Pipetting device

Abstract

The pipetting device comprises an adjusting plate and a pipetting plate, the adjusting plate comprises a first plate body and a sleeve, the first end of the sleeve is connected to the first plate body, the second end of the sleeve is provided with a partition part, and the partition part shields part of an opening in the second end of the sleeve; the pipetting plate comprises a second plate body and an adjusting rod arranged on the surface of the second plate body, and an open groove is formed in the end, away from the second plate body, of the adjusting rod and extends in the axial direction of the adjusting rod; wherein the adjusting plate is movably connected with the pipetting plate, the adjusting rod penetrates into the sleeve, the adjusting rod is in clearance fit with the sleeve, the slot penetrates out of the opening of the second end of the sleeve, and the length of the slot extending out of the opening of the second end of the sleeve is adjustable.

Description

Technical Field

[0001] This application relates to the field of pipetting equipment technology, and in particular to a pipetting device. Background Technology

[0002] The transfer of micro-solutions is in high demand in biomedical research, particularly in high-throughput screening and detection. Related technologies typically employ pneumatic pipetting, electrodynamic pipetting, acoustic pipetting, microfluidic chip pipetting, or capillary pipetting. However, pneumatic, electrodynamic, and acoustic pipetting rely on external power to adsorb or release the solution, resulting in high equipment costs and insufficient efficiency for high-throughput pipetting. Microfluidic chip pipetting has stringent requirements for fluid dynamics, and these methods are less effective at handling complex fluids (e.g., high-viscosity liquids).

[0003] Capillary pipetting utilizes the principle of capillary action, automatically controlling the absorption and distribution of liquids through surface tension. It has the advantage of not requiring external power for liquid adsorption and release, and is highly adaptable to various liquid properties. However, current capillary pipetting equipment can only transfer a fixed volume of solution, which is insufficient for most experimental needs. Utility Model Content

[0004] To solve at least one of the above-mentioned technical problems, this application provides a pipetting device capable of adjusting the volume of the pipetting tank, and the technical solution adopted is as follows.

[0005] The pipetting device provided in this application includes an adjusting plate and a pipetting plate. The adjusting plate includes a first plate body and a sleeve. A first end of the sleeve is connected to the first plate body, and a second end of the sleeve is provided with a partition portion that blocks part of the opening at the second end of the sleeve. The pipetting plate includes a second plate body and an adjusting rod disposed on the surface of the second plate body. A slot is provided at the end of the adjusting rod away from the second plate body, and the slot extends axially along the adjusting rod. The adjusting plate and the pipetting plate are movably connected. The adjusting rod passes through the sleeve and is clearance-fitted with the sleeve. The slot extends out from the opening at the second end of the sleeve, and the length of the slot extending out from the opening at the second end of the sleeve is adjustable.

[0006] In some embodiments of this application, the pipetting device further includes an adjustment component connected to the first plate and / or the second plate, the adjustment component being used to adjust the distance between the first plate and the second plate.

[0007] In some embodiments of this application, the adjustment assembly includes an adjustment screw, the second plate has an adjustment hole, the first plate has a mounting hole corresponding to the adjustment hole, the adjustment screw passes through the adjustment hole and the mounting hole, and the adjustment screw is threadedly connected to the adjustment hole to adjust the distance between the first plate and the second plate.

[0008] In some embodiments of this application, one end of the adjusting screw that passes through the mounting hole is provided with a base, the base being embedded in the mounting hole, and the thickness of the base being less than or equal to the opening depth of the mounting hole.

[0009] In some embodiments of this application, the minimum distance between the adjusting hole and the edge of the adjusting rod connected to one end of the second plate is greater than or equal to 0.5 mm.

[0010] In some embodiments of this application, the opening depth of the mounting hole is less than or equal to the thickness of the first plate, the opening radius of the mounting hole is greater than the radius of the adjustment hole, and the minimum distance between the mounting hole and the edge of the first end of the sleeve is greater than or equal to 0.5 mm.

[0011] In some embodiments of this application, the first plate or the second plate is provided with an indicator scale.

[0012] In some embodiments of this application, the second plate is provided with the adjustment hole, the indicator scale is disposed on the surface of the second plate opposite to the first plate, and the indicator scale is disposed on the outer periphery of the adjustment hole.

