Wall-mounted sterile liquid storage bag

Abstract

The utility model discloses a wall-mounted sterile liquid storage bag, which comprises a liquid storage bag body, the supporting structure is arranged on the liquid storage bag body; the sterile gas filter is arranged on the liquid storage bag body; the first circulating pipeline and the second circulating pipeline are arranged on the liquid storage bag body, the two ends of the first circulating pipeline and the second circulating pipeline are communicated with the internal space of the liquid storage bag body, and the upper ends of the first circulating pipeline and the second circulating pipeline are crossed; and the temperature measuring assembly is arranged on the liquid storage bag body. According to the utility model, the liquid can be fully mixed, and the use is convenient.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological pharmacy liquid storage equipment technical field, in particular to a wall -hanging sterile liquid storage bag. BACKGROUND

[0002] In the biological pharmacy production process, the liquid storage bag is an important storage and transport tool. The existing liquid storage bag usually adopts simple bag body structure, and there are many technical problems in the use process: the liquid in the liquid storage bag cannot be fully mixed, which leads to uneven distribution of liquid temperature and composition; temperature monitoring is not accurate, since the temperature measuring element is directly in contact with the outer wall of the liquid storage bag, it is easy to be affected by the external environment, which affects the accuracy of temperature monitoring; the liquid storage bag is easy to deform in the use process, which affects the stability of liquid storage. The existing liquid storage bag is simple in structure, lacks effective support structure and internal circulation system, and cannot meet the requirements of liquid mixing uniformity, temperature monitoring accuracy and use stability in the biological pharmacy production process.

[0003] Therefore, it is urgent to provide a wall -hanging sterile liquid storage bag to solve the above problems. UTILITY MODEL CONTENT

[0004] The utility model discloses a wall -hanging sterile liquid storage bag, which can realize the full mixing of liquid and is convenient to use.

[0005] To solve the above technical problems, the utility model provides a wall -hanging sterile liquid storage bag, which comprises:

[0006] Liquid storage bag body;

[0007] Supporting structure arranged on the liquid storage bag body;

[0008] Sterile gas filter arranged on the liquid storage bag body;

[0009] First circulation pipeline and second circulation pipeline arranged on the liquid storage bag body, both ends of the first circulation pipeline and the second circulation pipeline are communicated with the internal space of the liquid storage bag body, and one end position is crossed;And

[0010] Temperature measuring assembly arranged on the liquid storage bag body.

[0011] Further, the supporting structure comprises a supporting rod and at least one hook hole, the supporting rod is sealed in the top of the liquid storage bag body, and the hook hole is arranged below the supporting rod.

[0012] Further, it further includes liquid inlet pipe and liquid outlet pipe, one end of the liquid inlet pipe and the liquid outlet pipe is communicated with the liquid storage bag body, and the other end of the liquid inlet pipe and the liquid outlet pipe is provided with sterile joint.

[0013] Further, the upper and lower ends of the first circulation pipeline and the second circulation pipeline are arranged on the liquid storage bag body, and the upper ends of the first circulation pipeline and the second circulation pipeline are located on the same side of the liquid storage bag body and cross each other.

[0014] Further, the first circulation pipeline and the second circulation pipeline are provided with a pipe clamp structure for connecting a peristaltic pump.

[0015] Further, the sterile gas filter is located higher than the upper ends of the first circulation pipeline and the second circulation pipeline.

[0016] Further, the liquid storage bag body comprises two layers of films which are connected by edge sealing.

[0017] Further, the two layers of films are connected by heat sealing or ultrasonic welding.

[0018] Further, the temperature measuring assembly comprises:

[0019] a temperature measuring sleeve arranged in the liquid storage bag body, one end of the temperature measuring sleeve being closed and located in the liquid storage bag body, and the other end being open and extending out of the liquid storage bag body; and

[0020] a sensor arranged in the temperature measuring sleeve, and the sensing end of the sensor being located at the closed end of the temperature measuring sleeve.

[0021] Further, the temperature measuring sleeve has a welded section connected to the bottom of the liquid storage bag body, and the welded section is located between the two layers of films.

