Precipitation device for biopharmacy

Abstract

The utility model discloses a precipitation device for biopharmacy, and relates to the technical field of biopharmacy devices, in particular to a precipitation device for biopharmacy, which comprises a precipitation tank, an isolation component and a filter pressing component, the inner bottom wall of the settling tank is fixedly connected with a guide rod; pharmaceutical solids in the settling tank are pressed down and filtered by the filter pressing component, and after the pharmaceutical solids are settled in the settling tank for a certain time, the interior of the settling tank is separated by the round surface structure in the isolating component, so that most of supernate is positioned above the round surface structure, and the supernate is separated from the settling tank. A small part of supernate and pharmaceutical solids are located below the round surface structure, and the supernate above the round surface structure is extracted and conveyed through a liquid discharge pipe. Compared with the prior art, the technical scheme adopts an isolation mode, so that the sediment is prevented from being influenced by the discharge of the upper-layer supernatant, the aims of standing the lower-layer sediment and normally discharging the upper-layer supernatant are fulfilled, and the disturbance fluctuation of the sediment is avoided.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological pharmacy device technical field, concretely is a kind of biological pharmacy is used to precipitate device. BACKGROUND

[0002] In the field of biological pharmacy, the precipitate device is indispensable equipment in the pharmaceutical process such as extracting plant effective components. The traditional precipitate device is mostly ordinary precipitate barrel, and there are many deficiencies, such as when taking supernatant after precipitation, the precipitate is easy to float up again, affecting the purity of liquid medicine, and only relying on natural sedimentation, the precipitation time is long, and the efficiency is low. To solve these problems, patent CN218011591U discloses a biological pharmacy is used to precipitate device, which effectively accelerates the precipitation speed by setting accelerating filter press, corrugated pipe, hard pipe and other structures, reduces the disturbance to the precipitate during the separation of liquid, and improves the separation efficiency and quality.

[0003] However, the prior art has certain limitations in specific implementation. In the specific implementation process of the prior art, the push rod pushes the liquid discharge pipe head below the supernatant liquid surface, and the supernatant above the liquid discharge pipe head flows into the liquid discharge pipe and is discharged. In this liquid discharge process, the supernatant is in a state of flowing from the periphery to the liquid discharge pipe head, and the continuous flow of supernatant causes the fluctuation of the upper precipitate. Although the prior art can reduce the disturbance and fluctuation of the precipitate, it cannot avoid the disturbance and fluctuation of the precipitate. UTILITY MODEL CONTENT

[0004] (I) Technical problem solved

[0005] In view of the deficiencies of the prior art, the utility model provides a biological pharmacy is used to precipitate device, which solves the problems raised in the above background art.

[0006] (II) Technical scheme

[0007] To achieve the above object, the utility model discloses a biological pharmacy is with precipitator, including precipitator, isolation component, filter pressing part, the inner bottom wall of precipitator is fixedly connected with guide rod, the filter pressing part includes at least one filter pressing assembly, and the filter pressing assembly is sleeved on the outer side wall of guide rod and both sliding connections, the isolation component includes support cylinder, two fan assemblies, the fan assembly includes operating rod, a plurality of rotating rings, a plurality of fan baffles, the end where the center of one fan baffle is located is fixedly connected with the outer side wall of one rotating ring, each rotating ring is sleeved on the outer side wall of support cylinder and both rotationally connected, the lower end of operating rod is fixedly connected with the upper surface of the uppermost fan baffle, and the adjacent two fan baffles are transmission connection, and the fan baffle in the upper layer drives the adjacent fan baffle below it to rotate when rotating around support cylinder, and each fan baffle constitutes a fan surface structure of a semicircle after rotating and spreading, the fan baffle in the lowermost layer of two fan assemblies is fixedly connected, and two fan assemblies constitute a circular surface structure after rotating and spreading, and the circular surface structure divides the internal cavity of precipitator into two parts from top to bottom.

