Experimental sample grinder for molecular biology

Abstract

The utility model discloses an experimental sample grinder for molecular biology, which comprises a grinding box and a containing mechanism, grinding magnetic beads are placed in the containing mechanism, a through groove is arranged on the grinding box, a power mechanism for driving the containing mechanism to rotate and grind is arranged in the through groove, and the grinding magnetic beads are placed in the containing mechanism. The top of the power mechanism is fixedly provided with a lower positioning mechanism for positioning the bottom of the containing mechanism, and the lower positioning mechanism is provided with an upper positioning mechanism for positioning and fixing the top of the containing mechanism. The containing mechanism can contain a test sample needing to be ground, the grinding magnetic beads are arranged in the containing mechanism, then the lower positioning mechanism can position the bottom of the containing mechanism, then the upper positioning mechanism is rotated to descend, the containing mechanism is positioned through the upper positioning mechanism, and the grinding magnetic beads are arranged in the containing mechanism. Therefore, shaking displacement cannot be caused when the power mechanism drives the containing mechanism to rotate and grind, and sufficient grinding of the test sample is ensured.

Description

Technical Field

[0001] This utility model relates to the field of grinding device technology, specifically a grinding device for experimental samples in molecular biology. Background Technology

[0002] Sample grinders used in molecular biology experiments are key tools for breaking down biological materials such as cells and tissues to release molecules such as DNA, RNA, or proteins inside.

[0003] When using a sample grinder, a support device is usually used to support the sample, and then a power device is used to drive the support device to rotate rapidly, thereby using the rotation of magnetic beads to quickly grind the sample. However, if the support device shakes when it is fixed, it is easy to be thrown off by centrifugal force, which will affect the grinding effect of the sample. Therefore, we propose a sample grinder for molecular biochemistry. Utility Model Content

[0004] The purpose of this invention is to provide a sample grinder for molecular biology experiments to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a molecular biochemical experimental sample grinder, comprising a grinding chamber and a holding mechanism, wherein grinding magnetic beads are placed inside the holding mechanism, two sets of support frames are fixedly installed at the bottom of the grinding chamber, and a sealing frame is hinged to the top of the grinding chamber via a hinge seat. A through groove is provided on the grinding chamber, and a power mechanism for driving the holding mechanism to rotate and grind is provided inside the through groove. A lower positioning mechanism for positioning the bottom of the holding mechanism is fixedly installed on the top of the power mechanism, and an upper positioning mechanism for positioning and fixing the top of the holding mechanism is provided on the lower positioning mechanism.

[0006] Furthermore, the power mechanism includes a limiting groove, a limiting seat, a drive plate, and a drive motor. A limiting groove is formed on the through groove, and a limiting seat is rotatably connected inside the limiting groove. A drive plate is fixedly installed on the top of the limiting seat, and a drive motor is fixedly installed on the grinding box. The output end of the drive motor is fixedly connected to the limiting seat.

[0007] Furthermore, the lower positioning mechanism includes a fixed seat, a mounting plate, a bearing frame, and a lower positioning block. The fixed seat is fixedly installed on the top of the drive plate, and mounting plates are fixedly installed on both sides of the fixed seat. The bearing frame is fixedly installed on the top of the mounting plate by locking bolts, and a lower positioning block that engages with the bottom of the holding mechanism is fixedly installed on the bottom of the inner wall of the bearing frame.

[0008] Furthermore, the upper positioning mechanism includes a limiting sleeve, a limiting rod, a pressure plate, an upper positioning block, a threaded sleeve, and a threaded rod. Two sets of limiting sleeves are fixedly installed on the bearing frame. The limiting sleeve is slidably connected to the limiting rod inside. A pressure plate is fixedly installed at the bottom of the limiting rod. An upper positioning block that engages with the top of the holding mechanism is fixedly installed at the bottom of the pressure plate. A threaded sleeve is fixedly installed at the top of the bearing frame. A threaded rod is threadedly connected inside the threaded sleeve. The bottom of the threaded rod is rotatably connected to the pressure plate. A handle is fixedly installed at the top of the threaded rod.

[0009] Furthermore, the holding mechanism includes a carrier box, a sealing cover, and a threaded tube. The bottom of the sealing cover is fixedly connected to a threaded tube that is threadedly connected to the outer wall of the carrier box. The bottom of the carrier box is provided with a lower positioning groove that engages with the lower positioning block. The top of the carrier box is fixedly connected with an upper positioning tube that engages with the upper positioning block.

