with the belt wheels, and the two belt wheels are connected with each other through the belt.

[0011] Further improvement lies in that the bottom end of the filter cartridge is fixedly connected with a clamping rod, the clamping rod and the rotating shaft are provided with a clamping mechanism, and the rotating shaft and the preparation tank are provided with a sealing gasket.

[0012] Further improvement lies in that the clamping mechanism comprises a clamping block and a clamping groove, the top of the rotating shaft is fixedly connected with the clamping block, the inner part of the clamping rod is provided with the clamping groove, and the outer wall of the clamping block is clampedly connected with the inner wall of the clamping groove.

[0013] The cylinder can drive the piston to move to the left side of the collecting pipe, so that the inside of the collecting pipe presents a negative pressure state, the suction force is generated in the inside of the collecting pipe through the action of the air pressure difference, the raw material liquid in the inside of the liquid outlet pipe can be sucked, the lifting pipe can be inserted into the bottom of the liquid outlet pipe, the bottom end of the lifting pipe is contacted with the solid in the raw material at the bottom of the liquid outlet pipe, the input end of the air pump is communicated with the inside of the lifting pipe through the telescopic pipe and the discharge pipe, the air in the inside of the lifting pipe is extracted, the inside of the lifting pipe presents a negative pressure state, the suction force is generated in the inside of the lifting pipe through the action of the air pressure difference, the solid in the raw material at the bottom of the liquid outlet pipe is sucked, the time for taking the sample biological pharmaceutical raw material is saved, and the efficiency of sampling is improved. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 It is a front view of the utility model;

[0015] Figure 2 It is a bottom view of the utility model;

[0016] Figure 3 It is a structure schematic view of the No. 1 sampling mechanism of the utility model;

[0017] Figure 4 It is the internal structure schematic view of the preparation tank of the utility model.

[0018] Figure 5 It is the structure schematic view of the clamping mechanism of the utility model.

[0019] In the figure: 1, workbench; 2, preparation tank; 3, tank cover; 4, liquid outlet pipe; 5, filter cartridge; 6, material collecting pipe; 7, air cylinder; 8, piston; 9, check valve; 10, discharge pipe; 11, sealing gasket; 12, lifting pipe; 13, filter element; 14, air pump; 15, discharge pipe; 16, telescopic pipe; 17, support rod; 18, clamping rod; 19, rotating shaft; 20, clamping block; 21, clamping groove; 22, motor; 23, pulley; 24, belt. DETAILED DESCRIPTION

[0020] In order to deepen the understanding of the utility model, the utility model will be further described in conjunction with the embodiments below, and the present embodiment is only used to explain the utility model and does not constitute the limitation of the protection scope of the utility model.

[0021] According to Figures 1-5 The present embodiment proposes a sampler for biopharmaceuticals, which comprises a workbench 1, a preparation tank 2, a tank cover 3 and a liquid outlet pipe 4, the top of the workbench 1 is provided with the preparation tank 2, the top of the preparation tank 2 is provided with the tank cover 3, the bottom of the preparation tank 2 is communicated with the liquid outlet pipe 4, the inside of the workbench 1 is provided with the filter cartridge 5, the bottom of the workbench 1 is provided with a rotating mechanism, the liquid outlet pipe 4 and the tank cover 3 are respectively provided with a first and a second sampling mechanism, by opening the tank cover 3, the sampled biopharmaceutical raw materials are put into the inside of the liquid outlet pipe 4, the rotating mechanism drives the liquid outlet pipe 4 to rotate in the inside of the preparation tank 2, so that the liquid outlet pipe 4 generates centrifugal force to drive the solid and liquid in the raw materials to separate, the liquid passes through the filter hole of the liquid outlet pipe 4 to enter the bottom of the preparation tank 2 and flows to the inside of the liquid outlet pipe 4, the first sampling mechanism samples the liquid in the raw materials through the liquid outlet pipe 4, and at the same time, the second sampling mechanism samples the solid in the inside of the liquid outlet pipe 4, so as to save the time of sampling biopharmaceutical raw materials and improve the sampling efficiency.

[0022] The first sampling mechanism comprises a collecting pipe 6, a cylinder 7, a piston 8 and a discharge pipe 10, one end of the discharge pipe 4 is communicated with the collecting pipe 6, one end of the collecting pipe 6 is provided with the cylinder 7, one end of the cylinder 7 penetrates the inside of the collecting pipe 6 and is fixedly connected with the piston 8, the bottom of the collecting pipe 6 is communicated with the discharge pipe 10, the top of the collecting pipe 6 is communicated with a one-way valve 9, the outer wall of the piston 8 is connected with the inner wall of the collecting pipe 6, the discharge pipe 4 and the discharge pipe 10 are both provided with electromagnetic valves, the electromagnetic valve at the bottom end of the discharge pipe 4 is opened, and the electromagnetic valve on the discharge pipe 10 is in a closed state, the cylinder 7 can drive the piston 8 to move to the left inside the collecting pipe 6, the air inside the collecting pipe 6 is discharged through the one-way valve 9, so that the inside of the collecting pipe 6 presents a negative pressure state, through the action of the pressure difference, the suction force is generated in the inside of the collecting pipe 6, so as to suck the raw material liquid in the inside of the discharge pipe 4, and the volume of the inside of the collecting pipe 6 is fixed, so as to quantitatively sample the liquid, then the electromagnetic valve at the bottom end of the discharge pipe 4 is closed, the electromagnetic valve on the discharge pipe 10 is opened, the cylinder 7 drives the piston 8 to move to the right inside the collecting pipe 6, so as to push the liquid to flow to the discharge pipe 10, the liquid flows to the outside sampling bottle through the discharge pipe 10, the sampling of the liquid in the biological pharmaceutical raw material is completed, and finally the electromagnetic valves of the discharge pipe 4 and the discharge pipe 10 are both in a closed state.

