Colloidal gold immunochromatography analyzer with test paper pop-up structure

Abstract

The utility model discloses a colloidal gold immunochromatography analyzer with a test paper pop-up structure, which relates to the technical field of colloidal gold immunochromatography analyzers and comprises an analyzer shell and a connecting seat, and the head end of the connecting seat is telescopically mounted in the analyzer shell. A telescopic guide mechanism for limiting the telescopic speed of the connecting seat is mounted in the analyzer shell and mainly comprises a cylinder barrel, an oil tank, a push rod, a piston, a three-way pipe and a throttling bolt; according to the utility model, the telescopic speed of the connecting seat is limited by the telescopic guide mechanism, so that the colloidal gold test card in the connecting seat is effectively prevented from shaking due to rapid movement; in the detection process, a sample is prevented from being interfered by migration on a membrane in the colloidal gold test card, the stability of an antigen-antibody binding process is ensured, and the risk of incomplete reaction or non-specific binding is reduced, so that the accuracy of a detection result is remarkably improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to colloidal gold immune chromatography analyzer technical field, especially in a kind of colloidal gold immune chromatography analyzer with test paper pop-out structure. BACKGROUND

[0002] With the continuous development of biomedical detection technology, portable colloidal gold immune chromatography analyzer is widely used in clinical diagnosis, on-site detection and other fields due to its simple operation, rapidness, sensitivity and other advantages;Its basic principle is to use the specific binding reaction of antigen and antibody, and amplify the detection signal through colloidal gold labeling technology, so as to realize the qualitative or quantitative detection of target substance;In this kind of analyzer, stable placement and operation of test paper (colloidal gold test card) are crucial to the accuracy of detection results.

[0003] However, the existing portable colloidal gold immune chromatography analyzer has some deficiencies in the test paper pop-out structure;Traditional design often does not fully consider the stability of test paper during pop-out and retraction, and the speed is too fast, which can easily cause shaking when the test paper is quickly driven;This can interfere with the migration process of the sample on the NC membrane, affecting the antigen-antibody binding and causing deviations in the detection results, such as uneven color development, false positives or false negatives, etc.;Moreover, in actual use, due to the diversity of detection environment and the frequency of operation, higher requirements are put forward for the convenience and reliability of test paper pop-out structure;Therefore, a colloidal gold immune chromatography analyzer with test paper pop-out structure is proposed. UTILITY MODEL CONTENT

[0004] The main purpose of the utility model is to provide a colloidal gold immune chromatography analyzer with test paper pop-out structure, which can effectively solve the problems in the background art.

[0005] To achieve the above-mentioned purpose, the technical scheme adopted by the utility model is as follows:

[0006] A colloidal gold immune chromatography analyzer with test paper pop-out structure, comprising an analyzer shell and a connecting seat, the first end of the connecting seat is telescopic installed in the analyzer shell, and a telescopic guide mechanism for limiting the telescopic speed of the connecting seat is installed in the analyzer shell;

[0007] The telescopic guide mechanism is mainly composed of a cylinder, an oil tank, a push rod, a piston, a three-way pipe and a throttle bolt, the cylinder and the oil tank are filled with liquid medium, the cylinder and the oil tank are fixedly installed in the analyzer shell, the oil tank is fixedly connected to the top of the first end of the cylinder through the three-way pipe, the piston is coaxially fixedly installed at the first end of the push rod, the outer wall of the piston is telescopic installed in the cylinder, the end of the push rod is fixedly connected with one end of the connecting seat, and the throttle bolt is screwedly installed in the three-way pipe.

[0008] Preferably, a bottom frame is fixedly connected between the cylinder and the inner wall of the analyzer housing, two parallel guide cylinders are fixedly installed in the bottom frame, the guide cylinders are parallel to the cylinder, a guide column is telescopically installed in the guide cylinders, one end of the guide column is fixedly connected with the connecting seat, and the telescopically connected guide cylinders and guide column are provided with the first spring in a compressed state, and two ends of the first spring are fixedly connected with the bottom frame and the connecting seat.

[0009] Preferably, the connecting seat is provided with a positioning card slot for embedding and connecting a colloidal gold test card, and notches are provided on both sides of one end of the positioning card slot in the connecting seat.

