Nucleic acid extractor

Abstract

The embodiment of the utility model provides a nucleic acid extraction instrument. The nucleic acid extractor comprises: a base plate; the pore plate assembly is arranged on the bottom plate, and the pore plate assembly comprises a plurality of reagent plates which are arranged along a first direction; the nucleic acid extraction assembly is movably connected to the bottom plate in the first direction, the nucleic acid extraction assembly comprises a magnetic rod connecting plate, a plurality of magnetic rod supports connected with the magnetic rod connecting plate and magnetic rods, and the magnetic rod supports are arranged at intervals in the first direction; each magnetic bar bracket is connected with a plurality of magnetic bars in a single row along a second direction; the magnetic bar can extend into the reagent plate or be separated from the reagent plate in a third direction, the third direction is the height direction of the bottom plate, and the first direction, the second direction and the third direction are perpendicular to one another.

Description

Technical Field

[0001] This application relates to the field of forensic biological detection technology, and in particular to a nucleic acid extractor. Background Technology

[0002] In recent years, with the rapid development of molecular biology, nucleic acid-based molecular diagnostics and detection technologies have played an increasingly important role in many fields. Currently, magnetic bead extraction is commonly used for nucleic acid extraction.

[0003] However, current nucleic acid extraction equipment is compatible with general-purpose deep well plates such as 24-well and 96-well plates, which can easily lead to waste of deep well plate consumables when the number of samples is small. Utility Model Content

[0004] This application provides a nucleic acid extractor to improve the problem of wasted consumables when the number of samples is small.

[0005] The nucleic acid extractor includes: a base plate; a well plate assembly disposed on the base plate, the well plate assembly including a plurality of reagent plates arranged along a first direction; and a nucleic acid extraction assembly movably connected to the base plate along the first direction, the nucleic acid extraction assembly including a magnetic rod connecting plate, a plurality of magnetic rod supports connected to the magnetic rod connecting plate, and magnetic rods, the plurality of magnetic rod supports being spaced apart along the first direction, each magnetic rod support having a plurality of magnetic rods connected in a single row along a second direction; the magnetic rods are capable of extending into or detaching from the reagent plates in a third direction, the third direction being the height direction of the base plate, and the first direction, the second direction, and the third direction being perpendicular to each other.

[0006] The nucleic acid extractor of this application comprises multiple magnetic rod supports arranged along a first direction on a magnetic rod connecting plate, with each magnetic rod support having multiple magnetic rods connected in a single row along a second direction. This allows the single row of magnetic rods to be sequentially aligned with multiple wells in each row of a reagent plate, thereby enabling nucleic acid extraction from reagent plates of different sizes. For example, the reagent plate can be a specially designed deep-well plate with 8, 9, or 10 rows of wells; or each reagent plate can be composed of multiple specially designed sub-deep-well plates, with 4 or 5 rows of wells; or each reagent plate can consist of a plate substrate and multiple reagent strips disposed on the plate substrate, with the number of reagent strips, their arrangement, and the number of wells per strip flexibly designed according to the sample quantity. When the sample quantity is small, a reagent plate of a specific size can be configured to match the sample quantity. Because the multiple single rows of magnetic rods are arranged at intervals, nucleic acid extraction from reagent plates of a specific size can still be completed without wasting consumables. This can alleviate the problem of wasted consumables due to small sample sizes, thereby helping to reduce the cost of nucleic acid testing. Furthermore, since the magnetic rod support consists of multiple components, nucleic acid extraction can be performed simultaneously on multiple rows of spaced wells, further improving the efficiency of nucleic acid extraction.

[0007] In some embodiments, the spacing between two adjacent magnetic rod supports in the first direction is not exactly the same.

[0008] In some embodiments, the lengths of the plurality of reagent plates along the first direction are not exactly the same.

[0009] In some embodiments, the reagent plate is a deep-hole plate, or the reagent plate includes a plate substrate and a plurality of reagent strips. The plate substrate is provided with a receiving groove for accommodating the reagent strips. Each reagent strip is provided with at least one reagent hole. The plurality of reagent strips are arranged in a row along the first direction and in a column along the second direction.

[0010] In some embodiments, the spacing between two adjacent magnetic rod supports in the first direction is adjustable.

