Brine blending device for erythrocyte osmotic brittleness test

Abstract

The utility model discloses a brine blending device for a red blood cell osmotic brittleness test. The brine blending device comprises a main shell and a position mark sensing unit, a salt water blending unit and a center alignment unit; a master controller; a to-be-loaded test tube group is placed on the bottom placing table, the center alignment unit is used for placing the to-be-loaded test tube group in the middle position, the position mark sensing unit is used for measuring and calculating the distance between the head test tube and the tail test tube of the test tube group so as to guide the horizontal moving unit to rapidly move to the position over the test tubes relative to the center of the device, and the visual camera and the injection angle adjusting assembly are used for adjusting the injection angle. The injection head is aligned with a test tube opening, and the metering pump is started to inject saline water and distilled water into the test tube according to a fixed proportion. Based on a saline water filling mode of mobile hovering injection, a horizontal moving unit is arranged to realize movement of an injection head above a test tube group, so that the problem of material resource waste caused by a traditional one-tube one-path scheme is solved; in addition, by arranging a visual camera and an ejection angle adjusting assembly, the technical risk that saline water is injected out of the test tube is avoided to a great extent.

Description

TECHNICAL FIELD

[0001] The embodiment of the utility model belongs to the technical field of brine deployment, more particularly, relates to a kind of brine deployment devices for red blood cell osmotic fragility test. BACKGROUND

[0002] Red blood cell osmotic fragility test is mainly used to evaluate the resistance of red blood cells to different concentrations of salt solution, especially the stability in low osmotic environment. Its principle is that normal red blood cells can maintain double-concave disc shape when they are in isotonic solution (0.9% NaCl solution). However, in low osmotic salt solution, water molecules will flow into the cells to try to balance the osmotic pressure inside and outside, causing cell swelling and even hemolysis. Whether red blood cells hemolyze in low osmotic salt solution mainly depends on the ratio of surface area to volume of red blood cells. The larger the surface area / volume, the greater the resistance to low osmotic salt solution (less fragility), and vice versa. Based on the test principle, according to the 4th edition of "National Clinical Laboratory Operation Procedures", 14 kinds of different concentration gradient brine are needed to be prepared by using fixed ratio brine and distilled water. In actual work, the brine preparation process causes low efficiency consumption of time and labor. Therefore, a device for convenient multi-proportion brine preparation is proposed, which is of great significance to improve test efficiency.

[0003] To solve the above technical problems, a kind of brine automatic configuration device is disclosed in Chinese utility model patent CN219682429U, which comprises a salt dissolving pool, a plurality of brine storage tanks connected and conducted with the salt dissolving pool, a connecting pipeline for connecting and conducting the salt dissolving pool and each brine storage tank, a water inlet branch pipe connected and conducted with the connecting pipeline at one end and connected and conducted with an external tap water pipe at the other end, a mixing device arranged on the connecting pipeline and used for mixing brine on the connecting pipeline and tap water on the water inlet branch pipe, a Baumé meter for detecting the concentration of brine in each brine storage tank, and a proportional regulating valve for controlling and adjusting the flow of tap water in the water inlet branch pipe and controlling the flow of brine flowing from the salt dissolving pool to the connecting pipeline, and the proportional regulating valve acts according to the detection information of the Baumé meter.

[0004] The above-mentioned patent technology uses automatic means to realize the preparation of brine of each concentration, but still has the following technical problems: (1) the above-mentioned scheme sets a set of pipeline flow control system for each container, which can meet the demand of brine proportioning for large containers, but for small batch test tubes, the implementation difficulty will be limited due to size reasons; (2) in the above-mentioned scheme, the number of liquid storage tanks causes a substantial increase in cost of pipeline and high-precision control valve system, which should be combined with automatic mechanism to realize mobile injection; (3) in the above-mentioned scheme, the pipeline and the liquid storage tank port are in a fixed state, and in the application environment of whole-row test tube brine deployment and injection, the brine is usually injected from above the test tube port. In this process, the problem of port alignment reliability should be considered to prevent brine from being injected outside the tube. Utility Model Content

[0005] To address the aforementioned deficiencies or improvement needs of existing technologies, this utility model provides a saline preparation device for the erythrocyte osmotic fragility test. Based on a mobile hovering injection saline dispensing mode, a horizontal moving unit is set up to allow the injection head to move above the test tube group, solving the problem of material resource waste caused by the traditional "one tube, one path" solution. In addition, a vision camera and injection angle adjustment component that can accurately match the test tube opening are set at the front end of the horizontal moving unit, greatly avoiding technical risks beyond the saline injection into the test tube.

