Sample introduction device and detection system
By designing a sample introduction device, precise sample delivery to the liquid crystal sensor was achieved, solving the problem of environmental influence during sample addition and improving the repeatability and stability of the detection.
Patent Information
- Application Number
- CN202422957277.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-02
- Publication Date
- 2026-01-16
- Estimated Expiration
- 2034-12-02
AI Technical Summary
Existing liquid crystal sensors are easily affected by the environment when samples are added, resulting in low detection repeatability and poor stability, especially due to human operation affecting the contact position and angle.
A sample introduction device was designed, including a housing, a detection component, multiple delivery channels, and a light-transmitting component, to ensure accurate delivery of the detection liquid to the liquid crystal detection chip, avoid the influence of human factors, and improve the repeatability and stability of the experiment.
By precisely controlling the contact position and angle between the sample and the liquid crystal sensor chip, the repeatability and stability of the detection are improved, and the environmental influence problem of sample addition to the liquid crystal sensor is solved.
Smart Images
Figure CN223808329U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The embodiment of the utility model relates to the field of liquid crystal optical sensing technology, in particular to a sample feeding device and detection system. BACKGROUND
[0002] Since the discovery of liquid crystal, it has attracted extensive attention due to its unique structure and special performance. It is an ordered fluid between liquid and solid, which has both the fluidity of liquid and the optical anisotropy of crystal. At present, the most widely used is nematic liquid crystal, because external stimuli (such as temperature, physical, chemical interaction, etc.) can affect the short-range interaction and long-range order of nematic liquid crystal molecules, thereby causing the change of liquid crystal orientation, and different response signals can be observed under polarizing microscope. Some research groups first used liquid crystal as a signal converter to convert the antigen-antibody immune response on the liquid crystal-solid interface into an optical response signal and conducted pioneering research, finding that sodium dodecyl sulfate (a kind of amphiphilic molecule containing long alkyl chain) adsorbed on the liquid crystal-water interface can induce vertical ordered arrangement of liquid crystal. This discovery laid the foundation for the development of liquid-liquid crystal interface sensor. Since then, new liquid crystal sensors have been widely used in the detection of biological molecules or environmental pollutants such as pathogens, proteins, antigens, enzymes, glucose, and cholesterol.
[0003] Up to now, sample feeding systems have been widely used in the fields of environment, biology, industry, and clinical medicine. In the field of liquid crystal sensing, the response of liquid crystal to external stimuli is at the molecular level, so high-sensitivity detection can be achieved. However, due to its high sensitivity, it is easily affected by the environment, especially the instantaneous state when the sample is added, which will affect the intermediate process optical image and response time of the reaction. Utility model content
[0004] The utility model provides a kind of to be able to accurately, stably realize the injection of detection liquid, improve the repeatability and stability of detection experiment sample feeding device and detection system.
[0005] In order to solve the above technical problems, the utility model embodiment provides a kind of sample feeding device, applied to liquid crystal optical sensing system, the sample feeding device includes:
[0006] Shell, upper surface side is equipped with sample inlet, detection port;
[0007] Detection component, is located in the upper surface side of the shell, and is communicated with the detection port, the detection component includes liquid crystal detection chip for contacting with detection liquid to assist sensing optical image;
[0008] A plurality of conveying channels are arranged in the shell and are connected with the sample inlet and the detection port respectively, for receiving the detection liquid and conveying the detection liquid to the detection port so that the detection liquid contacts with the liquid crystal detection chip;
[0009] A light transmission assembly is arranged in the shell, for receiving and transmitting light to the detection port.
[0010] In some embodiments, the sample inlet is one or more, and the plurality of conveying channels include a sample conveying channel corresponding to the sample inlet.
[0011] In some embodiments, a first boss is arranged on the upper surface side of the shell, the top of the first boss is concave to form a sample pool, and the sample inlet is arranged in the sample pool and communicates with the sample pool.