[0008] Optionally, the side wall of the precipitator is fixedly installed with a liquid discharge pipe in communication with the inside of the precipitator, a liquid discharge valve is installed at the inflow end of the liquid discharge pipe, and the inflow end port of the liquid discharge pipe is located above the circular surface structure.

[0009] Optionally, the filter pressing assembly includes an inner ring body, an outer ring body and a filter pressing screen, the outer side wall of the inner ring body is fixedly connected with the filter pressing screen, and the outer circumferential edge of the filter pressing screen is fixedly connected with the inner side wall of the outer ring body; the inner ring body is sleeved on the outer side wall of the guide rod and both are slidingly connected.

[0010] Optionally, a lower protruding strip is fixedly connected to the lower surface of the fan baffle and close to one radius side edge, and an upper protruding strip is fixedly connected to the upper surface of the fan baffle and close to the other radius side edge.

[0011] Optionally, a longitudinal sliding groove is formed in the inner side wall of the precipitator, an annular sliding groove is formed in the circumferential direction of the inner side wall of the precipitator, and the longitudinal sliding groove is in communication with the annular sliding groove; the outer circumferential edge of the fan baffle is slidingly connected with the annular sliding groove of the precipitator.

[0012] Optionally, a solid discharge pipe is fixedly installed in the middle of the bottom wall of the precipitator and in communication with the inside of the precipitator, and a check valve is installed on the solid discharge pipe; the inner bottom wall of the precipitator is gradually inclined downward from the periphery to the middle.

[0013] Optionally, a lid is further included, covering the upper end of the precipitator, and a plurality of supporting legs are fixedly installed below the precipitator.

[0014] (III) Beneficial Effects

[0015] The utility model provides a kind of biological pharmacy is used to precipitate device, with following beneficial effects:

[0016] The biological pharmacy is used to precipitate device, by the cooperation of sedimentation tank, guide rod, isolating component, filter-pressing component, the biological pharmacy is used to precipitate device with the effect that the internal cavity of sedimentation tank is divided into upper and lower two parts, by using filter-pressing component to filter the solid medicine in the internal cavity of sedimentation tank, after a certain time of precipitation, the internal cavity of sedimentation tank is separated using the circular surface structure in isolating component, most supernatant is located above the circular surface structure, and a small amount of supernatant and solid medicine are located below the circular surface structure, and the supernatant above the circular surface structure is extracted by drainage pipe. Compared with prior art, the technical scheme is isolated, and the precipitate is prevented from being affected by the supernatant of the upper layer, so that the lower layer of precipitate is stationary, and the supernatant of the upper layer is normally drained, to avoid the disturbance of precipitate. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or prior art, the drawings needed to be used in the following embodiment or prior art description will be briefly introduced, and obviously, the drawings in the following description are only embodiments of the utility model, and other drawings can be obtained by the drawings provided without creative labor for ordinary skilled in the art.

[0018] Figure 1 It is a cross-sectional structure schematic view of the biological pharmacy is used to precipitate device of the utility model;

[0019] Figure 2 It is a partial cross-sectional structure schematic view of the sedimentation tank in the biological pharmacy is used to precipitate device of the utility model;

[0020] Figure 3 It is a three-dimensional structure schematic view of filter screen in the biological pharmacy is used to precipitate device of the utility model;

[0021] Figure 4 It is a three-dimensional structure schematic view of isolating component in the biological pharmacy is used to precipitate device of the utility model (under folding state);

[0022] Figure 5 It is Figure 4 It is the enlarged structure schematic view of A in the biological pharmacy is used to precipitate device of the utility model;

[0023] Figure 6 It is a three-dimensional structure schematic view of isolating component in the biological pharmacy is used to precipitate device of the utility model (under unfolding state);

[0024] Figure 7The utility model provides a kind of biological pharmacy is used to the stereoscopic structure diagram of fan-shaped baffle in precipitator.