[0006] To achieve the above objectives, a saline preparation device for a red blood cell osmotic fragility test includes:

[0007] The main housing includes a side support, a bottom placement platform located below the front side of the side support for placing a test tube assembly, a top extension located above the front side of the side support, and a bottle placement hole for placing a storage tank containing a fixed ratio of saline and distilled water; the test tube assembly includes a test tube rack and internal test tubes.

[0008] A position sensor unit is installed on the front side of the bottom placement platform to measure the distance between the first and last test tubes of the test tube group.

[0009] A saline preparation unit, located on the top protruding eave for injecting saline solution into the test tube group below, includes a horizontally moving unit located within the top protruding eave, a saline injection assembly located at the output end of the horizontally moving unit, a visual camera located at the output end of the horizontally moving unit for capturing and positioning the test tube opening, and an injection angle adjustment assembly installed at the output end of the horizontally moving unit for adjusting the injection angle of the saline injection assembly; the saline injection assembly includes an injection head, a guide tube connected to the storage tank, and a metering pump;

[0010] Position the test tube group to the center alignment unit in the middle of the bottom placement platform;

[0011] The main controller used for device information processing and control;

[0012] Place the test tube group to be loaded on the bottom platform, use the center alignment unit to position it in the center, and use the position sensor unit to measure the distance between the first and last test tubes of the test tube group to guide the horizontal moving unit to move quickly relative to the center of the device to directly above the test tube. Then, use the vision camera and the injection angle adjustment component to align the injection head with the test tube opening, and start the metering pump to inject a fixed ratio of saline and distilled water into the test tube.

[0013] Preferably, the center alignment unit includes:

[0014] A second horizontal sliding slot is arranged on the upper surface of the bottom placement table, and a pair of sliding clamps are in sliding connection with the second horizontal sliding slot.

[0015] Preferably, the center alignment unit further comprises a scale arranged along the second horizontal sliding slot and at the side thereof.

[0016] Preferably, the position mark sensing unit comprises:

[0017] A first horizontal sliding slot is arranged on the front side of the bottom placement table, an inner connecting rod is in horizontal sliding connection with the first horizontal sliding slot, an adjusting block is arranged at the outer end of the inner connecting rod, a pointer is arranged above the adjusting block and used for pointing to the central axis of the inner end tube of the tube set, a sliding block is fixed to the inner end of the inner connecting rod, and an optical rod is fixed to the inner part of the bottom placement table in parallel with the first horizontal sliding slot, and the sliding block is in sleeve sliding connection with the optical rod.

[0018] The sliding block is a pair of sliding blocks, and a distance measuring sensor for measuring the distance is arranged on the opposite surfaces of the pair of sliding blocks.

[0019] By manually adjusting the left and right adjusting blocks, the pointer points to the central axis of the inner end tube of the tube set, and at this time, the distance measuring sensor transmits the distance between the two end tubes of the tube set to the main controller, and according to the number of tubes, the horizontal moving unit is guided to move to the point.

[0020] Preferably, the horizontal moving unit comprises:

[0021] A driving motor is fixed in the top extension eave, a horizontal transmission screw rod is fixed in horizontal connection with the output shaft of the driving motor, a threaded transmission block is in horizontal transmission with the horizontal transmission screw rod, an intermediate connecting block is fixed below the threaded transmission block, and a carrier block is arranged below the intermediate connecting block.

[0022] A horizontal notch is arranged below the top extension eave and used for passing through the intermediate connecting block.