[0012] In some embodiments, the sample inlet is upwardly open or obliquely upwardly open, the shape of the sample inlet matches the shape of the output end of the liquid feeding device, and a rubber ring is arranged on the sample inlet for corresponding abutting with the output end.
[0013] In some embodiments, the plurality of conveying channels include a detection channel for conveying the detection liquid to the detection port, and a first conveying channel communicating with the detection channel and the sample conveying channel, and when the sample conveying channel is a plurality of channels, the first conveying channel is connected with the plurality of sample conveying channels in the form of a manifold.
[0014] In some embodiments, part of the shell is concave from the upper surface side to form a detection pool, the detection port is arranged in the detection pool and communicates with the detection pool, and the liquid crystal detection chip is arranged in the detection pool.
[0015] In some embodiments, the shape of the detection pool matches the shape of the liquid crystal detection chip, and the upper surface side of the shell is further provided with an operation groove communicating with the detection pool for picking up the liquid crystal detection chip.
[0016] A positioning hole is further arranged on the shell, and a positioning column corresponding to the position of the positioning hole is arranged on the detection device in the liquid crystal optical sensing system, and the detection device at least includes a microscope.
[0017] In some embodiments, the plurality of conveying channels include a detection channel vertically arranged for conveying the detection liquid to the detection port, the light transmission assembly includes a light guide part arranged in the device, a light inlet hole arranged at the bottom of the shell and communicating with the light guide part, and a light inlet plate sealing the light inlet hole, and light can pass through the light inlet plate and the light guide part to enter the detection channel and then to the side of the liquid crystal detection chip contacting with the detection liquid.
[0018] In some embodiments, the sample outlet and the collection groove are arranged on the upper surface side of the shell, the sample outlet and the collection groove are one or more respectively, the plurality of delivery channels include a plurality of sample delivery channels, the sample outlet and the collection groove correspond to the plurality of sample delivery channels one by one and communicate with each other, and the plurality of sample delivery channels and the second delivery channel are connected in the form of a manifold.
[0019] The utility model discloses another embodiment simultaneously provides a detection system, comprising:
[0020] The sample injection device as claimed in any one of the preceding embodiments;
[0021] The liquid feeding device is used for feeding the detection liquid into the sample injection device through the sample injection port in the sample injection device.
[0022] The detection device is detachably connected with the sample injection device, can emit light to the light inlet at the bottom of the sample injection device, and can collect the polarized image presented by the liquid crystal detection chip in the sample injection device.
[0023] Based on the disclosure of the above embodiments, the embodiments of the utility model have the beneficial effects including solving the problems of low repeatability and poor stability of the sensing system in the prior art, in which the sample is directly dropped on the liquid crystal sensing chip by using the sample feeding device and the chip is manually moved for detection. Meanwhile, the contact position of the sample and the liquid crystal sensing chip can be accurately controlled, the influence of human factors on the contact position and the angle problem when dropping the detection liquid are avoided, and the repeatability and stability of the experiment are improved.
[0024] Other features and advantages of the present application will be set forth in the following description, and in part will become apparent to those skilled in the art from the following description, or can be learned by practice of the present application. The objects and other advantages of the present application can be realized and achieved by the structure particularly pointed out in the written description, claims, and drawings.
[0025] The technical solutions of the present application will be further described in detail below with the help of the drawings and examples. BRIEF DESCRIPTION OF DRAWINGS
[0026] In order to more clearly illustrate the specific embodiments of the utility model or the technical solutions in the prior art, the drawings needed in the specific embodiments or the prior art description will be briefly introduced. Obviously, the drawings in the following description are some embodiments of the utility model, and those skilled in the art can obtain other drawings according to these drawings without creating any creative labor.
[0027] Figure 1 It is a structure schematic view of the sample inlet device in the embodiment of the utility model.