[0013] In some embodiments of this application, the adjustment assembly further includes an adjustment knob connected to the adjustment screw, and at least one of the adjustment knob or the adjustment screw is provided with an indicator line, the adjustment knob being used to drive the adjustment screw to rotate.

[0014] In some embodiments of this application, the adjustment hole is located at the geometric center of the first plate or the second plate.

[0015] In some embodiments of this application, at least two adjustment holes are provided, the number of adjustment screws is the same as the number of adjustment holes, and the adjustment holes are diagonally arranged on the first plate or the second plate.

[0016] In some embodiments of this application, the gap between the adjusting rod and the sleeve is in the range of 10 μm to 50 μm.

[0017] In some embodiments of this application, the partition extends radially along the second end opening of the sleeve, the partition passes through the center of the second end opening of the sleeve, the partition divides the second end opening into two channel openings, the two channel openings are respectively located on both sides of the partition, and the two side walls of the slot extend from the two channel openings.

[0018] In some embodiments of this application, the partition portion includes a plurality of partition members, one end of the plurality of partition members being connected to each other, and the other end being connected to the outer periphery of the second end opening of the sleeve.

[0019] In some embodiments of this application, the adjusting plate includes a plurality of sleeves arranged in an array on the first plate body, and the pipette is provided with an adjusting rod of the same number as the sleeves, with each adjusting rod connected to a sleeve in a one-to-one correspondence.

[0020] In some embodiments of this application, the inner diameter of the sleeve gradually decreases from the first end to the second end.

[0021] The embodiments of this application have at least the following beneficial effects: By providing a partition at the second end of the sleeve to partially block the opening at the second end, and by providing a slot at one end of the adjusting rod, when the adjusting rod is inserted into the sleeve and one end of the adjusting rod extends out of the opening at the second end of the sleeve, the slotted portion of the adjusting rod can protrude from the unblocked portion of the opening at the second end of the sleeve. The slot and the partition of the adjusting rod can constitute a pipette for adsorbing or releasing liquid. By adjusting the length of the slot extending out of the opening at the second end, the depth of the pipette can be adjusted, thereby changing the volume of the pipette and achieving the effect of adjustable pipetting volume of the pipetting device. For scenarios requiring different pipetting volumes in experiments, the volume of the pipette can be changed by adjusting the relative positional relationship between the adjusting rod and the sleeve, achieving the effect of adjustable-range micro-liquid transfer to meet different experimental needs.

[0022] Liquid transfer is achieved by utilizing capillary action and the surface tension of liquids. This allows for liquid adsorption or release without external power, offering advantages such as low equipment cost and ease of operation and maintenance. In this application, a pipetting trough is formed by interlocking an adjusting plate and a pipetting plate, resulting in a simple structure. This facilitates the batch installation of sleeves and adjusting rods, increasing the throughput of the pipetting device and enabling batch operations on droplets, thereby improving pipetting efficiency. Attached Figure Description

[0023] The present application will be further illustrated below with reference to the accompanying drawings and embodiments. It should be noted that the embodiments illustrated in the following drawings are exemplary and are only used to explain the present application, and should not be construed as limiting the present application.

[0024] Figure 1 This is a schematic diagram of the structure of the pipetting plate of the pipetting device provided in the embodiments of this application;

[0025] Figure 2 This is a schematic diagram of the structure of the adjusting rod of the pipetting device provided in the embodiments of this application;

[0026] Figure 3 A schematic diagram of the adjustment plate of the pipetting device provided in an embodiment of this application;

[0027] Figure 4 A schematic diagram of the adjustment plate of the pipetting device provided in an embodiment of this application from another perspective;

[0028] Figure 5 This is a schematic diagram of the structure of the sleeve of the pipetting device provided in the embodiments of this application;

[0029] Figure 6 A schematic diagram of an example of a pipetting device provided in an embodiment of this application;

[0030] Figure 7 This is a schematic diagram of the structure of the adjustment component provided in the embodiments of this application;

[0031] Figure 8 A schematic diagram of the structure of the pipetting device provided in this application embodiment with the adjusting rod inserted into the sleeve;

[0032] Figure 9 A schematic diagram of another state in which the adjusting rod of the pipetting device provided in the embodiment of this application is inserted into the sleeve;

[0033] Figure 10 A schematic cross-sectional view of the sleeve of the pipetting device provided in the embodiments of this application;

[0034] Figure 11 This is a schematic diagram of another example of the pipetting device provided in the embodiments of this application.

