Device for crystallizing valaciclovir hydrochloride

Abstract

The utility model belongs to the technical field of valaciclovir hydrochloride production and processing, and particularly relates to a valaciclovir hydrochloride crystallization device which comprises a device body, a condensate inlet formed in one side of the device body, a sealing base arranged at the bottom of the device body, a cover plate arranged at the top of the device body, and a motor fixedly installed at the top of the cover plate. One end of the motor is provided with a driving wheel, one side of the driving wheel is provided with a driven wheel, the driven wheel is provided with a rotary connecting rod, and one end of the bottom of the rotary connecting rod is fixedly connected with a mounting plate. The motor, the driving wheel, the driven wheel, the rotary connecting rod, the mounting plate, the stirring frame and the stirring rod are matched for use, the motor is driven to work, the driving wheel can be rotated to drive the driven wheel to rotate, and the rotary connecting rod can be conveniently rotated to drive the mounting plate to rotate; therefore, the stirring frame can be rotated to quickly and uniformly mix the materials in the crystallization cavity, so that the materials can be quickly and uniformly cooled, and the working efficiency can be further improved.

Description

Technical Field

[0001] This utility model relates to the field of valacyclovir hydrochloride production and processing technology, specifically to an apparatus for valacyclovir hydrochloride crystallization. Background Technology

[0002] Solution crystallization is the process by which a substance transforms from a liquid state to a crystalline state, involving two steps: nucleation and crystal growth. Nucleation occurs when a certain number of crystal nuclei are formed in a supersaturated solution; crystal growth then occurs when crystals grow from these nuclei. In the production of valacyclovir hydrochloride crystallization, the material to be crystallized is typically placed in a crystallization tank. A reactant is then added to the tank, and the tank is cooled, ultimately resulting in the formation of crystalline particles within the tank.

[0003] The existing technology has the following shortcomings: The existing technology, disclosed in CN201821988618.3, discloses a valacyclovir hydrochloride crystallization device, including a crystallization tank. The crystallization tank has an outer shell, which, together with the crystallization tank, forms a cooling chamber. The cooling chamber has a first refrigerant inlet at its upper end and a first refrigerant outlet at its lower end. A cooling cylinder is located inside the crystallization tank, forming a crystallization cavity between the cooling cylinder and the side wall of the crystallization tank. The crystallization cavity has a feed inlet at its upper end and a discharge outlet at its lower end. A fixed box is connected to the top of the crystallization tank via a support rod. A guide pipe is rotatably installed at the bottom of the fixed box, and its lower end is rotatably installed on the top of the cooling cylinder. The upper and lower ends of the guide pipe are connected to the fixed box and the cooling cylinder, respectively. A motor is located at the top of the crystallization tank, with a drive gear at the motor's output end. A driven gear meshing with the drive gear is located on the guide pipe. A second refrigerant inlet is located on the fixed box, and a second refrigerant outlet is located at the lower end of the cooling cylinder. The guide pipe is connected to a stirring rod via a connecting frame. The stirring rod is located inside the crystallization cavity and has stirring blades.

[0004] The above-mentioned equipment can quickly cool the materials inside the equipment through the cooling chamber and cooling cylinder. However, it lacks a good heat exchange and heat conduction mechanism, resulting in relatively low heat exchange efficiency. At the same time, during the crystallization process, crystals tend to adhere to both sides of the inner wall of the equipment body, making it difficult to clean them quickly and effectively, and inconvenient to carry out more comprehensive collection work. Utility Model Content

[0005] In view of the shortcomings of the prior art, the present invention provides an apparatus for crystallizing valacyclovir hydrochloride to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: an apparatus for crystallizing valacyclovir hydrochloride, comprising a main body, a condensate inlet on one side of the main body, a sealed base at the bottom of the main body, a cover plate at the top of the main body, a motor fixedly mounted on the top of the cover plate, a drive wheel at one end of the motor, a driven wheel on one side of the drive wheel, a rotating connecting rod on the driven wheel, a mounting plate fixedly connected to the bottom end of the rotating connecting rod, a stirring frame fixedly mounted at the bottom of the mounting plate, and a stirring rod fixedly mounted inside the stirring frame.

