Reagent bottle and sample analysis equipment

Abstract

The utility model discloses a reagent bottle and sample analysis equipment, the reagent bottle comprises a bottle body and a bottle cap, the bottle body is provided with a bottle opening, the bottle cap comprises a cap body and a shielding piece, the cap body is connected with the bottle body to cover the bottle opening, the cap body is provided with a liquid suction hole, the liquid suction hole is communicated with the bottle opening, and the cap body is hinged to the shielding piece on the first side; the shielding piece is provided with a second sealing part and a second operation part, the second sealing part is in interference fit with the inner circumferential surface of the liquid suction hole so that the bottle opening can be sealed through the bottle cap, and the second operation part is used for being driven by external acting force to rotate in the direction away from the cap body so as to drive the shielding piece to rotate in the direction of exposing the liquid suction hole to unseal the bottle opening. In the application, the bottle cap meets the sealing requirement during logistics transportation and the liquid absorption requirement of the sample analysis equipment through the rotation of the shielding piece, the contact time of the reagent in the container and the outside air is shortened, the on-machine stability of the reagent is effectively improved, and meanwhile, different bottle caps do not need to be replaced during logistics transportation and loading of the sample analysis equipment; the reagent loading efficiency is improved.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical apparatuses, and particularly relates to a reagent bottle and a sample analysis device. BACKGROUND

[0002] The sample analysis device is used in the medical diagnosis field to perform method steps such as pipetting, sample adding, mixing, and measuring. Through such an analysis device, at least one detection reagent can be manually or automatically added to human or animal body fluid or other fluid containing analytes, and finally the amount of certain substances or a certain function in the body is detected by using biological, chemical, physical, or other principles.

[0003] In the related art, the sample analysis device is provided with a reagent bottle to carry detection reagents. During logistics transportation, a sealing cover cooperates with the bottle body to realize sealing of the bottle body, and then when the reagent bottle is loaded into the sample analysis device, the sealing cover is tightly matched with the bottle body, which causes the reagent bottle to be inconvenient to use. CONTENT OF THE UTILITY MODEL

[0004] The embodiments of the present application provide a reagent bottle and a sample analysis device to facilitate the use of the reagent bottle.

[0005] In a first aspect, the embodiments of the present application provide a reagent bottle, comprising:

[0006] a bottle body provided with a bottle opening; and

[0007] a bottle cap comprising a cap body and a shielding piece, the cap body is connected with the bottle body to cover the bottle opening, the cap body is provided with a liquid suction hole, the liquid suction hole is in communication with the bottle opening, the outer circumferential side of the cap body comprises a first side and a second side which are different in direction, the cap body is hinged to the shielding piece at the first side, the shielding piece is provided with a second sealing part and a second operating part, the second sealing part is in interference fit with the inner circumferential surface of the liquid suction hole, so that the bottle cap seals the bottle opening, the second operating part protrudes from the second side, the second operating part is used to be driven by external force to rotate in a direction away from the cap body, and then drives the shielding piece to rotate in a direction of exposing the liquid suction hole to unseal the bottle opening.

[0008] In a second aspect, the embodiments of the present application further provide a sample analysis device, comprising:

[0009] a reagent accommodating mechanism for accommodating the reagent bottle as described above; and

[0010] The reagent dispensing mechanism comprises a first cover opening device, a second cover opening device and a pipetting device, the first cover opening device is used to drive the shield to rotate to a first preset angle in a direction of exposing the liquid suction hole, the second cover opening device is used to drive the shield to rotate to a second preset angle in a direction of exposing the liquid suction hole, the second preset angle is greater than the first preset angle, and the pipetting device is used to suck the reagent carried in the reagent bottle through the liquid suction hole and transfer to a reaction container.

[0011] Technical effects of the embodiments of the present application:

[0012] On the one hand, before the reagent bottle is loaded into the sample analysis equipment, the second sealing part of the shield can be in interference fit with the inner circumferential surface of the liquid suction hole, so as to realize stable and reliable sealing of the bottle mouth, so as to meet the sealing requirement of the reagent bottle in the logistics transportation process. On the other hand, after the reagent bottle is loaded into the sample analysis equipment, taking the case that the first side and the second side are the right side and the left side respectively and the shield is located on the upper side of the cover body as an example, the second operation part can be driven to rotate upward to the right by an external force, so as to drive the shield to rotate in a direction of exposing the liquid suction hole (i.e. upward to the right), so that the sample analysis equipment can suck the reagent carried in the bottle body through the liquid suction hole, so that the reagent bottle does not need to be replaced with different bottle caps before and after being loaded into the sample analysis equipment, the reagent of the sample analysis equipment is conveniently taken, and the use of the reagent bottle is more convenient. BRIEF DESCRIPTION OF DRAWINGS

[0013] The technical scheme and the beneficial effects of the present application will be apparent from the following detailed description of the specific embodiments of the present application in combination with the accompanying drawings.

[0014] Figure 1 A structural schematic diagram of a reagent bottle provided by the embodiments of the present application is shown.

[0015] Figure 2 A second structural schematic diagram of the bottle cap shown in Figure 1 A partial sectional view of the bottle cap and the bottle body shown in

[0016] Figure 3 The shields of the reagent bottles shown in Figs. 3a, 3b and 3c are in a sealed state, a slightly closed state and an open state respectively. Figure 1 The shields of the reagent bottles shown in Figs. 3a, 3b and 3c are in a sealed state, a slightly closed state and an open state respectively.

[0017] Figure 4 A first structural schematic diagram of the bottle cap shown in Figure 1

[0018] Figure 5 A structural schematic diagram of the bottle body shown in Figure 1

[0019] Figure 6 A structural schematic diagram of the bottle body shown in Figure 1 ​​The diagram shows the second structural design of the bottle cap.

[0020] Figure 7 for Figure 6 The image shows a cross-sectional view of the bottle cap.

[0021] Figure 8 This is a schematic diagram of the structure of a sample analysis device according to an embodiment of this application.

[0022] Figure 9 for Figure 8 The schematic diagram of the first opening device shown is as follows. Figure 1 .

[0023] Figure 10 for Figure 8 The schematic diagram of the first opening device shown is as follows. Figure 2 .

[0024] Figure 11 for Figure 8 The schematic diagram of the first opening device shown is as follows. Figure 3 .

[0025] Figure 12 In the diagrams 12a, 12b, 12c, 12d, 12e, 12f, 12g, and 12h, respectively, it is a schematic diagram of the state from the first step to the eighth step in the opening process of the first opening device of this application embodiment.

[0026] Figure 13 In the middle, 13a, 13b, 13c, 13d, 13e, 13f, 13g, and 13h are respectively Figure 12 Partial schematic diagrams of the pushers corresponding to 12a, 12b, 12c, 12d, 12e, 12f, 12g and 12h.

[0027] Figure 14 Figures 14a, 14b, 14c, and 14d are schematic diagrams of the first to fourth steps in the process of sealing the bottle opening with the driving shield of the first cap opening device according to an embodiment of this application.

[0028] Figure 15 for Figure 8 The schematic diagram of the second cover opening device shown is as follows. Figure 1 .

[0029] Figure 16 for Figure 8 The schematic diagram of the second cover opening device shown is as follows. Figure 2 .

[0030] Figure 17 Figures 17a, 17b, 17c, and 17d are schematic diagrams of the first to fourth steps in the working process of the second lid-opening device according to an embodiment of this application.

[0031] The reference signs in the drawings respectively are:

[0032] 100, bottle body;

[0033] 11, main body part; 12, bottle mouth part; 121, bottle mouth; 13, first limiting part;

[0034] 200, bottle cap;

[0035] 21, cap body; 211, liquid suction hole; 212, first side wall; 213, first top wall; 214, first sealing part; 215, third sealing part; 216, second connecting part; 22, shielding part; 221, second sealing part; 222, second operation part; 223, first operation part; 23, first elastic part; 24, hinged part; 241, first part; 242, second part; 25, second limiting part; 26, third limiting part; 261, abutting surface; 262, guide inclined surface; 263, easily-deformable inclined surface;

[0036] 300, reagent accommodating mechanism;

[0037] 400, reagent dispensing mechanism;

[0038] 41, first cap opening device; 411, first mounting rack; 412, first driving unit; 413, pushing part; 414, buffer assembly; 4141, first rotating part; 4142, second rotating part; 415, first mounting seat; 416, second driving unit; 417, pressing assembly; 4171, second mounting rack; 4172, pressing part; 4172a, mounting part; 4172b, pressing part; 4173, second elastic part; 4174, third elastic part; 4175, first reset part; 4176, fourth elastic part; 42, second cap opening device; 421, third mounting rack; 422, third driving unit; 423, pressing assembly; 4231, pressing part; 424, second mounting seat; 425, fourth driving unit; 43, pipetting device;

[0039] 500, rack;

[0040] 51, pre-cap opening position;

[0041] 600, scheduling mechanism. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present application will be clearly and completely described in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0043] Reference is made to Figure 1 and Figure 2 The embodiment of the present application provides a reagent bottle, which comprises a bottle body 100 and a bottle cap 200. The bottle body 100 is provided with a bottle mouth 121. The bottle cap 200 comprises a cap body 21 and a shielding piece 22. The cap body 21 is connected with the bottle body 100 and covers the bottle mouth 121. The cap body 21 is provided with a liquid suction hole 211, which is in communication with the bottle mouth 121. The outer circumferential side of the cap body 21 comprises a first side and a second side which are different from each other. The cap body 21 is hinged with the shielding piece 22 at the first side. The shielding piece 22 is provided with a second sealing part 221 and a second operating part 222. The second sealing part 221 is in interference fit with the inner circumferential surface of the liquid suction hole 211, so that the bottle cap 200 seals the bottle mouth 121. The second operating part 222 protrudes from the second side. The second operating part 222 is used to be driven by external force to rotate in a direction away from the cap body 21, and further drives the shielding piece 22 to rotate in a direction of exposing the liquid suction hole 211, so as to unseal the bottle mouth 121.