[0035] Reference numerals: 100, pipetting device; 10, adjusting plate; 11, first plate body; 12, sleeve; 121, first end; 122, second end; 1221, partition; 1223, channel opening; 13, mounting hole; 20, pipetting plate; 21, second plate body; 22, adjusting rod; 221, slot; 23, adjusting hole; 30, adjusting assembly; 31, adjusting screw; 32, indicating scale; 33, adjusting knob; 34, indicating line; 35, base. Detailed Implementation

[0036] The embodiments of this application are described in detail below with reference to the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this application, and should not be construed as limiting this application.

[0037] In the description of this application, it should be understood that the terms "center", "middle", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0038] In the description of this application, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. The use of "first" and "second" in the description is merely for distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the order of the indicated technical features.

[0039] In the description of this application, unless otherwise expressly specified and limited, the terms "set up," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0040] In the description of this application, the use of terms such as "as one implementation," "an embodiment," "some examples," "some embodiments," "illustrative embodiment," "example," "specific example," "some examples," etc., indicates that the specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0041] The contents of this application are described in detail below with reference to specific embodiments. It should be noted that the following description is merely illustrative and not a specific limitation of this application.

[0042] This application provides a pipetting device 100. Please refer to [link to relevant documentation]. Figures 1 to 6 The pipetting device 100 includes an adjusting plate 10 and a pipetting plate 20. The adjusting plate 10 includes a first plate body 11 and a sleeve 12. A first end 121 of the sleeve 12 is connected to the first plate body 11, and a second end 122 of the sleeve 12 has a partition portion 1221 that blocks part of the opening of the second end 122 of the sleeve 12. The pipetting plate 20 includes a second plate body 21 and an adjusting rod 22 disposed on the surface of the second plate body 21. A slot 221 is provided at the end of the adjusting rod 22 away from the second plate body 21, and the slot 221 extends axially along the adjusting rod 22. The adjusting plate 10 and the pipetting plate 20 are movably connected. The adjusting rod 22 passes into the sleeve 12, and the adjusting rod 22 is clearance-fitted with the sleeve 12. The slot 221 extends out from the opening of the second end 122 of the sleeve 12, and the length of the slot 221 extending out from the opening of the second end 122 of the sleeve 12 is adjustable.

[0043] By providing a partition 1221 at the second end 122 of the sleeve 12, the opening of the second end 122 is partially blocked. A slot 221 is also provided at one end of the adjusting rod 22. Thus, when the adjusting rod 22 is inserted into the sleeve 12 and one end of the adjusting rod 22 extends out of the opening at the second end 122 of the sleeve 12, the slot 221 portion of the adjusting rod 22 can pass through the unblocked portion of the opening at the second end 122 of the sleeve 12. The slot 221 of the adjusting rod 22 and the partition 1221 can form a pipetting groove for adsorbing or releasing liquid. Specifically, the adjusting rod 22 and the sleeve 12 are fitted with a clearance fit, ensuring that the adjusting rod 22 can move smoothly within the sleeve 12, providing good stability and sealing during movement, and ensuring that the pipetting groove formed by the adjusting rod 22 has the effect of adsorbing or releasing liquid. By adjusting the length of the slot 221 extending beyond the opening of the second end 122, the depth of the pipette trough can be adjusted, thereby changing the volume of the pipette trough and achieving an adjustable pipetting volume effect for the pipetting device 100. For different pipetting volume requirements in experiments, the volume of the pipette trough can be changed by adjusting the relative position between the adjusting rod 22 and the sleeve 12, achieving an adjustable-range micro-liquid transfer effect to meet different experimental needs.

