Protein desalting membrane separation system equipment
By using spiral-wound columnar multilayer composite membranes for selective separation in a protein desalting membrane separation system, the problems of complex operation and high cost of existing protein desalting methods are solved, achieving efficient and low-energy protein desalting.
Patent Information
- Application Number
- CN202520017584.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-06
- Publication Date
- 2026-01-27
- Estimated Expiration
- 2035-01-06
AI Technical Summary
Existing protein desalting methods are complex and costly, can easily damage proteins, and traditional methods require a long time and specialized knowledge.
The protein desalting membrane separation system utilizes two sets of six spiral-wound multilayer composite membranes to selectively separate salts and proteins at room temperature. A nanofiltration membrane with a molecular weight of 200 is used to achieve efficient separation of salts and proteins.
It achieves a highly automated and low-energy protein desalting process at room temperature, retaining the effective components of the protein, preventing protein denaturation, and improving separation efficiency and recovery rate.
Smart Images
Figure CN223832116U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of food raw material processing, and in particular to a protein desalting membrane separation system. Background Technology
[0002] In the food industry, protein plays a vital role. As a functional substance, it interacts with other ingredients during food processing to improve properties such as texture, mouthfeel, and water retention. For example, in baked goods, the foaming and gelling properties of protein contribute to a soft structure and delicate texture, making the food more appealing in appearance and texture. At the same time, protein is rich in various essential amino acids, which are the basic components of body tissues and cells. For children and adolescents in their growth and development stages, adequate protein intake provides the body with the raw materials to build new tissues and repair damaged tissues, effectively promoting the normal development of bones, muscles, and organs, and ensuring healthy growth.
[0003] Currently, in the field of protein desalting, there are methods such as ammonium chloride precipitation, thin-film evaporation, dialysis, ion exchange, and electrophoresis. For example, ammonium chloride precipitation is one of the more traditional methods. It utilizes the difference in solubility of different proteins in a high-concentration ammonium chloride solution, gradually increasing the salt concentration to cause the protein to precipitate, thus achieving separation from the salt. However, the precipitated protein still needs to undergo desalting treatment to remove residual ammonium chloride. Thin-film evaporation uses heating to rapidly evaporate the solution in a thin-film state, continuously losing water while the salt remains in the remaining concentrate, thereby achieving the purpose of separating the protein from the salt.
[0004] However, the traditional methods mentioned above are complex to operate, require a long time and professional knowledge, cause significant damage to proteins, and are costly. Therefore, to address these shortcomings, a protein desalting separation system is adopted. The membrane separation element consists of two sets of six spiral-wound columnar multilayer composite membranes. Under normal temperature conditions, the selective function of the membrane is utilized to separate the salt, thereby retaining the effective components of the protein. A nanofiltration membrane with a molecular weight of 200 is used, which will not cause protein denaturation. This is a new type of separation technology with a high degree of automation and low energy consumption. Utility Model Content
[0005] To overcome the above shortcomings, this utility model provides a protein desalting membrane separation system, which aims to improve the problems of high cost and complex operation of protein desalting in the prior art.
[0006] To achieve the above objectives, the present invention adopts the following technical solution:
[0007] A protein desalting membrane separation system includes a circulation tank, a feed pump, a circulation pump, a membrane separation element, and a filtrate tank. The circulation tank is connected in series with the feed pump, the circulation pump, and the membrane separation element. The filtrate outlet of the membrane separation element is connected to the inlet of the filtrate tank.
