Heparinoid processing and purifying equipment

Abstract

The utility model relates to the technical field of heparin processing, in particular to heparinoid processing and purifying equipment, which comprises an ion exchange resin cylinder and a purifying cylinder, a filter screen frame is mounted at the upper end of the ion exchange resin cylinder through a mounting rack, ion exchange resin is arranged in the ion exchange resin cylinder, and the purifying cylinder is mounted on the filter screen frame. A purification cylinder is arranged at one end of the ion exchange resin cylinder, a top cover is clamped at the top of the purification cylinder, a glass observation opening is embedded in one side of the purification cylinder, an electric heater is mounted on one side of the bottom end of the glass observation opening through a mounting hole, and a temperature controller is mounted at the upper end of the electric heater through a screw; a through guide sleeve is arranged at one end of the top of the top cover, and a metal material taking straight pipe is arranged in the through guide sleeve in a sleeved mode. According to the heparinoid processing and purifying equipment, the supernate and the heparinoid-containing precipitate can be conveniently and rapidly separated and subjected to evaporation and dehydration treatment, water and organic solvents in the supernate and the heparinoid-containing precipitate are removed, the processing efficiency is improved, and manpower and material resources are saved.

Description

Technical Field

[0001] This utility model relates to the field of heparin processing technology, specifically to a heparin-like processing and purification device. Background Technology

[0002] The pretreated raw materials are added to an appropriate amount of enzymatic hydrolysate for enzymatic hydrolysis. The hydrolysate typically contains trypsin or other enzymes capable of breaking down proteins in the raw materials. Through enzymatic hydrolysis, the proteins in the raw materials are degraded into small peptides or amino acids, thereby releasing heparin-like substances bound to the proteins. After enzymatic hydrolysis, the heparin-like substances are purified and separated using processing and purification equipment.

[0003] Existing heparin processing and purification equipment is not convenient for quickly separating the supernatant and heparin-containing precipitate and performing evaporation and dehydration to remove water and organic solvents. The processing efficiency is low and it is time-consuming and labor-intensive. Utility Model Content

[0004] To address the problems in the existing technology, this utility model provides a heparin-like processing and purification device. This device facilitates the rapid separation of the supernatant and the heparin-like precipitate, followed by evaporation and dehydration to remove moisture and organic solvents, thereby improving processing efficiency and saving manpower and resources.

[0005] The technical solution adopted by this utility model to solve its technical problem is a heparin-like processing and purification equipment, including an ion exchange resin cylinder and a purification cylinder. A filter screen frame is installed on the upper end of the ion exchange resin cylinder through a mounting bracket. Ion exchange resin is disposed inside the ion exchange resin cylinder. A purification cylinder is provided at one end of the ion exchange resin cylinder, and a top cover is snapped onto the top of the purification cylinder. A glass observation port is embedded on one side of the purification cylinder. An electric heater is installed on one side of the bottom end of the glass observation port through a mounting hole. A temperature controller is installed on the upper end of the electric heater through screws.

[0006] The top of the top cover is provided with a through guide sleeve and a metal material taking straight tube is sleeved inside the through guide sleeve. The bottom end of the metal material taking straight tube is located at the bottom of the purification cylinder and the top end of the metal material taking straight tube is connected to a bend pipe. A suction pump B is provided on the bend pipe. An electric cylinder is installed at one end of the through guide sleeve through a mounting base and the output shaft of the electric cylinder is connected to the metal material taking straight tube through a connecting plate.

[0007] By adopting the above technical solution, the heparin-like processing and purification equipment can quickly separate the supernatant and heparin-like precipitate and perform evaporation and dehydration treatment to remove water and organic solvents, thereby improving processing efficiency and saving manpower and material resources.

[0008] Specifically, the heating end of the electric heater and the detection end of the temperature controller are both located inside the purification cylinder, and the output end of the temperature controller is electrically connected to the input end of the electric heater through a wire.

[0009] Specifically, the top of the top cover is connected to the condenser via a pipe at its axial center, and a control valve is installed at the end of the bend and close to the metal feed straight pipe.

[0010] By adopting the above technical solution, the control valve and suction pump B are opened, and the supernatant in the purification cylinder is easily extracted using the metal material extraction straight pipe.

[0011] Specifically, a dosing port is provided at the top of the top cover and a dispensing port is provided at the bottom of the purification cylinder. Both the dosing port and the dispensing port are fitted with sealing caps on their outer sides.

