Heating circulation device for villiflomide intermediate production
By designing a heating circulation device and adopting a heat transfer oil circulation and stirring structure, the problem of low heating efficiency in the production of vileamine intermediates was solved, and the hydrolysis reaction efficiency of acarbose and trifluoroacetic acid solution was improved.
Patent Information
- Application Number
- CN202423092960.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-16
- Publication Date
- 2026-01-20
- Estimated Expiration
- 2034-12-16
AI Technical Summary
Existing veliamine intermediate production equipment has weak heating efficiency in the reaction chamber and cannot continuously provide heat, resulting in low efficiency of the selective hydrolysis reaction of acarbose and trifluoroacetic acid solution.
Design a heating circulation device that uses a heat transfer oil circulation heating structure and sets up a stirring structure in the reaction tank and oil tank. The heat transfer oil is continuously circulated and stirred by a circulation pump and a motor. The heating tube is Z-shaped and the main rod is a single electrically controlled stirrer to improve heat exchange efficiency.
This technology enables comprehensive heating and stirring of the raw material liquid in the reaction chamber, improving the efficiency of the selective hydrolysis reaction and enhancing the synchronicity and continuity of heating.
Smart Images
Figure CN223811037U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of vileamine intermediate production technology, and in particular to a heating circulation device for vileamine intermediate production. Background Technology
[0002] Vileamine intermediate is an important compound, mainly used in the synthesis of voglibose, a drug used to treat diabetes. The final product of veliamine intermediate is generally granular crystals.
[0003] The production process of velevamine intermediate is as follows: Raw materials (acarbose and trifluoroacetic acid solution) are prepared. First, a certain amount of trifluoroacetic acid solution is fed into a reaction tank, followed by a certain amount of acarbose. Heating is then performed, allowing acarbose and trifluoroacetic acid solution to undergo selective hydrolysis while heating. During the reaction, acarbose is selectively hydrolyzed by TFA to generate a velevamine primary product solution. This solution is then fed into a filter to remove impurities. Next, the purified velevamine primary product solution is fed into a distillation tank for distillation and evaporation to form high-purity velevamine granular crystals. Finally, the product is discharged through a pipe.
[0004] Currently, existing production equipment for granular crystalline intermediates of velevamine cannot continuously circulate heat during selective hydrolysis in the reaction chamber, resulting in weak heating efficiency and significantly reducing the efficiency of selective hydrolysis of acarbose and trifluoroacetic acid solutions. Utility Model Content
[0005] The purpose of this invention is to address the aforementioned shortcomings in the existing technology by proposing a heating circulation device for the production of vileamine intermediates.
[0006] To achieve the above objectives, the present invention adopts the following technical solution:
[0007] Design a heating circulation device for the production of vileamine intermediates, including a circulation frame, a support and a motor on the circulation frame, a distillation tank and a filter box on the support, a drain pipe on the distillation tank, a first tube and a second tube on the filter box, a filter plate in the filter box, a reaction box on the support, a feed pipe and a liquid dosing pipe on the reaction box, a circulation pump and an oil tank on the circulation frame, an oil extraction pipe and a heating pipe on the circulation pump, a heating element and a return oil pipe on the oil tank, and an oil discharge hood on the return oil pipe;
[0008] The motor is provided with a main rod, and the main rod is provided with a first stirring blade and a second stirring blade;
[0009] The oil tank is provided with a first sealing cover, and the reaction tank is provided with a second sealing cover.
[0010] Further, the heating pipe is in a Z-shaped structure and is communicated with the circulating pump and the reaction tank respectively, and the right end of the oil extraction pipe is communicated with the oil tank.
[0011] Further, the two ends of the first pipe body are communicated with the distillation tank and the filter tank respectively, and the two ends of the second pipe body are communicated with the filter tank and the reaction tank respectively.
[0012] Further, the oil return pipe is in a U-shaped structure, and the left end of the oil return pipe penetrates into the reaction tank vertically and is connected with the heating pipe.
[0013] Further, the main rod is rotatably arranged with the oil tank through the first sealing cover and is rotatably arranged with the reaction tank through the second sealing cover.
[0014] Further, the oil discharge cover is a downward diffusion cover structure, and the lower end surface of the oil discharge cover has a spacing with the first stirring plate.
[0015] Further, the bracket is provided with a bearing, and the mounting hole of the bearing is connected with the main rod fixing sleeve.
[0016] The heating circulation device for the production of acesulfame intermediate has the beneficial effects that:
[0017] 1. The heat conducting oil circulation heating structure is arranged, and the stirring structure is arranged in the reaction tank and the oil tank, when the selective hydrolysis reaction is carried out in the reaction tank, the heat conducting oil is continuously circulated, the mixture of acarbose and trifluoroacetic acid solution in the reaction tank is fully and effectively stirred and heated, the low-temperature heat conducting oil in the oil tank is fully stirred and rapidly heated to form high-temperature heat conducting oil, and the high-temperature heat conducting oil is circulated into the reaction tank again to be effectively heated, the circulation heating efficiency is improved, and the efficiency of the selective hydrolysis reaction of acarbose and trifluoroacetic acid solution is greatly improved.