[0044] Optionally, the clearance range between the adjusting rod 22 and the sleeve 12 is from 10 μm to 50 μm. Specifically, the clearance refers to the gap between the outer wall of the adjusting rod 22 and the inner wall of the sleeve 12, which can be 10 μm, 15 μm, 20 μm, 30 μm, 40 μm, 50 μm, etc. By controlling the clearance between the adjusting rod 22 and the sleeve 12 within the above range, the adjusting rod 22 can move smoothly within the sleeve 12 while ensuring good stability and sealing. When the clearance between the adjusting rod 22 and the sleeve 12 is less than 10 μm, the friction between the adjusting rod 22 and the sleeve 12 increases, which is not conducive to the flexible movement of the adjusting rod 22 within the sleeve 12. When the clearance between the adjusting rod 22 and the sleeve 12 is greater than 50 μm, the surface tension of the liquid is insufficient to form a seal between the adjusting rod 22 and the sleeve 12, resulting in a decrease in the sealing performance of the pipette.

[0045] Liquid transfer is achieved by utilizing capillary action and the surface tension of liquids. This allows for liquid adsorption or release without external power, offering advantages such as low equipment cost and ease of operation and maintenance. In this application, the adjusting plate 10 and the pipetting plate 20 are interlocked to form a pipetting groove, resulting in a simple structure. This facilitates the batch installation of the sleeve 12 and adjusting rod 22, increasing the throughput of the pipetting device 100 and enabling batch operations on droplets, thereby improving pipetting efficiency.

[0046] For example, please refer to Figure 8 and Figure 9 The inner diameter of the sleeve 12 is 0.8 mm, the outer diameter of the adjusting rod 22 is 0.8 mm, the length of the sleeve 12 can be 12 mm, the length of the adjusting rod 22 is 17 mm, the width of the partition 1221 is 0.4 mm, and the thickness of the partition 1221 itself can be 1 mm. Correspondingly, the width D of the slot 221 of the adjusting rod 22 is 0.4 mm, and the depth H of the slot 221 can be 4 mm. In this way, the adjusting rod 22 can have a certain range of motion within the sleeve 12. When the adjusting rod 22 is inserted into the sleeve 12, the slot 221 extends out of the second end 122 opening of the sleeve 12 until the partition 1221 abuts against the bottom of the slot 221. Excluding the thickness of the partition 1221 itself, the distance from which the slot 221 extends out of the sleeve 12 is 3 mm. At this point, the formed pipetting groove has the maximum volume (e.g., Figure 8 (As shown).

[0047] For example, with Figure 10 For example, Figure 10A cross-sectional view of the sleeve 12 is shown, with the cross-sectional direction perpendicular to the axial direction of the sleeve 12. The area of ​​the partition portion 1221 is S, the distance from the slot 221 extending beyond the sleeve 12 is h, the radius of the sleeve 12 is r, the perpendicular distance from the center of the sleeve 12 to the outer periphery of the partition portion 1221 is d, and the arc of the sector corresponding to the outer edge of the partition portion 1221 is α. According to the calculation formula: Calculations show that the maximum pipetting volume of the pipette is 1.42 μl.

[0048] Based on this, when the adjusting rod 22 is adjusted in the opposite direction, and the distance of the slot 221 extending beyond the opening of the second end 122 of the sleeve 12 is shortened to the minimum range, the end of the slot 221 is approximately flush with the opening of the second end 122 of the sleeve 12. This results in a pipetting groove with a minimum volume (e.g., Figure 9 As shown in the figure, the volume can be 100 nl. Therefore, in this example, the volume of the pipette can be adjusted from 100 nl to 1.42 μl to meet the pipetting needs of different usage scenarios.

[0049] In practical applications, the pipetting device 100 can have different pipetting ranges by setting adjustment rods 22 of different diameters and slot widths 221 of different sizes. For example, the maximum pipetting volume of the pipetting device 100 can be around 100nl to 5μl, without specific limitation here.

[0050] Optionally, the pipette 20 and the adjusting plate 10 can be made of stainless steel or other materials that can achieve the corresponding processing precision.

[0051] In some embodiments, please refer to Figure 6 and Figure 7 The pipetting apparatus 100 also includes an adjustment component 30, which is connected to the first plate 11 and / or the second plate 21. The adjustment component 30 is used to adjust the distance between the first plate 11 and the second plate 21. By adjusting the distance between the first plate 11 and the second plate 21, the adjustment rod 22 can be moved in the sleeve 12 accordingly, thereby adjusting the extension length of the slot 221 from the sleeve 12, making it easy to adjust the length of the pipetting tank. Using the adjustment component 30 can improve the accuracy of the distance adjustment between the first plate 11 and the second plate 21, thereby achieving the effect of accurately setting the volume of the pipetting tank. Exemplarily, the adjustment component 30 can be connected to either the first plate 11 or the second plate 21, or the adjustment component 30 can be connected to both the first plate 11 and the second plate 21 simultaneously. The following description continues with the example of the adjustment component 30 being connected to both the first plate 11 and the second plate 21 simultaneously.