[0028] Figure 2 It is another structure schematic view of the sample inlet device in the embodiment of the utility model.
[0029] Figure 3 It is another structure schematic view of the sample inlet device in the embodiment of the utility model.
[0030] Figure 4 It is another structure schematic view of the sample inlet device in the embodiment of the utility model.
[0031] Figure 5 It is the microscope image of an application example of the sample inlet device in the embodiment of the utility model.
[0032] Figure 6 It is the polarized image of an application example of the sample inlet device in the embodiment of the utility model.
[0033] Figure 7 It is another polarized image of an application example of the sample inlet device in the embodiment of the utility model.
[0034] Reference signs:
[0035] 1 - shell, 2 - sample inlet, 3 - sample outlet, 4 - detection assembly, 5 - sample inlet channel, 6 - detection port, 7 - collection groove, 8 - detection cell, 9 - light inlet hole, 10 - detection channel, 11 - first conveying channel, 12 - second conveying channel, 13 - sample outlet channel, 14 - sample inlet cell, 15 - positioning hole. DETAILED DESCRIPTION
[0036] Below, the specific embodiments of the utility model are described in detail in combination with the drawings, but not as the limitation of the utility model.
[0037] It should be understood that various modifications can be made to the embodiments disclosed herein. Therefore, the following description should not be considered limiting, but only as an example of the embodiments. Those skilled in the art will think of other modifications within the scope of the present disclosure.
[0038] The drawings included in the specification and forming a part of the specification illustrate embodiments of the present disclosure and serve to explain the principles of the present disclosure together with the above general description of the present disclosure and the following detailed description of the embodiments.
[0039] These and other characteristics of the present utility model will become apparent from the following description of the preferred forms given, by way of non-limiting example, of embodiments of the present utility model, with reference to the attached drawings.
[0040] It should also be understood that, while the present application has been described with reference to some specific examples, many other embodiments of the present application will be apparent to those skilled in the art with the benefit of this disclosure, having the features as set out in the claims and therefore all fall within the scope of the protection defined by the claims.
[0041] The above and other aspects, features, and advantages of the present disclosure will become more apparent with reference to the following detailed description when taken in conjunction with the accompanying drawings, which illustrate
[0042] Specific embodiments of the present disclosure are described hereinafter with reference to the accompanying drawings; however, it is to be understood that the disclosed embodiments are merely examples of the present disclosure, which can be embodied in various ways. Well-known and / or repetitive functions and structures are not described in detail to avoid obscuring the present disclosure unnecessarily or redundantly. Therefore, specific structural and functional details disclosed herein are not intended to be limiting, but are merely as a basis for the claims and representative for teaching a person skilled in the art to use the present disclosure in a variety of ways with substantially any suitable detailed structure.
[0043] The specification can use phrases such as "in one embodiment", "in another embodiment", "in yet another embodiment", or "in other embodiments", which can refer to one or more of the same or different embodiments under the present disclosure.
[0044] Hereinafter, specific embodiments of the present application will be described in detail with reference to the accompanying drawings.
[0045] As shown in the drawings, the present application provides a sample injection device applied in a liquid crystal optical sensing system, the sample injection device comprises: Figure 1
[0046] A housing having a sample inlet and a detection port formed on the upper surface thereof;
[0047] A detection assembly disposed on the upper surface of the housing and in communication with the detection port, the detection assembly comprising a liquid crystal detection chip for contacting a detection liquid to assist in sensing an optical image;
[0048] A plurality of conveying channels disposed in the housing and connected to the sample inlet and the detection port respectively, for receiving the detection liquid and conveying the detection liquid to the detection port so that the detection liquid contacts the liquid crystal detection chip;
[0049] A light transmission assembly disposed in the housing for receiving and transmitting light to the detection port.
