Self-sealing joint for liquid chromatography

Abstract

The utility model relates to a self-sealing joint for liquid chromatography. The self-sealing joint comprises a base, an adjusting sleeve and a piston, the base is provided with a fluid channel. Joint parts are arranged at the two ends of the base; the base is also provided with a through hole; the piston is provided with a hole and can be inserted into the through hole in a sliding manner; the adjusting sleeve is sleeved on the base and is matched with the piston; a first inclined guide part is arranged at one end, close to the piston, of the adjusting sleeve; a second inclined guide part matched with the first inclined guide part is arranged at one end of the piston; a spring is further arranged between the piston and the base. According to the self-sealing joint for the liquid chromatography, the piston is controlled to act through the adjusting sleeve and the spring, so that a fluid channel is opened when a pipeline is connected and is closed when the pipeline is dismounted, and the loss of liquid in a liquid path when the pipeline or a chromatographic column is replaced is reduced; meanwhile, only the piston is in contact with the liquid, other structures such as the spring are not in contact with the liquid, and the service life of the spring is guaranteed.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography-related equipment, and in particular to a self-sealing connector used in liquid chromatography. Background Technology

[0002] Preparative liquid chromatography (PLC) is a branch of liquid chromatography technology. Unlike traditional analytical chromatography, the main purpose of preparative PL is not qualitative or quantitative analysis, but rather to remove impurities from samples and ultimately obtain target products that meet purity requirements. Typically, preparative PL uses high flow rates and large-diameter liquid tubing. Therefore, during tubing or column replacement, if the tubing seal is compromised, the remaining liquid in the tubing can be rapidly lost through siphoning, introducing air. This necessitates a tedious purging process after the replacement.

[0003] A typical check valve achieves unidirectional flow based on fluid pressure difference. It contains a valve core, rigid spring, and other structures, which increases fluid flow resistance and causes pressure to rise when fluid passes through. The rigid spring's lifespan is affected by prolonged contact with corrosive liquids, limiting the application range of typical check valves in liquid chromatography. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides a self-sealing connector for liquid chromatography. The piston movement is controlled by an adjusting sleeve and a spring, thereby opening the fluid passage when connecting the pipeline and closing the fluid passage when disconnecting the pipeline, reducing the loss of liquid in the liquid path when replacing pipelines or chromatographic columns. At the same time, only the piston is in contact with the liquid, while other structures such as the spring are not in contact with the liquid, ensuring the service life of the spring.

[0005] The technical solution adopted by this utility model to solve its technical problem is as follows: a self-sealing connector for liquid chromatography, comprising a base, an adjusting sleeve, and a piston; the base has a fluid channel; both ends of the base are provided with connectors for connecting to pipelines; the base is also provided with a through hole perpendicular to the fluid channel; the piston has a hole and is slidably inserted into the through hole; the adjusting sleeve is sleeved on the base and cooperates with the piston; the adjusting sleeve is provided with a first inclined guide at one end near the piston; one end of the piston is provided with a second inclined guide that cooperates with the first inclined guide. The adjusting sleeve is used to push the pipeline towards the piston along the base when it is installed on the base. The first inclined guide acts on the second inclined guide to move the piston along the through hole, so that the hole connects the fluid channels on both sides of the piston. A spring is also provided between the piston and the base. When the pipeline is detached from the base, the piston is used to move in the opposite direction along the through hole by the force of the spring, so that the hole is detached from the fluid channel, thereby disconnecting the fluid channel. At the same time, the second inclined guide acts on the first inclined guide, and the adjusting sleeve is pushed away from the piston along the base until it is detached from the piston.

[0006] Furthermore, the connectors at both ends of the base are external threads for threaded connection with the pipeline; when the pipeline is threadedly connected to the base, the adjusting sleeve is pushed by the pipeline to move along the base toward the piston.

[0007] Furthermore, the adjusting sleeve and piston adjusting sleeve are made of PEEK material; the first inclined guide and the second inclined guide utilize the lubricating component of PEEK material for sliding cooperation, thereby realizing the transmission between the adjusting sleeve and the piston.