[0044] On the one hand, before the reagent bottle is loaded into a sample analysis device, the interference fit between the second sealing part 221 of the shielding piece 22 and the inner circumferential surface of the liquid suction hole 211 can be used to realize stable and reliable sealing of the bottle mouth 121, so as to meet the sealing requirement of the reagent bottle in the logistics transportation process. On the other hand, after the reagent bottle is loaded into the sample analysis device, taking the case that the first side and the second side are the right side and the left side respectively, and the shielding piece 22 is located at the upper side of the cap body 21, the second operating part 222 can be driven by external force to rotate upwardly to the right, so as to drive the shielding piece 22 to rotate in a direction of exposing the liquid suction hole 211 (i.e. upwardly to the right), so that the sample analysis device can suck the reagent carried in the bottle body 100 through the liquid suction hole 211, and further, the reagent bottle does not need to be replaced by different bottle caps 200 before and after being loaded into the sample analysis device, and finally, the use of the reagent bottle is more convenient.

[0045] It should be noted that, in the actual use process, the first side and the second side can be the adjacent sides of the outer circumferential side of the cap body 21, or can be opposite sides. That is, the first side can be the left side of the cap body 21, and the second side can be the front side or the rear side of the cap body 21, or the first side can be the right side of the cap body 21, and the second side can be the front side, the rear side or the left side of the cap body 21. The embodiment of the present application does not limit this.

[0046] It should be further noted that, in the embodiment of the present application, the shielding piece 22 rotates in a direction of exposing the liquid suction hole 211 to unseal the bottle mouth 121, which can also be understood as that the shielding piece 22 rotates in a direction of exposing the liquid suction hole 211 to release the sealing between the second sealing part 221 and the liquid suction hole 211, so as to unseal the bottle mouth 121.

[0047] Before the technical solutions of the embodiments of the present application are described, the various states of the shielding piece 22 during rotation are described first.

[0048] Please continue to refer to Figure 3 The shielding piece 22 can have a sealed state, in which the second sealing portion 221 is inserted into the liquid suction hole 211 to seal the liquid suction hole 211, thereby sealing the bottle mouth 121.

[0049] The shielding piece 22 can have a micro-closed state, and the shielding piece 22 can be rotated from the sealed state to the micro-closed state in a direction in which the liquid suction hole 211 is exposed. In the micro-closed state, the second sealing portion 221 shields the liquid suction hole 211. Moreover, the contact area between the second sealing portion 221 and the inner circumferential surface of the liquid suction hole 211 in the micro-closed state is smaller than the contact area in the sealed state, and at this time, the inner circumferential surface of the liquid suction hole 211 and the second sealing portion 221 can have a ventilation gap that is connected to the outside of the reagent bottle, or can not have a ventilation gap, which is not limited in the embodiments of the present application.

[0050] The shielding piece 22 can also have an uncapped state, in which the shielding piece 22 is completely exposed to the liquid suction hole 211, so that an external device (such as a liquid suction needle) can draw the reagent carried in the reagent bottle through the liquid suction hole 211.

[0051] In some embodiments, the shielding piece 22 further includes a first operation portion 223, which protrudes from the first side of the cover 21. The first operation portion 223 is used to be driven by an external force to rotate in a direction close to the cover 21, thereby driving the shielding piece 22 to rotate in a direction in which the liquid suction hole 211 is exposed.

[0052] Then, continuing to take the shielding piece 22 located on the upper side of the cover 21 as an example, in the actual uncapping process, the shielding piece 22 can be exposed to the liquid suction hole 211 only by pushing the second operation portion 222 upward, or only by pressing the first operation portion 223 downward, or by simultaneously pushing the second operation portion 222 upward and pressing the first operation portion 223 downward. Of course, pushing the second operation portion 222 upward and pressing the first operation portion 223 downward can also be performed step by step, which is not limited in the embodiments of the present application, so that the shielding piece 22 can meet the opening requirements of more different scenes.

[0053] Taking the case where pushing the second operation portion 222 upward and pressing the first operation portion 223 downward are performed step by step as an example:

[0054] Firstly, the second operation part 222 can be pushed upwards, and then the shielding part 22 is rotated towards the direction of exposing the liquid suction hole 211. At this time, the shielding part 22 can be directly rotated to the micro-closed state, or the shielding part 22 can be reversely rotated by a certain angle to the micro-closed state after being rotated to the unsealed bottle opening 121 (or the unsealed liquid suction hole 211). In the micro-closed state, the shielding part 22 can separate the inside and outside of the reagent bottle to avoid foreign matters from directly falling into the bottle body 100 from the liquid suction hole 211 to pollute the reagent, and can reduce the contact between the reagent in the reagent bottle and the flowing air outside, thereby improving the stability and reliability of the reagent in the reagent bottle.

[0055] Then, when it is needed to suck the reagent loaded in the reagent bottle from the liquid suction hole 211 by an external device (such as a liquid suction needle), the liquid suction hole 211 can be exposed by pressing the first operation part 223, so that the shielding part 22 is in the open state, thereby allowing the liquid suction needle to suck the reagent loaded in the reagent bottle.

[0056] Finally, when it is needed to seal the bottle opening 121 again, the middle part or the second operation part 222 of the shielding part 22 can be pressed to rotate the shielding part 22 to the second sealing part 221 to again fit with the inner circumferential surface of the liquid suction hole 211 in interference, so as to be in the sealed state.

[0057] Therefore, in the whole process of rotating the shielding part 22 from the sealed state to the open state, a large kinetic energy is needed when the shielding part 22 is rotated from the sealed state to the micro-closed state, thereby easily causing the reagent bottle to shake, and then causing the reagent loaded in the reagent bottle to splash out from the liquid suction hole 211. Therefore, in the actual working process of the reagent bottle of the present application, the shielding part 22 can be first opened to the micro-closed state by the second operation part 222, and then each time the reagent loaded in the reagent bottle is sucked from the liquid suction hole 211 by an external device (such as a liquid suction needle), the shielding part 22 can be only opened to the open state from the micro-closed state by the first operation part 223, so that the opening operation in the subsequent each time of liquid suction by the external device is more simple and labor-saving, and the reagent bottle is avoided from shaking to cause the reagent to splash out in the subsequent each time of liquid suction by the external device.

[0058] In some embodiments, the first operation part 223 and the second operation part 222 are located at opposite ends of the shielding part 22.

[0059] It can be understood that the shielding piece 22 is hinged to the first side of the cover 21, so that the rotation fulcrum of the shielding piece 22 is also located at the first side. While the first operation part 223 protrudes from the first side of the cover 21, and the first operation part 223 and the second operation part 222 are located at opposite ends of the shielding piece 22, it means that the second operation part 222 is away from the first side of the cover 21, so that the force arm formed when the external device pushes the first operation part 223 upward is longer, so as to more easily unseal the bottle mouth 121, and also can reduce the deformation of the first operation part 223.

[0060] Please continue to refer to Figure 4 In some embodiments, the bottle cap 200 is further provided with a first elastic piece 23. When the opening angle of the shielding piece 22 is less than a first preset value, the first elastic piece 23 can drive the shielding piece 22 to shield the liquid suction hole 211. The opening angle of the shielding piece 22 is the included angle between the shielding piece 22 and the plane where the liquid suction hole 211 is located.