[0025] In the drawing: 1, precipitator jar;2, lid;3, supporting leg;4, solid discharge pipe;5, pass-stop valve;6, filter press screen;7, guide rod;8, liquid discharge pipe;9, liquid discharge valve;10, annular chute;11, longitudinal chute;12, operating lever;13, fan-shaped baffle;1301, upper protruding strip;1302, lower protruding strip;14, rotating ring;15, support cylinder. DETAILED DESCRIPTION

[0026] The technical scheme of the utility model will be described clearly and completely below in combination with the drawings.In the description of the utility model, it needs to be explained that the orientation or position relationship indicated by terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like is based on the orientation or position relationship shown in the drawing, and is only for the convenience of describing the utility model and simplifying the description, and therefore cannot be understood as limiting the utility model.It is understood that the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indication or implication.

[0027] In the description of the utility model, it needs to be explained that, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected;It can be mechanical connection, or electrical connection;It can be directly connected, or indirectly connected through intermediate medium, or the communication inside two elements.The specific meaning of the above terms in the utility model can be understood by the person skilled in the art according to specific circumstances.It is obvious that the described embodiments are only a part of the embodiments of the utility model, not all the embodiments.

[0028] Please refer to Figures 1 to 7 The utility model provides technical scheme: a kind of biological pharmacy is used to precipitator, including precipitator jar 1, isolation component, filter press component.Precipitator jar 1's inner bottom wall is fixedly connected with guide rod 7.

[0029] Among them, precipitator jar 1 is used to hold pharmaceutical material.Filter press component is used to press filter to pharmaceutical material, and solid substance is pressed below filter press component, and liquid is uplink through the mesh hole on filter press component.Meanwhile, after a certain period of precipitation, particulate matter is located in the lower part of precipitator jar 1.Isolation component is used to separate the internal cavity of precipitator jar 1, so that most supernatant is separated from another lower supernatant (and solid substance).

[0030] The filter-pressing part comprises at least one filter-pressing assembly, which is sleeved on the outer sidewall of the guide rod 7 and is in sliding connection with the guide rod 7. The filter-pressing assembly comprises an inner ring body, an outer ring body and a filter-pressing screen 6. The outer sidewall of the inner ring body is fixedly connected with the filter-pressing screen 6, and the outer circumferential edge of the filter-pressing screen 6 is fixedly connected with the inner sidewall of the outer ring body. The inner ring body is sleeved on the outer sidewall of the guide rod 7 and is in sliding connection with the guide rod 7.

[0031] The outer sidewall of the outer ring body is in abutment with the inner sidewall of the precipitation tank 1. The mesh diameter of the filter-pressing screen 6 is greater than the particle diameter of the solid medicine. The filter-pressing assembly can be multiple. The mesh diameter of the filter-pressing screen 6 in the filter-pressing assembly gradually decreases from bottom to top, so that the solid medicine is fully filtered.

[0032] The isolation part comprises a support cylinder 15 and two fan-shaped assemblies.

[0033] The support cylinder 15 is sleeved on the outer sidewall of the guide rod 7 and is in sliding connection with the guide rod 7. The support cylinder 15 has two functions. One is to support the two fan-shaped assemblies. The other is that, after the support cylinder 15 is sleeved on the guide rod 7 and slides downward, the lower end of the support cylinder 15 presses the inner ring body downward, so that the inner ring body drives the filter-pressing screen 6 and the outer ring body to move downward, thereby filtering the solid medicine.

[0034] The fan-shaped assembly comprises an operating rod 12, multiple rotating rings 14 and multiple fan-shaped partitions 13. The center of one fan-shaped partition 13 is fixedly connected with the outer sidewall of one rotating ring 14. Each rotating ring 14 is sleeved on the outer sidewall of the support cylinder 15 and is in rotating connection with the support cylinder 15. The lower end of the operating rod 12 is fixedly connected with the upper surface of the uppermost fan-shaped partition 13. The adjacent two fan-shaped partitions 13 are in transmission connection. The upper fan-shaped partition 13 drives the adjacent lower fan-shaped partition 13 to rotate when the upper fan-shaped partition 13 rotates around the support cylinder 15. Each fan-shaped partition 13 forms a semicircular fan structure after being rotated and expanded.