[0018] 2. The reaction tank and the oil tank are provided with the transverse single main rod electric control stirring structure, only the single main rod and the motor are used to simultaneously and electrically control the full stirring of the mixture of the reaction tank and the heat conducting oil in the oil tank, and the synchronization of the stirring is improved. DRAWINGS
[0019] Figure 1 It is a whole structure perspective view of the utility model;
[0020] Figure 2 It is a whole structure front view of the utility model;
[0021] Figure 3 For the present utility model Figure 2 Enlarged view of a partial cross-section at point H in the middle;
[0022] Figure 4 For the present utility model Figure 2 Enlarged view of a partial cross-section at point I in the middle;
[0023] Figure 5 This is a top view of the overall structure of this utility model.
[0024] In the diagram: 1. Circulation frame; 11. Circulation pump; 12. Oil extraction pipe; 13. Heating pipe; 2. Support; 20. Bearing; 21. Distillation tank; 22. Pipeline; 3. Filter box; 31. Filter plate; 32. First pipe body; 33. Second pipe body; 4. Reaction box; 41. Feed pipe; 42. Liquid dosing pipe; 5. Motor; 51. Main rod; 52. First stirring blade; 53. Second stirring blade; 6. Oil return pipe; 61. Oil discharge hood; 7. Oil tank; 70. Heating group; 71. Oil replenishment pipe; 72. First sealing sleeve; 8. Second sealing sleeve. Detailed Implementation
[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0026] Reference Figures 1-5 A heating circulation device for the production of vileamine intermediates includes a circulation frame 1, a support 2 and a motor 5 on the circulation frame 1, a distillation tank 21 and a filter box 3 on the support 2, a drain pipe 22 on the distillation tank 21, a first pipe body 32 and a second pipe body 33 on the filter box 3, a filter plate 31 in the filter box 3, a reaction box 4 on the support 2, a feed pipe 41 and a liquid dosing pipe 42 on the reaction box 4, a circulation pump 11 and an oil tank 7 on the circulation frame 1, an oil extraction pipe 12 and a heating pipe 13 on the circulation pump 11, a heating group 70 and a return oil pipe 6 on the oil tank 7, and an oil discharge hood 61 on the return oil pipe 6.
[0027] The motor 5 is equipped with a main rod 51, and the main rod 51 is equipped with a first stirring blade 52 and a second stirring blade 53;
[0028] The oil tank 7 is equipped with an oil replenishment pipe 71 and a first sealing sleeve 72. The reaction chamber 4 is equipped with a second sealing sleeve 8. The heating group 70 is composed of a dry-burning heating wire and a heat-conducting plate, which is embedded in the inner wall of the oil tank 7.
[0029] The heating tube 13 has a Z-shaped structure and is connected to the circulating pump 11 and the reaction tank 4 respectively. The right end of the oil extraction pipe 12 is connected to the oil tank 7. The circulating pump 11 is a circulating oil pump, which is existing technology.
[0030] The two ends of the first tube 32 are connected to the distillation tank 21 and the filter box 3, respectively. The two ends of the second tube 33 are connected to the filter box 3 and the reaction tank 4, respectively. Some of the structures described in this patent are common structures in the production equipment for the granular crystal product of velevamine intermediate. The related structures and working principles are all existing technologies. Some existing structures are not drawn or marked and need not be described in detail.
[0031] The return oil pipe 6 has a U-shaped structure. The left end of the return oil pipe 6 is vertically inserted into the reaction chamber 4 and connected to the heating pipe 13 to realize the circulation and transportation of low-temperature heat transfer oil to the oil tank 7.
[0032] The main rod 51 is rotatably connected to the oil tank 7 via the first sleeve 72, and the main rod 51 is rotatably connected to the reaction chamber 4 via the second sleeve 8. Both the first sleeve 72 and the second sleeve 8 are made of vulcanized rubber, which is oil-resistant, durable, and prevents oil leakage.
[0033] The oil drain cover 61 has a downward diffusion structure. There is a gap between the lower end face of the oil drain cover 61 and the first stirring plate 52, which increases the oil drain area of the circulating low-temperature heat transfer oil entering the oil tank 7.
[0034] The bracket 2 is equipped with a bearing 20, and the mounting hole of the bearing 20 is fixedly connected to the main rod 51 to prevent the main rod 51 from slipping to the left or right.
