Nucleic acid extractor

Abstract

The utility model provides a nucleic acid extractor. The nucleic acid extractor comprises a shell, a partition plate, a magnetic bar sleeve mechanism and a magnetic bar frame mechanism, a deep hole plate sliding plate used for bearing the deep hole plate assembly is arranged on the outer surface of the shell in a sliding mode, and a detachable magnetic rod sleeve is arranged on the deep hole plate assembly; the partition plate is vertically arranged in the shell; the magnetic rod sleeve mechanism comprises a magnetic rod sleeve assembly and a magnetic rod sleeve driving part which are connected, the magnetic rod sleeve assembly is arranged on one side of the partition plate in a sliding mode and used for fixing or loosening a magnetic rod sleeve, and the magnetic rod sleeve driving part is used for driving the magnetic rod sleeve assembly to ascend and descend; the magnetic bar frame mechanism comprises a magnetic bar frame assembly and a magnetic bar frame driving part which are connected, the magnetic bar frame assembly is arranged on one side of the partition plate in a sliding mode, and the magnetic bar frame driving part is used for driving the magnetic bar frame assembly to ascend and descend; wherein the magnetic bar sleeve driving part and the magnetic bar frame driving part are arranged on the other side of the partition plate in parallel and located at the bottom of the partition plate. The problem that an existing nucleic acid extraction instrument is large in occupied space can be solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to nucleic acid extraction technical field, specifically, relate to a nucleic acid extraction instrument. BACKGROUND

[0002] Nucleic acid research is an important subject in modern biology, medical research, with the process of biological test tends to automation and the rise of various laboratory workstation instruments, nucleic acid extraction instrument more and more towards energy saving, space saving, one machine multi -functional characteristics development, after adding nucleic acid extraction instrument in the automatic process, can save working time, reduce labor cost and can avoid the cross infection produced during the transfer, the nucleic acid extraction instrument of the prior art is to improve the working efficiency of nucleic acid extraction, often adopts various feeding structures and dismounting magnetic bar sleeve structure, because the movement structure and driving part in the nucleic acid extraction instrument are in various installation positions, the space layout is complex, leading to oversize, not only occupies a certain space, waste resources, at the same time, it will increase the complexity of the transfer process.

[0003] Therefore, how to provide a nucleic acid extraction instrument that saves space has become a technical problem that needs to be solved in the field. UTILITY MODEL CONTENT

[0004] In view of the deficiencies in the prior art, the utility model aims at providing a nucleic acid extraction instrument to solve the problem of large space occupation of nucleic acid extraction instrument.

[0005] The above technical purpose of the utility model is realized by the following technical scheme:

[0006] A nucleic acid extraction instrument, comprising: a shell, a partition plate, a magnetic bar sleeve mechanism and a magnetic bar rack mechanism; the outer surface of the shell is slidably provided with a deep hole plate sliding plate for carrying a deep hole plate assembly, and a detachable magnetic bar sleeve is arranged on the deep hole plate assembly; the partition plate is vertically arranged in the shell; the magnetic bar sleeve mechanism comprises a magnetic bar sleeve assembly and a magnetic bar sleeve driving part connected with each other, the magnetic bar sleeve assembly is slidably arranged on one side of the partition plate, and is used for fixing or loosening the magnetic bar sleeve; the magnetic bar sleeve driving part is used for driving the magnetic bar sleeve assembly to lift; the magnetic bar rack mechanism comprises a magnetic bar rack assembly and a magnetic bar rack driving part connected with each other, the magnetic bar rack assembly is slidably arranged on one side of the partition plate, and the magnetic bar sleeve driving part is used for driving the magnetic bar rack assembly to lift; wherein the magnetic bar sleeve driving part and the magnetic bar rack driving part are arranged side by side on the other side of the partition plate and located at the bottom of the partition plate.

[0007] Further, the magnetic bar sleeve assembly comprises a magnetic bar sleeve seat and a locking mechanism arranged on the magnetic bar sleeve seat, the magnetic bar sleeve is detachably connected with the magnetic bar sleeve seat, and the locking mechanism is used for locking the magnetic bar sleeve and the magnetic bar sleeve seat.

[0008] Further, the nucleic acid extractor comprises a push plate assembly, the push plate assembly comprises a push plate fixing seat and a push plate connected with each other, the push plate fixing seat is fixed on the partition plate, and the push plate is movably arranged on the push plate fixing seat, and the push plate is used for pushing the locking mechanism to move.

[0009] Further, the push plate assembly further comprises a guide shaft, one end of the guide shaft is telescopically connected with the push plate fixing seat, the other end of the guide shaft is connected with the push plate and is used for supporting the push plate, and a push plate driving component is connected with the guide shaft and is used for driving the guide shaft to telescopically move on the push plate fixing seat so as to drive the push plate to move.

[0010] Further, the shell is provided with an inlet and an outlet corresponding to the deep hole plate assembly, the deep hole plate sliding plate is connected with sliding members on both sides, the deep hole plate sliding plate slides along the sliding members and drives the deep hole plate assembly to reciprocate in the inlet and the outlet.

[0011] Further, the nucleic acid extractor comprises a front door lifting assembly, the front door lifting assembly is arranged on the partition plate in a sliding mode along a vertical direction, and the front door lifting assembly is located outside the magnetic rod sleeve assembly and the magnetic rod frame assembly and is used for covering the inlet and the outlet.

[0012] Further, the shell comprises a base, the partition plate is connected with the base, the deep hole plate sliding plate is located on the top of the base, an assembly chamber is formed in the base and is used for mounting components.