[0008] Furthermore, the contact surface between the first inclined guide portion of the adjusting sleeve and the second inclined guide portion of the piston is inclined at °.

[0009] Furthermore, the adjusting sleeve has a groove at one end near the piston; the top edge of the groove has the first inclined guide portion.

[0010] Furthermore, one end of the piston is provided with a piston head, the size of which is larger than the size of the through hole; the end of the piston head is provided with a second inclined guide portion.

[0011] Furthermore, the spring is a compression spring; a spring mounting bracket is provided on the base; one end of the compression spring abuts against the spring mounting bracket, and the other end abuts against the end of the piston.

[0012] Furthermore, the piston has a spring connector at one end corresponding to the spring; the spring is fitted onto the spring connector; the outer diameter of the spring is smaller than the diameter of the through hole.

[0013] The beneficial effects of this utility model are as follows: The self-sealing connector for liquid chromatography of this utility model controls the piston movement through the adjusting sleeve and spring, thereby opening the fluid channel when connecting the pipeline and closing the fluid channel when disconnecting the pipeline, reducing the loss of liquid in the liquid path when replacing the pipeline or the chromatographic column; at the same time, only the piston is in contact with the liquid, while other structures such as the spring are not in contact with the liquid, ensuring the service life of the spring. Attached Figure Description

[0014] Figure 1 A schematic diagram of a self-sealing connector used in liquid chromatography as an example;

[0015] Figure 2 This is a schematic diagram of the installation pipeline state of a self-sealing connector used in liquid chromatography as an example.

[0016] Figure 3 This is a schematic diagram of the disconnected tubing state of a self-sealing connector used in liquid chromatography, as an example.

[0017] Among them, 1-base, 2-adjusting sleeve, 3-piston, 4-spring, 5-pipeline, 11-fluid channel, 12-connector, 13-through hole, 14-spring mounting bracket, 21-first inclined guide surface, 22-groove, 31-hole, 32-second inclined guide surface, 33-piston head, 34-spring connector. Detailed Implementation

[0018] To enhance understanding of this utility model, it will be described in further detail below with reference to the accompanying drawings and embodiments. These embodiments are only used to explain this utility model and do not limit the scope of protection of this utility model.

[0019] Example

[0020] Please refer to Figures 1 to 3 As shown, this embodiment provides a self-sealing connector for liquid chromatography, including a base 1, an adjusting sleeve 2, and a piston 3; the base 1 has a fluid channel 11; both ends of the base 1 are provided with connector portions 12 for connecting to a pipeline 5; the base 1 is also provided with a through hole 13 perpendicular to the fluid channel 11; the piston 3 has a hole 31 and is slidably inserted into the through hole 13; the adjusting sleeve 2 is sleeved on the base 1 and cooperates with the piston 3; the adjusting sleeve 2 is provided with a first inclined guide portion 21 at one end near the piston 3; one end of the piston 3 is provided with a second inclined guide portion 32 that cooperates with the first inclined guide portion 21; the adjusting sleeve 2 is used for... When the pipe 5 is installed on the base 1, it is pushed along the base 1 toward the piston 3. The first inclined guide 21 acts on the second inclined guide 32, causing the piston 3 to move along the through hole 13, so that the hole 31 connects the fluid channels 11 on both sides of the piston 3. A spring 4 is also provided between the piston 3 and the base 1. When the pipe 5 is detached from the base 1, the piston 3 is used to move in the opposite direction along the through hole 13 by the force of the spring 4, so that the hole 31 is detached from the fluid channel 11, thereby disconnecting the fluid channel 11. At the same time, the second inclined guide 32 acts on the first inclined guide 21, and the adjusting sleeve 2 is pushed along the base 1 away from the piston 3 until it is detached from the piston 3.

[0021] In a self-sealing connector used in liquid chromatography according to this embodiment, the connector portions 12 at both ends of the base 1 are external threads for threaded connection with the pipeline 5. When the pipeline 5 is threadedly connected to the base 1, the adjusting sleeve 2 is pushed by the pipeline 5 to move along the base 1 toward the piston 3. Through the design of the threaded connection, the pipeline 5 provides a corresponding thrust to the adjusting sleeve 2 during installation, so that the adjusting sleeve 2 can act on the piston 3 to open the fluid channel. When the pipeline 5 is removed, space is provided for the adjustment sleeve 2 to detach, so that the piston 3 acts on the adjusting sleeve 2 under the action of the spring to push the adjusting sleeve away, thereby providing space for the movement of the piston 3, so that the hole is separated from the fluid channel, and the piston body disconnects the fluid channel to achieve sealing upstream of the fluid channel.