[0010] Furthermore, the carrier box, sealing cover, and threaded pipe are all made of stainless steel.

[0011] Compared with the prior art, the present invention has the following advantages: The holding mechanism of the present invention can hold the test sample to be ground, and the holding mechanism is equipped with a grinding magnetic bead. The lower positioning mechanism can position the bottom of the holding mechanism. Then, the upper positioning mechanism is rotated to descend and the holding mechanism is positioned. This ensures that the power mechanism drives the holding mechanism to rotate and grind without causing shaking or displacement, and ensures that the test sample is ground thoroughly. Attached Figure Description

[0012] Figure 1 This is a three-dimensional structural schematic diagram of the present utility model;

[0013] Figure 2 This is a three-dimensional structural diagram of the present invention after removing the lower positioning mechanism and the upper positioning mechanism;

[0014] Figure 3 This is a three-dimensional view of the installation structure of the drive board of this utility model;

[0015] Figure 4 This is a three-dimensional structural diagram of the lower positioning mechanism and the upper positioning mechanism of this utility model;

[0016] Figure 5 This is a first perspective structural schematic diagram of the holding mechanism of this utility model;

[0017] Figure 6 This is a second perspective structural diagram of the holding mechanism of this utility model.

[0018] In the diagram: 1 Grinding box, 2 Support frame, 3 Hinge seat, 4 Sealing frame, 5 Through groove, 6 Power mechanism, 7 Lower positioning mechanism, 8 Upper positioning mechanism, 9 Container mechanism, 10 Limiting groove, 11 Limiting seat, 12 Drive plate, 13 Drive motor, 14 Fixed seat, 15 Mounting plate, 16 Bearing frame, 17 Lower positioning block, 18 Limiting sleeve, 19 Limiting rod, 20 Pressure plate, 21 Upper positioning block, 22 Threaded sleeve, 23 Threaded rod, 24 Turning handle, 25 Bearing box, 26 Lower positioning groove, 27 Sealing cover, 28 Threaded pipe, 29 Upper positioning pipe. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] Please see Figures 1-6 This utility model provides a technical solution: a molecular biochemical experimental sample grinder, including a grinding box 1 and a holding mechanism 9. Grinding magnetic beads are placed inside the holding mechanism 9. Two sets of support frames 2 are fixedly installed at the bottom of the grinding box 1. A sealing frame 4 is hinged to the top of the grinding box 1 through a hinge seat 3. A through groove 5 is provided on the grinding box 1. A power mechanism 6 for driving the holding mechanism 9 to rotate and grind is provided inside the through groove 5. A lower positioning mechanism 7 for positioning the bottom of the holding mechanism 9 is fixedly installed on the top of the power mechanism 6. An upper positioning mechanism 8 for positioning and fixing the top of the holding mechanism 9 is provided on the lower positioning mechanism 7.

[0021] The container 9 is designed to hold the test sample to be ground. The container 9 is equipped with a grinding magnetic bead. The lower positioning mechanism 7 is designed to position the bottom of the container 9. The upper positioning mechanism 8 is then rotated to descend and position the container 9. This design ensures that the container 9 will not shake or shift when the power mechanism 6 drives it to rotate and grind, thus ensuring that the test sample is ground thoroughly.

[0022] Please see Figure 1 , Figure 2 and Figure 3The power mechanism 6 includes a limiting groove 10, a limiting seat 11, a drive plate 12, and a drive motor 13. The limiting groove 10 is formed on the through groove 5. The limiting seat 11 is rotatably connected inside the limiting groove 10. The drive plate 12 is fixedly installed on the top of the limiting seat 11. The drive motor 13 is fixedly installed on the grinding box 1. The output end of the drive motor 13 is fixedly connected to the limiting seat 11.

[0023] The holding mechanism 9 can be fixed by the lower positioning mechanism 7 and the upper positioning mechanism 8. Then the drive motor 13 operates, and the drive motor 13 drives the limit seat 11 and the drive plate 12 to rotate. This can drive the holding mechanism 9 to rotate and grind. When the drive plate 12 rotates, it can be limited by the limit seat 11 and the limit groove 10, so as to prevent the drive plate 12 from shifting when it rotates.