[0013] Further, the nucleic acid extractor comprises a heating module arranged in the assembly chamber, the top of the base is provided with a heating opening corresponding to the deep hole plate assembly, one side of the heating module is arranged on the partition plate in a sliding mode, and the heating module can ascend to the lower side of the heating opening along the partition plate.

[0014] Further, the nucleic acid extractor further comprises a heating component sliding base arranged in the assembly chamber and movably connected with the heating module, the heating component sliding base moves to drive the heating module to move, and a heating component driving mechanism is connected with the heating component sliding base and is used for driving the heating component sliding base to move.

[0015] Further, the nucleic acid extractor further comprises an anti-dripping plate, anti-dripping plate sliding rail assemblies are arranged on both sides of the top of the base, and the anti-dripping plate is arranged on the anti-dripping plate sliding rail assemblies in a sliding mode through connecting portions and moves from the inlet and the outlet to the shell.

[0016] The nucleic acid extractor provided by the embodiment has the following beneficial effects:

[0017] The nucleic acid extractor provided by the embodiment has the following beneficial effects: BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required to be used in the embodiments of the present application will be briefly introduced as follows.

[0019] Figure 1 The structure schematic diagram of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 1.

[0020] Figure 2 The internal structure schematic diagram of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 2.

[0021] Figure 3 The internal structure schematic diagram of the nucleic acid extractor shown in another embodiment of the present application is shown in FIG. 3.

[0022] Figure 4 The structure schematic diagram of the deep-well plate assembly and the drip-proof plate of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 4.

[0023] Figure 5 The structure schematic diagram of the push plate assembly of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 5.

[0024] Figure 6 The structure schematic diagram of the locking mechanism of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 6.

[0025] Figure 7 The structure schematic diagram of the locking mechanism of the nucleic acid extractor shown in another embodiment of the present application is shown in FIG. 7.

[0026] Figure 8 The structure schematic diagram of the magnetic rod sleeve buckle of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 8.

[0027] Figure 9 The structure schematic diagram of the magnetic rod frame assembly of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 9.

[0028] Figure 10 The structure schematic diagram of the heating module connecting the heating component guide rail of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 10.

[0029] Figure 11 The structure schematic diagram of the heating module of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 11.

[0030] Figure 12 The structure schematic diagram of the heating component sliding base connecting the heating module of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 12.

[0031] Figure 13 The internal structure schematic diagram of the base of the nucleic acid extractor shown in an embodiment of the present application is shown in FIG. 13.

[0032] Reference signs:

[0033] Housing 1; import and export 11; base 12; sliding base guide rail 121; assembly chamber 13; heating port 14; cover body 15; perspective window 16; deep hole plate sliding plate 2; sliding piece 21; deep hole plate buckle 22; deep hole plate assembly 3; magnetic rod sleeve 31; deep hole plate driving component 32; deep hole plate transmission component 33; partition plate 4; nucleic acid extraction chamber 41; mounting cavity 42; sliding port 43; magnetic rod guide rail assembly 44; magnetic rod sleeve mechanism 5; magnetic rod sleeve assembly 51; magnetic rod sleeve seat 511; locking mechanism 512; locking gear 5121; locking rack 5122; roller assembly 5123; elastic member 5124; magnetic rod sleeve buckle 5125; fixed disc 5126; magnetic rod sleeve driving component 52; first sliding seat 53; magnetic rod sleeve transmission component 54; magnetic rod holder mechanism 6; magnetic rod holder assembly 61; first magnetic rod holder fixed plate 611; second magnetic rod holder fixed plate 612; magnetic rod 613; magnetic rod holder driving component 62; second sliding seat 63; magnetic rod holder transmission component 64; push plate assembly 7; push plate 71; push plate fixed seat 72; guide shaft 73; push plate driving component 74; push plate induction sensor 75; induction sheet metal 76; front door lifting assembly 8; front door lifting slide rail assembly 81; front door support 82; front door lifting transmission component 83; front door lifting driving component 84; heating module 9; heating component sliding base 91; sliding support plate 911; guide groove 912; moving plate 921; screw nut 922; lead screw 923; heating component driving motor 924; heating component guide rail 93; heat conduction plate 94; heating plate 95; refrigeration fin 96; cooling fin 97; heating component fixed plate 98; heating component side plate 99; rolling bearing 991; thermal insulation cotton 992; fan 993; anti-dripping plate 10; anti-dripping plate slide rail assembly 101; connecting portion 102; anti-dripping plate driving component 103; anti-dripping plate transmission component 104. DETAILED DESCRIPTION

[0034] In the description of the present application, it should be noted that the terms "in", "out" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship commonly used when the product of the present application is used, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", etc. are only used for differentiation and cannot be understood as indicating or implying relative importance.

[0035] The utility model discloses a nucleic acid extractor to solve the problem of large space occupation in the prior art.

[0036] The technical solutions in the embodiments of the present application will be described below with reference to the drawings in the embodiments of the present application.

[0037] Referring toFigures 1-4 The embodiment of the application provides a nucleic acid extractor, which comprises a shell 1, a partition plate 4, a magnetic rod sleeve mechanism 5 and a magnetic rod frame mechanism 6.

[0038] The outer surface of the shell 1 is slidably provided with a deep hole plate sliding plate 2 for carrying a deep hole plate assembly 3, and the deep hole plate assembly 3 is provided with a detachable magnetic rod sleeve 31.

[0039] The partition plate 4 is vertically arranged in the shell 1.

[0040] The magnetic rod sleeve mechanism 5 comprises a magnetic rod sleeve assembly 51 and a magnetic rod sleeve driving part 52 connected with each other, the magnetic rod sleeve assembly 51 is slidably arranged on one side of the partition plate 4 and used for fixing or loosening the magnetic rod sleeve 31, and the magnetic rod sleeve driving part 52 is used for driving the magnetic rod sleeve assembly 51 to ascend and descend.

