Temperature-adjustable drug intermediate reaction kettle
By introducing a temperature-regulating stirrer and a media circulation system into the pharmaceutical intermediate reaction vessel, the problems of uneven temperature distribution and uneven stirring were solved, achieving uniform heating or cooling of the pharmaceutical intermediate reaction, improving the consistency and stability of the reaction, and increasing product quality and yield.
Patent Information
- Application Number
- CN202520147254.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-22
- Publication Date
- 2026-01-02
- Estimated Expiration
- 2035-01-22
AI Technical Summary
Traditional reaction vessels suffer from uneven temperature distribution and uneven stirring during the synthesis of drug intermediates, resulting in inconsistent reactions and poor stability, which affects product quality and yield.
A temperature-adjustable pharmaceutical intermediate reaction vessel is used, which achieves uniform temperature distribution and thorough mixing through a temperature-adjusting stirrer and a media circulation system. The system includes a stirring tube, a baffle plate, a temperature sensor, and a temperature control component. Combined with motor drive and media circulation, it ensures uniform heating or cooling of materials within the reaction vessel.
This method achieves uniform temperature distribution and thorough mixing of materials within the reactor, improving the consistency and stability of the reaction and enhancing the quality and yield of the drug intermediate reaction product.
Smart Images
Figure CN223747578U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of reaction kettle, concretely to a temperature adjustable medicine intermediate reaction kettle. BACKGROUND
[0002] In the drug research and production process, the synthesis reaction of medicine intermediate is very important, and as the core equipment, the performance of the reaction kettle directly affects the quality, yield and production efficiency of the medicine intermediate. With the continuous development of the pharmaceutical industry and the increasing demand for drug quality, the limitations of traditional reaction kettles are gradually highlighted.
[0003] Most of the reaction kettles on the market only rely on the simple way of heat medium or cold medium to adjust the temperature, and the materials in the middle of the inside of the reaction kettle are prone to uneven temperature distribution. The temperature at different positions in the kettle has a large difference, which leads to local overheating or overcooling, affecting the consistency and stability of the reaction, and reducing the uniformity of product quality. At the same time, during the stirring process of the reaction kettle, it is difficult to achieve full and uniform mixing of the medicine intermediate. Especially for some medicine intermediates with high viscosity and complex composition, simple stirring method is easy to cause local accumulation of materials, uneven reaction, and thus reduce the quality and yield of the reaction product.
[0004] Therefore, we propose a temperature adjustable medicine intermediate reaction kettle to solve the problems mentioned above. CONTENT OF THE UTILITY MODEL
[0005] 1. The technical problem to be solved by the utility model:
[0006] The utility model aims to provide a temperature adjustable medicine intermediate reaction kettle to solve the problems in the above background.
[0007] 2. Technical scheme:
[0008] To achieve the above purpose, the utility model provides the following technical scheme: a temperature adjustable medicine intermediate reaction kettle, comprising a reaction kettle body, a reaction kettle cover is installed at the upper end of the reaction kettle body, a jacket is installed at the lower end of the reaction kettle body, and a temperature adjusting stirrer is installed below the reaction kettle cover, a driving part is installed between the upper end of the temperature adjusting stirrer and the reaction kettle cover, and the driving part is used to drive the temperature adjusting stirrer to rotate;
[0009] A communication part is installed at the upper end of the temperature adjusting stirrer, a frame is fixed at the upper end of the reaction kettle cover, the communication part is located in the inside of the frame, a partition plate is installed in the inside of the frame, the inside of the frame is divided into a suction cavity, an injection cavity and a flow-through cavity by the partition plate, a siphoning part is installed in the inside of the flow-through cavity, and the siphoning part is used to drive the medium to flow in the inside of the suction cavity and the injection cavity.
[0010] Further, the temperature-adjusting stirrer comprises a central rod mounted on the cover of the reaction kettle, a stirring tube is mounted on the lower end of the central rod, a reinforcing plate is mounted on the middle part of the stirring tube, and a spoiler plate is mounted on the stirring tube, and the spoiler plate is provided with spoiler holes.
[0011] Through the above technical scheme, the disturbance of the fluid can be increased under the action of the spoiler holes, and the mixing effect is improved.
[0012] Further, the driving member comprises a motor mounted on the cover of the reaction kettle, a guide gear one is mounted on the output end of the motor, the guide gear one and a guide gear two are meshed with each other, and the guide gear two is fixedly sleeved on the outer side of the middle part of the central rod.
