Paclitaxel extraction and concentration device

Abstract

The utility model relates to the technical field of extraction devices, and discloses a paclitaxel extraction and concentration device which comprises a box body, crushing rollers are rotatably connected to the two ends of the top of the inner wall of the box body, first brushes penetrate through and are slidably connected to the top of the box body, and a filter screen is fixedly connected to the middle of the inner wall of the box body. And a first cutting rod penetrates through and is rotationally connected to the top of the filter screen, a shell penetrates through and is rotationally connected to the outer ring of the first cutting rod, a first bevel gear is fixedly connected to the outer ring of the first cutting rod, and second bevel gears are rotationally connected to the two sides of the inner wall of the shell correspondingly. According to the red bean shirts crushing device, through cooperation of the crushing roller, the first brush, the first cutting rod, the second cutting rod, the first bevel gear, the second bevel gear, the third bevel gear, the fourth bevel gear, the first servo motor and the shell and the synergistic effect of the crushing roller and the cutting rods, red bean shirts can be quickly and effectively crushed, and the extraction efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of extraction device, concretely is a paclitaxel extraction concentration device. BACKGROUND

[0002] Paclitaxel is a chemotherapy drug extracted from the bark of the Pacific yew tree (Taxus brevifolia). It is widely used in the treatment of various cancers, including ovarian cancer, breast cancer, and non-small cell lung cancer. It inhibits the proliferation of tumor cells by inhibiting cell division and interfering with the normal function of microtubules. Paclitaxel is usually used in combination with other chemotherapy drugs, which can significantly improve the prognosis and survival rate of patients. Although its side effects may include hair loss, nausea, and immune system suppression, its clinical effect makes it one of the important drugs in the treatment of cancer.

[0003] The method of paclitaxel extraction device for crushing yew is to use a mechanical crusher. First, the collected yew bark or branches are dried to reduce moisture. Then, the dried material is put into a mechanical crusher for crushing, and the commonly used equipment includes blade or hammer crusher to achieve the required particle size. Finally, the crushed yew fragments are collected and prepared for subsequent paclitaxel extraction processing.

[0004] Mechanical crushing may result in uneven particle size of the crushed material, affecting the subsequent extraction efficiency. For some types of yew material (such as biological samples in a wet state), the effect of mechanical crushing may not be ideal, resulting in a decrease in extraction efficiency, and the yew cannot be efficiently crushed. To solve the above problems, a paclitaxel extraction concentration device is proposed. Utility model content

[0005] The utility model aims at providing a paclitaxel extraction concentration device, which solves the problem of inefficient crushing of yew in the background technology.

[0006] To achieve the above object, the utility model provides the following technical scheme: a paclitaxel extraction and concentration device, including the box, both ends of the box inner wall top rotatably connected with the crushing roller, the first brush is slidably connected in the box top, the box inner wall middle fixedly connected with the filter screen, the first cutting rod is rotatably connected through the filter screen top, the outer ring of first cutting rod rotatably connected with the shell, the outer ring of first cutting rod fixedly connected with the bevel gear, both sides of the shell inner wall rotatably connected with the second bevel gear, and the second bevel gear is meshed with the first bevel gear, the second cutting rod is fixedly connected to one end of the second bevel gear, the third bevel gear is fixedly connected to the first cutting rod bottom, the first cutting rod bottom rotatably connected with the protective shell, the first servo motor is fixedly connected to the box one side middle, the fourth bevel gear is fixedly connected to the first servo motor output, and the fourth bevel gear is meshed with the third bevel gear, both sides of the box are fixedly connected with the fixed block, and the cleaning assembly is arranged on one side of the fixed block.

[0007] Through the meshing between the bevel gears, the fourth bevel gear drives the third bevel gear to rotate, the third bevel gear drives the first cutting rod to rotate, and the first bevel gear drives the second bevel gear to rotate.

[0008] As a further description of the above technical scheme: the cleaning assembly includes two second servo motors, the second servo motors are fixedly connected to both ends of one side of the fixed block, threaded rods are fixedly connected to the second servo motor outputs, the outer rings of the threaded rods are threadedly connected with sliding plates, first springs are fixedly connected to the sliding plate inner walls, and the second brush is fixedly connected to one end of the first spring.