[0041] The magnetic rod frame mechanism 6 comprises a magnetic rod frame assembly 61 and a magnetic rod frame driving part 62 connected with each other, the magnetic rod frame assembly 61 is slidably arranged on one side of the partition plate 4, and the magnetic rod sleeve driving part 52 is used for driving the magnetic rod frame assembly 61 to ascend and descend.

[0042] The magnetic rod sleeve driving part 52 and the magnetic rod frame driving part 62 are arranged side by side on the other side of the partition plate 4 and located at the bottom of the partition plate 4.

[0043] In the embodiment of the application, the magnetic rod sleeve driving part 52 and the magnetic rod frame driving part 62 are arranged side by side at the bottom of the other side of the partition plate 4, the space occupied by the driving parts is reduced, the height space of the nucleic acid extractor is reduced, a larger space is provided for installing other installation structures, the driving parts of the nucleic acid extractor are more firmly installed, the problem of part falling caused by collision in the carrying process is reduced, and the stability is higher.

[0044] In an embodiment, the magnetic rod sleeve driving part 52 can be a motor, and the magnetic rod frame driving part 62 can be a motor.

[0045] In the above embodiment, the partition plate 4 is vertically arranged in the shell 1, and the inner part of the shell 1 is divided into a nucleic acid extraction chamber 41 and a mounting chamber 42, wherein the magnetic rod sleeve assembly 51 and the magnetic rod frame assembly 61 are located in the nucleic acid extraction chamber 41, the magnetic rod sleeve driving part 52 and the magnetic rod frame driving part 62 are located in the mounting chamber 42, and the magnetic rod sleeve assembly 51 is located at the bottom of the magnetic rod frame assembly 61, so that the magnetic rod frame assembly 61 can disassemble the magnetic rod sleeve 31 fixed by the magnetic rod sleeve assembly 51.

[0046] In an embodiment, the partition plate 4 is provided with a vertical sliding opening 43, and at least two magnetic rod guide rail assemblies 44 are arranged on one side of the partition plate 4, which are vertically arranged on both sides of the sliding opening 43. The magnetic rod sleeve assembly 51 is connected with a first sliding seat 53, the two sides of the end of the first sliding seat 53 away from the magnetic rod sleeve assembly 51 are clamped on the magnetic rod guide rail assembly 44, and the first sliding seat 53 slides along the magnetic rod guide rail assembly 44. The magnetic rod frame assembly 61 is connected with a second sliding seat 63, the two sides of the end of the second sliding seat 63 away from the magnetic rod frame assembly 61 are clamped on the magnetic rod guide rail assembly 44, and the second sliding seat 63 slides along the magnetic rod guide rail assembly 44.

[0047] The magnetic rod sleeve mechanism 5 further comprises a magnetic rod sleeve transmission component 54 arranged on one side of the partition plate 4 close to the magnetic rod sleeve assembly 51. The magnetic rod sleeve transmission component 54 comprises a first transmission belt and a first transmission wheel. The first transmission wheel is vertically spaced apart on the partition plate 4 and connected with the magnetic rod sleeve driving component 52. The first transmission belt is arranged on the first transmission wheel, and the first sliding seat 53 is clamped on the first transmission belt. The magnetic rod sleeve driving component 52 drives the first transmission wheel to rotate to drive the first transmission belt to move, so as to drive the first sliding seat 53 to move, and finally make the magnetic rod sleeve assembly 51 move up and down.

[0048] The magnetic rod frame mechanism 6 further comprises a magnetic rod frame transmission component 64 arranged on one side of the partition plate 4 close to the magnetic rod frame assembly 61. The magnetic rod frame transmission component 64 comprises a second transmission belt and a second transmission wheel. The second transmission wheel is vertically spaced apart on the partition plate 4 and connected with the magnetic rod frame driving component 62. The second transmission belt is arranged on the second transmission wheel, and the second sliding seat 63 is clamped on the second transmission belt. The magnetic rod frame driving component 62 drives the second transmission wheel to rotate to drive the second transmission belt to move, so as to drive the second sliding seat 63 to move, and finally make the magnetic rod frame assembly 61 move up and down.

[0049] In an embodiment, the magnetic rod sleeve assembly 51 comprises a magnetic rod sleeve seat 511 and a locking mechanism 512 arranged on the magnetic rod sleeve seat 511. The magnetic rod sleeve 31 is detachably connected with the magnetic rod sleeve seat 511, and the locking mechanism 512 is used for fixing the magnetic rod sleeve 31 and the magnetic rod sleeve seat 511.

[0050] In an embodiment, the nucleic acid extractor further comprises a push plate assembly 7, which comprises a push plate fixing seat 72 and a push plate 71 connected with each other. The push plate fixing seat 72 is fixed on the partition plate 4 and located on one side of the partition plate 4 close to the installation cavity 42.

[0051] The partition plate 4 is provided with a pushing opening (not labeled in the figure), and the push plate 71 is movably arranged on the push plate fixing seat 72 and passes through the pushing opening to push the locking mechanism 512 to move.

[0052] The push plate assembly 7 further comprises a push plate driving component 74 connected to the push plate fixing seat 72, for driving the push plate 71 to move in and out.