[0023] Preferably, the salt water deployment unit further comprises a middle correction assembly, which comprises:

[0024] An edge portion is downwardly extended at the front end of the top extension eave, an infrared emission head is arranged at the horizontal center of the center of the inner side surface of the edge portion, and an infrared receiving head is fixed to the left side of the carrier block and arranged in alignment with the infrared emission head.

[0025] Under the action of the horizontal moving unit, when the carrier block moves to the middle part of the device, the infrared emission head and the infrared receiving head are in alignment, and the actual error in the horizontal moving process is calibrated and eliminated.

[0026] Preferably, the emission angle adjusting assembly comprises:

[0027] A rudder engine fixed to the side of the carrier block, and a swing rod fixedly connected with the output shaft of the rudder engine; the exit head is arranged at the front end of the swing rod.

[0028] Overall, the above technical scheme conceived by the utility model compared with the prior art can achieve the following beneficial effects:

[0029] (1) The saline dispensing device for red blood cell osmotic fragility test of the utility model is based on a mobile hovering injection saline filling mode, a horizontal moving unit is arranged to realize the movement of the injection head above the test tube group, and the material resource waste problem caused by the traditional "one tube one way" scheme is solved. In addition, a visual camera and an ejection angle adjusting assembly 320 that can accurately match the test tube port are arranged at the front end of the horizontal moving unit, which greatly avoids the technical risk of saline injection into the test tube.

[0030] (2) The saline dispensing device for red blood cell osmotic fragility test of the utility model manually clamps the test tube group to the horizontal center position by means of the center alignment unit 4 scale, calculates the distance between the two end test tubes in the test tube group through the position sensing unit 2, and uploads the distance to the main controller. After the number of test tubes is specified in advance in the main controller, the distance of each test tube relative to the horizontal center point of the device can be calculated through the interval / test tube fixed number, and the movement error in the complete horizontal movement process can be eliminated through the center correction assembly 310, so that the horizontal movement error is eliminated under the premise of improving the execution speed of the horizontal moving unit. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 It is a whole structure schematic view of the saline dispensing device for red blood cell osmotic fragility test of the utility model embodiment;

[0032] Figure 2 It is a side view structure schematic view of the saline dispensing device for red blood cell osmotic fragility test of the utility model embodiment;

[0033] Figure 3 It is an enlarged structure schematic view of the saline dispensing unit of the saline dispensing device for red blood cell osmotic fragility test of the utility model embodiment;

[0034] Figure 4 It is a local enlarged view A of the saline dispensing device for red blood cell osmotic fragility test of the utility model embodiment;

[0035] Figure 5 It is an internal transmission structure schematic view of the position sensing unit of the saline dispensing device for red blood cell osmotic fragility test of the utility model embodiment;

[0036] Figure 6The utility model discloses a test tube group structure schematic diagram of saline water deployment device for red blood cell osmotic fragility test.

[0037] In all drawings, same reference signs represent same technical features, specifically: 1 - main casing, 100 - side support body, 101 - bottom placing table, 102 - top eave, 103 - bottle body placing hole, 2 - position mark sensing unit, 201 - first horizontal sliding slot, 202 - adjusting block, 203 - pointer, 204 - inner connecting rod, 205 - sliding block, 206 - light pole, 207 - distance measuring sensor, 3 - saline water deployment unit, 301 - threaded transmission block, 302 - middle connecting block, 303 - carrier block, 304 - horizontal transmission screw rod, driving motor, 310 - middle position correction assembly, 311 - infrared emission head, 312 - infrared receiving head, 320 - emission angle adjustment assembly, 321 - rudder, 322 - swing rod, 330 - visual camera, 340 - saline water injection assembly, 341 - flow guide pipe, 342 - emission head, 343 - liquid storage tank, 3431 - fixed ratio saline water, 3432 - distilled water, 4 - center alignment unit, 401 - sliding clamp plate, 402 - second horizontal sliding slot, 403 - scale, 5 - test tube group, 501 - test tube rack, 502 - end test tube. DETAILED DESCRIPTION

[0038] In the description of the present application, it needs to be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present utility model and simplifying the description, and cannot be understood as indicating or implying that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present utility model.