[0010] Preferably, a self-locking mechanism for limiting movement of the connecting seat is installed in the analyzer housing, the self-locking mechanism mainly comprises a guide box, a pull rod, a second spring and a lock tongue, the lock tongue corresponds to the notch on the connecting seat, the outer wall of the guide box is fixedly connected with the inner wall of the analyzer housing, the second spring is compressively installed in the guide box, the lock tongue is telescopically installed in the guide box, one end of the second spring and one end of the lock tongue are in contact with each other, the pull rod is fixedly connected with the lock tongue, and the outer wall of the pull rod slides through the guide box and the analyzer housing.

[0011] Preferably, an oil tank is arranged above the oil tank, a filling port is arranged above the oil tank, a screw cap is threadedly connected above the filling port, a microporous material is fixedly connected to the top end of the screw cap, and the microporous material is preferably a polytetrafluoroethylene film.

[0012] Preferably, a handle is fixedly connected to one end of the outer side of the pull rod.

[0013] Compared with the prior art, the utility model has the following beneficial effects:

[0014] 1. Improve the detection accuracy: the telescopic guide mechanism limits the telescopic speed of the connecting seat, effectively avoiding the shaking of the colloidal gold test card in the connecting seat due to rapid movement; during the detection process, the migration of the sample on the NC film is prevented from being disturbed, ensuring the stability of the antigen-antibody combination process, reducing the risk of incomplete reaction or non-specific combination, thereby significantly improving the accuracy of the detection result; at the same time, in the color developing stage, the stable test card state ensures the uniform distribution of colloidal gold particles, avoiding abnormal changes in color developing intensity and uniformity, and reducing the occurrence of false positive or false negative results.

[0015] 2. Operation convenience is improved: the notch in the connecting seat facilitates the user to install and take out the colloidal gold test card, simplifies the operation process and improves the use efficiency; the design of the self-locking mechanism makes the fixing and releasing operation of the connecting seat simple and easy, and the displacement restriction on the connecting seat can be released or applied by pulling the handle on the pull rod, so that the user can conveniently replace the test card and maintain the analyzer.

[0016] 3. Structural stability is enhanced: the silicone oil regulation system composed of the three-way pipe and the throttle bolt between the cylinder and the oil tank, and the guide cylinder and the guide column provided for the cylinder, provide reliable guarantee for the stable movement of the connecting seat; the stable structure not only helps to improve the detection accuracy, but also prolongs the service life of the analyzer and reduces the failure probability caused by the shaking or collision of the components. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is the overall structure of the present application Figure 1 ;

[0018] Figure 2 is the overall structure of the present application Figure 2 ;

[0019] Figure 3 is the distribution connection diagram of the connecting seat, the telescopic guide mechanism and the self-locking mechanism in the present application.

[0020] Figure 4 is the connecting structure diagram of the guide cylinder and the oil tank in the present application.

[0021] Figure 5 is the structure diagram of the self-locking mechanism in the present application.

[0022] In the figure: 1, analyzer shell; 2, connecting seat; 201, positioning slot; 202, notch; 3, telescopic guide mechanism; 301, cylinder; 302, guide cylinder; 303, oil tank; 304, screw cap; 305, guide column; 306, first spring; 307, bottom frame; 308, push rod; 309, piston; 310, three-way pipe; 311, throttle bolt; 312, microporous material; 4, self-locking mechanism; 401, guide box; 402, pull rod; 403, handle; 404, second spring; 405, lock tongue. DETAILED DESCRIPTION

[0023] In order to make the technical means, creative features, purposes and effects realized by the present application easy to understand, the present application is further described below in combination with specific embodiments.

[0024] For example, Figures 1-5As shown, a colloidal gold immunochromatographic analyzer with test paper ejection structure, comprising an analyzer shell 1 and a connecting seat 2, the first end of the connecting seat 2 is telescopic installed in the analyzer shell 1.