[0053] In an embodiment, the shell 1 comprises a base 12 and a cover 15 connected to the top of the base 12, the cover 15 is arranged on one side of the base 12, the partition plate 4 is located in the cover 15, and the nucleic acid extraction chamber 41 and the installation chamber 42 are located in the cover 15. The cover 15 is provided with an inlet and outlet 11 corresponding to the deep well plate assembly 3, the deep well plate sliding plate 2 is slidingly arranged on the upper surface of the base 12, and the deep well plate sliding plate 2 is detachably connected to the deep well plate assembly 3 through the deep well plate buckle 22. The deep well plate assembly 3 is driven to slide into the nucleic acid extraction chamber 41 from the inlet and outlet 11 or slide out of the nucleic acid extraction chamber 41 through the deep well plate sliding plate 2.

[0054] In the embodiment, the movement mode of the deep well plate assembly 3 is arranged to move towards the partition plate 4 and away from the partition plate 4, and the activity space is limited to the upper side of the base 12, thereby saving the occupation of the left and right spaces of the nucleic acid extractor.

[0055] The cover 15 is further provided with a perspective window 16, the perspective window 16 is located on the side of the cover 15 and the upper side of the inlet and outlet 11, and the perspective window 16 is respectively covered with a transparent acrylic plate, for a user to observe the working state in the nucleic acid extraction chamber 41.

[0056] In an embodiment, the nucleic acid extractor further comprises a front door lifting assembly 8, the front door lifting assembly 8 is slidingly arranged on the partition plate 4 in the vertical direction, and the front door lifting assembly 8 is located outside the magnetic rod sleeve assembly 51 and the magnetic rod holder assembly 61, for being lowered to the inlet and outlet 11 when the magnetic rod sleeve assembly 51 is fixed with the magnetic rod sleeve 31 and performs the oscillation process, so as to cover the inlet and outlet 11.

[0057] In the embodiment, the front door lifting assembly 8 is arranged to cover the inlet and outlet 11 when the nucleic acid extractor performs the oscillation reaction, so that the nucleic acid extraction chamber 41 forms a closed space. On the one hand, it prevents the reagent from splashing out of the magnetic rod sleeve 31 during the oscillation process, thereby preventing the reagent from polluting other reagents outside the shell 1. On the other hand, the closed space can also prevent the external air from polluting the reagent in the magnetic rod sleeve 31, thereby affecting the accuracy of the extraction result.

[0058] In an embodiment, the front door lifting slide rail assembly 81 is arranged on the partition plate 4, and the front door lifting slide rail assembly 81 is arranged in two, and the two front door lifting slide rail assemblies 81 are arranged on the two sides of the partition plate 4 respectively, and the front door lifting assembly 8 is slidably arranged on the front door lifting slide rail assembly 81 through the front door support 82, and the corresponding nucleic acid extractor further comprises a front door lifting transmission component 83 and a front door lifting driving component 84 connected with each other, and the front door lifting driving component 84 is arranged on one side of the partition plate 4 close to the installation cavity 42, and the front door lifting transmission component 83 is arranged on one side of the partition plate 4 close to the nucleic acid extraction chamber 41.

[0059] The front door lifting driving component 84 can be a motor.

[0060] The front door lifting transmission component 83 comprises a third transmission belt and a third transmission wheel, the third transmission wheel is connected with the front door lifting driving component 84, the third transmission belt is sleeved on the third transmission wheel, and the front door support 82 is clamped on the third transmission belt, and the third transmission wheel is driven to rotate by the front door lifting driving component 84 to drive the third transmission belt to move, so as to drive the front door lifting assembly 8 to move up and down along the slide rail assembly.

[0061] In an embodiment, the shell 1 comprises a base 12, the partition plate 4 is connected with the base 12, the deep hole plate sliding plate 2 is located on the top of the base 12, the base 12 is formed with an assembly chamber 13 for installing components, and the assembly chamber 13 is in communication with the installation cavity 42, so as to install components.

[0062] In an embodiment, the nucleic acid extractor comprises a heating module 9, the heating module 9 is arranged in the assembly chamber 13, and a heating port 14 corresponding to the deep hole plate assembly 3 is formed on the top of the base 12, one side of the heating module 9 is slidably arranged on the partition plate 4, and the heating module 9 can be lifted to the lower side of the heating port 14 along the partition plate 4, so as to heat the reagent in the magnetic rod sleeve 31 in the deep hole plate assembly 3 slid to the heating port 14.

[0063] In an embodiment, as shown in Figures 3-4 The nucleic acid extractor further comprises an anti-dripping plate 10, the top of the base 12 is provided with an anti-dripping plate slide rail assembly 101 on both sides, and the two sides of the anti-dripping plate 10 are slidably arranged on the anti-dripping plate slide rail assembly 101 through a connecting portion 102, and are moved from the inlet and outlet 11 to the shell 1, that is, the anti-dripping plate 10 reciprocates along the direction close to and away from the partition plate 4.

[0064] The drip-proof plate 10 can be located on the top of the deep-well plate assembly 3, and is used to slide away from the direction of the partition plate 4 during the oscillation reaction of the nucleic acid extractor, until being located on the base 12 away from one side of the deep-well plate assembly 3, so as to prevent the liquid splashed from the magnetic rod sleeve 31 from dropping on the base 12, thereby preventing the reagent from contaminating the workbench, and the connection and movement mode of the drip-proof plate 10 can further reduce the left and right space occupied by the nucleic acid extractor.

[0065] In the embodiment, some transmission components and driving components are fixed on the partition plate 4, so that the occupied space is reduced, the positioning reference is ensured, the assembly error is reduced, and the subsequent maintenance work is facilitated.