[0009] Through the above technical scheme, the second servo motor drives the threaded rod to rotate, and the sliding plate moves.

[0010] As a further description of the above technical scheme: the sealing cover is slidably connected through the box two sides, the sealing cover one side is fixedly connected with the rack, and the box rear end is fixedly connected with the fixed frame.

[0011] Through the above technical scheme, the red yew crushed in the box can be crushed by opening the sealing cover.

[0012] As a further description of the above technical scheme: the third servo motor is fixedly connected to one side of the fixed frame, and the rotating rod is fixedly connected to the third servo motor output.

[0013] Through the above technical scheme, the third servo motor drives the rotating rod to rotate.

[0014] As a further description of the above technical solution: the outer circle of the rotating rod is fixedly connected with the first gear, and the first gear is in meshing connection with the rack.

[0015] By adopting the above technical scheme, the rotation of the first gear can make the rack move.

[0016] As a further description of the above technical solution: the outer circle of the rotating rod is fixedly connected with the first gear, and the first gear is in meshing connection with the rack.

[0017] By adopting the above technical scheme, the filter plate can filter the broken taxus.

[0018] As a further description of the above technical solution: the outer circle of the rotating rod is fixedly connected with the first gear, and the first gear is in meshing connection with the rack.

[0019] By adopting the above technical scheme, the vibration motor can drive the box to vibrate.

[0020] As a further description of the above technical solution: the outer circle of the rotating rod is fixedly connected with the first gear, and the first gear is in meshing connection with the rack.

[0021] By adopting the above technical scheme, the movement of the sliding plate can slide at the sliding rod, so that the sliding of the sliding plate can be supported.

[0022] Compared with the prior art, the utility model has the advantages that:

[0023] 1. The taxol extraction and concentration device provided by the utility model can quickly and effectively crush taxus through the cooperation of the crushing roller and the cutting rod, increase the contact surface area in the extraction process, and improve the extraction efficiency.

[0024] 2. The taxol extraction and concentration device provided by the utility model can automatically clean the filter plate during the discharge process, effectively prevent the accumulation of taxus residues, reduce the risk of equipment blockage, and ensure the continuous operation of the equipment. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 It is a perspective view of the utility model;

[0026] Figure 2 It is a box section view of the utility model;

[0027] Figure 3 It is the shell section view of the utility model;

[0028] Figure 4 It is the spring explosion drawing of the utility model;

[0029] Figure 5 It is the first gear explosion drawing of the utility model.

[0030] Legend:

[0031] 1, box body;2, crushing roller;3, first brush;4, first cutting rod;5, second cutting rod;6, shell;7, filter screen;8, first bevel gear;9, second bevel gear;10, third bevel gear;11, fourth bevel gear;12, protective shell;13, first servo motor;14, fixed block;15, second servo motor;16, threaded rod;17, slide bar;18, slide plate;19, first spring;20, second brush;21, filter plate;22, rotating shaft;23, rack;24, fixed frame;25, third servo motor;26, first gear;27, rotating rod;28, damping spring;29, vibration motor;30, sealing cover. DETAILED DESCRIPTION

[0032] The technical scheme in the embodiments of the utility model will be described clearly and completely below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the utility model.

[0033] For further understanding the contents of the utility model, the utility model is described in detail with reference to the drawings.

[0034] With reference to Figure 1 The utility model discloses a paclitaxel extraction and concentration device, including the box body 1, the both sides top of box body 1 are fixedly connected with vibration motor 29, vibration motor 29 can drive the vibration of box body 1, the bottom of box body 1 is fixedly connected with damping spring 28, and damping spring 28 can buffer the vibration of box body 1, and the top of slide plate 18 is all connected with slide bar 17 and is slidably connected, and slide plate 18 can slide at slide bar 17, and the outer ring of slide bar 17 is fixedly connected with box body 1.

