Movable liquid chromatograph-mass spectrometer experiment table
By using an automatic sampler and positioning component to hold the reagent tube, and a guiding component to guide the flexible tube, the problems of reagent tube falling and flexible tube tangling during sampling on the mass spectrometer experimental platform are solved, thus improving the stability and detection accuracy of the experimental platform.
Patent Information
- Application Number
- CN202520146747.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-22
- Publication Date
- 2026-01-23
- Estimated Expiration
- 2035-01-22
AI Technical Summary
Existing mass spectrometry instrument benches suffer from mechanical contact during sampling, which can cause reagent tubes to fall off. Tubes are also prone to tangling or bending, leading to poor liquid flow and affecting detection accuracy.
An automatic sampler and positioning assembly are used to hold the reagent tubes, and a guiding assembly guides the tubing to prevent the reagent tubes from falling and the tubing from getting tangled, thus improving stability and smoothness.
It effectively prevents reagent tubes from falling out, reduces tubing tangling, improves reagent tube clamping efficiency and tubing transport smoothness, and ensures testing accuracy.
Smart Images
Figure CN223827633U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the field of liquid chromatography technology, specifically a portable liquid chromatography-mass spectrometry experimental platform. Background Technology
[0002] Liquid chromatography is a commonly used physicochemical analysis method that is widely applied in life sciences, medicinal chemistry and other disciplines. It is used to separate biological macromolecules, medical macromolecules, ionic compounds and various unstable compounds from samples. When conducting experiments using liquid chromatography, mass spectrometry is often used in conjunction with the experiment.
[0003] Liquid chromatography typically uses a liquid chromatograph to determine the composition of a sample. The principle is as follows: the mobile phase in the reservoir of the liquid chromatograph is pumped into the system by a high-pressure pump. The sample solution enters the mobile phase through the injector and is carried into the liquid chromatography column. Because the components move at different speeds within the liquid chromatography column, they are separated into individual components and flow sequentially from the column into the test bench to detect their concentration.
[0004] However, existing mass spectrometry (MS / MS) benches use mechanical sampling, which can easily damage reagent tubes, causing them to fall to the ground and resulting in reagent loss. Furthermore, during the use of the MS / MS bench, flexible tubing is used, which can easily become tangled or bent, obstructing the flow of liquid within the tubing. Therefore, to address these issues, a portable liquid chromatography-mass spectrometry (LC-MS) bench is proposed. Utility Model Content
[0005] To address the problems mentioned in the background section, this invention provides a portable liquid chromatography-mass spectrometry (LC-MS) experimental platform. This platform solves the problems associated with mechanical sampling of reagents in LC-MS platforms, which can easily damage reagent tubes, causing them to fall to the ground and resulting in reagent loss. Furthermore, the use of flexible tubing during LC-MS operation can lead to knots or bends, hindering the smooth flow of liquid within the tubing.
[0006] To achieve the above objectives, this utility model provides the following technical solution: a portable liquid chromatography-mass spectrometry (LC-MS) experimental platform, comprising an experimental platform, a column oven on the top of the experimental platform, an automatic sampler on the top of the column oven, a sampling groove on the surface of the automatic sampler, a positioning component inside the sampling groove, a quaternary pump on the top of the automatic sampler, a vacuum degasser on the top of the quaternary pump, a solvent bottle tank on the top of the vacuum degasser, mounting grooves at the four corners of the surface of the solvent bottle tank, a bottle body inside the mounting groove, a flexible tube on the top of the bottle body, and a guide component fixedly installed on one side of the surface of the solvent bottle tank.
[0007] Preferably, the experimental platform is provided with support feet at each of the four corners of the bottom, and the bottom of the support feet is provided with casters.
[0008] Preferably, positioning plates are fixedly installed on both sides of the surface of the experimental platform, and a threaded groove is opened in the middle of the surface of the positioning plate. A threaded rod passes through the internal thread of the threaded groove, and a clamping plate is rotatably connected to the bottom of the threaded rod.
[0009] Preferably, the positioning component includes a plurality of positioning slots formed inside the sampling slot, a positioning ring is provided inside the positioning slot, a telescopic rod is fixedly installed on both sides inside the positioning ring, a spring is sleeved on the surface of the telescopic rod, and an arc plate is fixedly installed at one end of the telescopic rod.
[0010] Preferably, the surface of the arc-shaped plate is provided with an embedding groove, and an anti-slip pad is provided inside the embedding groove, the anti-slip pad being in contact with the surface of the reagent tube.
[0011] Preferably, the guiding assembly includes support seats fixedly installed on both sides of the surface of the solvent bottle box, a guide ring fixedly installed on the surface of the support seat, a guide groove is formed on one side of the surface of the guide ring, a guide rod is threadedly connected inside the guide groove, and a positioning arc plate is rotatably connected to one end of the guide rod.
