Medical titanium plate

Abstract

The utility model provides a medical titanium plate which comprises a base body, the base body is a medical grade titanium alloy plate, a nanometer structure layer changing in a gradient mode in the thickness direction is arranged in the base body, and the sizes of nanometer crystal grains in the nanometer structure layer are gradually increased from the surface of the base body to the inside of the base body. A porous structure which is integrally formed through chemical etching is also arranged on the surface of the base body; by adding the nano structure layer, the hardness and the wear resistance of the surface of the substrate are improved, the scratch resistance and the corrosion resistance of the substrate are enhanced, and the overall mechanical property is optimized while good toughness and plasticity of the interior of the material are kept through gradient change of nano crystal grains; the structure is favorable for reducing the mechanical stress concentration after implantation and improving the long-term stability and durability of the implant.

Description

Technical Field

[0001] This utility model relates to the field of metal sheets, and more particularly to a medical titanium sheet. Background Technology

[0002] With the rapid development of modern medicine, the requirements for orthopedic surgery and other medical implants are increasing. Against this backdrop, titanium and its alloys, due to their unique physical, chemical, and biological properties, have been widely used in the medical field, especially in orthopedic implants, where they occupy a pivotal position.

[0003] Traditional medical titanium plates rely solely on the properties of the titanium alloy itself, which has limitations in its integration with bone tissue. From the perspective of osseointegration, the relatively smooth and flat surface of ordinary titanium plates makes it difficult for bone cells to effectively attach and proliferate, resulting in a slower bone healing rate after implantation. Furthermore, due to the lack of special structural design, the mechanical interlocking between the implant and bone tissue is not stable enough, posing a long-term risk of implant loosening. In addition, regarding biocompatibility, although titanium itself has a certain degree of biocompatibility, it lacks the characteristics to actively promote bone tissue growth and integration, making it difficult to meet the requirements of modern medicine for rapid and effective osseointegration and long-term stability of implant materials. Utility Model Content

[0004] To address the shortcomings of existing medical titanium plates in terms of their integration with bone tissue, this invention provides a medical titanium plate.

[0005] The medical titanium plate provided by this utility model adopts the following technical solution:

[0006] A medical titanium plate includes a substrate, which is a medical-grade titanium alloy plate. The substrate has a nanostructure layer with a gradient along the thickness direction, and the size of the nanocrystals in the nanostructure layer gradually increases from the surface of the substrate to the interior. The surface of the substrate is also provided with a porous structure formed integrally by chemical etching.

[0007] Furthermore, the nanostructure layer is formed by surface mechanical rolling or laser processing, and the average size of its nanocrystals is 10nm-50nm on the substrate surface and gradually increases to 100nm-500nm inside.

[0008] Furthermore, the porous structure is composed of several through holes that completely penetrate the substrate in three-dimensional space.

[0009] Furthermore, the pore size of the through hole ranges from 100μm to 800μm, and the porosity is 20% to 60%.

[0010] Furthermore, the inner wall surface of the through hole is roughened, with a root mean square value of 5nm-50nm, to enhance bone cell attachment and growth.

[0011] Furthermore, the substrate is also subjected to surface bioactive treatment to form an outer coating, in order to further improve its biocompatibility and bone integration ability;

[0012] Furthermore, the outer coating is either a hydroxyapatite coating or a collagen coating.

[0013] In summary, the beneficial effects of this utility model are as follows:

[0014] This invention improves the surface hardness and wear resistance of the substrate by adding a nanostructure layer, enhancing its scratch resistance and corrosion resistance. Furthermore, by varying the gradient of nanocrystals, it optimizes the overall mechanical properties while maintaining good internal toughness and plasticity of the material. This structure helps reduce mechanical stress concentration after implantation, improving the long-term stability and durability of the implant.