[0012] By adopting the above technical solution, ethanol, acetone, etc. are added from the dosing port to precipitate heparin, and the sealing cap of the dispensing port is opened to facilitate dispensing.

[0013] Specifically, a connecting pipe is provided between the bottom side of the ion exchange resin cylinder and the top side of the purification cylinder, and a suction pump A is provided on the connecting pipe.

[0014] The beneficial effects of this utility model are:

[0015] (1) The heparin-like processing and purification equipment of this utility model, after enzymatic hydrolysis, removes solid impurities and undegraded proteins by filtering through a filter screen to obtain a filtrate containing heparin. The filtrate is then treated with ion exchange resin to remove ionic impurities. The treated filtrate is stored at the bottom of the ion exchange resin cylinder. The filtrate containing heparin is then drawn into the purification cylinder by a suction pump A. Ethanol, acetone, etc. are added from the dosing port to precipitate the heparin.

[0016] (2) The heparin-like processing and purification equipment described in this utility model uses an electric cylinder to drive the metal material picking tube to move up and down, so as to facilitate the extraction of the supernatant of the purification cylinder by turning on the suction pump B, leaving the precipitate. The electric heater is automatically controlled by the temperature controller to keep the temperature of the purification cylinder constant. The heparin obtained by precipitation is evaporated and dehydrated to remove the water and organic solvents. The generated steam is condensed by the condenser. Then, the heparin-like product is obtained by drying. The material picking port sealing cover is opened to facilitate material picking. Attached Figure Description

[0017] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a side view of the present invention;

[0020] Figure 3This is a schematic diagram of the ion exchange resin structure of this utility model.

[0021] In the diagram: 1. Electric heater; 2. Temperature controller; 3. Feed port; 4. Glass observation port; 5. Purification cylinder; 6. Top cover; 7. Through guide sleeve; 8. Electric cylinder; 9. Bend; 10. Metal feed straight pipe; 11. Suction pump B; 12. Control valve; 13. Connecting plate; 14. Condenser; 15. Dosing port; 16. Suction pump A; 17. Filter screen frame; 18. Ion exchange resin cylinder; 19. Connecting pipe; 20. Ion exchange resin. Detailed Implementation

[0022] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0023] To facilitate the rapid separation of the supernatant and heparin-containing precipitate in the heparin-like processing and purification equipment, and to perform evaporation and dehydration treatment to remove water and organic solvents, thereby improving processing efficiency and saving manpower and resources, such as... Figure 1-3 As shown, the heparin-like processing and purification equipment of this utility model includes an ion exchange resin cylinder 18 and a purification cylinder 5. A filter screen frame 17 is installed on the upper end of the ion exchange resin cylinder 18 through a mounting bracket. Ion exchange resin 20 is disposed inside the ion exchange resin cylinder 18. The purification cylinder 5 is disposed at one end of the ion exchange resin cylinder 18, and a top cover 6 is engaged with the top of the purification cylinder 5. A glass observation port 4 is embedded on one side of the purification cylinder 5. An electric heater 1 is installed on one side of the bottom end of the glass observation port 4 through a mounting hole. A temperature controller 2 is installed on the upper end of the electric heater 1 through screws.

[0024] The top end of the top cover 6 is provided with a through guide sleeve 7 and a metal material taking straight tube 10 is sleeved inside the through guide sleeve 7. The bottom end of the metal material taking straight tube 10 is located at the bottom of the purification cylinder 5 and the top end of the metal material taking straight tube 10 is connected to a bend 9. A suction pump B11 is provided on the bend 9. One end of the through guide sleeve 7 is equipped with an electric cylinder 8 through a mounting base and the output shaft of the electric cylinder 8 is connected to the metal material taking straight tube 10 through a connecting plate 13.

[0025] When in use, the heparin-like processing and purification equipment facilitates the rapid separation of the supernatant and heparin-containing precipitate, and performs evaporation and dehydration treatment to remove water and organic solvents, thereby improving processing efficiency and saving manpower and resources.

[0026] For example, such as Figure 1 As shown, the present invention also includes the fact that the heating end of the electric heater 1 and the detection end of the temperature controller 2 are both located inside the purification cylinder 5, and the output end of the temperature controller 2 is electrically connected to the input end of the electric heater 1 through a wire.

[0027] During use, the temperature controller 2 automatically controls the electric heater 1 to maintain a constant temperature inside the purification cylinder 5.

[0028] For example, such as Figure 1 As shown, the present invention also includes a condenser 14 connected to the top axis of the top cover 6 via a pipe, and a control valve 12 is provided at the end of the bend 9 and close to the metal feed straight pipe 10.