[0008] As a further description of the above technical solution:
[0009] It also includes a thermometer, a temperature sensor, a pre-membrane pressure sensor, a pre-membrane pressure gauge, a post-membrane pressure sensor, a post-membrane pressure gauge, a concentrate flow meter, a filtrate flow meter, and a control cabinet. The bottoms of the thermometer and the pre-membrane pressure gauge are installed outside the inlet pipe of the membrane separation element. The bottoms of the post-membrane pressure gauge and the concentrate flow meter are installed outside the concentrate outlet pipe of the membrane separation element. The bottom of the filtrate flow meter is installed outside the filtrate outlet pipe of the membrane separation element. The signal output terminals of the temperature sensor, the pre-membrane pressure sensor, and the post-membrane pressure sensor are all electrically connected to the signal input terminal of the control cabinet. The control input terminals of the feed pump and the circulation pump are all electrically connected to the output terminal of the control cabinet.
[0010] As a further description of the above technical solution:
[0011] A feed valve is installed outside the pipe between the outlet of the circulation tank and the inlet of the feed pump; a circulation valve is installed outside the pipe between the concentrate outlet of the membrane separation element and the circulation pump; a regulating valve is installed outside the pipe between the concentrate outlet of the membrane separation element and the inlet of the circulation tank; a filtrate production valve is installed outside the pipe between the filtrate outlet of the membrane separation element and the inlet of the filtrate tank; a filtrate circulation valve is installed outside the pipe between the filtrate outlet of the membrane separation element and the circulation tank; a first drain pipe is fixedly connected to the outlet of the circulation tank; a first drain valve is installed outside the first drain pipe; a second drain pipe is fixedly connected to the outlet of the circulation pump; a second drain valve is installed outside the second drain pipe; a flushing valve is installed outside the concentrate outlet of the membrane separation element; and a filtrate drain valve is installed outside the filtrate outlet of the membrane separation element.
[0012] As a further description of the above technical solution:
[0013] It also includes a heat exchanger, the concentrated liquid outlet of the membrane separation element is connected to the liquid inlet of the heat exchanger, the liquid outlet of the heat exchanger is connected to the liquid inlet of the circulating pump, the liquid outlet of the circulating pump is connected to the liquid inlet of the membrane separation element, a circulation valve is installed on the outside of the pipe between the liquid outlet of the heat exchanger and the circulating pump, and the outlet of the heat exchanger (15) is connected to the liquid inlet of the circulating tank (1).
[0014] As a further description of the above technical solution:
[0015] The data from the thermometer is transmitted from the signal output terminal of the temperature sensor to the signal input terminal of the control cabinet. The data from the pre-membrane pressure gauge is transmitted from the signal output terminal of the pre-membrane pressure sensor to the control input terminal of the control cabinet. The data from the post-membrane pressure gauge is transmitted from the signal output terminal of the post-membrane pressure sensor to the control input terminal of the control cabinet. The control input terminals of the feed pump and the circulation pump are both electrically connected to the control output terminal of the control cabinet.
[0016] As a further description of the above technical solution:
[0017] The inlet and outlet of the circulating tank, the feed pump, the circulating pump, the membrane separation element, and the heat exchanger are all connected by 304 stainless steel pipes, and the 304 stainless steel pipes are connected by quick-release chucks to achieve detachable connection.
[0018] As a further description of the above technical solution:
[0019] The membrane separation element consists of two sets of six spiral-wound columnar multilayer composite membranes with a molecular weight cutoff of 200 Daltons, an operating pressure of less than 2.5 MPa, and an operating pH of 3-11.
[0020] This utility model has the following beneficial effects:
[0021] In this invention, under normal temperature conditions, the selective function of the membrane is utilized to separate salts, thereby retaining the effective components of the protein. A nanofiltration membrane with a molecular weight of 200 is used, which will not cause protein denaturation. This is a novel separation technology with a high degree of automation and low energy consumption. Attached Figure Description
[0022] Figure 1 This is a schematic diagram of the structure of a protein desalting membrane separation system proposed in this utility model.