[0035] The lowermost fan-shaped partition 13 in the two fan-shaped assemblies is fixedly connected. The two fan-shaped assemblies form a circular structure after being rotated and expanded. The circular structure divides the internal cavity of the precipitation tank 1 into two parts from top to bottom.

[0036] The operating rod 12 is used for facilitating the operation of the staff. The staff holds the operating rod 12 and slowly pushes the operating rod to rotate around the support cylinder 15.

[0037] The operating rod 12 in one sector assembly rotates clockwise around the supporting cylinder 15, the lower end of the operating rod 12 drives the uppermost sector partition 13 to rotate clockwise around the supporting cylinder 15, the uppermost sector partition 13 drives the adjacent sector partition 13 below it (the second sector partition 13 from top to bottom) to rotate after rotating by a certain angle, the second sector partition 13 drives the third sector partition 13 to rotate after rotating by a certain angle, and so on, until the sector assembly is unfolded from the folded state (see Figure 4 ) into the semicircular sector structure (see Figure 6 ).

[0038] The operating rod 12 in the other sector assembly rotates counterclockwise around the supporting cylinder 15, the lower end of the operating rod 12 drives the uppermost sector partition 13 to rotate counterclockwise around the supporting cylinder 15, the uppermost sector partition 13 drives the adjacent sector partition 13 below it (the second sector partition 13 from top to bottom) to rotate after rotating by a certain angle, the second sector partition 13 drives the third sector partition 13 to rotate after rotating by a certain angle, and so on, until the sector assembly is unfolded from the folded state (see Figure 4 ) into the semicircular sector structure (see Figure 6 ).

[0039] After the two sector assemblies are fully unfolded, they jointly form a circular surface structure, as shown in Figure 6 . The circular surface structure divides the internal cavity of the sedimentation tank 1 into two parts from top to bottom, the upper cavity is separated from the lower cavity, avoiding the flow of liquid in the upper and lower cavities, so as to avoid the disturbance of the precipitate. The unfolding process of the two sector assemblies needs to be slow to avoid the upward movement of the precipitate due to too fast speed, so the artificial operation process needs attention.

[0040] Specifically, the side wall of the sedimentation tank 1 is fixedly installed with a drainage pipe 8, and the drainage pipe 8 communicates with the inside of the sedimentation tank 1, the inflow end of the drainage pipe 8 is installed with a drainage valve 9, and the inflow end port of the drainage pipe 8 is located above the circular surface structure.

[0041] The drainage pipe 8 is used to discharge most of the supernatant above the circular surface structure, and the part of the supernatant is discharged out of the sedimentation tank 1. During the drainage process, due to the separation of the upper and lower layers, the discharge of the upper supernatant will not disturb the lower supernatant, and the precipitate in the lower layer cannot flow into the upper cavity, ensuring the purity of the upper supernatant. The drainage valve 9 is used to control the on-off of the drainage pipe 8. The outflow end port of the drainage pipe 8 is located below the liquid level and above the circular surface structure.

[0042] Specifically, a lower protrusion 1302 is fixedly connected to the lower surface of the fan-shaped partition 13 and to the side edge near one radius, and an upper protrusion 1301 is fixedly connected to the upper surface of the fan-shaped partition 13 and to the side edge near the other radius.

