Silicone-oil-free pre-filled syringe

Abstract

The utility model discloses a silicone-oil-free pre-filled syringe, which relates to the technical field of medical equipment, and aims to solve the problem that the existing silicone-oil-containing pre-filled syringe affects the stability of medicines, the silicone-oil-free pre-filled syringe comprises a syringe needle cylinder which is of a hollow structure with a bottom and without a top, a liquid medicine containing cavity is formed in the syringe needle cylinder, an air inlet channel and a liquid outlet channel are formed in the two sides of the bottom of the syringe needle cylinder, the liquid outlet channel is communicated with the liquid medicine containing cavity, an air outlet channel communicated with the air inlet channel is formed in the liquid medicine containing cavity, and the air outlet channel extends to the top of the syringe needle cylinder. The top of the syringe needle cylinder is provided with the elastic piece used for sealing the air outlet channel and the liquid medicine containing cavity, so that interaction between medicine and silicone oil is avoided, the adsorption and aggregation risk of protein medicine is reduced, and the stability and the curative effect of the medicine are ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical equipment technical field more specifically, relate to a kind of silicon oil-free pre-filled syringe. BACKGROUND

[0002] As a new type of medicine packaging form, pre-filled syringe is used to store medicine in advance in the syringe, so that the medicine can be directly injected without the secondary pollution and inaccurate dosage caused by the traditional ampoule and vial.

[0003] Most of the pre-filled syringes on the market have silicone oil on the inner wall, which can react with the medicine, increasing the risk of protein drug adsorption and aggregation, and reducing the stability and efficacy of the medicine.

[0004] Therefore, how to solve the problem of the existing pre-filled syringe containing silicone oil affecting the stability of the medicine is a problem that needs to be solved by the technical personnel in this field. UTILITY MODEL CONTENT

[0005] Therefore, the utility model provides a pre-filled syringe without silicone oil, which avoids the interaction between the medicine and the silicone oil, thereby reducing the risk of protein drug adsorption and aggregation, and ensuring the stability and efficacy of the medicine.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical scheme:

[0007] A pre-filled syringe without silicone oil, comprising: a syringe barrel, the syringe barrel is a hollow structure without top, the inside of the syringe barrel is provided with a liquid chamber, the bottom of the syringe barrel is provided with an air inlet channel and a liquid outlet channel, the liquid outlet channel is in communication with the liquid chamber, the liquid chamber is provided with an air outlet channel in communication with the air inlet channel, the air outlet channel extends to the top of the syringe barrel, and the top of the syringe barrel is provided with an elastic element for sealing the air outlet channel and the liquid chamber.

[0008] Preferably, the center axes of the air inlet channel and the liquid outlet channel are arranged at an angle of 45 degrees with the center axis of the syringe barrel.

[0009] Preferably, the syringe barrel is provided with two liquid chambers arranged symmetrically about the center, and the top of each liquid chamber is open and the bottom is communicated by a flow channel.

[0010] Preferably, the first liquid chamber is provided with an air outlet channel, and the second liquid chamber is provided with a closed cavity arranged symmetrically about the center with the air outlet channel, the bottom of the second liquid chamber is in communication with the liquid outlet channel, and the lengths of the air outlet channel and the closed cavity are longer than that of the liquid chamber.

[0011] Preferably, the inner periphery of the top end of the syringe barrel is provided with a limiting groove or a limiting protrusion, and the outer periphery of the elastic member is provided with a limiting protrusion matched with the limiting groove or a limiting groove matched with the limiting protrusion.

[0012] Preferably, the elastic member comprises an elastic body, the outer periphery of the elastic body is provided with a limiting protrusion or a limiting groove, one end of the elastic body is provided with a tapered portion for sealing the air outlet channel, the closed cavity and the liquid containing cavity, the top end of the air outlet channel and the closed cavity is beveled, and the other end of the elastic body is provided with a limiting portion for sealing the syringe barrel, and the diameter of the limiting portion is greater than the diameter of the elastic body.

[0013] Preferably, the outer periphery of the syringe barrel is provided with two fan-shaped openings arranged in a central symmetry, the fan-shaped openings extend to the bottom end of the syringe barrel, the fan-shaped openings are arranged in intersection with the liquid containing cavity, and the included angle of the fan-shaped openings is provided with a scale.

[0014] Preferably, the fan-shaped opening is provided with a reinforcing plate.

[0015] Preferably, the end of the air inlet channel is detachably provided with a tapered plug for sealing the air inlet channel.

[0016] Preferably, the end of the liquid outlet channel is detachably provided with a tapered cap for sealing the liquid outlet channel.