[0050] The structure of the shell is not definite, for example, in the form of a cube, and the shell in the embodiment is in the form of a cube with a rectangular cross section. The interior can be a hollow structure, such as a box, or a solid structure with a plurality of conveying channels formed therein. During operation, the worker can use the liquid feeding device to inject the detection liquid into the sample injection device through the sample injection port to contact the detection liquid with the liquid crystal detection chip to complete the detection. The liquid crystal detection chip is selected in the embodiment because in the field of liquid crystal sensing, the response of liquid crystal to external stimulation is at the molecular level, and therefore high-sensitivity detection of biological molecules such as pathogens, proteins, antigens, enzymes, glucose, cholesterol, and environmental pollutants can be achieved. However, due to the high sensitivity of liquid crystal detection, it is easily affected by the environment, especially the instantaneous state when the sample is added, which can affect the intermediate process optical image and response time of the reaction. The use of the sample injection device in the embodiment can solve the problems of low repeatability and poor stability of the sensing system in the prior art, in which the sample is directly dropped on the liquid crystal sensing chip using a sample feeding device and the chip is manually moved for detection. At the same time, the contact position of the added sample with the liquid crystal sensing chip can be accurately controlled to avoid the influence of human factors on the contact position and the angle problem when the detection liquid is dropped, thereby improving the repeatability and stability of the experiment.
[0051] The liquid crystal detection chip in the embodiment can be a glass chip, a PDMS chip, or the like, such as a glass liquid crystal optofluidic chip.
[0052] Continuing to combine the drawings, the shell in the embodiment is made of a solidifiable material such as alumina and polyester, and the sample injection port is one or more. The plurality of conveying channels include a sample injection channel corresponding to the sample injection port. That is, the plurality of sample injection channels are connected one by one to the plurality of sample injection ports, and when the detection liquid is fed through each sample injection port, the detection liquid at each sample injection port enters the shell through the corresponding sample injection channel.
[0053] The upper surface side of the shell in the embodiment is provided with a first boss, and the structure of the first boss is not definite. The first boss in the embodiment is in the form of an oblong, and can also be in the form of a rectangle or the like. The top of the first boss is recessed to form a sample injection pool, and the sample injection port is formed at the bottom of the sample injection pool and communicates with the sample injection pool. In this way, even if the detection liquid overflows, it can still enter the sample injection pool and then flow into the sample injection port, thereby avoiding waste and reducing the difficulty of the sample feeding operation for the worker.
[0054] In another embodiment, the sample inlet opening is upward, that is, the sample inlet is vertically provided, or the sample inlet can also be provided in an upwardly inclined manner, that is, the sample inlet is provided in an inclined manner, and the degree of inclination is not limited and can be comprehensively determined according to the structure and type of the sample feeding device. In order to facilitate sample feeding, in the embodiment, the outer shape structure of the sample inlet is matched with the outer shape structure of the output end of the liquid feeding device, and a rubber ring for abutting against the output end is further provided on the sample inlet. The rubber ring not only provides a contact friction force to enable the output end of the sample feeding device to stably contact the sample inlet, but also has a sealing effect to avoid waste or pollution caused by overflow of the detection liquid.
[0055] Further, the plurality of conveying channels include a detection channel for conveying the detection liquid to the detection port, and a first conveying channel in communication with the detection channel and the sample feeding channel, respectively. When the sample feeding channel is a plurality of channels, the first conveying channel is connected to the plurality of sample feeding channels in the form of a manifold. In this way, each sample feeding channel is connected to the same first conveying channel, so that the first conveying channel collects the detection liquid of all sample feeding channels and conveys it to the detection channel, so that the detection liquid contacts the liquid crystal detection chip and forces the liquid crystal on the liquid crystal detection chip to change.
[0056] The detection channel in the embodiment is vertically provided, and the detection liquid in the first conveying channel flows to the detection port along the detection channel by the detection liquid continuously input at the sample inlet as a driving force, and then contacts the liquid crystal detection chip.