[0061] Then, in the process of using the reagent bottle, the first operation part 223 and / or the second operation part 222 can be driven by the external device to rotate the shielding piece 22 to an opening angle less than the first preset value, so as to unseal the bottle mouth 121 (or the liquid suction hole 211), and the shielding piece 22 is reversely rotated to a micro-closed state by the first elastic piece 23 after the action force of the external device is removed, so as to reduce the difficulty of the external device to open the cap. In addition, when the external device does not need to suck liquid, the first elastic piece 23 can drive the shielding piece 22 to shield the liquid suction hole 211, so as to protect the reagent in the bottle body 100.

[0062] In some embodiments, when the opening angle of the shielding piece 22 is greater than the first preset value, the first elastic piece 23 can drive the shielding piece 22 to expose the liquid suction hole 211. Therefore, after the shielding piece 22 is rotated to be greater than the first preset value by the external device when liquid suction is needed, the shielding piece 22 is driven by the first elastic piece 23 to rotate and remain in the open state, so as to facilitate the external device to suck the reagent carried in the reagent bottle through the liquid suction hole 211.

[0063] It can also be understood that one first elastic piece 23 can not only achieve the purpose of driving the shielding piece 22 to selectively rotate to a micro-closed state or an open state, but also make the bottle cap 200 have the advantages of simple structure and low manufacturing cost.

[0064] In some embodiments, the first preset value can be 40° to 60°.

[0065] It can be understood that, on one hand, if the first preset value is too small, the force for precisely driving the shielding piece 22 in the process of rotating the shielding piece 22 to unseal the liquid suction hole 211 is required to avoid the opening angle of the shielding piece 22 being greater than the first preset value, and then the shielding piece 22 can be driven to rotate to the micro-closed state by the first elastic piece 23, which finally leads to a greater difficulty in opening the cover of the external device. On the other hand, if the first preset value is too large, the shielding piece 22 needs to be rotated to a larger opening angle to enable the first elastic piece 23 to drive the shielding piece 22 to rotate to expose the liquid suction hole 211, so that the force applied by the external device and the stroke required for driving the shielding piece 22 to rotate become larger, which finally leads to a greater difficulty in opening the cover of the external device. As can be seen, the embodiments of the present application enable the external device to more simply and conveniently control the rotating state of the shielding piece 22.

[0066] For example, the first preset value can be 40°, 43.4°, 45°, 46.7°, 48°, 50°, 52.3°, 54°, 55°, 57.8°, 59° or 60°, which is not limited in the embodiments of the present application.

[0067] In some embodiments, one end of the first elastic piece 23 is connected to the outer circumferential side of the cover body 21, and the other end of the first elastic piece 23 is connected to the shielding piece 22.

[0068] For example, the first elastic piece 23 can be connected to the side surface of the shielding piece 22 close to the liquid suction hole 211.

[0069] In some embodiments, the first elastic piece 23 can be in a strip shape. When the opening angle of the shielding piece 22 is equal to the first preset value, the first elastic piece 23 is in a straightened state; when the opening angle of the shielding piece 22 is less than the first preset value, one end of the first elastic piece 23 connected to the shielding piece 22 bends towards the direction close to the liquid suction hole 211 to drive the shielding piece 22 to shield the liquid suction hole 211; and when the opening angle of the shielding piece 22 is greater than the first preset value, one end of the first elastic piece 23 connected to the shielding piece 22 bends away from the direction close to the liquid suction hole 211 to drive the shielding piece 22 to expose the liquid suction hole 211.

[0070] In some embodiments, the bottle cap 200 further comprises a hinge piece 24 connected to the cover body 21 and the shielding piece 22 respectively to enable the cover body 21 and the shielding piece 22 to be hinged. For example, the hinge piece 24 can be connected to the first side of the cover body 21 in the circumferential direction.

[0071] In some embodiments, the bottle cap 200 can be a plastic piece integrally formed, so that the bottle cap 200 has the advantages of being easy to form and low in cost.

[0072] For example, the bottle cap 200 can be injection molded. Correspondingly, the hinge 24 can include a first part 241 connected with the cover 22 and a second part 242 connected with the cap body 21, the first part 241 and the second part 242 are connected, and the first part 241 can rotate around the connection between the first part 241 and the second part 242, thereby driving the cover 22 to rotate around the cap body 21. Then, compared with the case that the hinge 24, the cap body 21 and the cover 22 are all independent parts, the number of parts of the cap body 21 and the assembly steps can be reduced, thereby reducing the manufacturing cost and difficulty of the bottle cap 200.

[0073] In some embodiments, the bottle cap 200 is made of polypropylene, so that the bottle cap 200 is suitable for the injection molding process and can avoid the reaction between the bottle cap 200 and the reagent, which can cause the denaturation of the reagent and the corrosion of the bottle body 100 by the reagent.

[0074] Of course, in some other embodiments, the bottle cap 200 can also be made of glass, metal or alloy, which is not limited in the embodiments of the application.

[0075] In some embodiments, a second connecting part 216 is provided on the outer periphery of the cap body 21. The hinge 24 and the first elastic member 23 are both connected between the second connecting part 216 and the cover 22. Thus, by connecting the hinge 24 and the first elastic member 23 to the same position of the cap body 21, the integrated molding of the bottle cap 200 is simpler.

[0076] In some embodiments, the number of hinges 24 is two, and the first elastic member 23 is located between the two hinges 24. Therefore, when the first elastic member 23 drives the cover 22 to rotate, the hinges 24 located on different sides of the first elastic member 23 can be stressed more uniformly, so that the cover 22 can be more accurately and stably rotated to cover or expose the liquid suction hole 211.

[0077] In some embodiments, the bottle body 100 and the cap body 21 are detachably connected to facilitate the disassembly of the bottle cap 200. For example, the bottle body 100 and the cap body 21 can be threadedly connected.

[0078] Please continue to refer to Figure 5 and Figure 6 In some embodiments, the bottle body 100 is provided with a first limiting part 13, and the bottle cap 200 is provided with a second limiting part 25, the first limiting part 13 is used to abut against the second limiting part 25 to limit the stroke of the cap body 21 in the tightening direction.

[0079] Therefore, the angle of the bottle cap 200 after being screwed to the bottle body 100 on the circumference of the bottle mouth 121 can be accurately controlled through the cooperation of the first limiting member 13 and the second limiting member 25, and then the first operation part 223 and the second operation part 222 are located at the preset position on the circumference of the bottle mouth 121. Then, when the bottle body 100 is fixed to the external device, the external device can more accurately drive the first operation part 223 and the second operation part 222.

[0080] In some embodiments, the bottle cap 200 is further provided with a third limiting member 26, which is used to abut against the first limiting member 13 to limit the travel of the cap body 21 in the loosening direction.

[0081] Therefore, after the cap body 21 is screwed in place, the third limiting member 26 can play a loosening-preventing effect on the cap body 21 to avoid the cap body 21 rotating in the loosening direction due to vibration during the transportation of the reagent bottle. In turn, it can not only avoid the leakage of the reagent in the bottle body 100 from the bottle mouth 121, but also avoid the change of the positions of the first operation part 223 and the second operation part 222 on the circumference of the bottle mouth 121 caused by the rotation of the cap body 21, which eventually leads to the inaccuracy of the external device in driving the first operation part 223 and the second operation part 222.

[0082] In some embodiments, the third limiting member 26 and the second limiting member 25 are arranged at intervals on the circumference of the cap body 21 to interval the space for clamping the first limiting member 13. Thus, after the cap body 21 is screwed in place, the first limiting member 13 and the second limiting member 25 can play a better positioning effect to ensure the accuracy of the positions of the first operation part 223 and the second operation part 222 on the circumference of the bottle mouth 121.

[0083] In some embodiments, the third limiting member 26 comprises an abutting surface 261 and a guide inclined surface 262. The abutting surface 261 is used to abut against the first limiting member 13 to limit the rotation of the cap body 21 in the loosening direction. The guide inclined surface 262 is connected with the abutting surface 261 and is located on one side of the abutting surface 261 in the loosening direction. The guide inclined surface 262 is used to guide the first limiting member 13 to move to the side where the abutting surface 261 of the third limiting member 26 is located during the screwing of the cap body 21. Thus, during the screwing of the cap body 21, the guide inclined surface 262 and the first limiting member 13 can play a better guiding effect through the guiding cooperation, so that the first limiting member 13 can be more conveniently clamped between the third limiting member 26 and the second limiting member 25.

[0084] In some embodiments, the guide inclined surface 262 comprises a first guide inclined surface, and the distance between the first guide inclined surface and the circumferential surface of the cap body 21 increases in the tightening direction. Thus, during the screwing of the cap body 21, the first limiting member 13 can slide along the first guide inclined surface relative to the second limiting member 25.

[0085] In some embodiments, the guide slope 262 comprises a second guide slope, the distance between the second guide slope and the orifice of the liquid suction hole 211 increases in the screwing direction. Alternatively, it can also be understood that the distance between the second guide slope and the shielding member 22 increases. Thus, in the process of screwing the cover 21, the first limiting member 13 can slide along the second guide slope relative to the second limiting member 25.