[0022] In this embodiment of a self-sealing connector used in liquid chromatography, the adjusting sleeve 2 and piston 3 are made of PEEK material. The first inclined guide 21 and the second inclined guide 32 utilize the lubricating components of the PEEK material for sliding engagement, thereby realizing the transmission between the adjusting sleeve 2 and the piston 3. In this embodiment, the material's own lubricating components reduce friction during the sliding engagement of the first and second inclined guides, allowing the adjusting sleeve 2 and piston 3 to better engage and transmit power. Simultaneously, no external oil supply system is required for lubrication between the first and second inclined guides, making it suitable for sealed environments and extending the maintenance cycle of this self-sealing connector.

[0023] In a self-sealing connector used in liquid chromatography according to this embodiment, the contact surface between the first inclined guide portion 21 of the adjusting sleeve 2 and the second inclined guide portion 32 of the piston 3 is inclined at 45°; the 45° contact surface design can better realize the transmission between the adjusting sleeve 2 and the piston 3.

[0024] In a self-sealing connector used in liquid chromatography according to this embodiment, the adjusting sleeve 2 is provided with a groove 22 at one end near the piston 3; the top edge of the groove 22 is provided with the first inclined guide portion 21; the design of the groove 22 can leave sufficient space for the first inclined guide portion 21.

[0025] In a self-sealing connector used in liquid chromatography according to this embodiment, one end of the piston 3 is provided with a piston head 33, the size of which is larger than the size of the through hole 13; the end of the piston head 33 is provided with a second inclined guide portion 32. The design of the piston head 33 can effectively control the position of the piston 3 inserted into the through hole 13, thereby controlling the position of the hole 31 in the fluid channel 11.

[0026] In this embodiment of a self-sealing connector used in liquid chromatography, the spring 4 is a compression spring; a spring mounting bracket 14 is provided on the base 1; one end of the compression spring abuts against the spring mounting bracket 14, and the other end abuts against the end of the piston 3. This embodiment only provides one arrangement of the spring, as long as the spring can exert a force that moves the piston 3 to disengage the orifice 31 from the fluid channel 11.

[0027] In a self-sealing connector used in liquid chromatography according to this embodiment, the piston 3 is provided with a spring connector 34 at one end corresponding to the spring 4; the spring 4 is fitted onto the spring connector 34; the outer diameter of the spring 4 is smaller than the diameter of the through hole 13. The design of the spring connector 34 allows the spring 4 to be installed more stably; at the same time, the design of the outer diameter of the spring 4 ensures that the spring 4 is not restricted by the through hole 13 when it acts on the piston 3.

[0028] This embodiment describes a self-sealing connector used in liquid chromatography. When used in liquid chromatography, such as... Figure 2 As shown, the two ends of the base 1 are respectively connected to the corresponding pipelines in the liquid chromatograph; at this time, the orifice of the piston connects to the fluid channels on both sides of the piston; the fluid flow rate of the fluid channel can be matched by setting the orifice diameter to reduce the resistance to fluid flow; at the same time, the pipeline also limits the adjustment sleeve, the adjustment sleeve restricts the movement of the piston, and the spring is compressed and stores force; when it is necessary to replace the downstream pipeline, such as Figure 3 As shown, the pipe is unscrewed outwards. As the pipe exits, the piston, under the action of the spring, gradually pushes the orifice out of the fluid channel. Simultaneously, the piston also transmits the spring force through the second inclined guide surface to the second inclined guide surface of the adjusting sleeve, thereby causing the adjusting sleeve to move away from the piston, allowing the adjusting sleeve to make room for the piston to move, until the piston is completely separated from the adjusting sleeve. At this time, the orifice of the piston is also completely out of the fluid channel, and the piston body blocks the fluid channel, making the upstream of the fluid channel sealed. Then, the pipe is continued to be unscrewed outwards until it is completely separated from the base.