[0022] Through the above technical solution, the utility model has the following beneficial effects:

[0023] Through the arrangement of the liquid storage bag body, the support structure arranged on the liquid storage bag body, the sterile gas filter arranged on the liquid storage bag body, the first circulation pipeline and the second circulation pipeline arranged on the liquid storage bag body, the two ends of the first circulation pipeline and the second circulation pipeline being in communication with the internal space of the liquid storage bag body, and the upper ends being cross arranged, and the temperature measuring assembly arranged on the liquid storage bag body, the device realizes the full mixing of the liquid by arranging the cross arranged circulation pipeline, and ensures the uniform distribution of the temperature and the composition.

[0024] In addition, the closed temperature measuring sleeve and the sensor combination are arranged, the interference of the external environment on the temperature measurement is avoided, the accuracy of the temperature monitoring is improved, and the stability of the liquid storage bag during use is ensured through the design of the support structure.

[0025] In addition, the device adopts a structure of two-layer film heat sealing or ultrasonic welding, which ensures the sealing performance of the liquid storage bag; through the setting of a sterile joint, the sterile requirement of the liquid transfer process is ensured; through the design of a pipe clamp structure, the connection with external circulating equipment is facilitated, and the use convenience is improved. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 It is a whole structure schematic view of the wall-mounted sterile liquid storage bag in an embodiment of the present application.

[0027] Figure 2 It is a front view of the wall-mounted sterile liquid storage bag applied to a peristaltic pump in an embodiment of the present application.

[0028] Figure 3 It is a structure schematic view of a temperature measuring assembly in the wall-mounted sterile liquid storage bag in an embodiment of the present application.

[0029] In the figure, 1, liquid storage bag body; 2, support rod; 3, hook hole; 4, sterile gas filter; 5, first circulating pipeline; 6, second circulating pipeline; 7, temperature measuring sleeve; 8, temperature sensor; 9, liquid inlet pipe; 10, liquid outlet pipe; 11, pipe clamp structure; 12, peristaltic pump. DETAILED DESCRIPTION

[0030] The wall-mounted sterile liquid storage bag of the present application will be described in more detail below with reference to the drawings, in which the preferred embodiments of the present application are represented, and it should be understood that the person skilled in the art can modify the present application described herein while still achieving the advantageous effects of the present application. Therefore, the following description should be understood as a broad knowledge for the person skilled in the art, and not as a limitation of the present application.

[0031] The present application will be described in more detail in the following paragraphs with reference to the drawings. The advantages and features of the present application will be more apparent according to the following description. It should be noted that the drawings are all in a very simplified form and all use non-precise proportions, only to facilitate, clearly assist in the purpose of explaining the embodiments of the present application.

[0032] As Figure 1As shown, the utility model embodiment proposes a kind of wall-mounted sterile liquid storage bag of convenient and practical, it include: liquid storage bag body 1;Supporting structure being arranged on the liquid storage bag body 1;Sterile gas filter 4 being arranged on the liquid storage bag body 1;First circulation pipeline 5 and second circulation pipeline 6 being arranged on the liquid storage bag body 1, the two ends of the first circulation pipeline 5 and the second circulation pipeline 6 are mutually communicated with the internal space of the liquid storage bag body 1, and upper end position intersection.So, the liquid in left lower side can flow to right upper side by second circulation pipeline 6, and the liquid in right lower side can flow to left upper side by first circulation pipeline 5, to improve mixing effect.And temperature measuring component being arranged on the liquid storage bag body 1.

[0033] More specifically, one end of the first circulation pipeline 5 and the second circulation pipeline 6 is communicated with the bottom of the liquid storage bag body 1, and the other end is communicated with the upper part of the liquid storage bag body 1 and arranged in cross, which is beneficial to the left-right exchange of the liquid in the liquid storage bag body 1 and improves the mixing effect.