[0011] In some embodiments, the number of magnetic rod supports is three, and each magnetic rod support has eight magnetic rods connected in a single row along the second direction.

[0012] In some embodiments, the nucleic acid extraction assembly further includes a mounting bracket, which is connected to the base plate via a first driving structure, the first driving structure being used to drive the mounting bracket to move along the first direction;

[0013] The magnetic rod connecting plate is connected to the mounting bracket via a second driving structure, which drives the magnetic rod connecting plate to move along the third direction.

[0014] In some embodiments, the nucleic acid extraction assembly further includes a magnetic sleeve connecting plate, a plurality of magnetic sleeve supports connected to the magnetic sleeve connecting plate, and magnetic sleeves. The magnetic sleeve connecting plate is located below the magnetic rod connecting plate. The magnetic sleeve connecting plate is connected to the mounting bracket through a third driving structure. The third driving structure is used to drive the magnetic sleeve connecting plate to move along the third direction. The plurality of magnetic sleeve supports are arranged opposite to the plurality of magnetic rod supports. Each magnetic sleeve support has a plurality of magnetic sleeves connected in a single row along the second direction. The magnetic rods and magnetic sleeves correspond one-to-one.

[0015] In some embodiments, the first drive structure is a synchronous belt drive structure, and the second drive structure and the third drive structure are both ball screw drive structures. The second drive structure includes a first motor, and the third drive structure includes a second motor. The first motor is located on the side of the magnetic rod connecting plate opposite to the magnetic sleeve connecting plate, and the second motor is located on the side of the magnetic sleeve connecting plate opposite to the magnetic rod connecting plate.

[0016] In some embodiments, the nucleic acid extractor further includes an extractor chamber connected to the base plate, the extractor chamber and the base plate together defining a receiving cavity for accommodating the nucleic acid extraction component and the well plate component;

[0017] The nucleic acid extractor also includes a lighting lamp and / or an ultraviolet germicidal lamp disposed within the receiving cavity.

[0018] In some embodiments, the nucleic acid extractor further includes a heating element and a heat insulation element disposed on the base plate, the heating element being located between the reagent plate and the base plate, and the heat insulation element being located between the heating element and the base plate. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the structure of a nucleic acid extractor according to an embodiment of this application;

[0021] Figure 2 This is a schematic diagram of the structure of a nucleic acid extraction component according to an embodiment of this application;

[0022] Figure 3 This is a schematic diagram of the structure of a nucleic acid extraction component according to an embodiment of this application from another perspective;

[0023] Figure 4 This is a schematic diagram of the structure of the base plate, reagent plate, heating element, and heat insulation element according to an embodiment of this application;

[0024] Figure 5 This is a schematic diagram of the structure of a reagent plate according to an embodiment of this application.

[0025] The attached figures are labeled as follows:

[0026] 10- Nucleic acid extractor;

[0027] 100-Base plate, 120-Heating element, 130-Heat insulation element, 140-Extractor chamber, 200-Well plate assembly, 210-Reagent plate, 211-Plate substrate, 212-Reagent strip, 213-Receptor slot, 2121-Reagent well position, 300-Nucleic acid extraction assembly, 310-Magnetic rod connecting plate, 320-Magnetic rod support, 330-Magnetic rod, 340-Mounting bracket, 350-Magnetic sleeve connecting plate, 360-Magnetic sleeve support, 400-First drive structure, 500-Second drive structure, 510-First motor, 600-Third drive structure, 610-Second motor. Detailed Implementation

[0028] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0029] In the description of this application, it should be understood that if terms such as "upper," "lower," "left," and "right" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, they are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the terms used to describe positional relationships in the accompanying drawings are only for illustrative purposes and should not be construed as limiting this patent. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0030] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as implying or suggesting relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified. "And / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A alone, A and B simultaneously, or B alone. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship.