[0025] Reference Figure 3 And Figure 4 The telescopic guide mechanism 3 for limiting the telescopic speed of the connecting seat 2 is installed in the analyzer shell 1, which is mainly composed of a cylinder barrel 301, an oil tank 303, a push rod 308, a piston 309, a three-way pipe 310 and a throttle bolt 311, the cylinder barrel 301 and the oil tank 303 are filled with liquid medium, which is preferably silicone oil, the cylinder barrel 301 and the oil tank 303 are fixedly installed in the analyzer shell 1, the oil tank 303 is fixedly communicated with the top of the first end of the cylinder barrel 301 through the three-way pipe 310, the piston 309 is coaxially fixedly installed at the first end of the push rod 308, the outer wall of the piston 309 is telescopic installed in the cylinder barrel 301, the end of the push rod 308 is fixedly connected with one end of the connecting seat 2, and the throttle bolt 311 is screwedly installed in the three-way pipe 310, by rotating the throttle bolt 311, the opening size of the passage between the cylinder barrel 301 and the oil tank 303 in the three-way pipe 310 can be changed, by adjusting the size of the above opening, the speed of the silicone oil in and out can be limited, so as to control the telescopic speed between the cylinder barrel 301 and the push rod 308, so that the connecting seat 2 can only be slowly pushed in or out, because in the process of colloidal gold immunochromatographic analysis, if the connecting seat 2 is quickly ejected and pressed into the analyzer shell 1, the colloidal gold test card in the connecting seat 2 may be shaken, for example, the normal migration of the sample on the NC membrane may be interfered, resulting in the influence of the antigen-antibody combination process, the sample may not be uniformly contacted with the coating on the membrane, resulting in incomplete reaction or non-specific combination, thereby affecting the accuracy of the detection result, if the test card is shaken during the color development process, the distribution of colloidal gold particles may be uneven, the intensity and uniformity of the color development may be changed, the detection line may appear too light or too dark, or even false positive or false negative.

[0026] Reference Figure 3 And Figure 4The bottom frame 307 is fixedly connected between the cylinder 301 and the inner wall of the analyzer shell 1, and two parallel guide cylinders 302 are further fixedly installed in the bottom frame 307. The guide cylinders 302 are parallel to the cylinder 301, the guide cylinders 302 are telescopically installed with guide columns 305, one end of the guide column 305 is fixedly connected with the connecting seat 2, the telescopically connected guide cylinders 302 and guide columns 305 are provided with the first spring 306 which is always in a compressed state, and the two ends of the first spring 306 are fixedly connected with the bottom frame 307 and the connecting seat 2. The two parallel guide cylinders 302 and guide columns 305 of the cylinder 301 can stably guide the connecting seat 2 to move smoothly, and the first spring 306 which is always in a compressed state can automatically push the connecting seat 2 out of the analyzer shell 1 after the displacement restriction of the connecting seat 2 by the locking tongue 405 of the self-locking mechanism 4 is released, by using the elastic thrust of the two first springs 306.

[0027] According to the application Figure 3 The connecting seat 2 is provided with a positioning card slot 201 for embedding and connecting a colloidal gold test card, and the positioning card slot 201 is provided with notches 202 on both sides of one end. The notches 202 are used for facilitating the user to install or take out the colloidal gold test card, and are used for cooperating with the self-locking mechanism 4.

[0028] According to the application Figure 5 The analyzer shell 1 is provided with a self-locking mechanism 4 for limiting the movement of the connecting seat 2. The self-locking mechanism 4 mainly comprises a guide box 401, a pull rod 402, a second spring 403 and a locking tongue 405. The locking tongue 405 corresponds to the notches 202 on the connecting seat 2, the outer wall of the guide box 401 is fixedly connected with the inner wall of the analyzer shell 1, the second spring 403 is telescopically installed in the guide box 401, the locking tongue 405 is telescopically installed in the guide box 401, one end of the second spring 403 and one end of the locking tongue 405 are in contact with each other, the pull rod 402 is fixedly connected with the locking tongue 405, and the outer wall of the pull rod 402 slides through the guide box 401 and the analyzer shell 1. When the connecting seat 2 is slowly and completely pressed into the analyzer shell 1, the second spring 403 of the self-locking mechanism 4 automatically extends into the notches 202 by the elastic force of the second spring 403, thereby limiting the movement of the connecting seat 2. When the handle 403 at the end of the pull rod 402 is pulled outward, the locking tongue 405 can be telescopically installed in the guide box 401 and away from the notches 202 on the connecting seat 2, thereby releasing the displacement restriction of the connecting seat 2 by the self-locking mechanism 4.

[0029] According to the application Figure 4 The oil tank 303 is provided with a filling port, and a screw cap 304 is threadedly connected above the filling port. The top end of the screw cap 304 is fixedly connected with a microporous material 312, and the microporous material 312 is preferably a polytetrafluoroethylene film.