[0039] In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "multiple" is two or more than two, unless otherwise specifically limited.

[0040] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0041] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the present utility model and are not intended to limit the present utility model. Furthermore, the technical features involved in the various embodiments of the present utility model described below can be combined with each other as long as they do not conflict with each other.

[0042] like Figures 1-6 As shown in this embodiment of the invention, the saline preparation device for the erythrocyte osmotic fragility test includes:

[0043] The main housing 1 includes a side support 100, a bottom placement platform 101 located below the front side of the side support 100 for placing the test tube assembly 5, a top extension 102 located above the front side of the side support 100, and a bottle placement hole 103 for placing a storage tank 343 containing a fixed ratio of saline and distilled water; the test tube assembly 5 includes a test tube rack 501 and internal test tubes;

[0044] A position sensor unit 2 is installed on the front side of the bottom placement platform 101 to measure the distance between the first and last test tubes of the test tube group 5.

[0045] A saline preparation unit 3, located on the top extension 102 for injecting saline solution into the test tube group 5 below, includes a horizontal moving unit located within the top extension 102, a saline injection assembly 340 located at the output end of the horizontal moving unit, a visual camera located at the output end of the horizontal moving unit for capturing and positioning the test tube opening, and an injection angle adjustment assembly 320 located at the output end of the horizontal moving unit for adjusting the injection angle of the saline injection assembly 340. The saline injection assembly 340 includes an injection head 342, a guide tube connected to the storage tank 343, and a metering pump.

[0046] Position the test tube group 5 to the center alignment unit 4 in the middle of the bottom placement platform 101;

[0047] The main controller used for device information processing and control;

[0048] The test tube group 5 to be loaded is placed on the bottom placement table 101, the center alignment unit 4 is used to place the test tube group 5 in the center, the distance between the front and rear test tubes of the test tube group 5 is measured by the position mark sensing unit 2, the horizontal movement unit is guided to move quickly to the top of the test tube relative to the device center, the visual camera 330 and the emission angle adjustment assembly 320 are used to align the emission head 342 with the test tube opening, and the fixed ratio of saline and distilled water is injected into the test tube by starting the quantitative pump.

[0049] In the embodiment of the utility model, based on the mobile hovering injection salt water filling mode, the horizontal movement unit is arranged to realize the movement of the injection head above the test tube group, and the material resource waste problem caused by the traditional 'one tube one way' scheme is solved; in addition, the visual camera and the emission angle adjustment assembly 320 that can accurately match the test tube opening are arranged at the front end of the horizontal movement unit, and the technical risk of salt water injection outside the test tube is greatly avoided.

[0050] As shown in Figure 1 , Figure 2 and Figure 6 , in the embodiment of the utility model, the center alignment unit 4 comprises:

[0051] The second horizontal sliding groove 402 is arranged on the upper surface of the bottom placement table 101, and a pair of sliding clamping plates 401 are slidably connected with the second horizontal sliding groove 402.

[0052] As shown in Figure 1 , Figure 2 and Figure 6 , in the embodiment of the utility model, the center alignment unit 4 further comprises a scale 403 arranged along the direction of the second horizontal sliding groove 402 and at the side of the second horizontal sliding groove 402.

[0053] As shown in Figure 1 , Figure 2 , Figure 4 and Figure 5 , in the embodiment of the utility model, the position mark sensing unit 2 comprises:

[0054] The first horizontal sliding groove 201 is arranged on the front side of the bottom placement table 101, the inner connecting rod 204 is horizontally slidably connected with the first horizontal sliding groove 201, the adjusting block 202 is arranged at the outer end of the inner connecting rod 204, the pointer 203 is arranged above the adjusting block 202 and used to point to the central axis position of the test tube at the inner end of the test tube group, the sliding block 205 is fixed to the inner end of the inner connecting rod 204, the light rod is fixed to the inside of the bottom placement table 101 and parallel to the first horizontal sliding groove 201, and the sliding block 205 is slidably connected with the light rod in a sleeving mode;

[0055] The sliding block 205 is a pair of sliding blocks, and the distance measuring sensor 207 for measuring the distance is arranged on the opposite surfaces of the pair of sliding blocks 205.