[0017] The silicon oil-free pre-filled syringe comprises a syringe barrel, and specifically, the syringe barrel is a bottomed hollow structure without a top end, the inside of the syringe barrel is provided with a liquid containing cavity, the liquid containing cavity is arranged to contain and store liquid medicine, the bottom of the syringe barrel is provided with an air inlet channel and a liquid outlet channel, the liquid containing cavity is provided with an air outlet channel communicated with the air inlet channel, the air outlet channel extends to the top of the syringe barrel, air is injected into the syringe barrel through the air inlet channel, the air sequentially passes through the air inlet channel and the air outlet channel and enters the liquid containing cavity, so that the liquid medicine in the liquid containing cavity is pressurized, the liquid outlet channel is communicated with the liquid containing cavity, the air in the liquid containing cavity is compressed to push the liquid medicine to flow out of the liquid containing cavity through the liquid outlet channel, the top of the syringe barrel is provided with an elastic member for sealing the air outlet channel and the liquid containing cavity, the elastic member is arranged to seal the top of the syringe barrel, the liquid containing cavity and the air outlet channel, so as to prevent the liquid medicine from flowing out of the top of the syringe barrel and entering the air outlet channel.

[0018] When the syringe is needed to be used, air is injected into the air inlet channel through an air injector, the air enters the air outlet channel through the air inlet channel, the top end of the air outlet channel is sealed by the elastic member, when the internal pressure of the air outlet channel reaches a certain degree, the gas will enter the liquid containing cavity of the syringe barrel through the gap between the elastic member and the top end of the air outlet channel, and push the liquid medicine to flow through the liquid outlet channel and flow out of a disposable sterile injection needle assembled on the liquid outlet channel, so as to complete the injection.

[0019] The silicon oil-free pre-filled syringe arranged in the above manner is injected by air compression, discards the injection mode of a traditional piston, and can completely avoid the risk of adsorption and aggregation of protein drugs caused by the presence of silicon oil, thereby ensuring the stability and curative effect of the drugs. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced. Obviously, the drawings in the following description are only embodiments of the present application, and other drawings can be obtained by the provided drawings without creative labor for those skilled in the art.

[0021] Figure 1 The structure diagram of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure.

[0022] Figure 2 The exploded view of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure.

[0023] Figure 3 The sectional view of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure.

[0024] Figure 4 The partial view of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure.

[0025] Figure 5 The sectional view of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure. Figure 4

[0026] Figure 6 The injection angle of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure.

[0027] Figure 7 The sectional view of the silicon oil-free pre-filled syringe provided by the present application is shown in the figure.

[0028] Figure 8 The structure diagram of the elastic member provided by the present application is shown in the figure.

[0029] Figure 9 The structure diagram of the tapered head plug provided by the present application is shown in the figure.

[0030] Figure 10 The structure diagram of the tapered head cap provided by the present application is shown in the figure.

[0031] Reference signs:

[0032] 1-syringe barrel, 101-limiting groove ​

[0033] 2-liquid medicine containing cavity;

[0034] 3-air inlet channel;

[0035] 4-liquid outlet channel;

[0036] 5-air outlet channel;

[0037] 6-elastic member, 61-limiting protrusion, 62-elastic body, 63-tapered portion, 64-limiting portion;

[0038] 7-flow channel;

[0039] 8-closed cavity;

[0040] 9-fan-shaped opening;

[0041] 10-stiffening plate;

[0042] 11-conical plug, 111-connection portion, 112-sealing portion, 113-handheld portion;

[0043] 12-conical cap. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0045] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting", "fixing" and the like should be understood in a broad sense, for example, can be fixedly connected, or can be detachably connected, or integrally connected; can be mechanically connected, or can be electrically connected; can be directly connected, or can be indirectly connected through an intermediate medium, or can be the communication inside two elements. For those skilled in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0046] The core of the present application is to provide a silicon oil-free pre-filled syringe. The silicon oil is removed without affecting the product performance such as injection force and injection precision, and the risk of silicon oil reacting with the drug is avoided.

[0047] Please refer to Figure 1 , Figure 2 and Figure 3 , a silicon oil-free pre-filled syringe includes a syringe barrel 1.