[0034] The wall-mounted sterile liquid storage bag of the embodiment realizes the effective circulation of the liquid in the liquid storage bag by arranging the first circulation pipeline 5 and the second circulation pipeline 6 in cross in the liquid storage bag body 1, and connecting the external peristaltic pump 12 by cooperating with the pipe clamp structure 11, guarantees the uniformity of temperature distribution and the uniformity of component mixing, and improves the mixing effect;And the mixing effect of the medium that is prone to sedimentation in the preparation is obvious, which greatly improves the uniformity of the liquid in the liquid storage bag;By arranging the supporting structure of the supporting rod 2 and the hook hole 3, the liquid storage bag can be stably hung on the wall surface, and the use stability is improved;By arranging the closed temperature measuring sleeve 7 and the temperature sensor 8 combination, the temperature sensor 8 is avoided from directly contacting the liquid, and the interference of external environment on temperature measurement is also avoided, and the accuracy of temperature monitoring is improved.

[0035] Among them, the setting of sterile gas filter 4 can balance the gas pressure in liquid storage bag body 1, and can be automatically adjusted according to the amount of liquid in liquid storage bag body 1, to prevent the pressure in liquid storage bag body 1 from being abnormal, so as to improve the reliability of consumables.

[0036] In an embodiment, the supporting structure includes a supporting rod 2 and at least one hook hole 3, the supporting rod 2 is sealed in the top of the liquid storage bag body 1, and the hook hole 3 is arranged below the supporting rod 2. The supporting rod 2 of the embodiment can be made of stainless steel material, and the surface is polished to have corrosion resistance. For example, 2-4 hook holes 3 can be arranged on the supporting rod 2, and the spacing of the hook holes 3 can be adjusted according to actual use requirements.

[0037] Further, the embodiment further comprises a liquid inlet pipe 9 and a liquid outlet pipe 10, one end of the liquid inlet pipe 9 and the liquid outlet pipe 10 are communicated with the liquid storage bag body 1. In the embodiment, the liquid inlet pipe 9 and the liquid outlet pipe 10 are located at the bottom of the liquid storage bag body 1.

[0038] Preferably, the other end of the liquid inlet pipe 9 and the liquid outlet pipe 10 is provided with a sterile joint. The sterile joint can adopt a quick joint design, which is convenient for the operator to quickly complete the sterile connection. And can facilitate the connection of subsequent processes, such as liquid transfer, preparation of sub-packaging, etc.

[0039] In the embodiment, the first circulation pipeline 5 and the second circulation pipeline 6 are located on the same side of the liquid storage bag body 1, and the upper and lower ends are arranged on the liquid storage bag body 1. Although the upper and lower ends of the circulation pipeline extend into the internal space of the liquid storage bag body 1 can also improve the mixing effect, but due to the complex manufacturing process, therefore, the mode of directly arranging the end on the liquid storage bag body 1 is more simple.

[0040] In the embodiment, the first circulation pipeline 5 and the second circulation pipeline 6 are provided with a pipe clamp structure 11 for connecting a peristaltic pump 12, as shown in the combination Figure 2 The pipe clamp structure 11 can adopt silica gel material, which can ensure good cooperation with the peristaltic pump 12 and has sufficient service life.

[0041] Preferably, the position of the sterile gas filter 4 is higher than the upper end of the first circulation pipeline 5 and the second circulation pipeline 6, so as to prevent the liquid from wetting the sterile gas filter 4.

[0042] Preferably, the material of the liquid storage bag body 1 includes a biopharmaceutical film material. The embodiment adopts a biopharmaceutical film material, and realizes the sealing connection of the two layers of film through heat sealing or ultrasonic welding, which ensures the sealing performance and biocompatibility of the liquid storage bag; by arranging the sterile gas filter 4, the sterile requirement during the liquid storage process is ensured; by arranging the sterile joint on the liquid inlet pipe 9 and the liquid outlet pipe 10, the sterile connection with other equipment is facilitated, and the use convenience and safety are improved. In addition, under the same effect, the material of the liquid storage bag body 1 can also include other embodiments except the embodiment.

[0043] In a specific embodiment, the biopharmaceutical film material used in the liquid storage bag body 1 can select medical-grade EVA, PE and PP materials, which have good biocompatibility and chemical stability. The thickness of the two layers of film can be between 100-300 microns, and the specific thickness can be set according to the actual demand, which can ensure sufficient mechanical strength and maintain good flexibility.

[0044] In the embodiment, the liquid storage bag 1 comprises two layers of film connected by edge sealing.