[0013] Through the above technical scheme, when the motor is started, the central rod can be driven to rotate by the guide gear one and the guide gear two.
[0014] Further, the communication member comprises a first through pipe and a second through pipe which are respectively communicated with the two ends of the stirring tube, a rotating disc is fixedly arranged on the middle part of the second through pipe, the rotating disc is bearing-mounted on the partition plate, the first through pipe is communicated with the injection cavity, and the second through pipe is communicated with the suction cavity.
[0015] Through the above technical scheme, the two ends of the stirring tube can be respectively communicated with the suction cavity and the injection cavity.
[0016] Further, the centers of the rotating disc and the guide gear two are located on the central axis of the central rod.
[0017] Through the above technical scheme, the rotating disc can ensure that the first through pipe and the second through pipe stably rotate.
[0018] Further, temperature sensors and temperature control assemblies are mounted in the interiors of the suction cavity and the injection cavity, the temperature control assembly comprises a refrigeration element and a heating element, and the suction cavity and the injection cavity are communicated with the interior of the flow-through cavity through one-way valves.
[0019] Through the above technical scheme, the temperature sensors and the temperature control assemblies can control the temperature of the medium, so that the medium exchanges heat with the material, and the material is uniformly heated or cooled subsequently.
[0020] 3. Beneficial effects:
[0021] Compared with the prior art, the temperature-adjustable drug intermediate reaction kettle has the advantages that: the medium can continuously exchange heat with the material in the reaction kettle, the uniform distribution of the temperature in the reaction kettle is ensured, the local overheating or overcooling phenomenon is avoided, and the consistency and stability of the reaction are improved.
[0022] When the electric push rod is started, the electric push rod drives the piston plate to slide in the inside of the flow-through cavity, the medium in the inside of the stirring pipe is extracted from the second through pipe and the suction cavity to the inside of the flow-through cavity in the sliding process, then the electric push rod drives the piston plate to move reversely, the medium in the flow-through cavity is extruded into the injection cavity and the first through pipe in sequence, then enters the inside of the other end of the stirring pipe, the efficient circulation of the medium is realized, the medium can continuously exchange heat with the material in the reaction kettle under the cooperation of the temperature sensor and the temperature control assembly, the uniform distribution of the temperature in the reaction kettle is ensured, the local overheating or overcooling phenomenon is avoided, and the consistency and stability of the reaction are improved.
[0023] When the motor is started, the temperature-adjustable stirrer is driven to rotate through the meshing effect between the guide gear one and the guide gear two, the drug intermediate can be fully mixed in the reaction kettle, the reinforcing plate can ensure the structural strength of the stirring pipe when rotating at high speed, the spoiler and the spoiler hole increase the disturbance of the fluid, improve the mixing effect, promote the reaction of the drug intermediate, and help to improve the quality and yield of the reaction product. BRIEF DESCRIPTION OF DRAWINGS
[0024] Figure 1 It is the overall structure schematic view of the utility model;
[0025] Figure 2 It is the inside structure schematic view of the reaction kettle body of the utility model;
[0026] Figure 3 It is the side view three-dimensional structure schematic view of the temperature-adjustable stirrer of the utility model;
[0027] Figure 4 It is the temperature-adjustable stirrer of the utility model Figure 3 It is the enlarged structure schematic view of A place in the utility model.
[0028] In the drawing: 1, reaction kettle body; 2, reaction kettle cover; 3, jacket; 4, temperature-adjustable stirrer; 41, center rod; 42, stirring pipe; 43, reinforcing plate; 44, spoiler; 45, spoiler hole; 5, driving part; 51, motor; 52, guide gear one; 53, guide gear two; 6, frame body; 61, suction cavity; 62, injection cavity; 63, flow-through cavity; 7, partition plate; 8, temperature sensor; 9, temperature control assembly; 10, electric push rod; 11, piston plate; 12, communicating part; 121, first through pipe; 122, second through pipe; 123, rotating disc. DETAILED DESCRIPTION
[0029] In order to facilitate the understanding of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.
[0030] In the description of the present application, it should be understood that the orientations or positional relationships indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "page", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.
[0031] In addition, the terms "first" and "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "multiple" is two or more, unless otherwise specifically limited.