[0048] Specifically, the syringe barrel 1 is a hollow structure with a bottom and no top, the inside of the syringe barrel 1 is provided with a drug liquid containing cavity 2, the drug liquid containing cavity 2 is arranged to contain and store drug liquid, the bottom of the syringe barrel 1 is provided with an air inlet channel 3 and a liquid outlet channel 4, the drug liquid containing cavity 2 is provided with an air outlet channel 5 in communication with the air inlet channel 3, the air outlet channel 5 extends to the top of the syringe barrel 1, air is injected into the syringe barrel 1 through the air inlet channel 3, the air sequentially passes through the air inlet channel 3 and the air outlet channel 5 and enters the drug liquid containing cavity 2, so as to pressurize the drug liquid in the drug liquid containing cavity 2, the liquid outlet channel 4 is in communication with the drug liquid containing cavity 2, the air entering the drug liquid containing cavity 2 is compressed to push the drug liquid to flow out of the drug liquid containing cavity 2 through the liquid outlet channel 4, the top of the syringe barrel 1 is provided with an elastic element 6 for sealing the air outlet channel 5 and the drug liquid containing cavity 2, the elastic element 6 is arranged to seal the top of the syringe barrel, the drug liquid containing cavity 2 and the air outlet channel 5, so as to avoid the drug liquid from flowing out of the top of the syringe barrel and entering the air outlet channel 5.

[0049] When the syringe needs to be used, air is injected into the air inlet channel 3 by an air injector, the air enters the air outlet channel 5 through the air inlet channel 3, the top end of the air outlet channel 5 is sealed by the elastic element 6, when the pressure in the air outlet channel 5 reaches a certain degree, the gas will enter the drug liquid containing cavity 2 of the syringe barrel 1 through the gap between the elastic element 6 and the top end of the air outlet channel 5, and push the drug liquid to flow through the liquid outlet channel 4 and flow out of the disposable sterile injection needle assembled on the liquid outlet channel 4, so as to complete the injection.

[0050] The syringe needs to be used in cooperation with an air injector for injecting air and a disposable sterile injection needle, mainly composed of a syringe barrel 1, a cone head cap 12, an elastic element 6 and a cone head plug 11; when injecting, the cone head cap 12 is removed and the disposable sterile injection needle is assembled, the cone head plug 11 is removed and the air injector for injecting air is assembled (the inside of the air injector needs to be filled with sterile air before being assembled), and then the injection is completed.

[0051] The above-mentioned silicon oil-free pre-filled syringe is injected by air compression, discards the traditional piston injection method, can completely avoid the risk of protein drug adsorption and aggregation caused by the existence of silicon oil, and thus ensures the stability and curative effect of the drug.

[0052] Please refer to Figure 4 , Figure 5 , Figure 6 and Figure 7 , the inside of the syringe barrel 1 is provided with two drug liquid containing cavities 2 arranged in a central symmetry, the top of the two drug liquid containing cavities 2 is arranged in an open manner and the bottom is communicated through a flow channel 7.

[0053] It should be noted that the two drug storage liquid containing chambers 2 are communicated at the top of the chamber, so that the liquid level and air pressure of the two liquid containing chambers 2 are the same. The bottom of the two liquid containing chambers 2 is also communicated through the flow channel 7, so that the liquid can flow freely in the two liquid containing chambers 2. When the silicone-free pre-filled syringe is shaken to the left, the liquid in the right liquid containing chamber 2 flows to the left liquid containing chamber 2 through the flow channel 7, and at the same time, the excess air in the left liquid containing chamber 2 flows into the right liquid containing chamber 2 through the top, so that the liquid level and air pressure of the two liquid containing chambers 2 are the same.

[0054] Further, the outer periphery of the syringe barrel 1 is provided with two center-symmetrically arranged fan-shaped openings 9, which extend to the bottom end of the syringe barrel 1. The fan-shaped openings 9 are arranged across the liquid containing chambers 2, and the angle between the fan-shaped openings 9 is provided with a scale line D. The center axes of the air inlet channel 3 and the liquid outlet channel 4 are arranged at an angle of 45 degrees with the center axis of the syringe barrel 1, so as to ensure the integrity of the injection function and the accuracy of the scale of the syringe between the horizontal and vertical positions.

[0055] In this way, the two liquid containing chambers 2 are arranged in a center-symmetric manner, and the two fan-shaped openings 9 are also arranged in a center-symmetric manner. When the syringe is placed horizontally, i.e. the center axes of the air inlet channel 3 and the liquid outlet channel 4 are at an angle of 0 degrees with the horizontal direction, the liquid level height of the center points of the two liquid containing chambers 2 is A. When the syringe is placed vertically, i.e. the center axes of the air inlet channel 3 and the liquid outlet channel 4 are at an angle of 90 degrees with the horizontal direction, the liquid level height of the center points of the two liquid containing chambers 2 is B. During use, no matter how the syringe barrel 1 is rotated, the values of the liquid level height A and the liquid level height B on the scale line D are consistent.