[0066] Referring to Figures 5-8 In an embodiment, the push plate assembly 7 further comprises a guide shaft 73, one end of the guide shaft 73 is telescopically connected to a push plate fixing seat 72, the other end of the guide shaft 73 is connected to the push plate 71 for supporting the push plate 71, and a push plate driving component 74 is arranged on the push plate fixing seat 72 and connected to one end of the guide shaft 73 for driving the guide shaft 73 to telescopically extend on the push plate fixing seat 72, so as to drive the push plate 71 to move.

[0067] The push plate assembly 7 further comprises a push plate induction sensor 75 and an induction sheet metal 76, the push plate induction sensor 75 is fixedly installed on the push plate fixing seat 72 and connected to a controller (not shown in the figure) of the nucleic acid extractor, so as to transmit an induction signal to the controller of the nucleic acid extractor and transmit the induction signal to the platform workstation through the controller.

[0068] The induction sheet metal 76 is arranged on the push plate 71 close to one side of the push plate induction sensor 75, and is arranged corresponding to the push plate induction sensor 75, when the induction sheet metal 76 moves towards the direction close to the push plate induction sensor 75, the magnetic field changes, the push plate induction sensor 75 senses the change of the magnetic field, generates a corresponding induction signal, and transmits the induction signal to the controller, so as to detect the state of the push plate 71.

[0069] The locking mechanism 512 comprises a locking gear 5121, a locking rack 5122, a roller assembly 5123, an elastic member 5124, a magnetic rod sleeve buckle 5125, and a fixing disc 5126.

[0070] The locking gear 5121, the locking rack 5122, and the roller assembly 5123 are arranged on the side of the magnetic rod sleeve seat 511 away from the magnetic rod sleeve 31, and the fixing disc 5126 is arranged on the side of the magnetic rod sleeve seat 511 for fixing the magnetic rod sleeve 31.

[0071] The locking gear 5121 is arranged on the magnetic rod sleeve base 511 of the magnetic rod sleeve assembly 51, and the locking gear 5121 is arranged in multiple, and the multiple locking gears 5121 are arranged on both sides of the magnetic rod sleeve base 511, and the locking rack 5122 is arranged between the side of the locking base 12 and the locking gear 5121, and is used for moving forward and backward in the horizontal direction to drive the locking gear 5121 to rotate.

[0072] The roller assembly 5123 is installed at one end of the locking rack 5122, and is used for contacting the push plate 71 of the push plate assembly 7 to drive the locking rack 5122 to move.

[0073] The elastic member 5124 is arranged at one end of the locking rack 5122 away from the roller assembly 5123, and is located between the inner wall of the magnetic rod sleeve base 511 and the outer surface of the locking rack 5122, and is used for resetting the locking rack 5122.

[0074] The fixing disc 5126 is installed on one side of the magnetic rod sleeve base 511 close to the magnetic rod sleeve 31, and rotates coaxially with the locking gear 5121, and the fixing disc 5126 is provided with a limiting portion, and the limiting portion is abutted on the magnetic rod sleeve 31 by rotating the fixing disc 5126, so as to support the magnetic rod sleeve base 511 and the magnetic rod sleeve 31, so as to unlock the connection between the magnetic rod sleeve 31 and the magnetic rod sleeve base 511, and vice versa, the limiting portion is separated from the magnetic rod sleeve 31 by rotating the fixing disc 5126, so as to unlock the connection between the magnetic rod sleeve 31 and the magnetic rod sleeve base 511.

[0075] In order to assist the fixing disc 5126 to fix the magnetic rod sleeve 31 and the magnetic rod sleeve base 511, a plurality of magnetic rod sleeve buckles 5125 are arranged on the side of the magnetic rod sleeve base 511, when the surface of the magnetic rod sleeve 31 is attached to the magnetic rod sleeve base 511, the side wall of the magnetic rod sleeve 31 is engaged on the magnetic rod sleeve buckle 5125, so as to strengthen the fixation of the magnetic rod sleeve 31, prevent the magnetic rod sleeve 31 from deforming, and prevent the magnetic rod sleeve 31 from falling off from the magnetic rod sleeve base 511 during subsequent operation, and has certain stability.

[0076] When the nucleic acid extractor does not receive the installation magnetic rod sleeve 31 instruction, the push plate 71 is in the retracted state, and the push plate inductive sensor 75 generates an inductive signal due to the proximity of the push plate 71 metal plate.

[0077] When the nucleic acid extractor receives the installation or disassembly of the magnetic rod sleeve 31 instruction, the push plate driving part 74 is controlled to rotate forward by the controller (not shown in the figure) to drive the guide shaft 73 to move the push plate 71 to move towards the roller assembly 5123, push the roller assembly 5123 to move a certain distance, drive the locking rack 5122 to move towards the elastic member 5124 to compress the elastic member 5124, and drive the locking gear 5121 to rotate, finally drive the fixed disc 5126 to rotate, so that the limiting part of the fixed disc 5126 is engaged with the outer surface of the magnetic rod sleeve 31, and the push plate driving part 74 stops rotating when the push plate inductive sensor 75 does not generate an inductive signal, and the installation of the magnetic rod sleeve 31 on the magnetic rod sleeve seat 511 or the disassembly process of the magnetic rod sleeve 31 is completed.

[0078] After the installation or disassembly process of the magnetic rod sleeve 31 is completed, the controller controls the push plate driving part 74 to rotate in the direction, drives the push plate 71 to move away from the roller assembly 5123, and the locking rack 5122 moves away from the elastic member 5124 under the action of the elastic force of the elastic member 5124 until it contacts the inner wall of the magnetic rod sleeve seat 511.

[0079] The embodiment of the application sets the installation and removal of the magnetic rod sleeve 31 as an automatic installation and removal structure, can realize automatic replacement, does not need manual replacement, improves work efficiency and user experience, has high flexibility, and can switch different specifications of the magnetic rod sleeve 31 according to different types of deep well plate assemblies 3, and improves the adaptability of the nucleic acid extractor.