[0052] In some embodiments, the adjusting assembly 30 includes an adjusting screw 31, a second plate 21 having an adjusting hole 23, and a first plate 11 having a mounting hole 13 corresponding to the adjusting hole 23. The adjusting screw 31 passes through the adjusting hole 23 and the mounting hole 13, and is threadedly connected to the adjusting hole 23 to adjust the distance between the first plate 11 and the second plate 21. By utilizing the threaded connection between the adjusting screw 31 and the adjusting hole 23, the distance between the first plate 11 and the second plate 21 can be adjusted by rotating the adjusting screw 31, thereby converting the axial linear movement between the sleeve 12 and the adjusting rod 22 into the circumferential movement of the adjusting screw 31. The volume of the pipette is adjusted by rotating the adjusting screw 31. Since the volume adjustment range of the pipette is small, usually within micro-level changes, the adjustment range of the distance between the sleeve 12 and the adjusting rod 22 is also small. Therefore, by setting a suitable helix angle for the adjusting screw 31, the axial movement between the sleeve 12 and the adjusting rod 22 can be amplified, which facilitates precise adjustment of the distance between the first plate 11 and the second plate 21, reducing the operational difficulty of adjusting the volume of the pipette.

[0053] Optionally, the adjusting hole 23 can be provided in the first plate 11 or the second plate 21, and correspondingly, the mounting hole 13 is provided on the second plate 21 or the first plate 11. The adjusting screw 31 can pass through the mounting hole 13 and rotate relative to the mounting hole 13. Taking the mounting hole 13 being provided in the first plate 11 as an example, the first end 121 of the sleeve 12 has an opening formed on the first plate 11. The mounting hole 13 is set to avoid the opening, which can prevent the mounting hole 13 from communicating with the opening and ensure that the opening of the sleeve 12 has sufficient strength. Similarly, the adjusting hole 23 is set to avoid the position of the adjusting rod 22 on the second plate 21, ensuring that the setting of the adjusting hole 23 does not affect the strength of the adjusting rod 22 or the second plate 21.

[0054] In some embodiments, the adjusting screw 31 may extend through the mounting hole 13 or only partially into the mounting hole 13. Specifically, the example of the adjusting screw 31 partially extending into the mounting hole 13 will be described. A base 35 is provided at one end of the adjusting screw 31 that extends into the mounting hole 13. The base 35 is embedded in the mounting hole 13, and its thickness is less than or equal to the opening depth of the mounting hole 13. By providing the base 35, the stability of the connection between the adjusting screw 31 and the mounting hole 13 is improved, as well as the accuracy of the adjusting screw 31 in adjusting the volume of liquid being pipetted. Optionally, the base 35 at the lower end of the adjusting screw 31 is typically larger than the diameter of the adjusting screw 31, which helps to increase the stability of the mounting plate 20 and achieve uniformity in liquid pipetting.

[0055] In some embodiments, the minimum distance between the adjusting hole 23 and the edge of the adjusting rod 22 connected to one end of the second plate 21 is greater than or equal to 0.5 mm. By limiting the minimum distance between the adjusting hole 23 and the edge of the adjusting rod 22 connected to one end of the second plate 21, it is possible to prevent the adjusting hole 23 and the adjusting rod 22 from getting too close, ensuring that the setting of the adjusting hole 23 does not affect the strength of the adjusting rod 22 or the second plate 21, thereby preventing a decrease in the strength of the second plate 21.

[0056] In some embodiments, the opening depth of the mounting hole 13 is less than or equal to the thickness of the first plate 11, the opening radius of the mounting hole 13 is greater than the radius of the adjusting hole 23, and the minimum distance between the mounting hole 13 and the edge of the first end 121 of the sleeve 12 is greater than or equal to 0.5 mm. By limiting the opening depth and opening radius of the mounting hole 13, on the one hand, it can prevent the first plate 11 from being hollowed out to an excessive depth or area, ensuring that the first plate 11 has sufficient strength and preventing deformation of the first plate 11. On the other hand, the mounting hole 13 can limit the screwing depth of the adjusting screw 31, improving the stability and reliability of the adjusting screw 31 during operation.