[0031] In the description of this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0032] This application provides an embodiment of a nucleic acid extractor 10. For example... Figure 1 and Figure 2 As shown, the nucleic acid extractor 10 includes a base plate 100, a well plate assembly 200, and a nucleic acid extraction component 300. The well plate assembly 200 is disposed on the base plate 100 and includes multiple reagent plates 210 arranged along a first direction X. The nucleic acid extraction component 300 is movably connected to the base plate 100 along the first direction X. The nucleic acid extraction component 300 includes a magnetic rod connecting plate 310, multiple magnetic rod supports 320 connected to the magnetic rod connecting plate 310, and magnetic rods 330. The multiple magnetic rod supports 320 are arranged at intervals along the first direction X. Each magnetic rod support 320 is connected in a single row with multiple magnetic rods 330 along a second direction Y. The magnetic rods 330 can extend into or detach from the reagent plates 210 in a third direction Z. The third direction Z is the thickness direction of the base plate 100, and the first direction X, the second direction Y, and the third direction Z are perpendicular to each other.

[0033] In this application, the base plate 100 is the substrate of the nucleic acid extractor 10, and the well plate assembly 200 includes a plurality of reagent plates 210 arranged along the first direction X. The reagent plates 210 can be deep well plates or plate structures with reagent strips installed.

[0034] The nucleic acid extraction component 300 is movably connected to the base plate 100 along the first direction X, allowing the magnetic rods 330 to be positioned and adjusted along the first direction X. The magnetic rods 330 and the wells of the reagent plate 210 can be aligned along the third direction Z. Specifically, a magnetic rod support 320 has multiple magnetic rods 330 connected in a single row along the second direction Y. That is, the multiple magnetic rods 330 in a single row can correspond to multiple wells in a column of the reagent plate 210, and each magnetic rod support 320 can be sequentially aligned with multiple wells in each column of the reagent plate 210, thereby achieving nucleic acid extraction from all wells of a reagent plate 210. Furthermore, multiple magnetic rod supports 320 are arranged at intervals along the first direction X, allowing for simultaneous nucleic acid extraction from multiple columns of wells.

[0035] The nucleic acid extractor 10 of this application comprises multiple magnetic rod supports 320 arranged along a first direction on a magnetic rod connecting plate 310, and each magnetic rod support 320 is connected in a single row along a second direction Y with multiple magnetic rods 330. This allows the single row of magnetic rods 330 to be sequentially aligned with multiple wells in each row of a reagent plate 210, thereby enabling nucleic acid extraction from reagent plates 210 of different specifications. For example, the reagent plate 210 can be a specially designed deep-well plate with 8, 9, or 10 rows of wells; or, each reagent plate 210 can be composed of multiple specially designed sub-deep-well plates, with 4 or 5 rows of sub-deep-well plates; or, each reagent plate 210 can consist of a plate base 211 and multiple reagent strips 212 disposed on the plate base 211, the number of reagent strips 212, their arrangement, and the number of wells in each reagent strip 212 can be flexibly designed according to the number of samples. When the number of samples is small, reagent plates 210 of a specific size can be configured to match the number of samples. Since multiple single-row magnetic rods are arranged at intervals, nucleic acid extraction can still be completed on reagent plates 210 of a specific size without wasting consumables. This improves the problem of consumable waste caused by a small number of samples, thus helping to reduce the cost of nucleic acid testing. Furthermore, since there are multiple magnetic rod supports 320, nucleic acid extraction can be completed simultaneously on multiple rows of wells, further improving the efficiency of nucleic acid extraction.

[0036] In some embodiments, the spacing between two adjacent magnetic rod supports 320 in the first direction X is not exactly the same. This results in different distances between the well positions of the two rows of reagent plates 210 corresponding to the two rows of magnetic rods 330 of adjacent magnetic rod supports 320. In related technologies, multiple magnetic rods are arranged in an array and are typically extracted sequentially in 1-6 or 7-12 equidistant rows. This method is monotonous and leads to waste of consumables. In this embodiment, however, multiple magnetic rod supports 320 are arranged at intervals with varying spacing, and each support 320 has one row of magnetic rods 330. This allows for single-row well nucleic acid extraction, reducing consumable waste, while also enabling extraction from multiple rows of wells with varying spacing, improving nucleic acid extraction efficiency and the operational flexibility of the nucleic acid extractor 10.

[0037] In some embodiments, the lengths of the multiple reagent plates 210 along the first direction X are not exactly the same. In this embodiment, since the magnetic rod 330 is in a single row, the lengths of the multiple reagent plates 210 along the first direction X can be different, that is, the specifications of the multiple reagent plates 210 can be different. In this way, on the one hand, the problem of consumable waste can be improved, and on the other hand, it is beneficial to further improve the working flexibility of the nucleic acid extractor 10.