[0029] This embodiment describes a self-sealing connector for liquid chromatography. By adjusting the sleeve and spring, the piston movement is controlled, thereby opening the fluid passage when connecting the pipeline and closing the fluid passage when disconnecting the pipeline, reducing the loss of liquid in the liquid path when replacing the pipeline or column. At the same time, only the piston is in contact with the liquid, while other structures such as the spring are not in contact with the liquid, ensuring the service life of the spring.

[0030] The above embodiments should not limit the present invention in any way. All technical solutions obtained by equivalent substitution or equivalent conversion fall within the protection scope of the present invention.

Claims

1. A self-sealing fitting for use with liquid chromatography, characterized by: The utility model provides a kind of fluid control device, including base (1), adjusting sleeve (2) and piston (3);The base (1) has fluid passage (11);The both ends of the base (1) are provided with joint portion (12) for being connected with pipeline (5);The base (1) is further provided with through hole (13) perpendicular to fluid passage (11);The piston (3) has hole (31), and is slidably inserted in through hole (13);The adjusting sleeve (2) is sleeved in base (1), and is matched with piston (3);The adjusting sleeve (2) is provided with first inclined guide portion (21) in one end close to piston (3);One end of the piston (3) is provided with second inclined guide portion (32) matched with first inclined guide portion (21);The adjusting sleeve (2) is used to be pushed along base (1) towards piston (3) when pipeline (5) is installed in base (1), and by first inclined guide portion (21) acting on second inclined guide portion (32), piston (3) is moved along through hole (13), so that hole (31) is connected with fluid passage (11) on both sides of piston (3);Spring (4) is further provided between the piston (3) and the base (1);The piston (3) is used to be reversely moved along through hole (13) by the action force of spring (4) when pipeline (5) is separated from base (1), so that hole (31) is separated from fluid passage (11), and then fluid passage (11) is disconnected, simultaneously, second inclined guide portion (32) acts on first inclined guide portion (21), and adjusting sleeve (2) is pushed away from piston (3) along base (1) to be separated from piston (3).

2. A self-sealing fitting for use with liquid chromatography as claimed in claim 1, wherein: The joint portion (12) of both ends of the base (1) is external thread for being screwed with pipeline (5);Pipeline (5) is screwed in base (1), and adjusting sleeve (2) is pushed along base (1) towards piston (3) by pipeline (5).

3. A self-sealing fitting for use with liquid chromatography as defined in claim 1, wherein: The adjusting sleeve (2) and the piston (3) adjusting sleeve (2) adopt PEEK material;First inclined guide portion (21) and second inclined guide portion (32) are slidably matched by using the lubricating component of PEEK material, and then the transmission between adjusting sleeve (2) and piston (3) is realized.

4. A self-sealing fitting for use with liquid chromatography as claimed in any one of claims 1 to 3, wherein: The contact surface between first inclined guide portion (21) of the adjusting sleeve (2) and second inclined guide portion (32) of the piston (3) is inclined (45) °.

5. A self-sealing fitting for use with liquid chromatography as defined in claim 1, wherein: The adjusting sleeve (2) is provided with recess (22) in one end close to piston (3);The top edge of recess (22) is provided with first inclined guide portion (21).

6. A self-sealing fitting for use with liquid chromatography as defined in claim 5, wherein: One end of the piston (3) is provided with piston head (33), and the size of piston head (33) is greater than the size of through hole (13);The end of piston head (33) is provided with second inclined guide portion (32).

7. A self-sealing fitting for use with liquid chromatography as defined in claim 1, wherein: The spring (4) is compression spring;Spring mounting bracket (14) is provided on the base (1);One end of the compression spring abuts against spring mounting bracket (14), and the other end abuts against the end of piston (3).

8. A self-sealing fitting for use with liquid chromatography as defined in claim 1, wherein: The piston (3) is provided with spring connector (34) in one end corresponding to spring (4);Spring (4) is sleeved on spring connector (34);The outer diameter of spring (4) is less than the hole diameter of through hole (13).

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