[0057] In some embodiments, the first plate 11 or the second plate 21 is provided with an indicator scale 32. By providing the indicator scale 32, the rotation angle of the adjusting screw 31 can be easily displayed, thereby improving the operating accuracy of the adjusting screw 31.

[0058] Optionally, the adjustment hole 23 can be provided on the second plate 21, that is, the second plate 21 is provided with the adjustment hole 23, and the indicator scale 32 is provided on the surface of the second plate 21 opposite to the first plate 11, and the indicator scale 32 is provided on the outer periphery of the adjustment hole 23. The indicator scale 32 is provided on the outer periphery of the adjustment hole 23, which can indicate the rotation angle of the adjustment screw 31, thereby improving the accuracy of the distance adjustment between the first plate 11 and the second plate 21.

[0059] In some embodiments, the adjustment assembly 30 further includes an adjustment knob 33 connected to the adjustment screw 31. The adjustment knob 33 is provided with an indicator line 34. The adjustment knob 33 is used to drive the adjustment screw 31 to rotate so that the indicator line 34 can be aligned with the indicator scale 32. By rotating the adjustment knob 33, the adjustment screw 31 can be driven to rotate. Optionally, the diameter of the adjustment knob 33 is usually larger than the diameter of the adjustment screw 31, thereby helping to reduce the difficulty of rotating the adjustment screw 31 and improve the ease of operation of the adjustment screw 31. By setting the indicator line 34, the rotation angle of the adjustment screw 31 can be indicated, so as to achieve accurate adjustment of the volume of the pipette.

[0060] In some embodiments, the indicator lines 34 may also be disposed on the outer peripheral surface of the adjusting screw 31. The indicator lines 34 are spaced apart along the axial direction of the adjusting screw 31. When the adjusting screw 31 is screwed into the second plate 21, a portion of the indicator lines 34 on the outer peripheral surface of the adjusting screw 31 is covered by the edge of the mounting hole 13 of the second plate 21, while another portion of the indicator lines 34 is exposed outside the mounting hole 13. By reading the indicator lines 34 exposed on the outer peripheral surface of the adjusting screw 31, the screwing depth of the adjusting screw 31 can be indicated.

[0061] For example, before using the pipette 100 to pipette, the target pipette volume can be calibrated using a fluorescent dye calibration method, and the relative positions of the adjustment plate 10 and the pipette plate 20 when the target pipette volume is reached can be marked on the indicator line 34 or the indicator scale 32.

[0062] Optionally, the adjustment knob 33 can be manually operated to adjust to the target position, or it can be used in conjunction with other automated equipment (such as a robotic arm) for accurate adjustment. Furthermore, the operation of the pipetting device 100 can be carried out manually, or it can be used with equipment with plate transfer function (such as a pipetting workstation, plate transfer machine, etc.) to achieve automated, high-throughput micro-liquid transfer operations.

[0063] As an alternative implementation, in addition to being configured as an adjusting screw 31, the adjusting component 30 can also be configured with calipers between the first plate 11 and the second plate 21. The calipers have multiple slots. By adjusting the relative position of the first plate 11 and the second plate 21, for example, the first plate 11 or the second plate 21 can be engaged with any slot. In this way, the position of the first plate 11 and the second plate 21 can be locked by the calipers, thereby realizing the volume adjustment of the pipette.

[0064] As an alternative implementation, the adjustment component 30 can also be configured as a dial, which is located between the first plate 11 and the second plate 21. By rotating the dial, the distance between the first plate 11 and the second plate 21 can be adjusted, thereby realizing the volume adjustment of the pipette.

[0065] Optionally, one or more adjusting holes 23 can be provided, and correspondingly, one or more adjusting screws 31 can also be provided. Depending on the number of adjusting holes 23, the positions of the adjusting holes 23 can be arranged in different ways, which will be described separately below.