[0035] Working method: Prepare raw materials (acarbose and trifluoroacetic acid solution). First, a certain amount of trifluoroacetic acid solution is fed into reaction tank 4 through injection pipe 42. Then, a certain amount of acarbose is fed into reaction tank 4 through feed pipe 41. Then, heating is carried out. In reaction tank 4, acarbose and trifluoroacetic acid solution undergo selective hydrolysis reaction while being heated. During the reaction, acarbose is selectively hydrolyzed by TFA to generate a vileamine primary product solution. Then, the vileamine primary product solution is fed into filter box 3 through second pipe 33. The impurity particles contained in the vileamine primary product solution are filtered through filter plate 31. Next, the filtered vileamine primary product pure solution is fed into distillation tank 21 through first pipe 32 for distillation and evaporation to form high-purity vileamine granular crystal product. Finally, the product is discharged through discharge pipe 22 (existing technology).
[0036] During the heating process in reaction chamber 4, the circulating pump 11, heating unit 70, and motor 5 can be started. The circulating pump 11 draws high-temperature heat transfer oil from oil tank 7 through oil extraction pipe 12. The heating pipe 13 in reaction chamber 4 contains high-temperature heat transfer oil, which can exchange heat with the mixed raw material liquid in reaction chamber 4 to achieve rapid heating. At the same time, motor 5 drives the second stirring blade 53 to rotate at high speed through main rod 51 to stir and mix, further improving the heat exchange heating effect. The heat transfer oil is cooled down through heat exchange, and the low-temperature heat transfer oil will enter oil tank 7 through oil return pipe 6, and then be stirred by the first stirring blade that is rotating at high speed. The heating elements 52 and 70 rapidly stir and heat to form high-temperature heat transfer oil, which is then circulated into the heating tube 13 for heating, thus achieving continuous circulation of the heat transfer oil. At the same time, the mixed raw material liquid of acarbose and trifluoroacetic acid solution in the reaction tank 4 is thoroughly and effectively stirred and heated, and the low-temperature heat transfer oil circulating into the oil tank 7 is thoroughly stirred and rapidly heated to form high-temperature heat transfer oil. The high-temperature heat transfer oil is then circulated back into the reaction tank 4 for effective heating, which improves the circulation heating efficiency and greatly improves the efficiency of the selective hydrolysis reaction of acarbose and trifluoroacetic acid solution.
[0037] In addition, by using only a single main rod 51 and motor 5, the mixed raw material liquid in the reaction tank 4 and the heat transfer oil in the oil tank 7 can be simultaneously and electrically controlled to fully stir, thus improving the synchronization of stirring.
[0038] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.
Claims
1. A heating circulation device for the production of vileamine intermediates, comprising a circulation rack (1), characterized in that: The circulation rack (1) is equipped with a support (2) and a motor (5). The support (2) is equipped with a distillation tank (21) and a filter box (3). The distillation tank (21) is equipped with a drain pipe (22). The filter box (3) is equipped with a first pipe body (32) and a second pipe body (33). The filter box (3) is equipped with a filter plate (31). The support (2) is equipped with a reaction box (4). The reaction box (4) is equipped with a feed pipe (41) and a liquid dosing pipe (42). The circulation rack (1) is equipped with a circulation pump (11) and an oil tank (7). The circulation pump (11) is equipped with an oil extraction pipe (12) and a heating pipe (13). The oil tank (7) is equipped with a heating group (70) and a return oil pipe (6). The return oil pipe (6) is equipped with an oil drain cover (61). The motor (5) is provided with a main rod (51), and the main rod (51) is provided with a first stirring plate (52) and a second stirring plate (53). The oil tank (7) is provided with an oil replenishment pipe (71), the oil tank (7) is provided with a first cover (72), and the reaction tank (4) is provided with a second cover (8).
2. The heating circulation device for producing vileamine intermediates according to claim 1, characterized in that: The heating tube (13) has a Z-shaped structure and is connected to the circulating pump (11) and the reaction tank (4) respectively. The right end of the oil extraction tube (12) is connected to the oil tank (7).
3. The heating circulation device for producing vileamine intermediates according to claim 1, characterized in that: The two ends of the first tube (32) are connected to the distillation tank (21) and the filter tank (3) respectively, and the two ends of the second tube (33) are connected to the filter tank (3) and the reaction tank (4) respectively.
4. The heating circulation device for producing vileamine intermediates according to claim 1, characterized in that: The return oil pipe (6) has a U-shaped structure. The left end of the return oil pipe (6) is vertically inserted into the reaction tank (4) and connected to the heating pipe (13).
5. A heating circulation device for producing vileamine intermediates according to claim 1, characterized in that: The main rod (51) is rotatably connected to the oil tank (7) via the first sleeve (72), and the main rod (51) is rotatably connected to the reaction chamber (4) via the second sleeve (8).
6. A heating circulation apparatus for producing vileamine intermediates according to claim 1, characterized in that: The oil drain cover (61) is a downward diffusion type cover structure, and there is a gap between the lower end face of the oil drain cover (61) and the first stirring plate (52).
7. A heating circulation apparatus for producing vileamine intermediates according to claim 1, characterized in that: The bracket (2) is provided with a bearing (20), and the mounting hole of the bearing (20) is fixedly connected to the main rod (51).