[0045] In the embodiment, the two layers of film are connected by heat sealing or ultrasonic welding.

[0046] In an embodiment, the liquid storage bag 1 is connected to a liquid inlet pipe 9 and a liquid outlet pipe 10. Figure 3 As shown, the temperature measuring assembly comprises a temperature measuring sleeve 7 arranged in the liquid storage bag 1, one end of the temperature measuring sleeve 7 being closed and located in the liquid storage bag 1, and the other end being open and extending out of the liquid storage bag 1, and a sensor arranged in the temperature measuring sleeve 7, the sensing end of the sensor being located at the closed end of the temperature measuring sleeve 7, so as to monitor the temperature information in the liquid storage bag 1 in real time. In the embodiment, one end of the liquid storage bag 1 is closed to ensure a sterile environment in the bag, and the other end is open to facilitate the placement of the temperature measuring device. Since most biological agents are extremely sensitive to temperature and need to be stored at a suitable temperature, the structure allows the sensor to extend into the interior of the liquid storage bag 1 to obtain the real-time temperature of the agent in the liquid storage bag 1, which is beneficial to the user's monitoring of the temperature state of the agent, and the operation is simple, and the sensor can be easily removed for maintenance.

[0047] Preferably, the temperature measuring sleeve 7 has a welded section connected to the bottom of the liquid storage bag 1, and the welded section is located between the two layers of film. The material of the temperature measuring sleeve 7 can be the same as that of the liquid storage bag 1, and the temperature measuring sleeve 7 is fixedly connected to the bottom of the liquid storage bag 1 by heat sealing or ultrasonic welding.

[0048] In the embodiment, first, the liquid storage bag 1 is stably installed on the wall surface through the hook hole 3 on the support rod 2. During installation, it is ensured that the liquid storage bag 1 is in a vertical state, and the support rod 2 is fixedly connected to the wall surface to ensure the stability of the storage process.

[0049] Before the storage process starts, the liquid storage bag 1 needs to be sterilized. Ethylene oxide or gamma rays can be used for sterilization to ensure the sterile state of the interior of the liquid storage bag 1. Then, the sterile joint arranged on the liquid inlet pipe 9 is connected to the equipment in the upstream process in a sterile manner. During the liquid inlet process, the air in the liquid storage bag 1 is discharged through the sterile gas filter 4, which can effectively prevent bacteria and other microorganisms in the external environment from entering the liquid storage bag 1.

[0050] When the liquid is injected into the liquid storage bag 1, the liquid in the first circulation pipeline 5 and the second circulation pipeline 6 can be driven to circulate and flow by the cooperation of the external peristaltic pump 12 and the pipe clamp structure 11. Since the two pipelines are arranged in a cross manner, the liquid at the lower left can flow to the upper right through the second circulation pipeline 6, and the liquid at the lower right can flow to the upper left through the first circulation pipeline 5, thereby improving the mixing effect. Specifically, the liquid is transported from the bottom of the liquid storage bag 1 to the upper part through the circulation pipeline, and then falls back to the bottom, and so on, thereby ensuring the sufficient mixing of the liquid in the liquid storage bag 1 and the uniform distribution of the temperature.

[0051] During the liquid storage process, the temperature sensor 8 inserted into the temperature measuring sleeve 7 can monitor the liquid temperature in real time. Since one end of the temperature measuring sleeve 7 is closed and located in the liquid storage bag 1, and the other end is open and extends out of the liquid storage bag 1, such a setting not only ensures that the temperature sensor 8 does not directly contact the stored liquid, but also can accurately sense the liquid temperature, while avoiding the interference of the external environment on the temperature measurement. The temperature data can be transmitted to the external control system through the sensor for monitoring and recording.

[0052] When the stored liquid needs to be taken out, the sterile joint on the liquid outlet pipe 10 is connected with the equipment of the downstream process in a sterile manner, and the liquid is transported. The whole storage and transportation process is carried out in a closed sterile environment, which effectively guarantees the sterile requirement of the stored liquid.