[0015] Secondly, the porous structure on the substrate surface not only mimics the natural porosity of bone tissue, providing an ideal microenvironment for the migration, proliferation, and differentiation of osteocytes, but also promotes the vascularization process, providing the necessary nutrients and oxygen supply for the growth of new bone tissue; it accelerates the bone healing process, improves the bonding strength between the implant and bone tissue, and reduces the risk of implant loosening. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This utility model Figure 1 An enlarged schematic diagram of part A in the middle.

[0018] As shown in the figure: 1-substrate, 2-through pores, 3-nanocrystalline grains, 4-outer coating. Detailed Implementation

[0019] The following is in conjunction with the appendix Figure 1-2 The present invention will be further described in detail below:

[0020] This utility model discloses a medical titanium plate, such as... Figure 1 , 2As shown, a medical titanium plate includes a substrate 1, which is a medical-grade titanium alloy plate. The substrate 1 has a nanostructure layer with a gradient along its thickness direction. The size of the nanocrystals 3 in the nanostructure layer gradually increases from the surface of the substrate 1 to the interior. The surface of the substrate 1 also has a porous structure formed integrally by chemical etching. In this embodiment, the gradient nanostructure layer not only improves the overall mechanical properties of the titanium plate, but also enhances its interfacial bonding ability with bone tissue, which helps the long-term stability of the implant. In addition, the porous structure provides more attachment points and growth space for bone cells, which is conducive to the formation of new bone and the osseointegration of the implant. At the same time, this structure also helps to improve the air permeability and fluid permeability of the implant, reducing the risk of infection.

[0021] like Figure 1 , 2 As shown, the nanostructure layer is formed by surface mechanical rolling or laser processing. The average size of its nanocrystals 3 is 10nm-50nm on the surface of the substrate 1, gradually increasing to 100nm-500nm inside. In this embodiment, surface mechanical rolling or laser processing is an effective means of forming the nanostructure layer. Surface mechanical rolling applies pressure to the surface of the substrate 1 using a rolling tool, causing plastic deformation of the surface material, thereby refining the grains. Laser processing uses a high-energy-density laser beam to irradiate the surface of the substrate 1, causing rapid melting and solidification of the surface material, forming fine nanocrystals 3. In the direction from the surface of the substrate 1 inward, the size of the nanocrystals 3 gradually increases due to the gradient changes in energy transfer and stress distribution during processing. From the perspective of materials science, according to the Hall-Petch relationship, the smaller the grain size, the higher the hardness of the material. Forming smaller nanocrystals 3 on the surface of the substrate 1, such as 10nm-50nm, can improve the surface hardness and wear resistance, which helps to resist friction and wear after implantation. Meanwhile, the internal grains gradually increase to 100nm-500nm, which can maintain good toughness and plasticity inside the material and avoid the overall material from being too brittle.

[0022] like Figure 1 , 2 As shown, the porous structure consists of several through holes 2 that completely penetrate the substrate in three-dimensional space. In this embodiment, chemical etching is a technique for precisely controlling the microstructure of the material surface. By selecting appropriate etchants and etching conditions, the etchant reacts chemically with the surface of the substrate 1, selectively removing part of the titanium alloy material, thereby forming a porous structure. This porous structure design that completely penetrates the substrate in three-dimensional space draws inspiration from the porous characteristics of bone tissue. Bone tissue is a natural porous material, and its pore network provides channels for the exchange of cells, nutrients, and metabolic waste.

[0023] The porous structure mimics the natural structure of bone tissue, making it easier for bone cells to attach and grow on the surface and in the internal pores of the titanium plate. In addition, this structure facilitates the ingrowth of vascular endothelial cells, promotes the vascularization process, provides the necessary nutrients and oxygen supply for the growth of new bone tissue, and accelerates the bone healing process. Moreover, the presence of the porous structure can reduce the elastic modulus of the titanium plate, making it closer to the elastic modulus of bone tissue, reducing the stress shielding effect, and further improving the integration effect between the implant and bone tissue.