[0086] In some embodiments, the third limiting member 26 further comprises a deformable slope 263. In the case that the shielding member 22 seals the bottle mouth 121, the deformable slope 263 is located on the side of the third limiting member 26 away from the shielding member 22, and the distance between the deformable slope 263 and the orifice of the liquid suction hole 211 increases in the screwing direction, so that the end of the third limiting member 26 close to the second limiting member 25 is thinned. Then, in the process of screwing the cover 21, the end of the third limiting member 26 close to the second limiting member 25 can be more easily deformed, so that the first limiting member 13 can be more conveniently clamped between the third limiting member 26 and the second limiting member 25.

[0087] In some embodiments, the bottle body 100 comprises a main body part 11 and a bottle mouth part 12. The bottle mouth part 12 is protruded on one side of the main body part 11, and the end of the bottle mouth part 12 away from the main body part 11 forms the bottle mouth 121, and the main body part 11 is used for fixing the bottle body 100 by external equipment. Thus, when the external equipment drives the first operation part 223 and / or the second operation part 222, the bottle body 100 can be fixed by the main body part 11, so as to reduce or even avoid the shaking of the bottle body 100, and further avoid the reagent carried in the reagent bottle from spilling out of the liquid suction hole 211.

[0088] Correspondingly, the second limiting member 25 and the third limiting member 26 can be arranged on the outer circumferential side of the cover 21, which is not limited in the embodiments of the present application.

[0089] Of course, in some other embodiments, the second limiting member 25 and the third limiting member 26 can also be arranged on the inner circumferential side of the cover 21, which is not limited in the embodiments of the present application.

[0090] In some embodiments, the bottle body 100 is an integrally formed plastic part.

[0091] For example, the bottle body 100 is a blow molding part, so that the bottle body 100 has the advantages of easy molding and low manufacturing cost. It can also be understood that when the bottle cap 200 is also a plastic part, for example, an injection molding part, the overall manufacturing cost of the reagent bottle can be lower.

[0092] In some embodiments, the bottle body 100 is made of polyethylene, so that the bottle body 100 is suitable for a blow molding process and can avoid the bottle body 100 reacting with the reagent to cause the reagent to denature, the bottle body 100 to be corroded, and the like.

[0093] Of course, in some other embodiments, the bottle body 100 can also be made of glass, metal, or alloy, and the embodiments of the present application do not limit this.

[0094] Please continue to refer to Figure 7 In some embodiments, the cap 21 includes a first top wall 213 and a first side wall 212 that surrounds the outer circumferential side of the first top wall 213 and is threadedly connected to the bottle body 100, so that the first top wall 213 covers the bottle mouth 121.

[0095] For example, the bottle mouth portion 12 of the bottle body 100 can be provided with external threads, and the first side wall 212 can be provided with internal threads to be threadedly connected to the bottle mouth portion 12, so that the cap 21 has the advantage of being easy to disassemble.

[0096] In some embodiments, the cap 21 further includes a first sealing portion 214. The first sealing portion 214 is protruded from the side of the first top wall 213 away from the bottle mouth 121, the inner circumferential surface of the first sealing portion 214 forms the liquid suction hole 211, and the inner circumferential surface of the first sealing portion 214 is interference-fitted with the shielding member 22 (i.e., the second sealing portion 221 of the shielding member 22) to seal the liquid suction hole 211.

[0097] It can be understood that, in the process of threadedly connecting the cap 21 to the bottle body 100 through the first side wall 212, when the cap 21 is tightened, the first side wall 212 is prone to a large deformation, and the deformation is prone to being directly transmitted to the first top wall 213. At this time, if the first top wall 213 directly forms the liquid suction hole 211, the inner circumferential surface of the liquid suction hole 211 is prone to a large deformation, thereby affecting the sealing of the liquid suction hole 211 by the shielding member 22. In contrast, the embodiments of the present application form the liquid suction hole 211 through the first sealing portion 214 protruded from the first top wall 213, so that the liquid suction hole 211 is away from the first side wall 212, and thus the deformation at the first side wall 212 is difficult to be transmitted to the first sealing portion 214, thereby reducing or even eliminating the deformation of the liquid suction hole 211 when the cap 21 is tightened, and finally improving the sealing effect of the bottle cap 200.

[0098] The first sealing portion 214 can be an annular protrusion, so that the inner circumferential surface of the first sealing portion 214 forms the liquid suction hole 211.

[0099] Correspondingly, the first operation portion 223 and the second operation portion 222 can protrude from the outer circumferential side of the first sealing portion 214.

[0100] In some embodiments, the second sealing portion 221 can be an annular protrusion, and the second sealing portion 221 can also be a solid structure, which is not limited in the embodiments of the present application.

[0101] In some embodiments, the cover 21 further comprises a third sealing portion 215. The third sealing portion 215 is protruded from a side of the first top wall 213 facing the bottle mouth 121, and the outer circumferential surface of the third sealing portion 215 is in interference fit with the inner circumferential surface of the bottle mouth 121 to seal the bottle mouth 121.

[0102] It can be understood that, as mentioned above, when the cover 21 is screwed with the bottle body 100 through the first side wall 212, a certain deformation is likely to occur at the first side wall 212 when the cover 21 is tightened, and the deformation is likely to be transmitted to the first top wall 213. At this time, if the sealing is formed by the first side wall 212 and the outer circumferential surface of the bottle mouth portion 12 of the bottle body 100, or the sealing is formed by the first top wall 213 and the opening end surface of the bottle mouth 121, the sealing failure is likely to occur due to the excessive deformation of the first side wall 212 and the first top wall 213. In contrast, the third sealing portion 215 protruded from the first top wall 213 is in interference fit with the inner circumferential surface of the bottle mouth 121 to seal the bottle mouth 121 in the embodiments of the present application, so that the deformation at the first side wall 212 is difficult to be transmitted to the third sealing portion 215, thereby reducing or even eliminating the deformation at the third sealing portion 215 when the cover 21 is tightened, so as to improve the sealing effect at the bottle mouth 121.

[0103] It can also be understood that, by forming the third sealing portion 215 on the cover 21 to seal the cover 21 and the bottle mouth 121, the reagent bottle can not need to be sealed by the sealing ring between the first side wall 212 and the bottle mouth portion 12, so that the manufacturing cost of the reagent bottle can also be reduced.

[0104] The above is a description of the reagent bottle in the embodiments of the present application.

[0105] Please continue to refer to Figure 8 The embodiments of the present application also provide a sample analysis device, which comprises a reagent containing mechanism 300 and a reagent dispensing mechanism 400. The reagent containing mechanism 300 is used to contain the reagent bottle as described above. The reagent dispensing mechanism 400 is used to transfer the reagent carried by the reagent bottle contained by the reagent containing mechanism 300 to a reaction container. Thus, the dispensing function of the reagent can be realized by the sample analysis device.

[0106] For example, the reagent dispensing mechanism 400 can comprise an opening and closing cover device and a pipetting device 43. The opening and closing cover device is used to drive the shielding piece 22 to move to shield or expose the liquid suction hole 211. The pipetting device 43 is used to suck the reagent carried in the bottle body 100 through the liquid suction hole 211 and transfer the reagent to the reaction container.

[0107] Thus, when the reagent in the reagent bottle needs to be aspirated, the reagent dispensing mechanism 400 can drive the reagent bottle to expose the liquid suction hole 211 by the opening and closing cover device, and the pipette device 43 aspirates the reagent carried in the bottle body 100 through the liquid suction hole 211 and transfers it to the reaction container. When the reagent transfer to the reaction container is completed, the reagent dispensing mechanism 400 can drive the reagent bottle to block the liquid suction hole 211 by the opening and closing cover device, so as to protect the reagent in the reagent bottle.

[0108] The pipette device 43 can include a liquid suction needle which can be inserted into the bottle body 100 through the liquid suction hole 211 to aspirate the reagent carried in the reagent bottle. The pipette device 43 can also include a mechanical arm which drives the liquid suction needle to move between the reagent containing mechanism 300 and the corresponding reaction container, so that after the liquid suction needle aspirates the reagent at the reagent containing mechanism 300, it can be driven to the corresponding reaction container to transfer the reagent carried in the bottle body 100 to the reaction container by the liquid suction needle.

[0109] In some embodiments, the opening and closing cover device includes a first cover opening device 41 and a second cover opening device 42. The first cover opening device 41 is used to drive the blocking piece 22 to rotate to a first preset angle in the direction of exposing the liquid suction hole 211, and the second cover opening device 42 is used to drive the blocking piece 22 to rotate to a second preset angle in the direction of exposing the liquid suction hole 211, the second preset angle is greater than the first preset angle.

[0110] Thus, the first cover opening device 41 and the second cover opening device 42 can realize the control of the blocking piece 22 rotating to different opening angles.