[0080] Referring to Figure 9 In an embodiment, the magnetic rod holder assembly 61 includes a first magnetic rod holder fixed plate 611, a second magnetic rod holder fixed plate 612, and a plurality of magnetic rods 613.

[0081] The first magnetic rod holder fixed plate 611 is fixed to one end of the second sliding seat 63.

[0082] The second magnetic rod holder fixed plate 612 is fixed to the bottom surface of the first magnetic rod holder fixed plate 611, and correspondingly, the magnetic rod 613 is detachably installed on the bottom surface of the second magnetic rod holder fixed plate 612 to fix the magnetic rod 613 and the second magnetic rod 613 fixed plate into a magnetic rod adapter suitable for the magnetic rod 613. At the same time, different models of magnetic rods 613 can be replaced according to different specifications of the magnetic rod sleeve 31, so that the nucleic acid extractor can adapt to different types of deep well plate assemblies 3, and has a certain flexibility.

[0083] Referring to Figures 10-13 In an embodiment, the partition plate 4 is provided with a heating component guide rail 93 on one side in the base 12, one side of the heating module 9 is connected with the heating component guide rail 93, and the heating module 9 moves up and down along the heating component guide rail 93.

[0084] In an embodiment, the nucleic acid extractor further comprises a heating component sliding base 91 and a heating component driving mechanism connecting the heating component sliding base 91, the heating component sliding base 91 is arranged in the assembly chamber 13 and is movably connected to the heating module 9, and the reciprocating movement of the heating component sliding base 91 is driven by the heating component driving mechanism to drive the heating module 9 to ascend and descend.

[0085] Specifically, the heating module 9 comprises a heat conduction plate 94, a heating plate 95, heat preservation cotton 992, a refrigeration sheet 96, a heat dissipation sheet 97, and oppositely arranged heating component fixing plates 98 and oppositely arranged heating component side plates 99.

[0086] The heating component side plates 99 are connected to the heating component fixing plates 98 to form a heating installation cavity.

[0087] The heat conduction plate 94, the heating plate 95, the refrigeration sheet 96, and the heat dissipation sheet 97 are sequentially arranged from top to bottom in the installation cavity, and the heat dissipation sheet 97 is wrapped by the heat preservation cotton 992 to keep warm.

[0088] Rolling bearings 991 are arranged on both sides of the heating component side plates 99 to cooperate with the heating component sliding base 91.

[0089] Sliding support plates 911 are arranged on both sides of the heating component sliding base 91, guide grooves 912 matching the rolling bearings 991 are formed in the sliding support plates 911, the guide grooves 912 are obliquely arranged on the sliding support plates 911, the rolling bearings 991 are clamped in the guide grooves 912 and slide along the guide grooves 912.

[0090] A sliding base guide rail 121 is arranged on the surface of the lower bottom plate of the base 12, and the bottom surface of the heating component sliding base 91 is fixed on the sliding base guide rail 121 so that the heating component sliding base 91 slides along the guide rail.

[0091] The heating component driving mechanism comprises a moving plate 921, a screw nut 922, a screw rod 923, and a heating component driving motor 924.

[0092] The moving plate 921 is connected to the screw nut 922, and the moving plate 921 is fixed on the heating component sliding base 91, the heating component driving motor 924 is fixed in the base 12 through a motor fixing seat, the screw rod 923 is connected to the side of the motor fixing seat close to the heating component sliding base 91, the screw nut 922 is sleeved on the screw rod 923, and the screw rod 923 is driven to rotate by the heating component driving motor 924 to drive the screw nut 922 to move to the side close to or away from the heating component sliding base 91, so as to drive the heating component sliding base 91 to move.

[0093] The heat-conducting plate 94 of the heating module 9 provided in this application embodiment is detachable. The corresponding heat-conducting plate 94 can be replaced according to different models, heights and structures of the deep hole plate assembly 3, which has high flexibility and improves the adaptability of the nucleic acid extractor.

[0094] Specifically, the working process of heating module 9 is as follows:

[0095] When the heating module 9 needs to heat the deep hole plate assembly 3, the heating component drive motor 924 drives the lead screw 923 to rotate, thereby driving the lead screw nut 922 to move towards the side closer to the heating component sliding base 91, so as to drive the heating component sliding base 91 to move along the sliding base guide rail 121 towards the partition 4. The rolling bearing 991 of the heating module 9 is subjected to force and slides along the bottom of the guide groove 912 to the top of the guide groove 912. At the same time, the heating module 9 rises along the heating component guide rail 93 so that the heating module 9 rises to the heating port 14, and the cooling plate 96 on the surface of the heating module 9 is used for heating to realize the heating process.

[0096] This embodiment of the application realizes the lifting and lowering movement of the heating module 9 by setting the heating component guide rail 93 and the heating component sliding base 91, which improves the balance force of the heating module 9 during the lifting and lowering process, so that the heating module 9 always maintains a balanced state when it moves to the heating port 14, ensuring uniform heating of the reagent in the magnetic rod sleeve 31 on the deep well plate assembly 3. At the same time, the heating module 9 and the mechanism that drives the movement of the heating module 9 are set in the base 12, further reducing the space occupied by the nucleic acid extractor.

[0097] Furthermore, the heating module 9 is equipped with a cooling element 96, which can perform both heating and cooling functions. After heating is completed, the cooling function can quickly reduce the temperature and improve work efficiency.

[0098] In one embodiment, the nucleic acid extractor also includes a fan 993, which is located in the assembly chamber 13 and close to the heating module 9, and is used to dissipate heat when the heating module 9 is cooled.