[0029] When in use, opening the control valve 12 and the suction pump B11 allows the supernatant in the purification cylinder 5 to be extracted using the metal material handling straight pipe 10.

[0030] For example, such as Figure 1 As shown, the present invention also includes a dosing port 15 at the top of the top of the top cover 6 and a material extraction port 3 at the bottom of the bottom of the purification cylinder 5. Both the dosing port 15 and the material extraction port 3 are fitted with sealing caps on their outer sides.

[0031] When using, add ethanol, acetone, etc. through the dosing port 15 to precipitate heparin, and open the sealing cap of the dispensing port 3 to facilitate dispensing.

[0032] For example, such as Figure 1 As shown, the present invention also includes a connecting pipe 19 provided between the bottom end of the ion exchange resin cylinder 18 and the top end of the purification cylinder 5, and a suction pump A16 is provided on the connecting pipe 19.

[0033] During use, the filtrate containing heparin is drawn into the purification cylinder 5 using the suction pump A16.

[0034] In use, after enzymatic hydrolysis, the solid impurities and undegraded proteins are removed by filtering through the filter frame 17 to obtain a filtrate containing heparin-like substances. The filtrate is then treated with ion exchange resin 20 to remove ionic impurities. The treated filtrate is then stored at the bottom of the ion exchange resin cylinder 18.

[0035] The filtrate containing heparin is drawn into the purification cylinder 5 by the suction pump A16. Ethanol, acetone and other substances are added through the dosing port 15 to precipitate the heparin. The metal material picking tube 10 is moved up and down by the electric cylinder 8, so that the supernatant of the purification cylinder 5 can be extracted by turning on the suction pump B11, leaving the precipitate.

[0036] The temperature controller 2 automatically controls the electric heater 1 to heat the purification cylinder 5 at a constant temperature. The precipitated heparin is evaporated and dehydrated to remove water and organic solvents. The generated steam is condensed by the condenser 14. Then, the heparin product is obtained by drying. The sealing cover of the feeding port 3 is opened to facilitate feeding.

[0037] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The descriptions of the above embodiments and specifications are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of protection claimed by this utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. An apparatus for heparinoid processing and purification, characterized in that, Including ion exchange resin cylinder (18) and purification cylinder (5), the upper end of the ion exchange resin cylinder (18) is installed with filter screen frame (17) through mounting bracket, ion exchange resin (20) is arranged in the ion exchange resin cylinder (18), the ion exchange resin cylinder (18) is provided with purification cylinder (5) at one end and the top of purification cylinder (5) is clamped with top cover (6), one side of the purification cylinder (5) is embedded with glass observation port (4), the bottom end of the glass observation port (4) is installed with electric heater (1) through mounting hole at one side, the upper end of the electric heater (1) is installed with temperature controller (2) through screw; The top end of the top cover (6) is provided with through guide sleeve (7), and the metal material taking straight pipe (10) is sleeved in the through guide sleeve (7), the bottom end of the metal material taking straight pipe (10) is located in the bottom of the purification cylinder (5), and the top end of the metal material taking straight pipe (10) is connected with elbow pipe (9), the elbow pipe (9) is provided with suction pump B (11), one end of the through guide sleeve (7) is installed with electric cylinder (8) through mounting seat, and the output shaft of the electric cylinder (8) is connected with the metal material taking straight pipe (10) through connecting plate (13).

2. A heparinoid processing and purification apparatus according to claim 1, characterized in that The heating end of the electric heater (1) and the detection end of the temperature controller (2) are located in the purification cylinder (5), and the output end of the temperature controller (2) and the input end of the electric heater (1) are electrically connected through wires.

3. A heparinoid processing and purification apparatus according to claim 1, wherein, The top center of the top cover (6) is connected with condenser (14) through pipeline, the end of the elbow pipe (9) and close to the metal material taking straight pipe (10) is provided with control valve (12).

4. A heparinoid processing and purification apparatus according to claim 1, wherein, The other end of the top of the top cover (6) is provided with dosing port (15), the other end of the bottom of the purification cylinder (5) is provided with material taking port (3), and the outer sides of the dosing port (15) and the material taking port (3) are clamped with sealing covers.

5. A heparinoid processing and purification apparatus according to claim 1, wherein, The bottom end of the ion exchange resin cylinder (18) and the top end of the purification cylinder (5) are provided with communication pipe (19), and the communication pipe (19) is provided with suction pump A (16).

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