[0111] For example, the first cover opening device 41 is used to drive the blocking piece 22 to rotate to unseal the bottle mouth 121; the second cover opening device 42 is used to drive the blocking piece 22 to rotate to selectively expose the liquid suction hole 211 so as to aspirate the reagent carried in the bottle body by the pipette device 43.

[0112] Then, in combination with the above-mentioned blocking piece 22 which can have a sealed state, a slightly closed state and an open cover state. The working process of the opening and closing cover device can be as follows:

[0113] First, the first cover opening device 41 pushes the second operation part 222 upward, and then drives the blocking piece 22 to rotate in the direction of exposing the liquid suction hole 211 to an opening angle of the blocking piece 22 which is less than the first preset value, so as to unseal the bottle mouth 121 (or unseal the liquid suction hole 211).

[0114] Then, the first uncapping device 41 is away from the reagent bottle, and the shielding piece 22 is reversely rotated by the first elastic member 23 to the micro-closed state by a certain angle. In the micro-closed state, the shielding piece 22 can separate the inside and outside of the reagent bottle to avoid foreign matters from directly falling into the bottle body 100 from the liquid suction hole 211 to pollute the reagent, and can reduce the contact of the reagent in the reagent bottle with the flowing air outside, thereby improving the stability and reliability of the reagent in the reagent bottle.

[0115] Then, when it is needed to suck the reagent loaded in the reagent bottle by the pipetting device 43 from the liquid suction hole 211, the first operation part 223 can be pressed by the second uncapping device 42 to expose the liquid suction hole 211, so that the shielding piece 22 is in the uncapped state, thereby allowing the pipetting needle to suck the reagent loaded in the reagent bottle.

[0116] Finally, when it is needed to seal the bottle mouth 121 again, the shielding piece 22 can be pushed by the second uncapping device 42 to an opening angle less than the first preset value, and then the shielding piece 22 is rotated to the micro-closed state by the first elastic member 23, and the shielding piece is pressed from the micro-closed state to the sealed state by the first uncapping device 41, that is, the middle part or the second operation part 222 of the shielding piece 22 is pressed by the first uncapping device 41, so that the shielding piece 22 is rotated to the second sealing part 221 to again fit with the inner circumferential surface of the liquid suction hole 211 to be in the sealed state.

[0117] It can be understood that in the whole process of rotating the shielding piece 22 from the sealed state to the uncapped state, a large kinetic energy is needed when the shielding piece 22 is rotated from the sealed state to the micro-closed state, thereby easily causing the reagent bottle to shake, and then causing the reagent loaded in the reagent bottle to splash from the liquid suction hole 211. Then, in the actual working process of the reagent bottle of the embodiment of the present application, the first uncapping device 41 can first open the shielding piece 22 to the micro-closed state by the second operation part 222, and then every time the pipetting device 43 needs to suck the reagent loaded in the reagent bottle from the liquid suction hole 211, the second uncapping device 42 can only open the shielding piece 22 from the micro-closed state to the uncapped state by the first operation part 223. In this way, it can make the subsequent each time the pipetting device 43 needs to suck liquid more simple and labor-saving, and can avoid the reagent bottle from shaking and causing the reagent to splash during the subsequent each time the pipetting device 43 sucks liquid.

[0118] For example, in the case that the first cover opening device 41 is used to drive the cover 22 to rotate to a first preset angle in the direction of exposing the liquid suction hole 211, the opening angle of the cover 22 is less than the first preset value. Therefore, the cover 22 can be first driven to rotate by the first cover opening device 41, and then driven to rotate to the micro-closed state by the first elastic member 23 in the direction of covering the liquid suction hole 211 after the first cover opening device 41 is separated from the cover 22. Then, when the pipette device 43 needs to suck the reagent carried in the reagent bottle, the cover 22 can be driven to rotate from the micro-closed state to completely expose the liquid suction hole 211 by the second cover opening device 42.

[0119] In some embodiments, in the case that the second cover opening device 42 is used to drive the cover 22 to rotate to a second preset angle in the direction of exposing the liquid suction hole 211, the opening angle of the cover 22 is greater than the second preset value. Therefore, after the cover 22 is driven to rotate to the second preset angle by the second cover opening device 42, the second cover opening device 42 can be moved away from the reagent bottle to avoid interference with the pipette device 43, so that the pipette device 43 can be moved to the second cover opening device 42 to suck the reagent carried in the reagent bottle by the first elastic member 23.

[0120] In some embodiments, the sample analysis apparatus further comprises a rack 500, and the rack 500 is installed with the reagent containing mechanism 300. The rack 500 is provided with a pre-cover opening position 51, and the pre-cover opening position 51 is arranged outside the reagent containing mechanism 300 and is used to carry the reagent bottle.

[0121] The first cover opening device 41 is used to drive the cover 22 of the reagent bottle located at the pre-cover opening position 51 to rotate. The second cover opening device 42 is used to drive the cover 22 of the reagent bottle located in the reagent containing mechanism 300 to rotate. The pipette device 43 is used to carry the reagent carried in the reagent bottle to the reaction container.

[0122] In addition, on the one hand, the first cover opening device 41 can avoid occupying too much space in the reagent containing mechanism 300. On the other hand, the sample analysis apparatus can first drive the cover 22 to rotate to the pre-cover opening position 51 outside the reagent containing mechanism 300, and then the second cover opening device 42 can simply and stably drive the cover 22 to expose the liquid suction hole 211 in the reagent containing mechanism 300 to suck the reagent, so as to avoid the large kinetic energy generated in the process of unsealing the cover 22 from the sealed state from affecting the stability and normal operation of the reagent containing mechanism 300.

[0123] Correspondingly, the sample analysis apparatus can further comprise a scheduling mechanism 600, and the scheduling mechanism 600 is used to schedule the reagent bottle. For example, the scheduling mechanism 600 can be used to schedule the reagent bottle to move between the pre-cover opening position 51 and the reagent containing mechanism 300.

[0124] Of course, in actual use, the first cover opening device 41 and the second cover opening device 42 can also be used to implement the liquid suction operation of the shielding piece 22 at the first preset angle and the second preset angle, so as to meet the diversified liquid suction requirements of the sample analyzer, and the embodiments of the present application do not limit this.

[0125] The technical solutions of the embodiments of the present application will be described below in combination with the specific structure of the first cover opening device 41.

[0126] Please continue to refer to Figure 9 The first cover opening device 41 can include a first mounting frame 411, a first driving unit 412, and a pushing piece 413. The first driving unit 412 is mounted on the first mounting frame 411. The pushing piece 413 is in transmission connection with the first driving unit 412, and the first driving unit 412 can drive the second operation part 222 to rotate away from the cover 21, so that the shielding piece 22 rotates away from the liquid suction hole 211, thereby achieving the unsealing of the liquid suction hole 211.

[0127] In some embodiments, the first driving unit 412 can also drive the second operation part 222 to rotate towards the cover 21, so that the second sealing part 221 of the shielding piece 22 seals the liquid suction hole 211, thereby achieving the sealing of the liquid suction hole 211.

[0128] For example, when the second sealing part 221 seals the liquid suction hole 211 so that the bottle mouth 121 is in a sealed state, the pushing piece 413 can push the second operation part 222 from bottom to top to unseal the bottle mouth 121 (or the liquid suction hole 211). When the shielding piece 22 is in a micro-closed state, the pushing piece 413 can push the second operation part 222 from top to bottom to make the second sealing part 221 seal the liquid suction hole 211, and then make the bottle mouth 121 in a sealed state.

[0129] The first driving unit 412 can be an electric motor, a motor, a pneumatic cylinder, etc., and the embodiments of the present application do not limit this.

[0130] In some embodiments, the first cover opening device 41 further includes a buffer assembly 414. The buffer assembly 414 is mounted on the first mounting frame 411, and the buffer assembly 414 is located on the path of the shielding piece 22 rotating under the driving of the pushing piece 413, so as to provide buffering when the shielding piece 22 moves away from the liquid suction hole 211.

[0131] It can be understood that the above has been mentioned that a large kinetic energy is generated in the process that the shielding member 22 rotates from the sealing state to the unsealing bottle mouth 121. Therefore, the buffering assembly 414 buffers when the shielding member 22 unseals the bottle mouth 121 (or the liquid suction hole 211), which can effectively absorb the large kinetic energy generated by the shielding member 22, so that the unsealing of the liquid suction hole 211 is more stable, and thus the reagent in the bottle body 100 can be prevented from splashing out.

[0132] For example, the buffering assembly 414 includes a first rotating member 4141 and a fifth elastic member (not shown in the figure). The first rotating member 4141 is rotatably installed on the first mounting frame 411. The fifth elastic member is installed on the first mounting frame 411, and the fifth elastic member is used to drive the first rotating member 4141 to rotate towards the direction close to the pushing member 413, so as to abut against the shielding member 22 of the reagent bottle to provide buffering.