[0057] Continuing to combine the drawings, part of the shell is recessed from the upper surface side to form a detection pool, the detection port is provided in the detection pool and is in communication with the detection pool, and the liquid crystal detection chip is located in the detection pool. The outer shape of the detection pool is preferably matched with the liquid crystal detection chip, and the size of the detection pool is greater than that of the liquid crystal detection chip, so as to facilitate the placement and picking of the liquid crystal detection chip by the staff. The liquid crystal detection chip is placed in the detection pool and covers the detection port, and the detection liquid flows out of the detection port and contacts the liquid crystal detection chip. In addition, a plurality of limiting bars can be provided in the detection pool, and the plurality of limiting bars are arranged in different directions to abut against the side edges of the liquid crystal detection chip in different directions, so as to limit the position of the liquid crystal detection chip and avoid displacement of the liquid crystal detection chip, which causes unstable contact with the detection liquid.
[0058] Further, the upper surface side of the shell is also provided with an operation groove in communication with the detection pool for picking up the liquid crystal detection chip. The operation groove can be of any shape. In the embodiment, the operation groove is circular to facilitate the insertion of a finger. The shell is also provided with positioning holes. The detection device in the liquid crystal optical sensing system is provided with positioning columns corresponding to the positions of the positioning holes and capable of being fitted into the corresponding positioning holes. The number of positioning holes corresponds to the number of positioning columns. Multiple positioning holes can be arranged along the edge of the shell.
[0059] Continuing to refer to the drawings, the plurality of conveying channels include a detection channel vertically arranged to convey the detection liquid to the detection port. The light transmission assembly includes a light guide arranged inside the device, a light inlet hole arranged at the bottom of the shell and in communication with the light guide, and a light inlet plate sealed at the light inlet hole. The light inlet plate can be high-transmittance glass or the like. Alternatively, a light inlet channel can be arranged in the shell corresponding to the detection channel. One end of the light inlet channel is in communication with the light inlet hole, and the other end is in communication with the detection channel. The communication port is also provided with a light transmission member for allowing light to enter the detection channel while sealing the detection channel to prevent the detection liquid from flowing into the light inlet channel. The light inlet channel forms the light guide as a whole, or the shell is hollow, and the internal detection channel is made of a light-transmitting material. The light guide is any area in the shell that can guide light into the detection channel. That is, light can pass through the light inlet plate and the light guide to enter the detection channel and then contact the side of the liquid crystal detection chip in contact with the detection liquid.
[0060] In another embodiment, the sample inlet device further includes a sample outlet hole and a collection groove arranged on the upper surface side of the shell. The sample outlet hole and the collection groove are one or more, respectively. The plurality of conveying channels include a plurality of sample outlet channels. The sample outlet hole and the collection groove correspond to the plurality of sample outlet channels one by one and are in communication with each other. The plurality of sample outlet channels and the detection channel are provided with a second conveying channel in communication with the sample outlet channels and the detection channel. The plurality of sample outlet channels and the second conveying channel are connected in the form of a manifold. The sample outlet channel is arranged to accommodate or guide the excess detection liquid to ensure the smooth completion of the detection process while ensuring that the detection liquid smoothly enters the detection channel and contacts the liquid crystal detection chip.