[0012] Preferably, a threaded ring is fixedly installed on one side of the guide ring surface, and a threaded groove is formed inside the threaded ring, through which a guide rod is threaded.
[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:
[0014] This invention utilizes an automatic sampler and positioning components. During use, the personnel place the reagent tube inside the positioning slot, and the reagent tube will squeeze the arc-shaped plate. After being squeezed, the arc-shaped plate will be reset by a spring, and the arc-shaped plate will then clamp the reagent tube, improving the efficiency of clamping reagent tubes of different sizes and reducing the occurrence of reagent tubes falling to the ground.
[0015] This invention utilizes a solvent bottle box, bottle body, hose, and guide assembly. During use, the hose is passed through a guide ring, and a positioning plate inside the guide ring positions the hose. The guide ring guides the hose, reducing the likelihood of bending during liquid transport, which could lead to uneven liquid flow and affect detection accuracy. Attached Figure Description
[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;
[0017] Figure 2 This is a schematic diagram of the guide component structure of this utility model;
[0018] Figure 3 This is a schematic diagram of the positioning component structure of this utility model;
[0019] Figure 4 This is a schematic diagram of the clamping plate structure of this utility model.
[0020] In the diagram: 1. Experimental bench; 2. Column oven; 3. Automatic sampler; 4. Positioning assembly; 41. Positioning ring; 42. Telescopic rod; 43. Spring; 44. Arc plate; 5. Quaternary pump; 6. Vacuum degasser; 7. Solvent bottle box; 8. Bottle body; 9. Tube; 10. Guide assembly; 101. Support base; 102. Guide ring; 103. Guide rod; 104. Positioning arc plate; 11. Casters; 12. Positioning plate; 13. Threaded rod; 14. Clamping plate. Detailed Implementation
[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0022] like Figures 1 to 4As shown, this utility model provides a portable liquid chromatography-mass spectrometry (LC-MS) experimental platform, including an experimental platform 1. A column oven 2 is installed on the top of the experimental platform 1. An automatic sampler 3 is installed on the top of the column oven 2. A sampling groove is opened on the surface of the automatic sampler 3. A positioning component 4 is installed inside the sampling groove. A quaternary pump 5 is installed on the top of the automatic sampler 3. A vacuum degasser 6 is installed on the top of the quaternary pump 5. A solvent bottle tank 7 is installed on the top of the vacuum degasser 6. Mounting grooves are opened at the four corners of the surface of the solvent bottle tank 7. Bottles 8 are installed inside the mounting grooves. A hose 9 is installed on the top of the bottle 8. A guide component 10 is fixedly installed on one side of the surface of the solvent bottle tank 7. Support feet are installed at the four corners of the bottom of the experimental platform 1. Universal wheels 11 are installed at the bottom of the support feet. Positioning plates 12 are fixedly installed on both sides of the surface of the experimental platform 1. A threaded groove is opened in the middle of the surface of the positioning plate 12. A threaded rod 13 is threaded through the inside of the threaded groove. A clamping plate 14 is rotatably connected to the bottom of the threaded rod 13.
[0023] When the mass spectrometer stage needs to be moved, it is pushed, and the casters 11 will then move it. After moving it to the appropriate position, the operator will rotate the threaded rod 13 using the positioning plate 12. As the threaded rod 13 rotates, it will move downwards, which in turn will move the clamping plate 14 downwards. The clamping plate 14 then contacts the ground, supporting the mass spectrometer stage and improving its stability.
[0024] like Figures 1 to 4 As shown, the positioning component 4 includes several positioning slots inside the sampling slot. A positioning ring 41 is provided inside the positioning slot. Telescopic rods 42 are fixedly installed on both sides inside the positioning ring 41. A spring 43 is sleeved on the surface of the telescopic rod 42. An arc plate 44 is fixedly installed on one end of the telescopic rod 42. An embedding groove is provided on the surface of the arc plate 44. An anti-slip pad is provided inside the embedding groove. The anti-slip pad is in contact with the surface of the reagent tube.
[0025] During use, the personnel place the reagent tube inside the positioning slot, and then the reagent tube will squeeze the arc plate 44 to both sides. After the arc plate 44 is squeezed, the spring 43 on its back telescopic rod 42 will drive the arc plate 44 to move towards the middle, and the arc plate 44 will clamp the reagent tube, reducing the possibility of the reagent tube accidentally falling.
[0026] like Figures 1 to 4As shown, the guide assembly 10 includes a support base 101 fixedly installed on both sides of the surface of the solvent bottle box 7. A guide ring 102 is fixedly installed on the surface of the support base 101. A guide groove is opened on one side of the surface of the guide ring 102. A guide rod 103 is threadedly connected inside the guide groove. A positioning arc plate 104 is rotatably connected to one end of the guide rod 103. A threaded ring is fixedly installed on one side of the surface of the guide ring 102. A threaded groove is opened inside the threaded ring. The guide rod 103 passes through the threaded groove.