[0032] In the present application, unless otherwise specifically defined and limited, the terms "mounting", "connection", "connection", "fixing", "provided with" and the like should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the communication between two elements inside. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances. EMBODIMENT
[0033] Please refer to Figures 1-4The utility model provides a temperature adjustable medicine intermediate reaction kettle, including the reaction kettle body 1, the upper end of reaction kettle body 1 is installed with the reaction kettle cover 2, and the lower end outside of reaction kettle body 1 is installed with the jacket 3, and the lower of reaction kettle cover 2 is installed with the temperature control stirrer 4, and the upper end of temperature control stirrer 4 is installed with the driving part 5 between reaction kettle cover 2, and driving part 5 is used to drive temperature control stirrer 4 rotation, temperature control stirrer 4 includes the central rod 41 of bearing installation on reaction kettle cover 2, the lower end of central rod 41 is installed with the stirring pipe 42, and the middle part of stirring pipe 42 is installed with the reinforcing plate 43, and stirring pipe 42 is installed with the spoiler 44, and spoiler 44 is opened with the spoiler hole 45, driving part 5 includes the motor 51 of installation on reaction kettle cover 2, the output of motor 51 is installed with the guide gear one 52, and guide gear one 52 and guide gear two 53 are mutually engaged, and guide gear two 53 is fixedly sleeved in the middle part outside of central rod 41,
[0034] start motor 51, drive guide gear one 52 rotation, under the engagement of guide gear one 52 and guide gear two 53, can drive temperature control stirrer 4 to rotate, so that the medicine intermediate can be fully mixed in the reaction kettle, and the reinforcing plate 43 can guarantee the structural strength of stirring pipe 42 when high-speed rotation, and the spoiler 44 and the spoiler hole 45 increase the disturbance of fluid, improve the mixing effect, promote the reaction of medicine intermediate, help to improve the quality and yield of reaction product,
[0035] the upper end of temperature control stirrer 4 is installed with the communicating part 12, the upper end of reaction kettle cover 2 is fixed with the frame 6, the communicating part 12 is located in the inside of frame 6, and the inside of frame 6 is installed with the partition 7, the inside of frame 6 is divided into the suction cavity 61, the injection cavity 62 and the flow-through cavity 63 through the partition 7, and the inside of flow-through cavity 63 is installed with the drawing part, and the drawing part is used to drive the medium to flow in the inside of suction cavity 61 and injection cavity 62, the communicating part 12 includes the first through pipe 121 and the second through pipe 122 that are connected with the both ends of stirring pipe 42 respectively, the middle part of second through pipe 122 is fixed with the rotating disc 123, and the rotating disc 123 is bearingly installed on the partition 7, and the first through pipe 121 is connected with the injection cavity 62, and the second through pipe 122 is connected with the suction cavity 61, the center of rotating disc 123 and guide gear two 53 are located on the central shaft of central rod 41, the inside of suction cavity 61 and injection cavity 62 is installed with temperature sensor 8 and temperature control assembly 9, and temperature control assembly 9 includes a refrigeration element and a heating element, and the inside of suction cavity 61 and injection cavity 62 is communicated with the inside of flow-through cavity 63 through one-way valve, the drawing part includes the electric push rod 10 of installation on frame 6, the output of electric push rod 10 is fixed with the piston plate 11, and the piston plate 11 is slidingly installed in the inside of flow-through cavity 63,
[0036] The electric push rod 10 is started, and the piston plate 11 is slid in the inside of the flow cavity 63, and in the sliding process, the medium in the inside of the stirring pipe 42 is sequentially extracted from the second through pipe 122 and the suction cavity 61 to the inside of the flow cavity 63, then the electric push rod 10 drives the piston plate 11 to move reversely, and the medium in the flow cavity 63 is sequentially extruded into the injection cavity 62 and the first through pipe 121, and then into the inside of the other end of the stirring pipe 42, realizing the efficient circulation flow of the medium, and under the cooperation of the temperature sensor 8 and the temperature control assembly 9, the medium can continuously exchange heat with the material in the reaction kettle, ensuring the uniform distribution of the temperature in the reaction kettle, avoiding the local overheating or overcooling phenomenon, and being beneficial to improving the consistency and stability of the reaction.