[0030] According to the applicationFigure 5 The one end outside of the pull rod 402 is fixedly connected with a handle 403, and it is necessary to note that the handle 403 can also be replaced by an existing electric push cylinder, the cylinder body of the electric push cylinder is fixedly installed in the analyzer shell 1, the pull rod 402 is relatively shortened and is also completely arranged in the analyzer shell 1, the second spring 403 is not used any more, and the pull rod 402 and the telescopic end of the electric push cylinder are connected, that is, the telescopic end of the electric push cylinder is telescoped, so that the lock tongue 405 is driven to move, the design guarantees that the connecting seat 2 is stably popped out and retracted, combines some elements in the prior art, makes the test paper pop-out structure of the analyzer more perfect and practical, effectively improves the accuracy and stability of the colloidal gold immunochromatographic analysis, provides better use experience for users, simultaneously provides a new thought and direction for the technical development in the field, has higher practical value and market prospect.

[0031] The basic principle and main features of the utility model and the advantages of the utility model are shown and described above. The skilled in the art should understand that the utility model is not limited by the above-mentioned embodiments, and the above-mentioned embodiments and the description in the specification only illustrate the principle of the utility model, and the utility model will have various changes and improvements without departing from the spirit and scope of the utility model, and these changes and improvements all fall within the scope of the utility model claimed. The protection scope of the utility model is defined by the appended claims and equivalents thereof.

Claims

1. A colloidal gold immunochromatographic analyzer with test paper ejection structure, comprising an analyzer shell (1) and a connecting seat (2), the leading end of the connecting seat (2) is telescopic installed in the analyzer shell (1), characterized in that: The telescopic guide mechanism (3) is mainly composed of a cylinder (301), an oil tank (303), a push rod (308), a piston (309), a tee pipe (310) and a throttle bolt (311), the cylinder (301) and the oil tank (303) are filled with liquid medium, the cylinder (301) and the oil tank (303) are fixedly installed in the analyzer shell (1), the oil tank (303) is fixedly communicated with the top of the first end of the cylinder (301) through the tee pipe (310), the piston (309) is coaxially fixedly installed at the first end of the push rod (308), the outer wall of the piston (309) is telescopically installed in the cylinder (301), the tail end of the push rod (308) is fixedly connected with one end of the connecting seat (2), and the throttle bolt (311) is screwedly installed in the tee pipe (310). The bottom frame (307) is fixedly connected between the cylinder (301) and the inner wall of the analyzer shell (1), two parallel guide cylinders (302) are further fixedly installed in the bottom frame (307), the guide cylinders (302) are parallel to the cylinder (301), a guide column (305) is telescopically installed in the guide cylinder (302), one end of the guide column (305) is fixedly connected with the connecting seat (2), the outer periphery of the telescopically connected guide cylinder (302) and guide column (305) is provided with the first spring (306) which is always in a compressed state, and the two ends of the first spring (306) are fixedly connected with the bottom frame (307) and the connecting seat (2) respectively.

2. The colloidal gold immunochromatographic analyzer with test paper ejection structure according to claim 1, characterized in that: The connecting seat (2) is provided with a positioning card slot (201) for embedding a colloidal gold test card, and notches (202) are arranged on the two sides of one end of the positioning card slot (201) in the connecting seat (2).

3. The colloidal gold immunochromatographic analyzer with test strip ejection structure according to claim 1, characterized in that: The analyzer shell (1) is provided with a self-locking mechanism (4) for limiting the movement of the connecting seat (2), the self-locking mechanism (4) is mainly composed of a guide box (401), a pull rod (402), a second spring (404) and a lock tongue (405), the lock tongue (405) corresponds to the notch (202) on the connecting seat (2), the outer wall of the guide box (401) is fixedly connected with the inner wall of the analyzer shell (1), the second spring (404) is compressively installed in the guide box (401), the lock tongue (405) is telescopically installed in the guide box (401), one end of the second spring (404) and one end of the lock tongue (405) are in contact with each other, the pull rod (402) is fixedly connected with the lock tongue (405), and the outer wall of the pull rod (402) slides through the guide box (401) and the analyzer shell (1).

4. The colloidal gold immunochromatographic analyzer with test paper ejection structure according to claim 3, characterized in that: The oil tank (303) is provided with a filling opening, a screw cover (304) is threadedly connected to the top of the filling opening, a microporous material (312) is fixedly connected to the top end of the screw cover (304), and the microporous material (312) is preferably a polytetrafluoroethylene film.

5. The colloidal gold immunochromatographic analyzer with test strip ejection structure according to claim 1, characterized in that: One end of the outer side of the pull rod (402) is fixedly connected with a handle (403).

6. The colloidal gold immunochromatographic analyzer with test paper ejection structure according to claim 4, characterized in that: ​

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