[0024] Please see Figure 1 , Figure 2 , Figure 5 and Figure 6 The holding mechanism 9 includes a carrying box 25, a sealing cover 27 and a threaded tube 28. The bottom of the sealing cover 27 is fixedly connected to the threaded tube 28, which is threadedly connected to the outer wall of the carrying box 25. The bottom of the carrying box 25 is provided with a lower positioning groove 26 that engages with the lower positioning block 17. The top of the carrying box 25 is fixedly connected with an upper positioning tube 29 that engages with the upper positioning block 21.

[0025] The test sample and the grinding magnetic beads are placed inside the carrier box 25, and then the carrier box 25 is sealed with the sealing cover 27 and the threaded tube 28. Then it can be placed between the lower positioning mechanism 7 and the upper positioning mechanism 8.

[0026] Please see Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 The lower positioning mechanism 7 includes a fixed base 14, a mounting plate 15, a bearing frame 16, and a lower positioning block 17. The fixed base 14 is fixedly installed on the top of the drive plate 12, and the mounting plate 15 is fixedly installed on both sides of the fixed base 14. The bearing frame 16 is fixedly installed on the top of the mounting plate 15 by locking bolts. The lower positioning block 17, which is engaged with the bottom of the holding mechanism 9, is fixedly installed on the bottom of the inner wall of the bearing frame 16.

[0027] The support frame 16 is fixedly connected to the mounting plate 15 on the fixed seat 14 by locking bolts. Then, the lower positioning block 17 set on the top of the support frame 16 can be engaged with the lower positioning groove 26 at the bottom of the support box 25, so as to complete the bottom positioning of the support box 25.

[0028] Please see Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 The upper positioning mechanism 8 includes a limiting sleeve 18, a limiting rod 19, a pressure plate 20, an upper positioning block 21, a threaded sleeve 22, and a threaded rod 23. Two sets of limiting sleeves 18 are fixedly installed on the bearing frame 16. The limiting rod 19 is slidably connected inside the limiting sleeve 18. The pressure plate 20 is fixedly installed at the bottom of the limiting rod 19. The upper positioning block 21, which is engaged with the top of the holding mechanism 9, is fixedly installed at the bottom of the pressure plate 20. The threaded sleeve 22 is fixedly installed at the top of the bearing frame 16. The threaded rod 23 is threadedly connected inside the threaded sleeve 22. The bottom of the threaded rod 23 is rotatably connected to the pressure plate 20. The top of the threaded rod 23 is fixedly installed with a handle 24.

[0029] Once the bottom of the carrying box 25 is fixed, the handle 24 is rotated. The rotation of the handle 24 can drive the threaded rod 23 to descend along the threaded sleeve 22. At this time, the pressure plate 20 can be pushed to drive the upper positioning block 21 to descend. The upper positioning block 21 can then extend into the interior of the upper positioning tube 29, and the pressure plate 20 can be pressed against the top of the upper positioning tube 29. This completes the installation and fixing of the holding mechanism 9. The limiting sleeve 18 and the limiting rod 19 can limit the pressure plate 20, thereby preventing the pressure plate 20 and the upper positioning block 21 from shifting when descending.

[0030] Please see Figure 1 and Figure 6 The carrier box 25, sealing cover 27, and threaded tube 28 are all made of stainless steel. The stainless steel carrier box 25, sealing cover 27, and threaded tube 28 can prevent contamination of the test sample.

[0031] In use, firstly, the holding mechanism 9 holds the test sample to be ground, and the holding mechanism 9 contains grinding magnetic beads. Then, the lower positioning mechanism 7 positions the bottom of the holding mechanism 9. Next, the upper positioning mechanism 8 rotates and descends, using the upper positioning mechanism 8 to position the holding mechanism 9. This ensures that the holding mechanism 9 does not wobble or shift when driven by the power mechanism 6, guaranteeing thorough grinding of the test sample. The holding mechanism 9 can be fixed using the lower positioning mechanism 7 and the upper positioning mechanism 8. Then, the drive motor 13 operates, driving the limiting seat 11 and the drive plate 12 to rotate, thus rotating the holding mechanism 9 for grinding. When the drive plate 12 rotates, it is limited by the limiting seat 11 and the limiting groove 10, preventing displacement during rotation. The test sample and grinding magnetic beads are placed inside the carrier box 25, and then sealed with the sealing cover 27 and... The threaded tube 28 seals the carrier box 25, which can then be placed between the lower positioning mechanism 7 and the upper positioning mechanism 8. The carrier frame 16 is fixedly connected to the mounting plate 15 on the fixed seat 14 by locking bolts. The lower positioning block 17 on the top of the carrier frame 16 can then engage with the lower positioning groove 26 at the bottom of the carrier box 25, thus completing the bottom positioning of the carrier box 25. After the bottom of the carrier box 25 is fixed, the handle 24 is rotated. The rotation of the handle 24 can drive the threaded rod 23 to descend along the threaded sleeve 22. At this time, the pressure plate 20 can be pushed to drive the upper positioning block 21 to descend. The upper positioning block 21 can then extend into the interior of the upper positioning tube 29, and the pressure plate 20 can be pressed against the top of the upper positioning tube 29. At this time, the installation and fixation of the holding mechanism 9 can be completed. The limiting sleeve 18 and the limiting rod 19 can limit the pressure plate 20, thereby preventing the pressure plate 20 and the upper positioning block 21 from shifting when descending.