[0027] During use, the guide ring 102 will be installed through the support base 101. After the guide ring 102 is installed, the personnel will rotate the guide rod 103 through the guide ring 102. When the guide rod 103 rotates, it will drive the positioning arc plate 104 to move towards the center. The positioning arc plate 104 will clamp and position the hose 9 inside the guide ring 102.
[0028] The working principle and usage process of this utility model are as follows: First, the reagent tube is placed inside the positioning groove. Then, the reagent tube will squeeze the arc plate 44 to both sides. After the arc plate 44 is squeezed, the spring 43 on its back telescopic rod 42 will drive the arc plate 44 to move towards the center. The arc plate 44 will clamp the reagent tube. Then, the guide ring 102 is installed through the support base 101. After the guide ring 102 is installed, the operator will rotate the guide rod 103 through the guide ring 102. When the guide rod 103 rotates, it will drive the positioning arc plate 104 to move towards the center. The positioning arc plate 104 will clamp and position the hose 9 inside the guide ring 102. When it is necessary to move the mass spectrometry experimental stage, the mass spectrometry experimental stage will be pushed, and then the caster wheel 11 will drive the mass spectrometry experimental stage to move. After moving to the appropriate position, the personnel will rotate the threaded rod 13 through the positioning plate 12. When the threaded rod 13 rotates, it will drive the threaded rod 13 to move downward. When the threaded rod 13 moves downward, it will drive the clamping plate 14 to move downward. The clamping plate 14 contacts the ground and supports the mass spectrometry experimental stage.
[0029] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.
[0030] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A portable liquid chromatography-mass spectrometry (LC-MS) experimental platform, comprising an experimental platform (1), characterized in that: The top of the experimental platform (1) is equipped with a column oven (2), the top of the column oven (2) is equipped with an automatic sampler (3), the surface of the automatic sampler (3) is provided with a sampling groove, the inside of the sampling groove is provided with a positioning component (4), the top of the automatic sampler (3) is equipped with a quaternary pump (5), the top of the quaternary pump (5) is equipped with a vacuum degasser (6), the top of the vacuum degasser (6) is equipped with a solvent bottle box (7), the four corners of the surface of the solvent bottle box (7) are provided with mounting grooves, the inside of the mounting groove is provided with a bottle body (8), the top of the bottle body (8) is provided with a flexible tube (9), and a guide component (10) is fixedly installed on one side of the surface of the solvent bottle box (7).
2. The portable liquid chromatography-mass spectrometry (LC-MS) experimental platform according to claim 1, characterized in that: The experimental platform (1) is equipped with support feet at the four corners of its bottom, and the bottom of the support feet is equipped with casters (11).
3. The portable liquid chromatography-mass spectrometry (LC-MS) experimental platform according to claim 1, characterized in that: Positioning plates (12) are fixedly installed on both sides of the surface of the experimental table (1). A threaded groove is provided in the middle of the surface of the positioning plate (12). A threaded rod (13) is threaded through the inside of the threaded groove. A clamping plate (14) is rotatably connected to the bottom of the threaded rod (13).
4. The portable liquid chromatography-mass spectrometry (LC-MS) experimental platform according to claim 1, characterized in that: The positioning component (4) includes several positioning slots opened inside the sampling slot. A positioning ring (41) is provided inside the positioning slot. Telescopic rods (42) are fixedly installed on both sides inside the positioning ring (41). A spring (43) is sleeved on the surface of the telescopic rod (42). An arc plate (44) is fixedly installed at one end of the telescopic rod (42).
5. The portable liquid chromatography-mass spectrometry (LC-MS) experimental platform according to claim 4, characterized in that: The surface of the arc plate (44) is provided with an embedding groove, and an anti-slip pad is provided inside the embedding groove. The anti-slip pad is in contact with the surface of the reagent tube.
6. The portable liquid chromatography-mass spectrometry (LC-MS) experimental platform according to claim 1, characterized in that: The guide assembly (10) includes a support base (101) fixedly installed on both sides of the surface of the solvent bottle box (7). A guide ring (102) is fixedly installed on the surface of the support base (101). A guide groove is opened on one side of the surface of the guide ring (102). A guide rod (103) is threadedly connected inside the guide groove. A positioning arc plate (104) is rotatably connected to one end of the guide rod (103).
7. The portable liquid chromatography-mass spectrometry (LC-MS) experimental platform according to claim 6, characterized in that: A threaded ring is fixedly installed on one side of the surface of the guide ring (102), and a threaded groove is opened inside the threaded ring. The guide rod (103) passes through the threaded groove.