[0038] In some embodiments, the spacing between two adjacent magnetic rod supports 320 in the first direction X is adjustable. This configuration allows for flexible adjustment of the spacing between two adjacent rows of magnetic rods 330 based on factors such as the number of samples, the specifications and arrangement of the reagent plates 210, and the nucleic acid extraction sequence. This helps to further reduce the waste of consumables while improving the working efficiency and flexibility of the nucleic acid extractor 10.

[0039] It is easy to understand that the magnetic rod support 320 can be adjusted in various ways. For example, the magnetic rod support 320 can be connected to the magnetic rod connecting plate 310 via an electric strut, making its position adjustable in the first direction X; or, the magnetic rod support 320 can be slidably connected to the magnetic rod connecting plate 310 via a guide rail, and then the magnetic rod support 320 and the magnetic rod connecting plate 310 can be locked by a locking member, thereby making the position of the magnetic rod support 320 adjustable in the first direction X. The specific design can be flexibly adapted to the actual situation, and this application does not impose any limitations on it.

[0040] In some embodiments, the reagent plate 210 is a deep-well plate. In this case, the deep-well plate can be a general-purpose deep-well plate or a specially designed deep-well plate, thereby improving the operational flexibility of the nucleic acid extractor 10 and further mitigating the problem of consumable waste.

[0041] In some embodiments, such as Figure 5As shown, the reagent plate 210 includes a plate base 211 and a plurality of reagent strips 212. The plate base 211 is provided with a receiving groove 213 for accommodating the reagent strips 212. Each reagent strip 212 is provided with at least one reagent hole 2121. The plurality of reagent strips 212 are arranged in a row along a first direction and in a column along a second direction.

[0042] In this embodiment, the reagent plate 210 includes a plate base 211 and multiple reagent strips 212. The reagent strips 212 are installed in receiving grooves 213 on the plate base 211. The well specifications of the reagent plate 210 are determined by the number and arrangement of the reagent strips 212 and the number of reagent wells 2121 in each reagent strip 212. When the sample volume is small, the number of reagent strips 212 can be reduced, or the number of reagent wells 2121 in each reagent strip can be reduced, or the arrangement of the reagent strips 212 can be changed, thereby matching the specifications of the reagent plate 210 with the sample volume. Then, multiple spaced-apart single-row magnetic rods 330 can perform nucleic acid extraction on the reagent plate 210. This further improves the problem of consumable waste and reduces costs. Furthermore, compared to preparing specially designed deep-well plates, changing the specifications of the reagent plate 210 by replacing the reagent strips 212 or changing their arrangement also improves the ease of preparation and reduces manufacturing costs. Optionally, in Figure 5 In the plate substrate 211, 16 reagent strips 212 are arranged in two columns and eight rows, and each reagent strip 212 has 5 reagent wells 2121.

[0043] In some embodiments, such as Figure 1 and Figure 2 As shown, there are three magnetic rod supports 320, and each magnetic rod support 320 has eight magnetic rods 330 connected in a single row along the second direction Y. Thus, the eight magnetic rods 330 in one row can complete the extraction of eight wells in one row of the reagent plate 210 each time, and the three magnetic rod supports 320 can complete the extraction of three rows each time. This helps to improve the efficiency of the nucleic acid extractor 10 while reducing the waste of consumables and lowering costs.

[0044] In some embodiments, such as Figures 1 to 4As shown, the nucleic acid extraction component 300 also includes a mounting bracket 340, which is connected to the base plate 100 via a first driving structure 400. The first driving structure 400 drives the mounting bracket 340 to move along a first direction X. The magnetic rod connecting plate 310 is connected to the mounting bracket 340 via a second driving structure 500, which drives the magnetic rod connecting plate 310 to move along a third direction Z. By setting the first driving structure 400 and the second driving structure 500, the magnetic rod connecting plate 310 can be displaced relative to the base plate 100 in the first direction X and the third direction Z. This allows for alignment of the magnetic rod 330 with the holes of the reagent plate 210 in the third direction Z, and also allows the magnetic rod 330 to extend into or detach from the holes of the reagent plate 210.