[0056] By manually adjusting the left and right adjustment blocks 202, the pointer 203 is made to point to the central axis of the test tube at the end of the test tube group. At this time, the distance sensor 207 transmits the distance between the two test tubes in the test tube group to the main controller, and guides the horizontal moving unit to move at a fixed point according to the number of test tubes.

[0057] like Figure 3 As shown in this embodiment of the invention, the horizontal moving unit includes:

[0058] The drive motor is fixed inside the top protruding eave 102; the horizontal transmission screw 304 is horizontally fixedly connected to the output shaft of the drive motor; the threaded transmission block 301 maintains horizontal transmission with the horizontal transmission screw 304; the intermediate connecting block 302 is fixedly connected to the lower part of the threaded transmission block 301; and the carrier block 303 is provided below the intermediate connecting block 302.

[0059] A horizontal slot for passing through the intermediate connecting block 302 is provided below the top protruding eave 102.

[0060] like Figures 1-3 As shown in this embodiment of the invention, the saline solution preparation unit 3 further includes a centering correction component 310, which includes:

[0061] The top protruding eaves 102 extend downwards from the front edge, the infrared transmitter 311 is located at the horizontal center of the inner side of the edge, and the infrared receiver 312 is fixed to the left side of the carrier block 303 and positioned opposite to the infrared transmitter 311.

[0062] When the carrier block moves to the middle of the device under the action of the horizontal moving unit, the infrared transmitter 311 and the infrared receiver 312 shoot at each other to calibrate and eliminate the actual error during the horizontal movement process.

[0063] In this embodiment of the invention, the test tube group is manually clamped to a horizontal position using the scale of the center alignment unit 4. The distance between the two ends of the test tube group is calculated by the position sensor unit 2 and uploaded to the main controller. After specifying the number of test tubes in advance in the main controller, the distance of each test tube relative to the horizontal center point of the device can be calculated by dividing the distance by the fixed number of test tubes. The center alignment component 310 is used to eliminate the movement error during each complete horizontal movement process, thereby improving the execution speed of the horizontal movement unit while eliminating the horizontal movement error.

[0064] like Figure 3 As shown in this embodiment of the invention, the emission angle adjustment component 320 includes:

[0065] A steering engine 321 is fixed to the side of the carrier block 303, and a swing rod 322 is fixedly connected with the output shaft of the steering engine 321; the exit head 342 is arranged at the front end of the swing rod 322.

[0066] The above merely describes the preferred embodiments of the present application, and is not used to limit the present application, any modification, equivalent replacement and improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application. The above is only the preferred embodiment of the present application, and it should be pointed out that, for the ordinary skilled in the art, without departing from the technical principle of the present application, a number of improvements and variations can be made, and these improvements and variations shall be regarded as the protection scope of the present application.