[0099] In one embodiment, combined with Figure 4 ,like Figure 13 As shown, the nucleic acid extractor also includes an anti-drip plate drive mechanism and a deep well plate drive mechanism located on both sides of the base 12.

[0100] The anti-drip plate drive mechanism includes an anti-drip plate drive component 103 and an anti-drip plate transmission component 104 connected to each other.

[0101] The drip-proof plate driving component 103 is arranged in the base 12, and the drip-proof plate transmission component 104 is arranged on the outer surface of the base 12, wherein the drip-proof plate transmission component 104 comprises a drip-proof plate belt and a drip-proof plate driving wheel connected with each other, one of the connecting parts 102 is clamped on the drip-proof plate belt, the drip-proof plate driving component 103 is connected with the drip-proof plate driving wheel, the drip-proof plate driving component 103 drives the drip-proof plate driving wheel to rotate to drive the drip-proof plate belt to rotate, and then drives the connecting part 102 to slide along the slide rail assembly, and finally drives the drip-proof plate 10 to move to a specified position.

[0102] The base 12 is provided with slide grooves corresponding to the two sides of the deep-well plate sliding plate 2, and the two sides of the deep-well plate sliding plate 2 are provided with slide parts 21 clamped in the slide grooves and capable of sliding to the heating port 14 along the slide grooves.

[0103] The deep-well plate driving mechanism comprises a deep-well plate driving component 32 and a deep-well plate transmission component 33 connected with each other.

[0104] The deep-well plate driving component 32 is arranged in the base 12, and the deep-well plate transmission component 33 is arranged on the outer surface of the base 12, wherein the deep-well plate transmission component 33 comprises a deep-well plate transmission belt and a deep-well plate driving wheel connected with each other, one of the slide parts 21 is clamped on the deep-well plate transmission belt, and the deep-well plate driving component 32 drives the deep-well plate transmission wheel to rotate to drive the deep-well plate transmission belt to rotate, and then drives the slide part 21 to move, so as to realize the movement of the deep-well plate sliding plate 2 to the heating port 14.

[0105] The deep-well plate driving mechanism and the drip-proof plate driving mechanism are integrated on and in the base 12, so that the space occupied by the installation components of the nucleic acid extractor can be reduced, and then the space occupied by the nucleic acid extractor can be reduced.

[0106] The nucleic acid extractor connection platform workstation provided in the embodiment of the present application sends a control instruction to the controller in the nucleic acid extractor through the platform workstation, so that the nucleic acid extractor performs corresponding operation, and the working process of the nucleic acid extractor is specifically introduced as follows:

[0107] The platform workstation sends a running instruction to the nucleic acid extractor.

[0108] The controller drives the deep-well plate sliding plate 2 to move to a material taking position (a position away from the heating port 14 on the base 12) in a direction away from the partition plate 4 and waits, the mechanical hand of the platform workstation places the deep-well plate assembly 3 provided with the magnetic rod sleeve 31 on the deep-well plate sliding plate 2, and sends a complete feeding instruction to the controller.

[0109] The controller controls the deep-well plate driving component 32 to drive the deep-well plate sliding plate 2 to move to the extraction position (i.e. the heating port 14) close to the partition plate 4, the anti-dripping plate driving component 103 drives the anti-dripping plate 10 to move away from the partition plate 4, and the magnetic rod sleeve assembly 51 is installed on the magnetic rod sleeve 31.

[0110] The controller controls the magnetic rod sleeve assembly 51 to descend to the surface of the deep-well plate assembly 3 and contact the magnetic rod sleeve 31, and controls the front door lifting assembly 8 to descend until the inlet and outlet are sealed.

[0111] The push plate driving component drives the push plate to move until the magnetic rod sleeve 31 is fixed on the magnetic rod sleeve assembly 51 by the fixing disc, and then the magnetic rod sleeve driving component 52 drives the magnetic rod sleeve assembly 51 to move upward by a first preset distance, which can be 10 mm, and can be set according to actual conditions, and is not limited in this regard.

[0112] The heating driving mechanism drives the heating module 9 to ascend to the heating port 14 and abut against the bottom of the deep-well plate sliding plate 2, the controller controls the heating module 9 to work and heat to 100℃, then the magnetic rod sleeve driving component 52 drives the magnetic rod sleeve assembly 51 to oscillate for a preset period of time, after the oscillation is completed, the heating component drives the heating module 9 to descend into the heating component sliding base 129112, and the magnetic rod 613 rack driving component drives the magnetic rod rack assembly 61 to move close to the magnetic rod sleeve assembly 51 until the magnetic rod 613 abuts against the bottom end of the magnetic rod sleeve 31, at this time, the magnetic rod sleeve assembly 51 and the magnetic rod rack assembly 61 are controlled to ascend by a second preset distance away from the deep-well plate assembly 3 synchronously, and the next process is waited, wherein the second preset distance refers to a distance set in advance according to actual conditions, and is not limited in this regard.

[0113] The front door lifting driving component 84 drives the front door lifting assembly 8 to ascend and move away from the inlet and outlet, the anti-dripping plate driving component 103 drives the anti-dripping plate 10 to move close to the partition plate 4, and the deep-well plate driving component 32 drives the deep-well plate assembly 3 to run to the material taking position, and the mechanical hand of the platform workstation takes away the deep-well plate assembly 3 and places the deep-well plate assembly 3 of the next process.