[0061] In a specific application, for example, the glass chip is used to detect SDS. The sample injection system of the utility model is placed under a normal polarized microscope to collect optical images and verify its feasibility. A chip with an overall size of 18mmx18mm is placed at the detection position, and the sensing area of the chip used can be but is not limited to 2.72mmx2.72mm, wherein the side length of the microstructure is 80μm, the size between the two microstructures is 40μm, and the thickness is 16.5μm. The glass liquid crystal optofluidic chip can also be replaced by a PDMS liquid crystal optofluidic chip. For example, the sensing area of the chip is 2.72mmx2.72mm, wherein the side length of the microstructure is 80μm, the size between the two microstructures is 40μm, and the thickness is 20μm. Taking the glass chip used as an example, first, the light of the microscope is irradiated onto the chip through the light inlet hole, and the collected microscope image is as shown in Figure 5 When the liquid crystal is filled on the chip, the polarized image of the liquid crystal optofluidic chip is as shown in Figure 6 Further, at the sample inlet of the sample injection device, 840μL of 10μM SDS solution is added dropwise by using an electric pipette, the sample first passes through the sample injection channel, and then slowly enters the detection channel and the sample outlet channel, and the polarized image after the sample contacts for 1min is recorded, as shown in Figure 7 The results show that the imaging is uniform in the entire field of view. The electric pipette used can control a consistent flow rate to enter, and each time the liquid crystal sensing chip is contacted, the same initial state is achieved. The recording time of the sample is not limited to 1min, but can also be 2min or the like, and the specific time is indefinite.
[0062] The utility model also provides a detection system, comprising:
[0063] The sample injection device as described in any one of the above embodiments;
[0064] The liquid feeding device is used to feed the detection liquid into the sample injection device through the sample inlet in the sample injection device;
[0065] The detection device is detachably connected with the sample injection device, the detection device can irradiate light onto the light inlet hole at the bottom of the sample injection device, and can collect the polarized image presented by the liquid crystal detection chip in the sample injection device.
[0066] The above embodiments are only exemplary embodiments of the utility model, and are not used to limit the utility model, and the protection scope of the utility model is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements to the utility model within the spirit and protection scope of the utility model, and such modifications or equivalent replacements should also be regarded as falling within the protection scope of the utility model.
Claims
1. A sample injection device applied in a liquid crystal optical sensing system, characterized in that, The sample injection device comprises: a housing, an upper surface side of which is provided with a sample injection port and a detection port; a detection assembly arranged on the upper surface side of the housing and in communication with the detection port, the detection assembly comprising a liquid crystal detection chip for contacting a detection liquid to assist in sensing an optical image; a plurality of delivery channels arranged in the housing and respectively connected to the sample injection port and the detection port, for receiving the detection liquid and delivering the detection liquid to the detection port so that the detection liquid contacts the liquid crystal detection chip; a light transmission assembly arranged in the housing, for receiving and transmitting light to the detection port.
2. The sample introduction device of claim 1, wherein The sample injection port is one or more, and the plurality of delivery channels comprises a sample injection channel corresponding to the sample injection port.
3. The sample introduction device of claim 1, wherein, The upper surface side of the housing is provided with a first boss, the top of which is recessed to form a sample pool, and the sample injection port is arranged in the sample pool and in communication with the sample pool.
4. The sample introduction device of claim 1, wherein The sample injection port is upwardly open or inclined upwardly, the shape of the sample injection port matches the shape of the output end of the liquid delivery device, and the sample injection port is further provided with a rubber ring for corresponding abutment with the output end.
5. The sample introduction device of claim 2, wherein, The plurality of delivery channels comprises a detection channel for delivering the detection liquid to the detection port, and a first delivery channel in communication with the detection channel and the sample injection channel, and when the sample injection channel is a plurality of channels, the first delivery channel is connected to the plurality of sample injection channels in the form of a manifold.
6. The sample introduction device of claim 1, wherein Part of the housing is recessed from the upper surface side to form a detection pool, the detection port is arranged in the detection pool and in communication with the detection pool, and the liquid crystal detection chip is located in the detection pool.
7. The sample introduction device of claim 6, wherein The shape of the detection pool matches the shape of the liquid crystal detection chip, and the upper surface side of the housing is further provided with an operation groove in communication with the detection pool for picking up the liquid crystal detection chip; The housing is further provided with a positioning hole, and the detection device in the liquid crystal optical sensing system is provided with a positioning column corresponding in position to the positioning hole and capable of being fitted into the corresponding positioning hole, and the detection device at least comprises a microscope.