[0024] like Figure 1 , 2 As shown, the pore size of through-hole 2 ranges from 100μm to 800μm, and the porosity is 20% to 60%. In this embodiment, the appropriate pore size and porosity can guide bone cells to grow orderly along the pore walls. Bone cells can connect with each other in the pores and secrete extracellular matrix, gradually filling the entire porous structure and achieving a tight bond between the implant and bone tissue. This structure helps to evenly distribute the stress borne by the implant inside the human body, reduce local stress concentration, and improve the lifespan of the implant. At the same time, the appropriate porosity can also regulate the exchange of substances between the titanium plate and the surrounding tissues, such as the infiltration of nutrients and the excretion of metabolic waste, which is conducive to maintaining the stability of the physiological environment at the implantation site.

[0025] like Figure 1 , 2 As shown, the inner wall surface of the through-hole 2 is roughened with a root mean square value of 5nm-50nm to enhance bone cell attachment and growth. In this embodiment, the roughened inner wall surface provides more attachment points for bone cells, allowing them to spread better on the surface, activate intracellular signal transduction pathways, and promote cell proliferation and differentiation. This helps to accelerate the formation of new bone tissue inside the through-hole 2, improve the mechanical locking effect between the implant and bone tissue, enhance the stability of the implant in vivo, and reduce implant loosening caused by poor osteointegration.

[0026] like Figure 1 , 2As shown, the substrate 1 is further treated with a surface bioactivity treatment to form an outer coating 4, which further improves its biocompatibility and osteointegration ability. The outer coating 4 is either a hydroxyapatite coating or a collagen coating. In this embodiment, hydroxyapatite is the main inorganic component of bone tissue and has good bioactivity and osteoconductivity. When a hydroxyapatite coating is formed on the surface of the substrate 1, the calcium ions and phosphate ions in the coating can exchange with ions in the surrounding physiological environment, promoting the deposition of apatite on the coating surface and forming an apatite layer similar to natural bone tissue. Collagen is an important component of the extracellular matrix of bone tissue. The collagen coating can provide adhesion sites for cells, and its special structure can regulate cell behavior. When a collagen coating is formed on the surface of the substrate 1, collagen molecules can be fixed on the surface by physical adsorption or chemical cross-linking, forming a microenvironment conducive to bone cell attachment and growth.

[0027] Both coatings can reduce the body's immune system's rejection response to the implant after implantation, improve the integration of the implant with bone tissue, accelerate the bone healing process, and improve the long-term clinical efficacy of the implant.

[0028] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. The various components mentioned in this utility model are common technologies in the existing field. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A medical titanium plate, characterized in that, Includes a substrate (1), which is a medical-grade titanium alloy plate. The substrate (1) has a nanostructure layer with a gradient along the thickness direction inside. The size of the nanocrystals (3) in the nanostructure layer gradually increases from the surface of the substrate (1) to the inside. The surface of the substrate (1) is also provided with a porous structure formed by chemical etching.

2. A medical titanium plate according to claim 1, characterized in that, The nanostructure layer is formed by surface mechanical rolling or laser processing. The average size of its nanocrystals (3) is 10nm-50nm on the surface of the substrate (1) and gradually increases to 100nm-500nm inside.

3. A medical titanium plate according to claim 1, characterized in that, The porous structure is composed of several through holes (2) that completely penetrate the substrate in three-dimensional space.

4. A medical titanium plate according to claim 3, characterized in that, The pore size of the through hole (2) ranges from 100μm to 800μm, and the porosity is 20% to 60%.

5. A medical titanium plate according to claim 3, characterized in that, The inner wall surface of the through hole (2) is roughened, and the root mean square value of the roughness is 5nm-50nm; in order to enhance bone cell attachment and growth.

6. A medical titanium plate according to any one of claims 1-5, characterized in that, The substrate (1) is further subjected to surface bioactive treatment to form an outer coating (4) to further improve its biocompatibility and bone integration ability.

7. A medical titanium plate according to claim 6, characterized in that, The outer coating (4) is either a hydroxyapatite coating or a collagen coating.

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