[0056] The syringe can be used when the angle is between 0 and 90 degrees. The liquid level height A and the liquid level height B are the liquid levels of the liquid when the syringe is placed horizontally and vertically, respectively. The scale line D is designed at the angle of the fan-shaped opening 9, which can ensure the accuracy of the syringe at any angle between 0 and 90 degrees.

[0057] When the silicone-free pre-filled syringe is rotated forward and backward, as shown in the cross-sectional view of the syringe barrel 1, Figure 7 The syringe barrel 1 is center-symmetric in cross-section. When the syringe barrel 1 moves forward, backward, left and right, the liquid level height of the center point remains unchanged. Therefore, the scale line D is arranged at the position as shown in Figure 7 , which ensures the accuracy of the scale line D when the syringe barrel 1 is rotated forward, backward, left and right.

[0058] Please refer to Figure 1 , Figure 2 and Figure 4 , the fan-shaped opening 9 is provided with a reinforcing plate 10.

[0059] It can be understood that the overall strength can be improved without affecting the observation of the liquid level by additionally arranging the reinforcing plate 10 at the fan-shaped opening 9.

[0060] In the above case, the first drug liquid containing cavity 2 is provided with an air outlet channel 5, the second drug liquid containing cavity 2 is provided with a closed cavity 8 which is centrally symmetric with the air outlet channel 5, the bottom end of the second drug liquid containing cavity 2 is communicated with the liquid outlet channel 4, and the lengths of the air outlet channel 5 and the closed cavity 8 are longer than the length of the drug liquid containing cavity 2.

[0061] It can be understood that the drug liquid is stored in the two drug liquid containing cavities 2, the syringe for injecting air is assembled after removing the conical head plug 11, and the disposable sterile injection needle is assembled after removing the conical head cap 12, the air in the syringe enters the air outlet channel 5 through the air inlet channel 3 hole, the upper end of the air outlet channel 5 is sealed by the elastic element 6, when the internal pressure of the air outlet channel 5 reaches a certain degree, the gas will enter the two drug liquid containing cavities 2 through the gap between the elastic element 6 and the top end of the air outlet channel 5 and push the drug to be injected through the liquid outlet channel 4.

[0062] Please refer to Figure 1 、 Figure 2 、 Figure 3 and Figure 8 , the top inner periphery of the syringe barrel 1 is provided with a limiting groove 101 or a limiting protruding part, and the outer periphery of the elastic element 6 is provided with a limiting protrusion 61 matched with the limiting groove 101 or a limiting recess matched with the limiting protruding part.

[0063] It should be noted that the stability of the connection between the elastic element 6 and the syringe barrel 1 can be ensured by the cooperation of the limiting groove 101 and the limiting protrusion 61 or the cooperation of the limiting protruding part and the limiting recess.

[0064] In the above embodiment, the elastic element 6 includes an elastic body 62, the outer periphery of the elastic body 62 is provided with a limiting protrusion 61 or a limiting recess, one end of the elastic body 62 is provided with a conical part 63 for sealing the air outlet channel 5, the closed cavity 8 and the drug liquid containing cavity 2, the top end of the air outlet channel 5 and the closed cavity 8 is a bevel, the other end of the elastic body 62 is provided with a limiting part 64 for sealing the syringe barrel 1, and the diameter of the limiting part 64 is greater than the diameter of the elastic body 62.

[0065] Understandably, during use, the elastic element 6 is installed inside the syringe barrel 1. The elasticity of the elastic element 6 itself enables the connection with the syringe barrel 1. The cooperation between the limiting protrusion 61 or limiting groove of the elastic element 6 and the limiting groove 101 or limiting protrusion of the syringe barrel 1 ensures the stability of the connection between the elastic element 6 and the syringe barrel 1. After the elastic element 6 is installed in the syringe barrel 1, the limiting part 64 abuts against the end of the syringe barrel 1 to seal the inner cavity of the syringe barrel 1. The conical surface design of the conical part 63 ensures the integrity of the seal. If it were designed as a flat surface, the edges would easily lift up after the elastic element 6 is pressed into place, making it impossible to seal.

[0066] In a preferred embodiment, the elastic element 6 is a rubber stopper. In practical applications, the elastic element 6 can be configured with other structures, as long as the above-mentioned technical effects can be achieved.

[0067] Please refer to Figure 1 , Figure 2 , Figure 3 and Figure 9 The end of the air intake passage 3 is detachably provided with a cone plug 11 for sealing the air intake passage 3.