8. The sample introduction device of claim 6, wherein, The plurality of delivery channels comprises a vertically arranged detection channel for delivering the detection liquid to the detection port, the light transmission assembly comprises a light guide portion arranged inside the device, a light inlet hole arranged at the bottom of the housing and in communication with the light guide portion, and a light inlet plate sealed at the light inlet hole, and light can pass through the light inlet plate and the light guide portion to enter the detection channel and then be directed to the side of the liquid crystal detection chip contacting the detection liquid.
9. The sample introduction device of claim 5, wherein, Further comprising a sample outlet hole and a collection groove arranged on the upper surface side of the housing, the sample outlet hole and the collection groove are one or more, the plurality of delivery channels comprises a plurality of sample outlet channels, the sample outlet hole and the collection groove are respectively and correspondingly connected to the plurality of sample outlet channels, the plurality of sample outlet channels and the second delivery channel are connected in the form of a manifold.
10. A detection system characterized by, The sample injection device comprises: a housing, an upper surface side of which is provided with a sample injection port and a detection port; a detection assembly arranged on the upper surface side of the housing and in communication with the detection port, the detection assembly comprising a liquid crystal detection chip for contacting a detection liquid to assist in sensing an optical image; a plurality of delivery channels arranged in the housing and respectively connected to the sample injection port and the detection port, for receiving the detection liquid and delivering the detection liquid to the detection port so that the detection liquid contacts the liquid crystal detection chip; a light transmission assembly arranged in the housing, for receiving and transmitting light to the detection port. The sample injection port is one or more, and the plurality of delivery channels comprises a sample injection channel corresponding to the sample injection port. The upper surface side of the housing is provided with a first boss, the top of which is recessed to form a sample pool, and the sample injection port is arranged in the sample pool and in communication with the sample pool. The sample injection port is upwardly open or inclined upwardly, the shape of the sample injection port matches the shape of the output end of the liquid delivery device, and the sample injection port is further provided with a rubber ring for corresponding abutment with the output end. The plurality of delivery channels comprises a detection channel for delivering the detection liquid to the detection port, and a first delivery channel in communication with the detection channel and the sample injection channel, and when the sample injection channel is a plurality of channels, the first delivery channel is connected to the plurality of sample injection channels in the form of a manifold. Part of the housing is recessed from the upper surface side to form a detection pool, the detection port is arranged in the detection pool and in communication with the detection pool, and the liquid crystal detection chip is located in the detection pool. The shape of the detection pool matches the shape of the liquid crystal detection chip, and the upper surface side of the housing is further provided with an operation groove in communication with the detection pool for picking up the liquid crystal detection chip; The housing is further provided with a positioning hole, and the detection device in the liquid crystal optical sensing system is provided with a positioning column corresponding in position to the positioning hole and capable of being fitted into the corresponding positioning hole, and the detection device at least comprises a microscope. The plurality of delivery channels comprises a vertically arranged detection channel for delivering the detection liquid to the detection port, the light transmission assembly comprises a light guide portion arranged inside the device, a light inlet hole arranged at the bottom of the housing and in communication with the light guide portion, and a light inlet plate sealed at the light inlet hole, and light can pass through the light inlet plate and the light guide portion to enter the detection channel and then be directed to the side of the liquid crystal detection chip contacting the detection liquid. Further comprising a sample outlet hole and a collection groove arranged on the upper surface side of the housing, the sample outlet hole and the collection groove are one or more, the plurality of delivery channels comprises a plurality of sample outlet channels, the sample outlet hole and the collection groove are respectively and correspondingly connected to the plurality of sample outlet channels, the plurality of sample outlet channels and the second delivery channel are connected in the form of a manifold. A detection device is detachably connected to the sample injection device, and the detection device is capable of emitting light to the light inlet at the bottom of the sample injection device and capable of collecting the polarized image presented by the liquid crystal detection chip in the sample injection device.