[0045] In some embodiments, such as Figures 1 to 4 As shown, the nucleic acid extraction component 300 also includes a magnetic sleeve connecting plate 350, multiple magnetic sleeve supports 360 connected to the magnetic sleeve connecting plate 350, and magnetic sleeves (not shown in the figure). The magnetic sleeve connecting plate 350 is located below the magnetic rod connecting plate 310. The magnetic sleeve connecting plate 350 is connected to the mounting bracket 340 through a third driving structure 600. The third driving structure 600 is used to drive the magnetic sleeve connecting plate 350 to move along the third direction Z. The multiple magnetic sleeve supports 360 are arranged opposite to the multiple magnetic rod supports 320. Multiple magnetic sleeves are connected in a single row along the second direction Y on each magnetic sleeve support 360. The magnetic rods 330 and the magnetic sleeves correspond one-to-one.

[0046] In this embodiment, the magnetic sleeve connecting plate 350 is located below the magnetic rod connecting plate 310, and both can move relative to the mounting bracket 340 in the third direction Z. This allows for the combination or separation of the magnetic sleeve and the magnetic rod 330. When the two are combined, the magnetic bead is attracted to the outer surface of the magnetic sleeve by the magnetic rod 330; when the two are separated, the magnetic bead detaches from the magnetic sleeve.

[0047] Furthermore, multiple magnetic sleeve supports 360 are arranged opposite to multiple magnetic rod supports 320, with each magnetic rod 330 corresponding to a magnetic sleeve. In this way, each row of multiple magnetic rods 330 and its corresponding row of magnetic sleeves can complete the nucleic acid extraction from one row of wells on the reagent plate 210. This allows the nucleic acid extraction assembly 300 to be adapted to reagent plates 210 of various sizes, thus helping to reduce the waste of consumables. In addition, it also helps to improve the efficiency of nucleic acid extraction.

[0048] In some embodiments, such as Figures 1 to 4 As shown, the first drive structure 400 is a synchronous belt drive structure, while the second drive structure 500 and the third drive structure 600 are both ball screw drive structures. The synchronous belt drive structure features smooth operation, low noise, and convenient installation, while the ball screw drive structure features good transmission performance and high stability.

[0049] Furthermore, such as Figure 2 and Figure 3 As shown, the second drive structure 500 includes a first motor 510, and the third drive structure 600 includes a second motor 610. The first motor 510 is located on the side of the magnetic rod connecting plate 310 opposite to the magnetic sleeve connecting plate 350, and the second motor 610 is located on the side of the magnetic sleeve connecting plate 350 opposite to the magnetic rod connecting plate 310. This arrangement positions the first motor 510 and the second motor 610 on opposite sides in the third direction Z, thus making efficient use of the space in the mounting bracket 340, reducing the probability of interference between the second drive structure 500 and the third drive structure 600, and improving the ease of their arrangement.

[0050] In some embodiments, such as Figure 4 As shown, the nucleic acid extractor 10 also includes a heating element 120 and a heat insulation element 130 disposed on the base plate 100. The heating element 120 is located between the reagent plate 210 and the base plate 100, and the heat insulation element 130 is located between the heating element 120 and the base plate 100. By setting the heating element 120, the heating element 120 can heat the reagent plate 210, thereby improving extraction efficiency and reliability. The heating element 120 can be, for example, a heating wire or a heating plate. By setting the heat insulation element 130, heat can be prevented from being transferred to the base plate 100, avoiding burns to personnel from the nucleic acid extractor 10, thereby improving the safety of the equipment. The heat insulation element 130 can be, for example, aerogel, asbestos board, ceramic plate, etc. Optionally, a receiving groove can be provided on the heat insulation element 130, and the heating element 120 can be disposed in the receiving groove, thereby improving the heat insulation effect of the heat insulation element 130.

[0051] In some embodiments, such as Figure 1 As shown, the nucleic acid extractor 10 also includes an extractor chamber 140 connected to the base plate 100. The extractor chamber 140 and the base plate 100 together define a receiving cavity 141 for accommodating the nucleic acid extraction assembly 300 and the well plate assembly 200. By setting up the extractor chamber 140, the probability of nucleic acid samples being contaminated by the external environment can be reduced, thereby improving the reliability and accuracy of nucleic acid extraction.