[0023] Legend:
[0024] 1. Circulation tank; 2. Drain valve one; 3. Feed valve; 4. Thermometer; 5. Temperature sensor; 6. Feed pump; 7. Circulation valve; 8. Circulation pump; 9. Pre-membrane pressure sensor; 10. Pre-membrane pressure gauge; 11. Membrane separation element; 12. Drain valve two; 13. Post-membrane pressure sensor; 14. Post-membrane pressure gauge; 15. Heat exchanger; 16. Flushing valve; 17. Filtrate drain valve; 18. Filtrate flow meter; 19. Filtrate circulation valve; 20. Filtrate production valve; 21. Filtrate tank; 22. Control valve; 23. Concentrate flow meter. Detailed Implementation
[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0026] Reference Figure 1 This utility model provides an embodiment of a protein desalting membrane separation system, comprising a circulation tank 1, a feed pump 6, a circulation pump 8, a membrane separation element 11, and a filtrate tank 21. The circulation tank 1 is an important component of the entire system, used to store the protein solution to be treated and the solution during the circulation process. The filtrate tank 21 is used to collect the filtrate after desalting treatment by the membrane separation element 11. The circulation tank 1 is connected in series with the feed pump 6, the circulation pump 8, and the membrane separation element 11. The feed pump 6 is responsible for transporting the protein solution in the circulation tank 1 to the membrane separation element 11 for desalting treatment. The inlet and outlet of the circulation tank 1, the feed pump 6, the circulation pump 8, the membrane separation element 11, and the heat exchanger 15 are all connected by 304 stainless steel pipes, and the 304 stainless steel pipes are detachably connected by quick-release chucks. The function of the circulation pump 8 is to return a portion of the concentrated solution or circulating liquid after treatment by the membrane separation element 11 to the membrane separation element 11 for further treatment, thereby improving the protein recovery rate and desalting efficiency. The filtrate outlet of membrane separation element 11 is connected to the inlet of filtrate tank 21. Membrane separation element 11 consists of two sets of six spiral-wound columnar multilayer composite membranes with a molecular weight cutoff of 200 Daltons, an operating pressure of less than 2.5 MPa, and an operating pH of 3-11. All the membranes used are spiral-wound columnar multilayer composite membranes with a molecular weight cutoff of 200 Daltons, an operating pressure of less than 2.5 MPa, an operating temperature of 5-45℃, and a washing temperature of 10-55℃. They have a large membrane area, which can improve the efficiency and throughput of protein desalting. A molecular weight cutoff of 200 Daltons means that it can effectively retain large molecules such as proteins with a molecular weight greater than 200 Daltons, while allowing small molecules such as salt ions to pass through, thereby achieving the separation of protein and salt.
[0027] Reference Figure 1The system also includes a thermometer 4, a temperature sensor 5, a pre-membrane pressure sensor 9, a pre-membrane pressure gauge 10, a post-membrane pressure sensor 13, a post-membrane pressure gauge 14, a concentrate flow meter 23, a filtrate flow meter 18, and a control cabinet. The concentrate flow meter 23 is installed on the concentrate outlet pipe of the membrane separation element 11 and is used to measure the flow rate of the concentrate after membrane separation. By monitoring the concentrate flow rate, the retention of large molecules such as proteins during membrane separation and the concentration effect of the system can be understood. The filtrate flow meter 18 is used to measure the filtrate flow rate at the filtrate outlet of the membrane separation element 11. The data from the thermometer 4 is transmitted from the signal output terminal of the temperature sensor 5 to the signal input terminal of the control cabinet. The thermometer 4 is used to directly measure the temperature of the solution at the inlet of the membrane separation element 11, and the operator can intuitively understand the temperature of the solution by reading the thermometer 4. The temperature sensor 5 converts the temperature signal measured by the thermometer 4 into an electrical signal and transmits it to the signal input terminal of the control cabinet. The data from the pre-membrane pressure gauge 10 is transmitted from the signal output terminal of the pre-membrane pressure sensor 9 to the control input terminal of the control cabinet. The pre-membrane pressure sensor 9 and the pre-membrane pressure gauge 10 are used together to monitor the pressure at the inlet of the membrane separation element 11. The pre-membrane pressure gauge 10 can display the pressure value intuitively, which is convenient for operators to observe on site, while