[0066] In the first example, please refer to Figure 6An adjustment hole 23 is provided, located at the geometric center of either the first plate 11 or the second plate 21. This ensures a more uniform force exerted by the adjustment hole 23 on the first and second plates 11, contributing to consistent adjustment at all positions and preventing deformation due to uneven force distribution. This arrangement helps to ensure uniform force distribution on the first and second plates 11 during adjustment, reducing component deformation and liquid transfer errors caused by uneven force distribution. For example, when the second plate 21 is rectangular, the adjustment hole 23 is located at the intersection of its two diagonals; when the second plate 21 is circular, the adjustment hole 23 is located at its center.

[0067] In the second example, please refer to Figure 11 Two adjustment holes 23 are provided, and the number of adjustment screws 31 is the same as the number of adjustment holes 23. The adjustment holes 23 are diagonally arranged on the first plate 11 or the second plate 21. Taking the second plate 21 as an example, by setting the two adjustment holes 23 at diagonal positions on the second plate 21, the second plate 21 can be evenly stressed, improving the consistency of adjustment effect of various parts of the first plate 11 and the second plate 21. This arrangement also helps to adapt to scenarios where both hands operate simultaneously, that is, each hand operates one adjustment screw 31, which helps to further improve the stability and accuracy of adjustment.

[0068] Optionally, the adjustment holes 23 can be set to three, four or more. The adjustment holes 23 can be evenly distributed around the outer periphery of the second plate 21. For example, when the second plate 21 is triangular, the three adjustment holes 23 are respectively located at the three apex corners of the second plate 21; when the second plate 21 is rectangular, the four adjustment holes 23 are respectively located at the four corners of the second plate 21; when the second plate 21 is circular, the multiple adjustment holes 23 are evenly spaced along the circumference of the second plate 21. The number and distribution of the adjustment holes 23 can be flexibly set according to the actual situation and are not limited here.

[0069] In some embodiments, the partition portion 1221 extends radially along the opening of the second end 122 of the sleeve 12, passing through the center of the opening of the second end 122 of the sleeve 12. The partition portion 1221 divides the opening of the second end 122 into two channel openings 1223, which are located on opposite sides of the partition portion 1221. The two side walls of the slot 221 extend from the two channel openings 1223. In this way, the two side walls of the slot 221 and the partition portion 1221 can form a pipette, and the cross-section of the pipette is approximately rectangular. This arrangement allows for the construction of a pipette, and the structure of the pipette is simple and easy to implement.

[0070] In some embodiments, the partition portion 1221 includes a plurality of partition members, one end of which is connected to each other, and the other end is connected to the outer periphery of the opening at the second end 122 of the sleeve 12. By utilizing the inner walls of the partition members and the partition portion 1221, a pipette with a specific shape can also be constructed. For example, when four partition members are provided, and the other ends of the partition members are equally spaced at the opening at the second end 122 of the sleeve 12, a pipette with a "cross-shaped" cross-section can be constructed. It is understood that the specific shape of the pipette can be flexibly set according to actual needs and is not limited here.

[0071] In some embodiments, the adjusting plate 10 includes a plurality of sleeves 12, which are arrayed on the first plate 11. The pipetting plate 20 is provided with an equal number of adjusting rods 22 as the number of sleeves 12, and the adjusting rods 22 are connected to the sleeves 12 one-to-one. By arraying the plurality of sleeves 12 and the plurality of adjusting rods 22, multiple pipetting channels can be formed simultaneously, meeting the needs of performing multiple pipetting operations at once, improving pipetting efficiency, and meeting the needs of experimental operations. For example, the sleeves 12 can be arranged in an 8*12 array to form a pipetting device 100 with 96 channels. Alternatively, the sleeves 12 can be arranged in other array forms, such as 16*24, to form a pipetting device 100 with 384 channels. It is understood that the number of sleeves 12 and the array arrangement can be set according to other array forms used for experimental instruments, and are not specifically limited here. This allows the experimental instruments to be matched with each other, further improving the efficiency of pipetting operations.

[0072] In some embodiments, the inner diameter of the sleeve 12 gradually decreases from the first end 121 to the second end 122. That is, by setting the sleeve 12 as a tapered tube, the first end 121 of the sleeve 12 has a larger diameter, which can guide the insertion of the adjusting rod 22 by utilizing the tapered inner wall of the sleeve 12. This helps to reduce the difficulty of aligning the adjusting rod 22 into the sleeve 12, improves the alignment efficiency of the adjusting rod 22 and the sleeve 12, and improves the ease and efficiency of installing the adjusting plate 10 and the pipette plate 20.