[0007] As a preferred embodiment of this utility model, the main body of the device includes a first cooling chamber, a second cooling chamber, a crystallization chamber, a first heat-conducting plate, a first heat-conducting ring, a second heat-conducting plate, and a second heat-conducting ring. The first cooling chamber and the second cooling chamber are disposed inside the main body of the device. A crystallization chamber is disposed between the first cooling chamber and the second cooling chamber. A first heat-conducting plate is disposed outside the first cooling chamber, and a first heat-conducting ring is disposed inside the first cooling chamber. A second heat-conducting plate is disposed outside the second cooling chamber, and a second heat-conducting ring is disposed inside the second cooling chamber. One side of the first heat-conducting plate is connected to the first heat-conducting ring, and one side of the second heat-conducting plate is connected to the second heat-conducting ring.

[0008] In a preferred embodiment of this invention, the condensate inlet is connected to the first cooling chamber.

[0009] As a preferred embodiment of this utility model, the sealing base includes a first drain port, a second drain port, and a discharge port. The sealing base is provided with a first drain port, a second drain port, and a discharge port. Control valves are provided at the bottom of the first drain port, the second drain port, and the discharge port. The first drain port is connected to a first cooling chamber, the second drain port is connected to a second cooling chamber, and the discharge port is connected to a crystallization chamber.

[0010] In a preferred embodiment of this invention, the size of the driving wheel meshes with the size of the driven wheel, and the driving wheel and the driven wheel are rotatably connected.

[0011] As a preferred embodiment of this utility model, the rotating connecting rod has a through hole inside, and the through hole is connected to the second cooling chamber.

[0012] As a preferred embodiment of this utility model, the stirring rack is provided in multiple ways, and the two sides and the bottom of the stirring rack are in contact with the inner wall of the crystallization chamber.

[0013] Compared with the prior art, this utility model provides an apparatus for the crystallization of valacyclovir hydrochloride, which has the following beneficial effects:

[0014] 1. This apparatus for crystallizing valacyclovir hydrochloride, by using a first cooling chamber, a second cooling chamber, a first heat-conducting plate, a first heat-conducting ring, a second heat-conducting plate, and a second heat-conducting ring in combination, can facilitate rapid heat exchange and conduction of the material inside the crystallization chamber, allowing the internal heat to be quickly dissipated and discharged, thereby improving the efficiency of the crystallization process.

[0015] 2. This device for valacyclovir hydrochloride crystallization comprises a motor, a drive wheel, a driven wheel, a rotating connecting rod, a mounting plate, a stirring frame, and a stirring rod working together. The motor drives the drive wheel, which in turn rotates the driven wheel, facilitating the rotation of the connecting rod and the mounting plate. This, in turn, rotates the stirring frame to rapidly and uniformly mix the material inside the crystallization chamber, allowing for faster and more even cooling, thus improving work efficiency. Furthermore, by ensuring the stirring frame fits snugly against the sides and bottom of the crystallization chamber, it prevents crystallized material from easily adhering to the inner wall, facilitating rapid cleaning and more comprehensive collection. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a schematic cross-sectional view of the main body of the device of this utility model;

[0018] Figure 3 This is a schematic diagram of the bottom structure of the cover plate of this utility model;

[0019] Figure 4 This is a schematic diagram of the mixing rack structure of this utility model.