Claims

1. A saline preparation device for a red blood cell osmotic fragility test, characterized in that, The utility model relates to a kind of automatic pipette filling device, including: Main shell (1), it includes side support body (100), bottom placement table (101) for placing test tube group (5) is arranged below the front side of the side support body (100), top eaves (102) is arranged above the front side of the side support body (100), bottle body placement hole (103) for placing the bottle body of proportioned saline and distilled water storage tank (343) is arranged;The test tube group (5) includes test tube rack (501) and internal test tube; Position mark sensing unit (2) is arranged on the front side of the bottom placement table (101) for measuring the length of the distance between the first and last test tubes of the test tube group (5); Saline dispensing unit (3) is arranged on the top eaves (102) for injecting saline into the test tube group (5) below, which includes a horizontal moving unit arranged in the top eaves (102), a saline injection assembly (340) arranged at the output end of the horizontal moving unit, a visual camera arranged at the output end of the horizontal moving unit for capturing the position of the test tube opening, and a shooting angle adjusting assembly (320) mounted at the output end of the horizontal moving unit for adjusting the exit angle of the saline injection assembly (340);The saline injection assembly (340) includes an exit head (342), a flow guide pipe connected to the storage tank (343), and a quantitative pump; Center alignment unit (4) for positioning the test tube group (5) to the middle position of the bottom placement table (101); Main controller for device information processing and control; Place the test tube group (5) to be filled on the bottom placement table (101), use the center alignment unit (4) to place it in the middle position, and measure the distance between the first and last test tubes of the test tube group (5) by the position mark sensing unit (2) to guide the horizontal moving unit to move quickly to the position directly above the test tube relative to the center of the device, and align the exit head (342) with the test tube opening through the visual camera (330) and the shooting angle adjusting assembly (320), and start the quantitative pump to inject proportioned saline and distilled water into the test tube according to a fixed ratio.

2. The saline preparation device for red blood cell osmotic fragility test according to claim 1, characterized in that, The center alignment unit (4) includes: A second horizontal sliding groove (402) arranged on the upper surface of the bottom placement table (101), and a pair of sliding clamping plates (401) in sliding connection with the second horizontal sliding groove (402).

3. The saline preparation device for red blood cell osmotic fragility test according to claim 2, characterized in that, The center alignment unit (4) further includes a scale (403) arranged along the direction of the second horizontal sliding groove (402) and at the side edge thereof.

4. The saline preparation device for red blood cell osmotic fragility test according to claim 1, characterized in that, The position mark sensing unit (2) includes: A first horizontal sliding groove (201) arranged on the front side of the bottom placement table (101), an inner connecting rod (204) in horizontal sliding connection with the first horizontal sliding groove (201), an adjusting block (202) arranged at the outer end of the inner connecting rod (204), a pointer (203) arranged above the adjusting block (202) for pointing to the central axis position of the end test tube in the test tube group, a sliding block (205) fixed at the inner end of the inner connecting rod (204), and a light rod fixed in parallel with the first horizontal sliding groove (201) inside the bottom placement table (101), the sliding block (205) and the light rod are in sleeve sliding connection. The slider (205) is a pair, and the distance measuring sensor (207) for measuring the distance is arranged on the opposite surface of the pair of sliders (205); By manually adjusting the left and right side adjustment blocks (202), the pointer (203) points to the axis of the end tube in the tube group, at this time the distance measuring sensor (207) transmits the distance between the two end tubes in the tube group to the main controller, and according to the number of tubes, guides the horizontal moving unit to move to the fixed point.

5. The saline preparation device for red blood cell osmotic fragility test according to claim 1, wherein The horizontal moving unit comprises: The driving motor is fixed in the top extension eave (102), the horizontal transmission screw rod (304) is coaxially and horizontally fixed connected with the output shaft of the driving motor, the threaded transmission block (301) is horizontally transmitted with the horizontal transmission screw rod (304), the intermediate connecting block (302) is fixed connected below the threaded transmission block (301), and the carrier block (303) is arranged below the intermediate connecting block (302). The top extension eave (102) is provided with a horizontal notch below for passing through the intermediate connecting block (302).

6. The saline formulation device for red blood cell osmotic fragility test according to claim 5, wherein The brine deployment unit (3) further comprises a middle correction assembly (310), which comprises: The top extension eave (102) is provided with a horizontal notch below for passing through the intermediate connecting block (302). Under the action of the horizontal moving unit, when the carrier block moves to the middle part of the device, the infrared emission head (311) and the infrared receiving head (312) are opposite, and the actual error in the horizontal moving process is calibrated and eliminated.

7. The saline formulation device for red blood cell osmotic fragility test according to claim 6, wherein The emission angle adjusting assembly (320) comprises: The rudder (321) is fixed on the side surface of the carrier block (303), and the swing rod (322) is fixed connected with the output shaft of the rudder (321); the emission head (342) is arranged at the front end of the swing rod (322).

Images