[0133] The fifth elastic member can be a torsion spring, a compression spring, a disc spring, etc., and the embodiments of the present application do not limit this.

[0134] In some embodiments, the buffering assembly 414 further includes a second rotating member 4142 rotatably installed on the first mounting frame 411, and the second rotating member 4142 is located on the opposite side of the first rotating member 4141 from the pushing member 413. When the first rotating member 4141 drives the shielding member 22 to move towards the direction of exposing the liquid suction hole 211 to the first preset angle, the second rotating member 4142 contacts the first rotating member 4141 and drives the first rotating member 4141 to move away from the pushing member 413.

[0135] For example, the second rotating member 4142 can be a bearing, and the first rotating member 4141 is provided with a curved surface matched with the second rotating member 4142. When the shielding member 22 of the pre-opening cover position 51 moves towards the direction of exposing the liquid suction hole 211 to the first preset angle, the torque applied by the second rotating member 4142 to the first rotating member 4141 drives the first rotating member 4141 to rotate away from the pushing member 413. At this time, the pushing member 413 stops pushing the shielding member 22 to rotate, so that the pushing member 413 and the first rotating member 4141 can release the shielding member 22, so as to facilitate taking away the reagent bottle or driving the pushing member 413 and the first rotating member 4141 away from the reagent bottle.

[0136] In some embodiments, the pushing member 413 is provided with a first reset portion (not shown in the figure), and the first rotating member 4141 is provided with a second reset portion (not shown in the figure), and the second reset portion is located on the rotating path of the first reset portion. When the pushing member 413 drives the shielding member 22 to move in the direction of shielding the liquid suction hole 211, the first reset portion can push the second reset portion, so that the first rotating member 4141 rotates towards the direction close to the pushing member 413 to reset.

[0137] For example, the second reset part can be arranged in a reset slot of the first rotating member 4141, and the first reset part can be a push rod movably arranged in the reset slot. When the pusher 413 pushes the shielding member 22 to rotate to the first preset angle in the direction of exposing the liquid suction hole 211, the push rod moves in the reset slot; when the pusher 413 is reset, the push rod first moves to abut against the slot wall of the reset slot, and then pushes the slot wall of the reset slot to drive the second rotating member 4142 to reset.

[0138] In some embodiments, the sample analysis device is provided with a pre-opening cover position 51 for carrying a reagent bottle. The first cover opening device 41 is used to drive the shielding member 22 of the reagent bottle located at the pre-opening cover position 51 to rotate. Correspondingly, the first cover opening device 41 can further include a first mounting seat 415 and a second driving unit 416. The first mounting seat 415 is in sliding connection with the first mounting frame 411, so that the first mounting frame 411 can move towards or away from the pre-opening cover position 51. The second driving unit 416 is mounted on the first mounting seat 415, and the second driving unit 416 is in transmission connection with the first mounting frame 411, so as to drive the first mounting frame 411 to slide.

[0139] Therefore, when the bottle opening 121 of the reagent bottle at the pre-opening cover position 51 needs to be unsealed or resealed, the first mounting frame 411 can be driven by the second driving unit 416 to slide, so that the pusher 413 and the buffer assembly 414 on the first mounting frame 411 move towards the pre-opening cover position 51 to unseal or reseal the bottle opening 121 of the reagent bottle; after the bottle opening 121 of the reagent bottle is unsealed or resealed, the first mounting frame 411 can be driven by the second driving unit 416 to move away from the pre-opening cover position 51 to achieve avoidance.

[0140] In some embodiments, the corresponding carrying seat of the rack 500 can be provided with the pre-opening cover position 51.

[0141] In some embodiments, the second driving unit 416 can be an electric motor, a motor, an air cylinder, etc., and the present application does not limit the same.

[0142] In some embodiments, the first cover opening device 41 further includes a pressing assembly 417. The pressing assembly 417 is used to press or loosen the bottle body 100 of the reagent bottle. It can be understood that, as mentioned above, a large amount of kinetic energy can be generated during the movement of the shielding member 22 from the sealed state to the state of unsealing the bottle opening 121. Therefore, by means of the pressing assembly 417, the bottle body 100 can be effectively prevented from shaking to avoid spilling of the reagent in the bottle body 100.

[0143] For reference Figure 9 and Figure 10For example, the pressing assembly 417 can include a second mounting frame 4171 and a pressing member 4172. The second mounting frame 4171 is mounted to the first mounting seat 415. The pressing member 4172 includes a mounting portion 4172a and a pressing portion 4172b. The mounting portion 4172a is rotatably mounted to the second mounting frame 4171, and the pressing portion 4172b is located at a side of the mounting portion 4172a close to the pre-opening cover position 51. Thus, the pressing member 4172 can take the mounting portion 4172a as a rotating fulcrum to rotate the pressing portion 4172b to press or release the bottle body 100 of the reagent bottle.

[0144] In some embodiments, the pressing portion 4172b can be used to press or release the main body 11 of the bottle body 100.

[0145] In some embodiments, the pressing member 4172 abuts against the first mounting frame 411. When the first mounting frame 411 moves towards the pre-opening cover position 51, the pressing portion 4172b is allowed to rotate towards the pre-opening cover position 51, so that the pressing portion 4172b presses the bottle body 100 of the reagent bottle. When the first mounting frame 411 moves away from the pre-opening cover position 51, the pressing portion 4172b is pushed to rotate away from the pre-opening cover position 51, so that the pressing portion 4172b releases the bottle body 100 of the reagent bottle.

[0146] For example, a part of the pressing member 4172 between the mounting portion 4172a and the pressing portion 4172b can abut against the first mounting frame 411.

[0147] Further, the movement of the first mounting frame 411 can be driven by the second driving unit 416 to control the pressing member 4172 to press or release the bottle body 100 of the reagent bottle, so that the overall structure of the first cover opening device 41 is simpler.

[0148] It can be understood that, in the case where the first mounting frame 411 moves towards the pre-opening cover position 51 to allow the pressing portion 4172b to rotate towards the pre-opening cover position 51, the pressing portion 4172b can be driven to rotate downwards to press the bottle body 100 of the reagent bottle by its own gravity, or the pressing portion 4172b can be driven to rotate to press the bottle body 100 of the reagent bottle by other forces, which are not limited in the embodiments of the present application.

[0149] For example, the pressing assembly 417 further includes a second elastic member 4173. The second elastic member 4173 is mounted to the second mounting frame 4171 or the first mounting seat 415, and is used to drive the pressing portion 4172b to rotate towards the pre-opening cover position 51.

[0150] It can be understood that the second elastic member 4173 drives the pressing part 4172b to rotate towards the direction close to the pre-opening cover position 51, so that the pressing part 4172b can not only press the bottle body 100 of the reagent bottle, but also avoid the pressing part 4172b from being pressed to break the bottle body 100 of the reagent bottle due to too large stroke when rotating towards the direction close to the pre-opening cover position 51. Of course, the pressing part 4172b can also be suitable for pressing operation of reagent bottles with different height sizes, thereby improving the universality of the pressing assembly 417.

[0151] In addition, the second elastic member 4173 can reduce the driving unit required by the first cover opening device 41, thereby reducing the cost of the first cover opening device 41 and the whole sample analyzer.

[0152] The second elastic member 4173 can be a torsion spring, a compression spring, a disc spring, etc., and the embodiments of the present application do not limit this.

[0153] In some embodiments, the second mounting bracket 4171 is slidingly mounted on the first mounting seat 415, so that the second mounting bracket 4171 can move towards or away from the pre-opening cover position 51.

[0154] Therefore, when the bottle opening 121 of the reagent bottle at the pre-opening cover position 51 needs to be unsealed or resealed, the second mounting bracket 4171 slides to the pre-opening cover position 51, so that the pressing part 4172 on the second mounting bracket 4171 can rotate to press the bottle body 100 of the reagent bottle at the pre-opening cover position 51; after the bottle opening 121 of the reagent bottle is unsealed or resealed, the second mounting bracket 4171 slides away from the pre-opening cover position 51 to achieve avoidance.

[0155] Please continue to refer to Figure 11 In some embodiments, the pressing assembly 417 further comprises a third elastic member 4174, the third elastic member 4174 is mounted on the first mounting seat 415, and the third elastic member 4174 is used to drive the second mounting bracket 4171 to move towards the pre-opening cover position 51. Therefore, the third elastic member 4174 can reduce the driving unit required for the sliding of the first cover opening device 41, thereby reducing the cost of the first cover opening device 41 and the whole sample analysis device.

[0156] The third elastic member 4174 can be a torsion spring, a compression spring, a disc spring, etc., and the embodiments of the present application do not limit this.