[0114] After repeating the above steps until the last process is completed, the magnetic rod 613 rack driving assembly drives the magnetic rod sleeve assembly 51 to press down to cooperate with the push plate assembly 7 to act on the locking mechanism 512, so that the magnetic rod sleeve 31 falls off from the magnetic rod sleeve seat 511 into the deep-well plate assembly 3 of the last process, and the corresponding structures are driven to move by the driving components, and finally the deep-well plate assembly 3 at the material taking position is taken away by the mechanical hand of the platform workstation, at this time, a complete working process of the nucleic acid extractor is completed.

[0115] The application reduces the size of the nucleic acid extractor by reasonably arranging the installation positions of the magnetic rod sleeve driving part 52, the magnetic rod 613 frame driving part, the push plate assembly 7, the deep hole plate driving part 32, and the anti-dripping plate driving part 103, reasonably setting the installation structure and movement structure of the anti-dripping plate 10 and the deep hole plate assembly 3, and the movement mode of the heating module 9, so that the nucleic acid extractor is more portable, saves the space when the platform workstation is used, and has higher adaptability.

[0116] In the description of the application, it should be explained that, unless otherwise explicitly specified and limited, the terms “set”, “connected” should be understood broadly, for example, can be fixedly connected, can be detachably connected, or integrally connected; can be directly connected, or indirectly connected through an intermediate medium, can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the application can be understood according to the specific circumstances.

[0117] It should be noted that the features in the embodiments of the application can be combined with each other without conflict.

[0118] The above is only the preferred embodiment of the application and is not used to limit the application. For those skilled in the art, the application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. within the spirit and principle of the application should be included in the protection scope of the application.

Claims

1. A nucleic acid extractor, characterized by, The nucleic acid extractor comprises: a shell, an outer surface of the shell being provided with a deep hole plate sliding plate for carrying a deep hole plate assembly, the deep hole plate assembly being provided with a detachable magnetic rod sleeve; a partition plate vertically arranged in the shell; a magnetic rod sleeve mechanism comprising a magnetic rod sleeve assembly and a magnetic rod sleeve driving part connected with each other, the magnetic rod sleeve assembly being slidingly arranged on one side of the partition plate and used for fixing or loosening the magnetic rod sleeve, and the magnetic rod sleeve driving part being used for driving the magnetic rod sleeve assembly to ascend and descend; a magnetic rod holder mechanism comprising a magnetic rod holder assembly and a magnetic rod holder driving part connected with each other, the magnetic rod holder assembly being slidingly arranged on one side of the partition plate, and the magnetic rod holder driving part being used for driving the magnetic rod holder assembly to ascend and descend; wherein the magnetic rod sleeve driving part and the magnetic rod holder driving part are arranged side by side on the other side of the partition plate and located at the bottom of the partition plate.

2. The nucleic acid extractor of claim 1, wherein, The magnetic rod sleeve assembly comprises a magnetic rod sleeve seat and a locking mechanism arranged on the magnetic rod sleeve seat, the magnetic rod sleeve being detachably connected with the magnetic rod sleeve seat, and the locking mechanism being used for locking the magnetic rod sleeve and the magnetic rod sleeve seat.

3. The nucleic acid extractor of claim 2, wherein, The nucleic acid extractor comprises a push plate assembly, the push plate assembly comprising a push plate fixing seat and a push plate connected with each other, the push plate fixing seat being fixed on the partition plate, and the push plate being movably arranged on the push plate fixing seat, the push plate being used for pushing the locking mechanism to move.

4. The nucleic acid extractor of claim 3, wherein, The push plate assembly further comprises: a guide shaft, one end of the guide shaft being telescopically connected with the push plate fixing seat, the other end of the guide shaft being connected with the push plate and used for supporting the push plate; a push plate driving part connected with the guide shaft and used for driving the guide shaft to telescopically extend on the push plate fixing seat so as to drive the push plate to move.

5. The nucleic acid extractor of claim 1, wherein, An inlet and outlet corresponding to the deep hole plate assembly are formed on the shell, both sides of the deep hole plate sliding plate are connected with sliding members, the deep hole plate sliding plate slides along the sliding members and drives the deep hole plate assembly to reciprocally move in the inlet and outlet.

6. The nucleic acid extractor of claim 5, wherein, The nucleic acid extractor comprises a front door lifting assembly, the front door lifting assembly being slidingly arranged on the partition plate in a vertical direction and located at the periphery of the magnetic rod sleeve assembly and the magnetic rod holder assembly and used for covering the inlet and outlet.

7. The nucleic acid extractor of claim 1, wherein, An inlet and outlet corresponding to the deep hole plate assembly are formed on the shell, the shell comprises a base, the partition plate is connected with the base, the deep hole plate sliding plate is located at the top of the base, an assembly chamber is formed in the base and used for mounting components.

8. The nucleic acid extractor of claim 7, wherein, The nucleic acid extractor comprises a heating module arranged in the assembly chamber, a heating port corresponding to the deep hole plate assembly is formed on the top of the base, one side of the heating module is slidingly arranged on the partition plate, and the heating module can ascend along the partition plate to the lower side of the heating port.

9. The nucleic acid extractor of claim 8, wherein, The nucleic acid extractor further comprises: a heating part sliding base arranged in the assembly chamber and movably connected with the heating module, the heating part sliding base moving to drive the heating module to move; a heating part driving mechanism connected with the heating part sliding base and used for driving the heating part sliding base to move.

10. The nucleic acid extractor of claim 7, wherein, The nucleic acid extractor further comprises an anti-dripping plate, both sides of the top of the base are provided with anti-dripping plate sliding rail assemblies, both sides of the anti-dripping plate are slidably arranged on the anti-dripping plate sliding rail assemblies through connecting portions, and the anti-dripping plate is moved from the inlet and outlet to the shell.

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