[0032] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A sample grinder for molecular biochemistry experiments, comprising a grinding chamber (1) and a holding mechanism (9), wherein grinding magnetic beads are placed inside the holding mechanism (9), two sets of support frames (2) are fixedly installed at the bottom of the grinding chamber (1), and a sealing frame (4) is hinged to the top of the grinding chamber (1) via a hinge seat (3), characterized in that: The grinding box (1) is provided with a through groove (5). Inside the through groove (5) is a power mechanism (6) for driving the holding mechanism (9) to rotate and grind. The top of the power mechanism (6) is fixedly installed with a lower positioning mechanism (7) for positioning the bottom of the holding mechanism (9). The lower positioning mechanism (7) is provided with an upper positioning mechanism (8) for positioning and fixing the top of the holding mechanism (9).

2. The molecular biochemistry experimental sample grinder according to claim 1, characterized in that: The power mechanism (6) includes a limiting groove (10), a limiting seat (11), a drive plate (12), and a drive motor (13). The limiting groove (10) is opened on the through groove (5). The limiting seat (11) is rotatably connected inside the limiting groove (10). The drive plate (12) is fixedly installed on the top of the limiting seat (11). The drive motor (13) is fixedly installed on the grinding box (1). The output end of the drive motor (13) is fixedly connected to the limiting seat (11).

3. The molecular biochemistry experimental sample grinder according to claim 2, characterized in that: The lower positioning mechanism (7) includes a fixed seat (14), a mounting plate (15), a bearing frame (16), and a lower positioning block (17). The fixed seat (14) is fixedly installed on the top of the drive plate (12). The mounting plate (15) is fixedly installed on both sides of the fixed seat (14). The bearing frame (16) is fixedly installed on the top of the mounting plate (15) by locking bolts. The lower positioning block (17) that engages with the bottom of the holding mechanism (9) is fixedly installed on the bottom of the inner wall of the bearing frame (16).

4. A sample grinder for molecular biochemistry experiments according to claim 3, characterized in that: The upper positioning mechanism (8) includes a limiting sleeve (18), a limiting rod (19), a pressure plate (20), an upper positioning block (21), a threaded sleeve (22), and a threaded rod (23). Two sets of limiting sleeves (18) are fixedly installed on the bearing frame (16). The limiting sleeve (18) is slidably connected to the limiting rod (19). The bottom of the limiting rod (19) is fixedly installed with a pressure plate (20). The bottom of the pressure plate (20) is fixedly installed with an upper positioning block (21) that engages with the top of the holding mechanism (9). The top of the bearing frame (16) is fixedly installed with a threaded sleeve (22). The threaded sleeve (22) is threadedly connected to the threaded rod (23). The bottom of the threaded rod (23) is rotatably connected to the pressure plate (20). The top of the threaded rod (23) is fixedly installed with a throttle (24).

5. A sample grinder for molecular biochemistry experiments according to claim 4, characterized in that: The holding mechanism (9) includes a carrier box (25), a sealing cover (27) and a threaded tube (28). The bottom of the sealing cover (27) is fixedly connected to the threaded tube (28) which is threaded to the outer wall of the carrier box (25). The bottom of the carrier box (25) is provided with a lower positioning groove (26) that engages with the lower positioning block (17). The top of the carrier box (25) is fixedly connected to an upper positioning tube (29) that engages with the upper positioning block (21).

6. A sample grinder for molecular biochemistry experiments according to claim 5, characterized in that: The carrier box (25), sealing cover (27), and threaded pipe (28) are all made of stainless steel.

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