[0035] With reference to Figure 2 and Figure 3The top of the inner wall of the box body 1 is rotatably connected with a crushing roller 2 at both ends, an external motor drives the crushing roller 2 to rotate, the top of the box body 1 is slidably connected with a first brush 3, the first brush 3 can wipe the surface of the crushing roller 2, the inner wall of the box body 1 is fixedly connected with a filter screen 7, the filter screen 7 can filter the taxus, the top of the filter screen 7 is rotatably connected with a first cutting rod 4, the outer circle of the first cutting rod 4 and the second cutting rod 5 is provided with a cutting blade, the outer circle of the first cutting rod 4 is rotatably connected with an outer shell 6, the outer shell 6 protects the internal bevel gear, the outer circle of the first cutting rod 4 is fixedly connected with a first bevel gear 8, the inner wall of the outer shell 6 is rotatably connected with a second bevel gear 9 on both sides, and the second bevel gear 9 is rotatably connected with the first bevel gear 8, the rotation of the first cutting rod 4 drives the first bevel gear 8 to rotate, one end of the second bevel gear 9 is fixedly connected with the second cutting rod 5, the bottom of the first cutting rod 4 is fixedly connected with a third bevel gear 10, the rotation of the third bevel gear 10 drives the first cutting rod 4 to rotate, the bottom of the first cutting rod 4 is rotatably connected with a protective shell 12, one side of the box body 1 is fixedly connected with a first servo motor 13, the output end of the first servo motor 13 is fixedly connected with a fourth bevel gear 11, the first servo motor 13 can drive the fourth bevel gear 11 to rotate, and the fourth bevel gear 11 is rotatably connected with the third bevel gear 10, both sides of the box body 1 are fixedly connected with a fixed block 14, and one side of the fixed block 14 is provided with a cleaning assembly.

[0036] Referring to Figure 4 and Figure 5The cleaning assembly comprises two second servo motors 15 fixedly connected with two ends of one side of the fixed block 14, the fixed block 14 fixes the positions of the second servo motors 15, threaded rods 16 are fixedly connected with output ends of the second servo motors 15, the second servo motors 15 drive the threaded rods 16 to rotate, sliding plates 18 are threadedly connected with outer circles of the threaded rods 16, rotation of the threaded rods 16 makes the sliding plates 18 move, first springs 19 are fixedly connected with inner walls of the sliding plates 18, second brushes 20 are fixedly connected with one end of the first springs 19, the second brushes 20 can be tightly attached to filter plates 21 through the first springs 19, sealing covers 30 are penetratingly and slidingly connected with two sides of the box body 1, a rack 23 is fixedly connected with one side of the sealing cover 30, movement of the rack 23 drives the sealing cover 30 to move, a fixed frame 24 is fixedly connected with the rear end of the box body 1, a third servo motor 25 is fixedly connected with one side of the fixed frame 24, a rotating rod 27 is fixedly connected with an output end of the third servo motor 25, the third servo motor 25 can drive the rotating rod 27 to rotate, first gears 26 are fixedly connected with outer circles of the rotating rod 27, rotation of the rotating rod 27 makes the first gears 26 rotate, the first gears 26 are meshingly connected with the rack 23, rotating shafts 22 are rotatingly connected with two ends of the inner wall bottom of the box body 1, the rotating shafts 22 are driven by external motors to rotate, the filter plates 21 are fixedly connected with outer circles of the rotating shafts 22, and the filter plates 21 can filter the broken taxus yunnanensis.