[0043] The sector-shaped partitions 13 are made of, but are not limited to, materials such as high-density polyethylene, polytetrafluoroethylene, and composite materials that meet the hygiene requirements of biopharmaceutical manufacturing. The lower raised strip 1302 and the upper raised strip 1301 are both sealing strips used to enhance the sealing effect between two adjacent sector-shaped partitions 13, preventing the supernatant in the lower cavity from flowing into the upper cavity. Simultaneously, when the sector-shaped partitions 13 rotate, they cause the lower raised strip 1302 to rotate as well. When the lower raised strip 1302 contacts the upper raised strip 1301 on the adjacent sector-shaped partition 13 below, the lower raised strip 1302 pushes the upper raised strip 1301 to rotate, thereby causing the adjacent sector-shaped partition 13 below to also move, thus allowing each sector-shaped partition 13 to unfold after rotation.

[0044] Specifically, a longitudinal groove 11 is formed on the inner side wall of the sedimentation tank 1, and an annular groove 10 is formed around the inner side wall of the sedimentation tank 1. The longitudinal groove 11 and the annular groove 10 are connected. The outer periphery of the fan-shaped baffle 13 is slidably connected to the annular groove 10 of the sedimentation tank 1.

[0045] When the isolation component is lowered into the settling tank 1: its state at the time of lowering is as follows: Figure 4 In the indicated state, the support cylinder 15 is fitted onto the guide rod 7, and each sector-shaped partition 13 is in a folded state. The stacked sector-shaped partitions 13 slide downwards along the longitudinal groove 11 until they are located at the annular groove 10. When the sector assembly is unfolded, the sector-shaped partitions 13 rotate around the support cylinder 15, and their outer circumferences slide within the annular groove 10. The annular groove 10 is designed to enhance the sealing effect. The circumferential ends of the sector-shaped partitions 13 are located within the annular groove 10, preventing sediment from flowing vertically along the inner wall of the sedimentation tank 1, thereby preventing sediment from rising along the outer periphery of the circular structure through the gaps.

[0046] Specifically, a solid discharge pipe 4 is fixedly installed in the middle of the bottom wall of the sedimentation tank 1, and the solid discharge pipe 4 is connected to the inside of the sedimentation tank 1. A check valve 5 is installed on the solid discharge pipe 4. The inner bottom wall of the sedimentation tank 1 gradually slopes downward from the periphery to the middle.

[0047] The solids discharge pipe 4 is used to discharge solids (mainly fine sediments and large pieces of pharmaceutical materials) from the bottom of the sedimentation tank 1. The check valve 5 is used to control the opening and closing of the solids discharge pipe 4.

[0048] Specifically, a precipitation device for biopharmaceutical use also includes a cover 2, which covers the upper end of the precipitation tank 1, and multiple support legs 3 are fixedly installed below the precipitation tank 1.

[0049] The cover 2 is used to cover the sedimentation tank 1. Each leg 3 is used to support the sedimentation tank 1.

[0050] In use, pharmaceutical materials (including solid materials and liquid materials) are poured into the sedimentation tank 1. At least one filter pressing assembly is sleeved on the outer wall of the guide rod 7, and the filter pressing assembly slides downward along the guide rod 7 and presses the solid pharmaceutical materials downward.

[0051] After a certain period of sedimentation, the isolation component is slowly lowered into the sedimentation tank 1, and at this time, each sector-shaped partition 13 in the isolation component is not unfolded. After a certain period of sedimentation, the sector-shaped partition 13 on the uppermost layer is slightly shaken to make the sediment of the sector-shaped partition 13 on the uppermost layer fall off.

[0052] After complete sedimentation, when the supernatant needs to be discharged: the staff slowly pushes the operating rod 12, and the operating rod 12 drives each stacked sector-shaped partition 13 to unfold, and the two sector-shaped assemblies together form a circular surface structure, which is shown in Figure 6 The circular surface structure divides the internal cavity of the sedimentation tank 1 into two parts from top to bottom, separates the upper cavity from the lower cavity, avoids the flow of liquid in the upper and lower cavities, and thus avoids the disturbance of the sediment. The unfolding process of the two sector-shaped assemblies needs to be slow to avoid the upward movement of the sediment caused by too fast speed, and thus the artificial operation process needs attention.