the pre-membrane pressure sensor 9 converts the pressure signal into an electrical signal and transmits it to the control input terminal of the control cabinet. The data from the post-membrane pressure gauge 14 is transmitted from the signal output terminal of the post-membrane pressure sensor 13 to the control input terminal of the control cabinet. The control input terminals of the feed pump 6 and the circulation pump 8 are both electrically connected to the control output terminal of the control cabinet. The bottoms of the thermometer 4 and the pre-membrane pressure gauge 10 are both installed outside the inlet pipe of the membrane separation element 11. The bottoms of the post-membrane pressure gauge 14 and the concentrate flow meter 23 are both installed outside the concentrate outlet pipe of the membrane separation element 11. The bottom of the filtrate flow meter 18 is installed outside the filtrate outlet pipe of the membrane separation element 11. The signal output terminals of the temperature sensor 5, the pre-membrane pressure sensor 9, and the post-membrane pressure sensor 13 are all electrically connected to the signal input terminal of the control cabinet. The post-membrane pressure sensor 13 and the post-membrane pressure gauge 14 are used to monitor the pressure at the concentrate outlet after membrane separation. The control input terminals of the feed pump 6 and the circulation pump 8 are both electrically connected to the output terminal of the control cabinet.
[0028] Reference Figure 1A feed valve 3 is installed externally on the pipe between the outlet of the circulation tank 1 and the inlet of the feed pump 6. By opening and closing the feed valve 3, the flow rate of the solution entering the feed pump 6 can be precisely adjusted to adapt to different production needs and membrane separation process requirements. A circulation valve 7 is installed externally on the pipe between the concentrate outlet of the membrane separation element 11 and the circulation pump 8. The circulation valve 7 controls whether the concentrate after being processed by the membrane separation element 11 enters the circulation pump 8 for recirculation; it also controls the path of the solution after heat exchange in the heat exchanger 15 to the circulation pump 8. A regulating valve 22 is installed externally on the pipe between the concentrate outlet of the membrane separation element 11 and the inlet of the circulation tank 1. The function of the regulating valve 22 is to regulate the flow rate and pressure of the concentrate returning from the membrane separation element 11 to the circulation tank 1, so as to maintain the stability of the liquid level and the uniformity of the solution composition in the circulation tank 1. A filtrate production valve 20 is installed externally on the pipe between the filtrate outlet of the membrane separation element 11 and the inlet of the filtrate tank 21. By opening and closing the filtrate production valve 20, the filtrate collection process can be precisely controlled, ensuring that only filtrate meeting quality requirements enters the filtrate tank 21, preventing the mixing of substandard filtrate, thereby guaranteeing the purity of the filtrate and the effectiveness of subsequent treatment. A filtrate circulation valve 19 is installed externally on the pipe between the filtrate outlet of the membrane separation element 11 and the circulation tank 1. The function of the filtrate circulation valve 19 is to control whether the filtrate flows back to the circulation tank 1 for recirculation. The outlet of the circulating tank 1 is fixedly connected to a drain pipe, and a drain valve 2 is installed on the outside of the drain pipe. The drain valve 2 is mainly used to discharge impurities, sediments, and other contaminants that may affect system operation and product quality accumulated in the circulating tank 1. The outlet of the circulating pump 8 is fixedly connected to a drain pipe, and a drain valve 12 is installed on the outside of the drain pipe. The function of the drain valve 12 is to discharge impurities, wear particles, and other foreign objects that may be generated during the operation of the circulating pump 8, so as to protect the normal operation of the circulating pump 8 and extend its service life. A flushing valve 16 is installed on the outside of the concentrate outlet of the membrane separation element 11. The flushing valve 16 is mainly used to flush and empty the concentrate outlet pipe of the membrane separation element 11. A filtrate drain valve 17 is installed on the outside of the filtrate outlet of the membrane separation element 11. The function of the filtrate drain valve 17 is to discharge small amounts of impurities, unqualified filtrate, or waste liquid generated during system startup, cleaning, etc., that may exist in the filtrate outlet pipe.