[0037] Working principle: when the temperature-adjustable drug intermediate reaction kettle is used, as shown in the figure, Figures 1-4 The medium in the inside of the stirring pipe 42 is extracted from the second through pipe 122 and the suction cavity 61 to the inside of the flow cavity 63 by the drawing part, and then the medium in the flow cavity 63 is sequentially extruded into the injection cavity 62 and the first through pipe 121 by the drawing part, and then into the inside of the other end of the stirring pipe 42, realizing the efficient circulation flow of the medium, and under the cooperation of the temperature sensor 8 and the temperature control assembly 9, the medium can continuously exchange heat with the material in the reaction kettle, ensuring the uniform distribution of the temperature in the reaction kettle, avoiding the local overheating or overcooling phenomenon, and being beneficial to improving the consistency and stability of the reaction, under the action of the driving part 5, the temperature-adjusting stirrer 4 is driven to rotate, so that the drug intermediates can be fully mixed in the reaction kettle.
[0038] The contents not described in detail in the specification belong to the prior art known by the person skilled in the art.
[0039] Although the utility model has been described in detail with reference to the foregoing embodiments, for the person skilled in the art, the technical scheme recorded in the foregoing embodiments can be modified, or part of the technical features can be replaced, and any modification, equivalent replacement, improvement, etc. within the spirit and principle of the utility model should be included in the protection scope of the utility model.
Claims
1. A temperature adjustable pharmaceutical intermediate reaction kettle characterized in that: The utility model provides a reaction kettle, which comprises a reaction kettle body (1), a reaction kettle cover (2) is arranged at the upper end of the reaction kettle body (1), a jacket (3) is arranged at the lower end of the reaction kettle body (1), a temperature-adjusting stirrer (4) is arranged below the reaction kettle cover (2), a driving part (5) is arranged between the upper end of the temperature-adjusting stirrer (4) and the reaction kettle cover (2), and the driving part (5) is used for driving the temperature-adjusting stirrer (4) to rotate. A communication part (12) is arranged at the upper end of the temperature-adjusting stirrer (4), a frame (6) is fixed to the upper end of the reaction kettle cover (2), the communication part (12) is arranged in the frame (6), a partition plate (7) is arranged in the frame (6), the frame (6) is divided into a suction cavity (61), an injection cavity (62) and a flow-through cavity (63) by the partition plate (7), a pumping part is arranged in the flow-through cavity (63), and the pumping part is used for driving the medium to flow in the suction cavity (61) and the injection cavity (62).
2. The temperature adjustable pharmaceutical intermediate reactor of claim 1, wherein: The temperature-adjusting stirrer (4) comprises a central rod (41) arranged on the reaction kettle cover (2) through a bearing, a stirring pipe (42) is arranged at the lower end of the central rod (41), a reinforcing plate (43) is arranged at the middle of the stirring pipe (42), and a spoiler (44) is arranged on the stirring pipe (42), and a spoiler hole (45) is arranged in the spoiler (44).
3. The temperature adjustable pharmaceutical intermediate reactor of claim 1, wherein: The driving part (5) comprises a motor (51) arranged on the reaction kettle cover (2), a guide gear one (52) is arranged at the output end of the motor (51), the guide gear one (52) and a guide gear two (53) are in meshing connection, and the guide gear two (53) is fixedly arranged on the outer side of the middle of the central rod (41).
4. The temperature adjustable pharmaceutical intermediate reactor of claim 1, wherein: The communication part (12) comprises a first through pipe (121) and a second through pipe (122) in communication with the two ends of the stirring pipe (42) respectively, a rotating disc (123) is fixedly arranged at the middle of the second through pipe (122), the rotating disc (123) is arranged on the partition plate (7) through a bearing, the first through pipe (121) is in communication with the injection cavity (62), and the second through pipe (122) is in communication with the suction cavity (61).
5. The temperature adjustable pharmaceutical intermediate reactor of claim 4, wherein: The centers of the rotating disc (123) and the guide gear two (53) are located on the central axis of the central rod (41).
6. The temperature adjustable pharmaceutical intermediate reactor of claim 1, wherein: Temperature sensors (8) and temperature control assemblies (9) are arranged in the suction cavity (61) and the injection cavity (62) respectively, the temperature control assembly (9) comprises a refrigeration element and a heating element, and the suction cavity (61) and the injection cavity (62) are in communication with the flow-through cavity (63) through one-way valves.
7. The temperature adjustable pharmaceutical intermediate reactor of claim 1, wherein: The pumping part comprises an electric push rod (10) arranged on the frame (6), a piston plate (11) is fixedly arranged at the output end of the electric push rod (10), and the piston plate (11) is slidingly arranged in the flow-through cavity (63).