[0020] In the diagram: 1. Main body of the equipment; 101. First cooling chamber; 102. Second cooling chamber; 103. Crystallization chamber; 104. First heat-conducting plate; 105. First heat-conducting ring; 106. Second heat-conducting plate; 107. Second heat-conducting ring; 2. Condensate inlet; 3. Sealed base; 301. First drain outlet; 302. Second drain outlet; 303. Discharge outlet; 4. Cover plate; 5. Motor; 6. Drive wheel; 7. Driven wheel; 8. Rotating connecting rod; 9. Mounting plate; 10. Stirring frame; 11. Stirring rod. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Please see Figure 1-4 In this embodiment: an apparatus for valacyclovir hydrochloride crystallization includes a main body 1, a condensate inlet 2 on one side of the main body 1 for easy injection of condensate, a sealing base 3 at the bottom of the main body 1 for easy sealing of the bottom of the main body 1, a cover plate 4 at the top of the main body 1 for easy sealing of the top of the main body 1, a motor 5 fixedly mounted on the top of the cover plate 4 for easy rotation of the drive wheel 6, a drive wheel 6 at one end of the motor 5 for easy rotation of the driven wheel 7, a driven wheel 7 on one side of the drive wheel 6 for easy rotation of the rotating connecting rod 8, a rotating connecting rod 8 on the driven wheel 7 for easy connection of the mounting plate 9, a mounting plate 9 fixedly connected to one bottom end of the rotating connecting rod 8 for easy installation of the stirring frame 10, a stirring frame 10 fixedly mounted at the bottom of the mounting plate 9 for easy installation of the stirring rod 11, and a stirring rod 11 fixedly mounted inside the stirring frame 10 for easy stirring.

[0023] In this embodiment, the main body 1 of the device includes a first cooling chamber 101, a second cooling chamber 102, a crystallization chamber 103, a first heat-conducting plate 104, a first heat-conducting ring 105, a second heat-conducting plate 106, and a second heat-conducting ring 107. The first cooling chamber 101 and the second cooling chamber 102 are arranged inside the main body 1. The crystallization chamber 103 is arranged between the first cooling chamber 101 and the second cooling chamber 102. The first heat-conducting plate 104 is arranged outside the first cooling chamber 101, and the first heat-conducting ring 105 is arranged inside the first cooling chamber 101. The second heat-conducting plate 106 is arranged outside the second cooling chamber 102, and the second heat-conducting ring 107 is arranged inside the second cooling chamber 102. One side of the first heat-conducting plate 104 is connected to the first heat-conducting ring 105, and one side of the second heat-conducting plate 106 is connected to the second heat-conducting ring 107, which facilitates rapid heat exchange of the material inside the crystallization chamber 103 and improves the cooling efficiency.

[0024] In this embodiment, the condensate inlet 2 is connected to the first cooling chamber 101, which facilitates the injection of condensate and heat exchange.

[0025] In this embodiment, the sealing base 3 includes a first drain port 301, a second drain port 302, and a discharge port 303. The sealing base 3 is provided with the first drain port 301, the second drain port 302, and the discharge port 303. Control valves are provided at the bottom of the first drain port 301, the second drain port 302, and the discharge port 303. The first drain port 301 is connected to the first cooling chamber 101, the second drain port 302 is connected to the second cooling chamber 102, and the discharge port 303 is connected to the crystallization chamber 103, which facilitates the discharge of condensate and facilitates circulation.

[0026] In this embodiment, the size of the driving wheel 6 meshes with the size of the driven wheel 7, and the driving wheel 6 and the driven wheel 7 are rotatably connected, which facilitates the rotatable connection and makes it easy to drive the rotating connecting rod 8 to rotate.

[0027] In this embodiment, the rotating connecting rod 8 has a through hole inside, and the through hole is connected to the second cooling chamber 102, which facilitates the injection of coolant into the second cooling chamber 102 and further improves the cooling effect.

[0028] In this embodiment, multiple stirring racks 10 are provided. The sides and bottom of the stirring racks 10 are in contact with the inner wall of the crystallization chamber 103, which facilitates the mixing and stirring of materials, enabling them to perform heat exchange more fully and evenly.