[0053] In this embodiment, the liquid storage bag 1 is made of two layers of biopharmaceutical film which are heat sealed or ultrasonically welded, and has good sealing performance. The temperature measuring sleeve 7 is fixedly connected with the bottom of the liquid storage bag 1 through the welding section and is located between the two layers of film, thereby ensuring the reliability of the connection.

[0054] In summary, the wall-mounted sterile liquid storage bag has the following advantages:

[0055] Through the setting of the liquid storage bag body, the support structure arranged on the liquid storage bag body, the sterile gas filter arranged on the liquid storage bag body, the first circulation pipeline and the second circulation pipeline arranged on the liquid storage bag body, the two ends of the first circulation pipeline and the second circulation pipeline are communicated with the internal space of the liquid storage bag body, and the upper end positions are crossed, and the temperature measuring assembly arranged on the liquid storage bag body. The device realizes the sufficient mixing of the liquid by arranging the circulation pipelines in a cross manner, and guarantees the uniform distribution of the temperature and the composition.

[0056] In addition, by setting the closed temperature measuring sleeve and the sensor combination, the interference of the external environment on the temperature measurement is avoided, and the accuracy of the temperature monitoring is improved. And through the design of the support structure, the stability of the liquid storage bag during use is ensured.

[0057] In addition, the device adopts a structure of two-layer film heat sealing or ultrasonic welding, which ensures the sealing performance of the liquid storage bag; through the setting of the sterile joint, the sterile requirement of the liquid transfer process is ensured; through the design of the pipe clamp structure, the connection with the external circulating equipment is facilitated, and the use convenience is improved.

[0058] Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application also intends to include these modifications and variations.

Claims

1. A wall-hung sterile stock solution bag, characterized by The application relates to a liquid storage bag, comprising: a liquid storage bag body; a support structure arranged on the liquid storage bag body; a sterile gas filter arranged on the liquid storage bag body; a first circulation pipeline and a second circulation pipeline arranged on the liquid storage bag body, both ends of the first circulation pipeline and the second circulation pipeline are in communication with the internal space of the liquid storage bag body, and one end position of the first circulation pipeline and the second circulation pipeline is crossed; and a temperature measurement assembly arranged on the liquid storage bag body.

2. The wall-mounted sterile stock solution bag of claim 1, wherein, The support structure comprises a support rod and at least one hook hole, the support rod is sealed at the top of the liquid storage bag body, and the hook hole is arranged below the support rod.

3. The wall-mounted sterile stock solution bag of claim 1, wherein, The liquid storage bag further comprises an inlet pipe and an outlet pipe, one end of the inlet pipe and the outlet pipe is in communication with the liquid storage bag body, and the other end of the inlet pipe and the outlet pipe is provided with a sterile joint.

4. The wall-mounted sterile stock solution bag of claim 1, wherein, Both upper and lower ends of the first circulation pipeline and the second circulation pipeline are arranged on the liquid storage bag body, and the upper ends of the first circulation pipeline and the second circulation pipeline are located on the same side of the liquid storage bag body and cross each other.

5. The wall-mounted sterile stock solution bag according to claim 1 or 4, wherein The first circulation pipeline and the second circulation pipeline are provided with pipe clamp structures for connecting peristaltic pumps.

6. The wall-mounted sterile stock solution bag of claim 1, wherein, The sterile gas filter is located higher than the upper ends of the first circulation pipeline and the second circulation pipeline.

7. The wall-mounted sterile stock solution bag of claim 1, wherein The liquid storage bag body comprises two layers of films which are connected through edge sealing.

8. The wall-mounted sterile stock solution bag of claim 7, wherein, The two layers of films are connected through heat sealing or ultrasonic welding.

9. The wall-mounted sterile stock solution bag of claim 7, wherein, The temperature measurement assembly comprises: a temperature measurement sleeve arranged in the liquid storage bag body, one end of the temperature measurement sleeve is closed and located in the liquid storage bag body, and the other end is open and extends out of the liquid storage bag body; and a sensor arranged in the temperature measurement sleeve, and the sensing end of the sensor is located at the closed end of the temperature measurement sleeve.

10. The wall-mounted sterile stock solution bag of claim 9, wherein, The temperature measurement sleeve has a welding section connected with the bottom of the liquid storage bag body, and the welding section is located between the two layers of films.

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