[0157] In some embodiments, the pressing assembly 417 further comprises a first reset member 4175. The first reset member 4175 is arranged on the second mounting bracket 4171, and the first reset member 4175 is located on the path of the sliding of the first mounting bracket 411 away from the pre-opening cover position 51, so that when the first mounting bracket 411 moves away from the pre-opening cover position 51, the first reset member 4175 can drive the second mounting bracket 4171 to move away from the pre-opening cover position 51.

[0158] For example, the first reset member 4175 can include a reset rod, which is installed on the first mounting frame 411 and located on the side of the first mounting frame 411 away from the pre-opening cover position 51.

[0159] Therefore, on the one hand, when the first mounting frame 411 moves away from the pre-opening cover position 51, the first mounting frame 411 pushes the first reset member 4175 and the second mounting frame 4171 connected thereto to move away from the pre-opening cover position 51. On the other hand, when the first mounting frame 411 moves towards the pre-opening cover position 51, the third elastic member 4174 can drive the second mounting frame 4171 to also move towards the pre-opening cover position 51.

[0160] In some embodiments, the pressing assembly 417 further includes a fourth elastic member 4176. The fourth elastic member 4176 is installed on the first mounting seat 415, and is used to drive the second mounting frame 4171 to move away from the pre-opening cover position 51. The elastic coefficient of the fourth elastic member 4176 is smaller than that of the third elastic member 4174.

[0161] Therefore, even if the second driving unit 416 is accidentally in a power-off state during the operation of the sample analyzer, and the third elastic member 4174 drives the second mounting frame 4171 to slide towards the pre-opening cover position 51, the fourth elastic member 4176 can provide a buffer to prevent the first mounting frame 411 from quickly moving to the pre-opening cover position 51 and colliding with the reagent bottle at the pre-opening cover position 51.

[0162] For reference Figure 12 and Figure 13 Based on the above structure, a cover opening process of the first cover opening device 41 can be as follows:

[0163] Firstly, the reagent bottle is placed in the pre-opening cover position 51.

[0164] Secondly, the second driving unit 416 drives the first mounting frame 411 to move towards the pre-opening cover position 51. At the same time, the third elastic member 4174 drives the second mounting frame 4171 to move towards the pre-opening cover position 51, and the second elastic member 4173 drives the pressing part 4172b of the pressing member 4172 to rotate towards the pre-opening cover position 51, so that the pressing part 4172b of the pressing member 4172 presses the bottle body 100 of the reagent bottle.

[0165] Thirdly, the second driving unit 416 continues to drive the first mounting frame 411 to move towards the pre-opening cover position 51, so that the shielding member 22 of the reagent bottle is located between the pushing member 413 and the buffer assembly 414.

[0166] Fourthly, the first driving unit 412 drives the pusher 413 to push the shielding member 22 of the reagent bottle upwards to unseal the bottle mouth 121 (or the liquid suction hole 211) of the reagent bottle, and the buffering assembly 414 provides buffering to the shielding member 22 to avoid the reagent in the reagent bottle from splashing out due to the shaking of the reagent bottle when the shielding member 22 unseals the bottle mouth 121 (or the liquid suction hole 211).

[0167] Fifthly, the first driving unit 412 continues to drive the pusher 413 to push the shielding member 22 of the reagent bottle upwards, so that the first rotating member 4141 and the second rotating member 4142 of the buffering assembly 414 are in contact.

[0168] Sixthly, the first driving unit 412 continues to drive the pusher 413 to push the shielding member 22 of the reagent bottle upwards, so that the shielding member 22 rotates to a first preset angle. At this time, the second rotating member 4142 drives the first rotating member 4141 to rotate away from the pusher 413, so that the first rotating member 4141 and the pusher 413 switch from the state of clamping the shielding member 22 to the state of releasing the shielding member 22.

[0169] Seventhly, the second driving unit 416 drives the first mounting frame 411 to move away from the pre-cap opening position 51, and the first mounting frame 411 drives the second mounting frame 4171 to move away from the pre-cap opening position 51 through the first return member 4175, so that the first cap opening device 41 realizes avoidance; then, the shielding member 22 can rotate to a micro-closed state under the driving of the first elastic member 23.

[0170] Eighthly, the first driving unit 412 drives the pusher 413 to reset, and the pusher 413 drives the buffering assembly 414 to reset.

[0171] For reference Figure 14 Based on the above structure, a process of driving the shielding member 22 to seal the bottle mouth 121 (or the liquid suction hole 211) of the first cap opening device 41 can be as follows:

[0172] Firstly, the reagent bottle is placed on the pre-cap opening position 51, and the first driving unit 412 drives the pusher 413 to rotate towards the direction of pushing the shielding member 22 to expose the liquid suction hole 211.

[0173] Secondly, the second driving unit 416 drives the first mounting frame 411 to move towards the pre-cap opening position 51; at the same time, the third elastic member 4174 drives the second mounting frame 4171 to move towards the pre-cap opening position 51, and the second elastic member 4173 drives the pressing part 4172b of the pressing member 4172 to move towards the pre-cap opening position 51, so that the pressing part 4172b of the pressing member 4172 presses the bottle body 100 of the reagent bottle.

[0174] Thirdly, the second driving unit 416 continues to drive the first mounting frame 411 to move towards the direction of the pre-cover opening position 51, so that the shielding part 22 of the reagent bottle is located at the lower side of the pushing part 413.

[0175] Fourthly, the first driving unit 412 drives the pushing part 413 to push the shielding part 22, so that the shielding part 22 is rotated to the second sealing part 221 is inserted into the liquid suction hole 211 to seal the liquid suction hole 211, thereby realizing the sealing of the bottle mouth 121.

[0176] The above is some explanation and description of the first cover opening device 41 in the embodiments of the present application. The technical solutions of the embodiments of the present application will be described below in combination with the second cover opening device 42.

[0177] As mentioned above, the shielding part 22 can also include the first operation part 223, and the first operation part 223 and the second operation part 222 are protruded from the opposite sides of the cover body 21. Therefore, the second cover opening device 42 can be used to push the first operation part 223 of the shielding part 22 to drive the shielding part 22 to rotate.

[0178] Please refer to Figure 15 and Figure 16 In some embodiments, the second cover opening device 42 includes a third mounting frame 421, a third driving unit 422 and a pressing assembly 423. The third driving unit 422 is mounted on the third mounting frame 421. The pressing assembly 423 is in transmission connection with the third driving unit 422, so that the third driving unit 422 can drive the pressing assembly 423 to push the shielding part 22, for example, to push the first operation part 223 of the shielding part 22 to rotate towards the cover body 21.

[0179] The third driving unit 422 can be a motor, a cylinder or the like, and the embodiments of the present application do not limit it.

[0180] In some embodiments, the pressing assembly 423 includes at least two pressing parts 4231, and at least part of the pressing parts 4231 are used to push the first operation part 223 of different reagent bottles. Therefore, the second cover opening device 42 can complete the cover opening operation of at least two reagent bottles at one time, so as to improve the working efficiency of the second cover opening device 42 and the whole sample analysis equipment.

[0181] In some embodiments, the second uncovering device 42 further comprises a second mounting base 424 and a fourth driving unit 425. The second mounting base 424 is movably connected with the third mounting frame 421. The fourth driving unit 425 is mounted on the second mounting base 424 or the third mounting frame 421, and is configured to drive the third mounting frame 421 to move, so that the third mounting frame 421 drives the pressing assembly 423 to push the shielding member 22 to move towards the liquid suction hole 211.

[0182] In some embodiments, the third mounting frame 421 can be rotatably mounted on the second mounting base 424. The second mounting base 424 is provided with a first gear. The fourth driving unit 425 comprises a motor mounted on the third mounting frame 421, and the motor output shaft of the fourth driving unit 425 is provided with a second gear. The second gear is engaged with the first gear.

[0183] Therefore, the second gear and the first gear can constitute a planetary gear pair. When the fourth driving unit 425 drives the second gear to rotate, the second mounting base 424 can be fixed, and the fourth driving unit 425 and the second gear rotate around the circumference of the first gear.

[0184] In some embodiments, the first mounting base 415 and the second mounting base 424 can be fixed on the rack 500.

[0185] Please continue to refer to Figure 17 Based on the above structure, a working process of the second uncovering device 42 can be as follows:

[0186] In the first step, the third driving unit 422 drives the pressing assembly 423 to move downwards, so that the pressing assembly 423 pushes the first operating part 223 of the shielding member 22 of the reagent bottle to rotate downwards, so that the shielding member 22 is rotated to expose the liquid suction hole 211, so as to provide the liquid suction device 43 to suck the reagent carried in the reagent bottle.

[0187] In the second step, the third driving unit 422 drives the pressing assembly 423 to move upwards, and the fourth driving unit 425 drives the third mounting frame 421 and the pressing assembly 423 to rotate forward, so that the pressing assembly 423 rotates upwards, thereby pushing the shielding member 22 to move towards the liquid suction hole 211.