[0029] It also includes a heat exchanger 15. The concentrated liquid outlet of the membrane separation element 11 is connected to the inlet of the heat exchanger 15. The outlet of the heat exchanger 15 is connected to the inlet of the circulating pump 8. The outlet of the circulating pump 8 is connected to the inlet of the membrane separation element 11. A circulation valve 7 is installed on the outside of the pipe between the outlet of the heat exchanger 15 and the circulating pump 8. The function of the heat exchanger 15 is to exchange heat with the concentrated liquid after it has been treated by the membrane separation element 11 in order to regulate the temperature of the solution so that it is more suitable for the working requirements of the circulating pump 8 and the reprocessing conditions of the membrane separation element 11. The outlet of the heat exchanger 15 is connected to the inlet of the circulating tank 1.
[0030] Working principle: When this protein desalting membrane separation system is working, the protein solution in the circulation tank 1 is fed to the membrane separation element 11 by the feed pump 6 after the flow rate is adjusted by the feed valve 3. The membrane separation element 11 adopts two sets of six spiral-wound columnar multilayer composite membranes. Based on the characteristic of a molecular weight cutoff of 200 Daltons, large molecules such as proteins with a molecular weight greater than this are retained, while small molecules such as salt ions permeate through the membrane to form filtrate. The filtrate is controlled by the filtrate production valve 20 to enter the filtrate tank 21 for collection, or it is returned to the circulation tank 1 for further treatment via the filtrate circulation valve 19. The concentrate flows out from the outlet of the membrane separation element 11, and its flow rate is monitored by the concentrate flow meter 23. The pressure is monitored by the downstream pressure sensor 13 and the pressure gauge. The concentrate can be controlled by the circulation valve 7 to enter the circulation pump 8 for recirculation, or it can be returned to the circulation tank 1 via the regulating valve 22 to maintain the stability of the liquid level and composition in the tank. At the same time, part of the concentrate enters the heat exchanger 15 for heat exchange, and after the temperature is regulated, it is sent back to the membrane separation element 11 via the circulation pump 8. Throughout the process, the thermometer 4, the temperature sensor 5, and the upstream pressure sensor are used. The device 9 and pressure gauge monitor the inlet temperature and pressure, respectively. All valves, pumps and sensors are electrically connected to the control cabinet. The control cabinet automatically or manually adjusts the equipment operating parameters based on the monitoring data, thereby achieving efficient and stable protein desalting and separation. All components are connected by 304 stainless steel pipes and quick-release chucks, ensuring the system's sealing and disassembly capabilities, facilitating maintenance and operation. Each drain valve is used to discharge impurities and other contaminants accumulated in the corresponding parts. The flushing valve 16 and filtrate drain valve 17 respectively flush the concentrated liquid and filtrate outlet pipes and discharge waste liquid, ensuring the normal operation of the system and product quality.
[0031] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A protein desalting membrane separation system, comprising a circulation tank (1), a feed pump (6), a circulation pump (8), a membrane separation element (11), and a filtrate tank (21), characterized in that: The circulation tank (1) is connected in series with the feed pump (6), the circulation pump (8), and the membrane separation element (11). The filtrate outlet of the membrane separation element (11) is connected to the inlet of the filtrate tank (21).