[0052] Furthermore, the nucleic acid extractor 10 also includes a lighting lamp and / or an ultraviolet germicidal lamp disposed within the receiving cavity 141. The lighting lamp provides illumination for easy observation by personnel. The ultraviolet germicidal lamp can effectively kill microorganisms such as bacteria and viruses in the sample and extraction environment, preventing cross-contamination, thereby improving the reliability and accuracy of nucleic acid extraction.

[0053] The above are merely preferred embodiments of this application and are not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A nucleic acid extractor, characterized in that, include: Base plate; A well plate assembly is disposed on the base plate, the well plate assembly comprising a plurality of reagent plates arranged along a first direction; as well as A nucleic acid extraction component is movably connected to the base plate along a first direction. The nucleic acid extraction component includes a magnetic rod connecting plate, a plurality of magnetic rod supports connected to the magnetic rod connecting plate, and magnetic rods. The plurality of magnetic rod supports are arranged at intervals along the first direction, and each magnetic rod support is connected with a plurality of magnetic rods in a single row along a second direction. The magnetic rod can extend into or detach from the reagent plate in a third direction, where the third direction is the height direction of the base plate, and the first direction, the second direction, and the third direction are perpendicular to each other.

2. The nucleic acid extractor according to claim 1, characterized in that, The spacing between two adjacent magnetic rod supports is not exactly the same in the first direction.

3. The nucleic acid extractor according to claim 1, characterized in that, The reagent plate is a deep-hole plate; Alternatively, the reagent plate includes a plate base and a plurality of reagent strips. The plate base is provided with a receiving groove for accommodating the reagent strips. Each reagent strip is provided with at least one reagent hole. The plurality of reagent strips are arranged in a row along the first direction and in a column along the second direction.

4. The nucleic acid extractor according to claim 1, characterized in that, The spacing between two adjacent magnetic rod supports in the first direction is adjustable.

5. The nucleic acid extractor according to claim 1, characterized in that, The number of magnetic rod supports is three, and each magnetic rod support has eight magnetic rods connected in a single row along the second direction.

6. The nucleic acid extractor according to claim 1, characterized in that, The nucleic acid extraction component further includes a mounting bracket, which is connected to the base plate via a first driving structure. The first driving structure is used to drive the mounting bracket to move along the first direction. The magnetic rod connecting plate is connected to the mounting bracket via a second driving structure, which drives the magnetic rod connecting plate to move along the third direction.

7. The nucleic acid extractor according to claim 6, characterized in that, The nucleic acid extraction assembly further includes a magnetic sleeve connecting plate, a plurality of magnetic sleeve supports connected to the magnetic sleeve connecting plate, and magnetic sleeves. The magnetic sleeve connecting plate is located below the magnetic rod connecting plate. The magnetic sleeve connecting plate is connected to the mounting bracket through a third driving structure. The third driving structure is used to drive the magnetic sleeve connecting plate to move along the third direction. The plurality of magnetic sleeve supports are arranged opposite to the plurality of magnetic rod supports. Each magnetic sleeve support has a plurality of magnetic sleeves connected in a single row along the second direction. The magnetic rods and magnetic sleeves correspond one-to-one.

8. The nucleic acid extractor according to claim 7, characterized in that, The first drive structure is a synchronous belt drive structure, and the second drive structure and the third drive structure are both ball screw drive structures; The second driving structure includes a first motor, and the third driving structure includes a second motor. The first motor is located on the side of the magnetic rod connecting plate away from the magnetic sleeve connecting plate, and the second motor is located on the side of the magnetic sleeve connecting plate away from the magnetic rod connecting plate.

9. The nucleic acid extractor according to claim 1, characterized in that, The nucleic acid extractor also includes an extractor chamber connected to the base plate, the extractor chamber and the base plate together defining a receiving cavity for accommodating the nucleic acid extraction component and the well plate component; The nucleic acid extractor also includes a lighting lamp and / or an ultraviolet germicidal lamp disposed within the receiving cavity.

10. The nucleic acid extractor according to claim 1, characterized in that, The nucleic acid extractor also includes a heating element and a heat insulation element disposed on the base plate. The heating element is located between the reagent plate and the base plate, and the heat insulation element is located between the heating element and the base plate.

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