[0023] The inside of the tank cover 3 is provided with a sealing gasket 11, the inner wall of the sealing gasket 11 is slidably connected with the outer wall of the lifting pipe 12, one side of the top end of the lifting pipe 12 is fixedly connected with a clamping rod 18, the top of the tank cover 3 is fixedly connected with a supporting rod 17, the top end of the supporting rod 17 is clampingly connected with one end of the clamping rod 18, the lifting pipe 12 is pulled to move upward, the clamping rod 18 is moved out of the top end of the supporting rod 17, and the lifting pipe 12 is rotated to dislocate the position of the clamping rod 18 and the supporting rod 17, at this time, the lifting pipe 12 can be inserted into the bottom of the discharge pipe 4, so as to contact the bottom end of the lifting pipe 12 with the solid in the raw material of the discharge pipe 4, and facilitate the lifting pipe 12 to suck the solid, after the sampling is completed, the lifting pipe 12 is pulled to move upward, then the lifting pipe 12 is rotated to reset, and the clamping rod 18 is clampingly connected into the top end of the supporting rod 17.

[0024] The second sampling mechanism comprises a lifting pipe 12, a filter core 13, an air pump 14, a discharge pipe 15 and an extension pipe 16, the top of the tank cover 3 is provided with the lifting pipe 12, one side of the workbench 1 is provided with the filter core 13, one side of the filter core 13 is provided with the air pump 14, the input end of the air pump 14 is communicated with one end of the filter core 13, the other end of the filter core 13 is communicated with the discharge pipe 15, one end of the discharge pipe 15 is communicated with the top end of the lifting pipe 12 through the extension pipe 16, and the extension pipe 16 is also provided with an electromagnetic valve, the electromagnetic valve on the extension pipe 16 is opened, the input end of the air pump 14 is communicated with the inside of the lifting pipe 12 through the extension pipe 16 and the discharge pipe 15, so as to extract the air in the inside of the lifting pipe 12, so that the inside of the lifting pipe 12 is in a negative pressure state, the suction force is generated in the inside of the lifting pipe 12 through the air pressure difference, so as to extract the solid in the raw material at the bottom of the liquid pipe 4, the solid is intercepted in the inside of the discharge pipe 15 through the block of the filter core 13, and is discharged outward through the discharge pipe 15, and then the electromagnetic valve on the extension pipe 16 is closed.

[0025] The rotating mechanism comprises a rotating shaft 19, a motor 22, a belt pulley 23 and a belt 24, the bottom end of the preparation tank 2 is rotationally connected with the rotating shaft 19, one side of the workbench 1 is fixedly provided with the motor 22, the bottom end of the rotating shaft 19 penetrates through the bottom of the workbench 1, the output end of the motor 22 and the bottom end of the rotating shaft 19 are both fixedly connected with the belt pulley 23, the two belt pulleys 23 are connected with each other through the belt 24, the rotating shaft 19 and the preparation tank 2 are provided with a sealing pad, the motor 22 can drive the belt pulley 23 at the output end to rotate, another belt pulley 23 can be driven to rotate through the belt 24, and another belt pulley 23 is integrated with the rotating shaft 19, so that the motor 22 can drive the rotating shaft 19 to rotate at the bottom of the preparation tank 2, and the sealing pad fills the gap between the rotating shaft 19 and the preparation tank 2, so as to avoid the leakage.

[0026] The bottom end of the filter cylinder 5 is fixedly connected with a clamping rod 18, the clamping rod 18 and the rotating shaft 19 are provided with a clamping mechanism, the clamping mechanism comprises a clamping block 20 and a clamping groove 21, the top of the rotating shaft 19 is fixedly connected with the clamping block 20, the inside of the clamping rod 18 is provided with the clamping groove 21, the outer wall of the clamping block 20 is clamped and connected with the inner wall of the clamping groove 21, the clamping block 20 on the rotating shaft 19 is clamped and integrated with the clamping rod 18 at the bottom end of the filter cylinder 5 through the clamping groove 21, so as to integrate the filter cylinder 5 with the rotating shaft 19, the rotating shaft 19 can drive the filter cylinder 5 to rotate in the inside of the preparation tank 2, the centrifugal force is generated in the inside of the filter cylinder 5, and the liquid and the solid in the biological pharmaceutical raw material are separated through the filter hole arranged in the inside of the filter cylinder 5.