[0188] In the third step, the third driving unit 422 continues to drive the pressing assembly 423 to move upwards, and the fourth driving unit 425 continues to drive the third mounting frame 421 and the pressing assembly 423 to rotate forward, so that the pressing assembly 423 continues to rotate upwards to push the shielding member 22 to rotate to an opening angle less than the first preset value, and then the first elastic member 23 also synchronously drives the shielding member 22 to rotate to a micro-closed state.

[0189] In the fourth step, the fourth driving unit 425 continues to drive the pressing assembly 423 to move upward to reset, and the fourth driving unit 425 drives the third mounting frame 421 and the pressing assembly 423 to rotate reversely and reset.

[0190] In the above embodiments, the description of each embodiment has its own focus, and the parts not described in detail in a certain embodiment can be referred to the relevant description of other embodiments.

[0191] The reagent bottle and the sample analysis device provided by the embodiments of the present application are described in detail above, and the principles and implementation manners of the present application are described by applying specific examples. The above embodiment descriptions are only used to help understand the method of the present application and its core idea. Meanwhile, for those skilled in the art, the specific implementation manners and application ranges will be changed according to the idea of the present application. In summary, the content of the specification should not be understood as a limitation of the present application.

Claims

1. A reagent bottle characterized by, The bottle includes: a bottle body provided with a bottle mouth; and a bottle cap including a cap body and a shielding member, the cap body is connected with the bottle body to cover the bottle mouth, the cap body is provided with a liquid suction hole, the liquid suction hole is communicated with the bottle mouth, the outer circumferential side of the cap body includes a first side and a second side which are different from each other, the cap body is hinged with the shielding member at the first side, the shielding member is provided with a second sealing part and a second operating part, the second sealing part is in interference fit with the inner circumferential surface of the liquid suction hole, so that the bottle cap seals the bottle mouth, the second operating part protrudes from the second side, the second operating part is driven by external force to rotate in a direction away from the cap body, thereby driving the shielding member to rotate in a direction exposing the liquid suction hole to unseal the bottle mouth.

2. The reagent bottle according to claim 1, characterized by The shielding member further includes a first operating part, the first operating part protrudes from the first side of the cap body, the first operating part is driven by external force to rotate in a direction close to the cap body, thereby driving the shielding member to rotate in a direction exposing the liquid suction hole.

3. The reagent bottle of claim 1, wherein The bottle cap is further provided with a first elastic member; When the opening angle of the shielding member is less than a first preset value, the first elastic member can drive the shielding member to shield the liquid suction hole, the opening angle of the shielding member is the included angle between the shielding member and the plane where the hole of the liquid suction hole is located; When the opening angle of the shielding member is greater than the first preset value, the first elastic member can drive the shielding member to expose the liquid suction hole.

4. The reagent bottle of claim 3, wherein One end of the first elastic member is connected to the outer circumferential side of the cap body, and the other end of the first elastic member is connected with the shielding member.

5. The reagent bottle according to any one of claims 1 to 4, characterized in that, The bottle body includes a main body part and a bottle mouth part, the bottle mouth part protrudes from one side of the main body part, one end of the bottle mouth part away from the main body part forms the bottle mouth, and the main body part is used for fixing the bottle body by an external device.

6. A sample analysis apparatus, characterized by, The sample analysis device includes: a reagent containing mechanism for containing the reagent bottle according to any one of claims 1 to 5; and a reagent dispensing mechanism including a first cap opening device, a second cap opening device and a pipetting device, the first cap opening device is used to drive the shielding member to rotate in a direction exposing the liquid suction hole to a first preset angle, the second cap opening device is used to drive the shielding member to rotate in a direction exposing the liquid suction hole to a second preset angle, the second preset angle is greater than the first preset angle, and the pipetting device is used to suck the reagent carried in the reagent bottle through the liquid suction hole and transfer it to a reaction container.

7. The sample analysis device of claim 6, wherein, The sample analysis device further includes a rack, the rack is installed with the reagent containing mechanism, the rack is provided with a pre-cap opening position, the pre-cap opening position is located outside the reagent containing mechanism and is used to carry the reagent bottle; wherein the first cap opening device is used to drive the shielding member of the reagent bottle located in the pre-cap opening position to rotate; the second cap opening device is used to drive the shielding member of the reagent bottle located in the reagent containing mechanism to rotate, and the pipetting device is used to carry the reagent of the reagent bottle in the reagent containing mechanism and transfer it to the reaction container; and / or, The first uncapping device is used to drive the cover to rotate to unseal the bottle mouth; the second uncapping device is used to drive the cover to rotate to selectively expose the liquid suction hole to allow the pipetting device to suck the reagent carried in the bottle.

8. The sample analysis device of claim 6, wherein, The first uncapping device comprises: a first mounting frame; a first driving unit mounted on the first mounting frame; and a pushing member in transmission connection with the first driving unit, the first driving unit being capable of driving the second operating part to rotate towards the first uncapping device or away from the first uncapping device, so as to drive the cover to rotate towards the liquid suction hole or away from the liquid suction hole.

9. The sample analysis device of claim 8, wherein, The first uncapping device further comprises at least one of a buffer assembly and a pressing assembly; the buffer assembly is mounted on the first mounting frame and is located on the path of the cover driven by the pushing member to rotate, so as to provide a buffer when the cover moves towards the liquid suction hole; the pressing assembly is used to press or release the bottle body of the reagent bottle.

10. The sample analysis device of claim 8, wherein, The sample analysis device is provided with a pre-uncapping position for carrying the reagent bottle, and the first uncapping device is used to drive the cover of the reagent bottle located on the pre-uncapping position to rotate; wherein the first uncapping device further comprises: a first mounting seat in sliding connection with the first mounting frame, so that the first mounting frame can move towards the pre-uncapping position or away from the pre-uncapping position; and a second driving unit mounted on the first mounting seat and in transmission connection with the first mounting frame to drive the first mounting frame to slide.

11. The sample analysis device of claim 10, wherein, The first uncapping device further comprises a pressing assembly, which comprises: a second mounting frame mounted on the first mounting seat; and a pressing member comprising a mounting portion and a pressing portion, the mounting portion being rotatably mounted on the second mounting frame, and the pressing portion being located on the side of the mounting portion close to the uncapping position; wherein the pressing member abuts against the first mounting frame, the first mounting frame allows the pressing portion to rotate towards the pre-uncapping position when the first mounting frame moves towards the pre-uncapping position, so that the pressing portion presses the bottle body of the reagent bottle; and the first mounting frame pushes the pressing portion to rotate away from the pre-uncapping position when the first mounting frame moves away from the pre-uncapping position, so that the pressing portion releases the bottle body of the reagent bottle.

12. The sample analysis device of claim 11, wherein, The pressing assembly further comprises a second elastic member mounted on the second mounting frame or the first mounting seat, the second elastic member being used to drive the pressing portion to rotate towards the pre-uncapping position.

13. The sample analysis device of claim 11, wherein, The second mounting frame is slidably mounted on the first mounting seat, so that the second mounting frame can move towards the pre-uncapping position or away from the pre-uncapping position; the pressing assembly further comprises a third elastic member mounted on the first mounting seat, the third elastic member being used to drive the second mounting frame to move towards the pre-uncapping position; The pressing assembly further comprises at least one of a first reset member and a fourth elastic member; The first reset member is arranged on the second mounting frame, and is located on a path of the first mounting frame sliding away from the pre-cover opening position, so that the first mounting frame can drive the second mounting frame to move away from the pre-cover opening position when the first mounting frame moves away from the pre-cover opening position; The fourth elastic member is arranged on the first mounting seat, and is used to drive the second mounting frame to move away from the pre-cover opening position. The elastic coefficient of the fourth elastic member is smaller than that of the third elastic member.

14. The sample analysis device of any one of claims 6 to 13, wherein, When the shielding member further comprises a first operation part, the first operation part and the second operation part protrude from opposite sides of the cover body, the second cover opening device comprises: a third mounting frame; a third driving unit arranged on the third mounting frame; and a pressing assembly in transmission connection with the third driving unit, so that the third driving unit can drive the pressing assembly to push the first operation part to rotate towards the cover body.

15. The sample analysis device of claim 14, wherein, The pressing assembly comprises at least two pressing members, and at least part of the pressing members are used to push the first operation part of different reagent bottles.

16. The sample analysis device of claim 14, wherein, The second cover opening device further comprises: a second mounting seat in movable connection with the third mounting frame; and a fourth driving unit arranged on the second mounting seat or the third mounting frame, which can drive the third mounting frame to move, so that the third mounting frame drives the pressing assembly to push the shielding member to move towards the liquid suction hole.

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