[0037] Working principle: first, the taxus yunnanensis is placed at the crushing roller 2 to be crushed, then the surface of the crushing roller 2 can be wiped through the first brush 3, so that the taxus yunnanensis is prevented from sticking, then the first servo motor 13 drives the fourth bevel gear 11 to rotate, through the meshing between the bevel gears, the third bevel gear 10 drives the first cutting rod 4 to rotate, the first cutting rod 4 rotates to make the first bevel gear 8 rotate, the second bevel gear 9 drives the second cutting rod 5 to rotate, through the cooperation between the first cutting rod 4 and the second cutting rod 5, the taxus yunnanensis can be efficiently crushed, then the crushed taxus yunnanensis falls on the filter plate 21 through the filter screen 7, then the taxus yunnanensis is mixed with the medicament by pouring the medicament into the box body 1, the mixed liquid is discharged through the pipeline, after the discharge is completed, the filter plate 21 is swung through the rotation of the rotating shaft 22, at the same time, the third servo motor 25 drives the rotating rod 27 to rotate, so that the first gear 26 drives the rack 23 to move, the movement of the rack 23 drives the sealing cover 30 to move, so that the taxus yunnanensis above the filter plate 21 can be discharged, if in the process of discharging, the second servo motor 15 drives the threaded rod 16 to rotate, so that the sliding plate 18 moves, the second brush 20 can wipe the surface of the filter plate 21 through the pressure release of the first spring 19, so as to facilitate wiping the taxus yunnanensis above the filter plate 21, and the crushed taxus yunnanensis can be efficiently discharged.

[0038] It is to be noted that, in the present document, relational terms such as first and second and the like can be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus.

[0039] While the embodiments of the present application have been illustrated and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and alterations can be made therein without departing from the spirit and scope of the application, which is defined by the appended claims and their equivalents.

Claims

1. A device for extracting and concentrating paclitaxel, comprising a box (1), characterized in that: The box (1) inner wall top both ends are rotatably connected with crushing roller (2), the box (1) top is slidably connected with first brush (3), the box (1) inner wall middle is fixedly connected with filter screen (7), the filter screen (7) top is rotatably connected with first cutting rod (4), the first cutting rod (4) outer ring is rotatably connected with shell (6), the first cutting rod (4) outer ring is fixedly connected with first bevel gear (8), the shell (6) inner wall both sides are rotatably connected with second bevel gear (9), and second bevel gear (9) and first bevel gear (8) are rotatably connected, the second bevel gear (9) one end is fixedly connected with second cutting rod (5), the first cutting rod (4) bottom is fixedly connected with third bevel gear (10), the first cutting rod (4) bottom is rotatably connected with protective shell (12), the box (1) one side middle is fixedly connected with first servo motor (13), the first servo motor (13) output end is fixedly connected with fourth bevel gear (11), and fourth bevel gear (11) and third bevel gear (10) are rotatably connected, the box (1) both sides are fixedly connected with fixed block (14), the fixed block (14) one side is provided with cleaning assembly.

2. The paclitaxel extraction and concentration device of claim 1, wherein: The cleaning assembly comprises two second servo motors (15), the second servo motor (15) is rotatably connected with the both ends of the fixed block (14), the output end of the second servo motor (15) is fixedly connected with the threaded rod (16), the outer ring of the threaded rod (16) is rotatably connected with the sliding plate (18), the inner wall of the sliding plate (18) is fixedly connected with the first spring (19), and the one end of the first spring (19) is fixedly connected with the second brush (20).

3. The device for extracting and concentrating paclitaxel according to claim 1, wherein: The box (1) both sides are rotatably connected with sealing cover (30), the sealing cover (30) one side is fixedly connected with rack (23), the box (1) rear end is fixedly connected with fixed frame (24).

4. The device for extracting and concentrating paclitaxel according to claim 3, wherein: The fixed frame (24) one side is fixedly connected with third servo motor (25), and the output end of the third servo motor (25) is fixedly connected with rotating rod (27).

5. The device for extracting and concentrating paclitaxel according to claim 4, wherein: The outer ring of the rotating rod (27) is fixedly connected with first gear (26), and the first gear (26) is rotatably connected with rack (23).

6. The paclitaxel extraction and concentration device of claim 1, wherein: The box (1) inner wall bottom both ends are rotatably connected with rotating shaft (22), and the outer ring of the rotating shaft (22) is fixedly connected with filter plate (21).

7. The device for extracting and concentrating paclitaxel according to claim 1, wherein: The box (1) both sides top are fixedly connected with vibration motor (29), and the box (1) bottom is fixedly connected with damping spring (28).

8. The device for extracting and concentrating paclitaxel according to claim 2, wherein: The top of the sliding plate (18) is rotatably connected with sliding rod (17), and the outer ring of the sliding rod (17) is fixedly connected with the box (1).

Images