[0027] The biological medicine sampler, the cylinder 7 can drive the piston 8 to move to the left inside the collecting pipe 6, so that the inside of the collecting pipe 6 presents a negative pressure state, through the action of air pressure difference, the inside of the collecting pipe 6 generates suction, to suck the raw material liquid inside the liquid outlet pipe 4, the lifting pipe 12 can be inserted into the bottom of the liquid outlet pipe 4, to contact the bottom end of the lifting pipe 12 with the solid in the raw material of the bottom of the liquid outlet pipe 4, and the input end of the air pump 14 is communicated with the inside of the lifting pipe 12 through the telescopic pipe 16 and the discharge pipe 15, to extract the air inside the lifting pipe 12, so that the inside of the lifting pipe 12 presents a negative pressure state, through the action of air pressure difference, the inside of the lifting pipe 12 generates suction, to suck the solid in the raw material of the bottom of the liquid outlet pipe 4, to save the time of sampling biological medicine raw materials, improve the sampling efficiency.

[0028] The basic principle, main features and advantages of the present application are shown and described above. Those skilled in the art should understand that the present application is not limited by the above embodiments, and the above embodiments and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. A sampler for biopharmaceutical applications, comprising a workbench (1), a preparation vessel (2), a vessel lid (3), and a liquid outlet tube (4), characterized in that: The top of the workbench (1) is provided with a preparation tank (2), the top of the preparation tank (2) is provided with a tank cover (3), the bottom of the preparation tank (2) is connected to a liquid outlet pipe (4), the inside of the workbench (1) is provided with a filter cylinder (5), the bottom of the workbench (1) is provided with a rotating mechanism, and the liquid outlet pipe (4) and the tank cover (3) are respectively provided with sampling mechanisms No. 1 and No.

2. The first sampling mechanism includes a collection pipe (6), a cylinder (7), a piston (8), and a discharge pipe (10). One end of the discharge pipe (4) is connected to the collection pipe (6), and a cylinder (7) is installed at one end of the collection pipe (6). One end of the cylinder (7) passes through the inside of the collection pipe (6) and is fixedly connected to the piston (8). The bottom of the collection pipe (6) is connected to the discharge pipe (10). The second sampling mechanism includes a lifting pipe (12), a filter element (13), an air pump (14), a discharge pipe (15), and a telescopic pipe (16). The top of the can cover (3) is provided with a lifting pipe (12). A filter element (13) is installed on one side of the workbench (1). An air pump (14) is provided on one side of the filter element (13). The input end of the air pump (14) is connected to one end of the filter element (13). The other end of the filter element (13) is connected to the discharge pipe (15). One end of the discharge pipe (15) is connected to the top of the lifting pipe (12) through the telescopic pipe (16). A solenoid valve is also provided on the telescopic pipe (16).

2. The sampler for biopharmaceutical use according to claim 1, characterized in that: The top of the collecting pipe (6) is connected to a one-way valve (9), the outer wall of the piston (8) is fitted and connected to the inner wall of the collecting pipe (6), and both the liquid outlet pipe (4) and the discharge pipe (10) are equipped with solenoid valves.

3. A sampler for biopharmaceutical use according to claim 1, characterized in that: The can lid (3) is provided with a sealing gasket (11) inside. The inner wall of the sealing gasket (11) is slidably connected to the outer wall of the lifting tube (12). A locking rod (18) is fixedly connected to one side of the top of the lifting tube (12). A support rod (17) is fixedly connected to the top of the can lid (3). The top of the support rod (17) is engaged with one end of the locking rod (18).

4. A sampler for biopharmaceutical use according to claim 1, characterized in that: The rotating mechanism includes a rotating shaft (19), a motor (22), a pulley (23), and a belt (24). The bottom end of the preparation tank (2) is rotatably connected to the rotating shaft (19). The motor (22) is fixedly installed on one side of the workbench (1). The bottom end of the rotating shaft (19) extends through the bottom of the workbench (1). The output end of the motor (22) and the bottom end of the rotating shaft (19) are both fixedly connected to pulleys (23). The two pulleys (23) are connected to each other by a belt (24).

5. A sampler for biopharmaceutical use according to claim 4, characterized in that: The bottom end of the filter cylinder (5) is fixedly connected to a clamping rod (18), and a clamping mechanism is provided between the clamping rod (18) and the rotating shaft (19), and a sealing gasket is provided between the rotating shaft (19) and the preparation tank (2).

6. A sampler for biopharmaceutical use according to claim 5, characterized in that: The engaging mechanism includes a locking block (20) and a locking groove (21). The top of the rotating shaft (19) is fixedly connected to the locking block (20), and the inside of the locking rod (18) is provided with a locking groove (21). The outer wall of the locking block (20) is engaged with the inner wall of the locking groove (21).

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