[0029] The working principle and usage process of this utility model are as follows: The operator adds material into the crystallization chamber 103 by opening the cover plate 4, and then adds condensate into the first cooling chamber 101 by adding condensate into the condensate inlet 2. At the same time, the condensate can be injected into the second cooling chamber 102 through the through hole inside the rotating connecting rod 8, which facilitates rapid heat exchange of the material inside the crystallization chamber 103. Then, the drive motor 5 is used to rotate the drive wheel 6 to drive the driven wheel 7 to rotate, which facilitates the rotation of the rotating connecting rod 8 to drive the mounting plate 9 to rotate. This allows the stirring frame 10 to rotate quickly and evenly mix the material inside the crystallization chamber 103, enabling faster and more uniform cooling and improving work efficiency. After crystallization is completed, the discharge port 303 can be opened to discharge and collect the material.

[0030] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. An apparatus for crystallizing valacyclovir hydrochloride, comprising a main body (1), wherein a condensate inlet (2) is provided on one side of the main body (1), characterized in that: The equipment body (1) is provided with a sealed base (3) at the bottom and a cover plate (4) at the top. A motor (5) is fixedly installed on the top of the cover plate (4). A drive wheel (6) is provided at one end of the motor (5). A driven wheel (7) is provided on one side of the drive wheel (6). A rotating connecting rod (8) is provided on the driven wheel (7). A mounting plate (9) is fixedly connected to one end of the rotating connecting rod (8). A stirring rack (10) is fixedly installed at the bottom of the mounting plate (9). A stirring rod (11) is fixedly installed inside the stirring rack (10). The main body of the device (1) includes a first cooling chamber (101), a second cooling chamber (102), a crystallization chamber (103), a first heat-conducting plate (104), a first heat-conducting ring (105), a second heat-conducting plate (106), and a second heat-conducting ring (107). The first cooling chamber (101) and the second cooling chamber (102) are provided inside the main body of the device (1). The crystallization chamber (103) is provided between the first cooling chamber (101) and the second cooling chamber (102). The first cooling cavity (101) is provided with a first heat-conducting plate (104) on the outside and a first heat-conducting ring (105) on the inside. The second cooling cavity (102) is provided with a second heat-conducting plate (106) on the outside and a second heat-conducting ring (107) on the inside. One side of the first heat-conducting plate (104) is connected to the first heat-conducting ring (105), and one side of the second heat-conducting plate (106) is connected to the second heat-conducting ring (107).

2. The apparatus for crystallizing valacyclovir hydrochloride according to claim 1, characterized in that: The condensate inlet (2) is connected to the first cooling chamber (101).

3. The apparatus for crystallizing valacyclovir hydrochloride according to claim 1, characterized in that: The sealing base (3) includes a first drain port (301), a second drain port (302), and a discharge port (303). The sealing base (3) is provided with a first drain port (301), a second drain port (302), and a discharge port (303). The bottom of the first drain port (301), the second drain port (302), and the discharge port (303) are all provided with control valves. The first drain port (301) is connected to the first cooling chamber (101), the second drain port (302) is connected to the second cooling chamber (102), and the discharge port (303) is connected to the crystallization chamber (103).

4. The apparatus for crystallizing valacyclovir hydrochloride according to claim 1, characterized in that: The size of the driving wheel (6) meshes with the size of the driven wheel (7), and the driving wheel (6) and the driven wheel (7) are rotatably connected.

5. The apparatus for crystallizing valacyclovir hydrochloride according to claim 1, characterized in that: The rotating connecting rod (8) has a through hole inside, and the through hole is connected to the second cooling chamber (102).

6. The apparatus for crystallizing valacyclovir hydrochloride according to claim 1, characterized in that: Multiple stirring racks (10) are provided, and the two sides and bottom of the stirring racks (10) are in contact with the inner wall of the crystallization chamber (103).

Images