2. The protein desalting membrane separation system according to claim 1, characterized in that: It also includes a thermometer (4), a temperature sensor (5), a pre-membrane pressure sensor (9), a pre-membrane pressure gauge (10), a post-membrane pressure sensor (13), a post-membrane pressure gauge (14), a concentrate flow meter (23), a filtrate flow meter (18), and a control cabinet. The bottoms of the thermometer (4) and the pre-membrane pressure gauge (10) are installed outside the inlet pipe of the membrane separation element (11). The bottoms of the post-membrane pressure gauge (14) and the concentrate flow meter (23) are installed outside the concentrate outlet pipe of the membrane separation element (11). The bottom of the filtrate flow meter (18) is installed outside the filtrate outlet pipe of the membrane separation element (11). The signal output terminals of the temperature sensor (5), the pre-membrane pressure sensor (9), and the post-membrane pressure sensor (13) are electrically connected to the signal input terminal of the control cabinet. The control input terminal of the feed pump (6) and the control input terminal of the circulation pump (8) are electrically connected to the output terminal of the control cabinet.
3. The protein desalting membrane separation system according to claim 1, characterized in that: A feed valve (3) is installed outside the pipe between the outlet of the circulation tank (1) and the inlet of the feed pump (6); a circulation valve (7) is installed outside the pipe between the concentrate outlet of the membrane separation element (11) and the circulation pump (8); a regulating valve (22) is installed outside the pipe between the concentrate outlet of the membrane separation element (11) and the inlet of the circulation tank (1); a filtrate production valve (20) is installed outside the pipe between the filtrate outlet of the membrane separation element (11) and the inlet of the filtrate tank (21); the membrane separation element... A filtrate circulation valve (19) is installed outside the pipe between the filtrate outlet of the component (11) and the circulation tank (1). A sewage discharge pipe is fixedly connected to the outlet of the circulation tank (1). A sewage discharge valve (2) is installed outside the sewage discharge pipe. A sewage discharge pipe (2) is fixedly connected to the outlet of the circulation pump (8). A sewage discharge valve (12) is installed outside the sewage discharge pipe. A flushing valve (16) is installed outside the concentrate outlet of the membrane separation element (11). A filtrate sewage discharge valve (17) is installed outside the filtrate outlet of the membrane separation element (11).
4. The protein desalting membrane separation system according to claim 1, characterized in that: It also includes a heat exchanger (15), the concentrated liquid outlet of the membrane separation element (11) is connected to the liquid inlet of the heat exchanger (15), the liquid outlet of the heat exchanger (15) is connected to the liquid inlet of the circulating pump (8), the liquid outlet of the circulating pump (8) is connected to the liquid inlet of the membrane separation element (11), a circulation valve (7) is installed outside the pipe between the liquid outlet of the heat exchanger (15) and the circulating pump (8), and the outlet of the heat exchanger (15) is connected to the liquid inlet of the circulating tank (1).
5. The protein desalting membrane separation system equipment according to claim 2, characterized in that: The data from the thermometer (4) is transmitted from the signal output terminal of the temperature sensor (5) to the signal input terminal of the control cabinet. The data from the pre-membrane pressure gauge (10) is transmitted from the signal output terminal of the pre-membrane pressure sensor (9) to the control input terminal of the control cabinet. The data from the post-membrane pressure gauge (14) is transmitted from the signal output terminal of the post-membrane pressure sensor (13) to the control input terminal of the control cabinet. The control input terminals of the feed pump (6) and the circulation pump (8) are both electrically connected to the control output terminal of the control cabinet.
6. The protein desalting membrane separation system according to claim 4, characterized in that: The inlet and outlet ports of the circulating tank (1), the feed pump (6), the circulating pump (8), the membrane separation element (11), and the heat exchanger (15) are all connected by 304 stainless steel pipes, and the 304 stainless steel pipes are connected to each other by quick-release chucks.
7. The protein desalting membrane separation system according to claim 1, characterized in that: The membrane separation element (11) consists of two sets of six spiral-wound columnar multilayer composite membranes with a molecular weight cutoff of 200 Daltons, an operating pressure of less than 2.5 MPa, and an operating pH of 3-11.