[0053] Thereafter, the liquid discharge valve 9 is opened, and most of the supernatant in the upper cavity is discharged through the liquid discharge pipe 8. A small part of the supernatant and solid materials in the lower cavity are processed in subsequent process steps.

[0054] The above only describes the preferred specific embodiments of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art can make equivalent replacement or change according to the technical scheme and the inventive concept of the present application within the technical range disclosed by the present application, and all of them should be covered in the protection scope of the present application.

Claims

1. A biopharmaceutical use sedimentation device, characterized by: Including the precipitation tank (1), the isolation component, the filter pressing component, the inner bottom wall of the precipitation tank (1) is fixedly connected with the guide rod (7), The filter pressing component includes at least one filter pressing assembly, the filter pressing assembly is sleeved on the outer side wall of the guide rod (7) and is slidably connected with the guide rod (7). The isolation component includes a support cylinder (15), two fan-shaped assemblies, The fan-shaped assembly includes an operating rod (12), a plurality of rotating rings (14), a plurality of fan-shaped partitions (13), the center of one fan-shaped partition (13) is fixedly connected with the outer side wall of one rotating ring (14), each rotating ring (14) is sleeved on the outer side wall of the support cylinder (15) and is rotatably connected with the support cylinder (15), the lower end of the operating rod (12) is fixedly connected with the upper surface of the uppermost fan-shaped partition (13), adjacent two fan-shaped partitions (13) are transmissionally connected, the upper fan-shaped partition (13) drives the adjacent lower fan-shaped partition (13) to rotate when rotating around the support cylinder (15), each fan-shaped partition (13) forms a semicircular fan structure after being rotated and expanded. The lowermost fan-shaped partition (13) of the two fan-shaped assemblies is fixedly connected, the two fan-shaped assemblies form a circular structure after being rotated and expanded, and the circular structure divides the internal cavity of the precipitation tank (1) into two parts from top to bottom.

2. The device according to claim 1, wherein: The side wall of the precipitation tank (1) is fixedly provided with a drainage pipe (8) in communication with the inside of the precipitation tank (1), the inflow end of the drainage pipe (8) is provided with a drainage valve (9), and the inflow end port of the drainage pipe (8) is located above the circular structure.

3. The device as claimed in claim 1, wherein: The filter pressing assembly includes an inner ring body, an outer ring body and a filter pressing screen (6), the outer side wall of the inner ring body is fixedly connected with the filter pressing screen (6), and the outer circumferential edge of the filter pressing screen (6) is fixedly connected with the inner side wall of the outer ring body; the inner ring body is sleeved on the outer side wall of the guide rod (7) and is slidably connected with the guide rod (7).

4. The biopharmaceutical use settling device of claim 1, wherein: The lower surface of the fan-shaped partition (13) is fixedly provided with a lower protruding strip (1302) near one radius side edge, and the upper surface of the fan-shaped partition (13) is fixedly provided with an upper protruding strip (1301) near the other radius side edge.

5. The biopharmaceutical use settling device of claim 1, wherein: The inner side wall of the precipitation tank (1) is provided with a longitudinal sliding groove (11), the inner side wall of the precipitation tank (1) is provided with an annular sliding groove (10) along the circumference, the longitudinal sliding groove (11) is in communication with the annular sliding groove (10), and the outer circumferential edge of the fan-shaped partition (13) is slidably connected with the annular sliding groove (10) of the precipitation tank (1).

6. The biopharmaceutical use settling device of claim 1, wherein: The bottom wall of the precipitation tank (1) is fixedly provided with a solid discharge pipe (4) in communication with the inside of the precipitation tank (1), and the solid discharge pipe (4) is provided with a through valve (5); the inner bottom wall of the precipitation tank (1) is gradually inclined downward from the periphery to the middle.

7. The biopharmaceutical use settling device of claim 1, wherein: Further including a cover (2), the cover (2) covers the upper end of the precipitation tank (1), and a plurality of supporting legs (3) are fixedly arranged below the precipitation tank (1).

Images