[0068] Understandably, the cone plug 11 is designed as a plastic part with a certain degree of elasticity. This elasticity prevents the liquid medication from contacting air while also allowing gas to enter during injection. The cone plug 11 includes a connecting part 111 for installation in the air inlet channel 3. The cone plug 11 is installed or removed via a handle 113, and the sealing part 112 isolates the liquid medication from air, preventing contamination.

[0069] Please refer to Figure 1 , Figure 2 , Figure 3 and Figure 10 The end of the liquid outlet channel 4 is detachably provided with a conical cap 12 for sealing the liquid outlet channel 4.

[0070] It should be noted that the conical cap 12 is made of a plastic part with a certain degree of elasticity. The inner cavity of the conical cap 12 is provided with a protrusion to seal the liquid outlet channel 4, so as to prevent the risk of the liquid from contacting the air and at the same time prevent the liquid from flowing out.

[0071] In summary, the silicone-free pre-filled syringe provided by this invention reduces the interaction between the drug and silicone oil, thereby reducing the risk of adsorption and aggregation of protein drugs, ensuring drug stability and efficacy, reducing the risk of immunogenic reactions, and improving patient safety.

[0072] It should be noted that the relative terms, such as first and second, are used herein solely to distinguish one entity from another entity, and do not necessarily require or imply any actual relationship or order between or among the entities.

[0073] The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the difference from other embodiments, and the same or similar parts between the various embodiments can be referred to each other.

[0074] The above has carried out the detailed introduction to the pre-filled syringe without silicone oil provided by the utility model. The principle and implementation mode of the utility model are described by applying specific examples in this paper, and the above embodiment is only used for helping to understand the method and core idea of the utility model. It should be pointed out that for ordinary skilled person in the art, on the premise of not departing from the principle of the utility model, the utility model can be improved and modified in several ways, and these improvements and modifications also fall within the protection scope of the utility model claims.

Claims

1. A silicone oil-free pre-filled syringe, characterized by, The utility model provides an injection syringe, which comprises a bottomless hollow structure, an internal medicine liquid containing cavity, an air inlet channel and a liquid outlet channel, an air outlet channel, an elastic member, and a limiting groove or a limiting protruding part. The central axes of the air inlet channel and the liquid outlet channel are arranged at an angle of 45 degrees with the central axis of the injection syringe.

2. The silicone oil-free pre-filled syringe according to claim 1, characterized by The injection syringe is internally provided with two center-symmetrically arranged medicine liquid containing cavities, and the top of each medicine liquid containing cavity is open and the bottom is communicated through a flow channel.

3. The silicone oil-free pre-filled syringe according to claim 1, wherein The first medicine liquid containing cavity is internally provided with the air outlet channel, the second medicine liquid containing cavity is internally provided with a closed cavity which is center-symmetrically arranged with the air outlet channel, the bottom end of the second medicine liquid containing cavity is communicated with the liquid outlet channel, and the lengths of the air outlet channel and the closed cavity are longer than the length of the medicine liquid containing cavity.

4. The silicone oil-free pre-filled syringe according to claim 3, characterized by The top end of the injection syringe is internally provided with a limiting groove or a limiting protruding part, and the outer periphery of the elastic member is provided with a limiting protrusion matched with the limiting groove or a limiting groove matched with the limiting protruding part.

5. The silicone oil-free pre-filled syringe according to claim 4, characterized by The elastic member comprises an elastic body, the outer periphery of the elastic body is provided with the limiting protrusion or the limiting groove, one end of the elastic body is provided with a tapered part for sealing the air outlet channel, the closed cavity and the medicine liquid containing cavity, the top end of the air outlet channel and the closed cavity is a bevel, and the other end of the elastic body is provided with a limiting part for sealing the injection syringe, and the diameter of the limiting part is larger than the diameter of the elastic body.

6. The silicone oil-free pre-filled syringe according to claim 5, characterized by The outer periphery of the injection syringe is provided with two center-symmetrically arranged fan-shaped openings, the fan-shaped openings extend to the bottom end of the injection syringe, the fan-shaped openings are crosswise arranged with the medicine liquid containing cavities, and the fan-shaped openings are provided with scales at the included angle.

7. The silicone oil-free pre-filled syringe according to claim 2, wherein The fan-shaped openings are internally provided with reinforcing plates.

8. The silicone oil-free pre-filled syringe according to claim 7, characterized by The end of the air inlet channel is detachably provided with a tapered plug for sealing the air inlet channel.

9. The silicone oil-free pre-filled syringe according to any one of claims 1 to 8, wherein The end of the liquid outlet channel is detachably provided with a tapered cap for sealing the liquid outlet channel.

10. The silicone oil-free pre-filled syringe according to any one of claims 1 to 8, wherein ​

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