[0073] The embodiments of this application have been described in detail above with reference to the accompanying drawings. However, this application is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of this application. Furthermore, unless otherwise specified, the embodiments and features described in the embodiments of this application can be combined with each other.

Claims

1. A pipetting device, characterized in that: include An adjusting plate includes a first plate body and a sleeve. A first end of the sleeve is connected to the first plate body, and a second end of the sleeve is provided with a partition portion that blocks part of the opening at the second end of the sleeve. A pipette includes a second plate body and an adjusting rod disposed on the surface of the second plate body. The end of the adjusting rod away from the second plate body is provided with a slot, and the slot extends along the axial direction of the adjusting rod. The adjusting plate and the pipette are movably connected. The adjusting rod is inserted into the sleeve and is clearance-fitted with the sleeve. The slot extends out from the opening at the second end of the sleeve, and the length of the slot extending out from the opening at the second end of the sleeve is adjustable.

2. The pipetting device according to claim 1, characterized in that: The pipetting device further includes an adjustment component connected to the first plate and / or the second plate, the adjustment component being used to adjust the distance between the first plate and the second plate.

3. The pipetting device according to claim 2, characterized in that: The adjustment assembly includes an adjustment screw, the second plate has an adjustment hole, the first plate has a mounting hole corresponding to the adjustment hole, the adjustment screw passes through the adjustment hole and the mounting hole, and the adjustment screw is threadedly connected to the adjustment hole to adjust the distance between the first plate and the second plate.

4. The pipetting apparatus according to claim 3, characterized in that: The adjusting screw has a base at one end that passes through the mounting hole. The base is embedded in the mounting hole, and the thickness of the base is less than or equal to the opening depth of the mounting hole.

5. The pipetting device according to claim 3, characterized in that: The minimum distance between the adjustment hole and the edge of the adjustment rod connected to one end of the second plate is greater than or equal to 0.5 mm.

6. The pipetting apparatus according to claim 5, characterized in that: The depth of the mounting hole is less than or equal to the thickness of the first plate, the radius of the mounting hole is greater than the radius of the adjustment hole, and the minimum distance between the mounting hole and the edge of the first end of the sleeve is greater than or equal to 0.5 mm.

7. The pipetting apparatus according to any one of claims 3 to 6, characterized in that: The first plate or the second plate is provided with an indicator scale.

8. The pipetting apparatus according to claim 7, characterized in that: The second plate is provided with the adjustment hole, and the indicator scale is set on the surface of the second plate opposite to the first plate, and the indicator scale is set on the outer periphery of the adjustment hole.

9. The pipetting apparatus according to claim 7, characterized in that: The adjustment assembly further includes an adjustment knob connected to the adjustment screw. At least one of the adjustment knob or the adjustment screw is provided with an indicator line. The adjustment knob is used to drive the adjustment screw to rotate.

10. The pipetting apparatus according to any one of claims 3 to 6, characterized in that: The adjustment hole is located at the geometric center of the first plate or the second plate.

11. The pipetting apparatus according to any one of claims 3 to 6, characterized in that: At least two adjustment holes are provided, and the number of adjustment screws is the same as the number of adjustment holes. The adjustment holes are diagonally arranged on the first plate or the second plate.

12. The pipetting apparatus according to claim 1, characterized in that: The clearance range between the adjusting rod and the sleeve is 10μm to 50μm.

13. The pipetting apparatus according to claim 1, characterized in that: The partition extends radially along the second end opening of the sleeve, passes through the center of the second end opening of the sleeve, and divides the second end opening into two channels. The two channels are located on both sides of the partition, and the two side walls of the slot extend from the two channels.

14. The pipetting apparatus according to claim 1, characterized in that: The partition includes multiple partition members, one end of which is connected to each other, and the other end is connected to the outer periphery of the second end opening of the sleeve.

15. The pipetting apparatus according to claim 1, characterized in that: The adjusting plate includes a plurality of sleeves, which are arranged in an array on the first plate. The pipette plate is provided with an adjusting rod in the same number as the sleeves, and the adjusting rods are connected to the sleeves one by one.

16. The pipetting apparatus according to claim 1, characterized in that: The inner diameter of the sleeve gradually decreases from the first end to the second end.

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