Multi-nozzle position adjusting device, DNA biosynthesis multi-nozzle device and DNA biosynthesis multi-nozzle system

By designing a multi-nozzle position adjustment device, precise adjustment of the nozzles on the high-throughput synthesis chip is achieved, solving the problems of complex structure, large size and poor control precision in the existing technology, improving printing accuracy and ease of operation, and making it suitable for DNA biosynthesis on high-throughput synthesis chips.

CN223879719UActive Publication Date: 2026-02-06JETLIFE TECHNOLOGY (HANGZHOU) CO LTD
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Patent Information

Application Number
CN202520167218.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-01-24
Publication Date
2026-02-06
Estimated Expiration
2035-01-24

AI Technical Summary

Technical Problem

Existing nozzle position adjustment devices are complex in structure, large in size, and have poor control precision, which leads to a decrease in the printing accuracy of the nozzle on the high-throughput synthesis chip. The reaction reagents cannot fall accurately into the reaction site, which can easily cause reaction failure or contamination.

Method used

The device employs a multi-nozzle position adjustment mechanism, including a support plate, a horizontal deflection adjustment assembly, and a horizontal movement adjustment assembly. Through the cooperation of elastic elements and adjustment components, the nozzles can be deflected and moved precisely within a specific angle range. Combined with the use of leveling screws and spring plungers, the precise positioning of the nozzles in the horizontal and vertical directions is ensured.

Benefits of technology

It improves the flexibility and precision of the nozzle, simplifies the operation process, reduces the possibility of reaction failure and contamination, and increases the success rate and system throughput of DNA synthesis reactions.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a multi-nozzle position adjusting device, a DNA biosynthesis multi-nozzle device and a DNA biosynthesis multi-nozzle system. The multi-nozzle position adjusting device comprises a bearing plate, a plurality of spray nozzles, a plurality of spray nozzles, a plurality of spray nozzles, a plurality of spray nozzles and a plurality of spray nozzles, each nozzle mounting position is provided with a horizontal deflection adjusting assembly; the horizontal deflection adjusting assembly comprises an elastic piece and an adjusting piece which are arranged on the two sides of the spray head, and a preset angle is formed between the connecting line of the center of the adjusting piece and the center of the elastic piece and the longitudinal axis of the spray head. A horizontal movement adjusting assembly is installed on the bearing plate and comprises a leveling jackscrew and a spring plunger. A first hole for accommodating the leveling jackscrew and a second hole for accommodating the spring plunger are respectively formed in two sides of the bearing plate; the top of the leveling jackscrew and the top of the spring plunger abut against the two sides of the spray head respectively. The leveling jackscrew and the spring plunger have moving freedom degrees. The device can accurately and flexibly regulate and control the positions of the multiple nozzles, and is small and simple in structure and convenient and fast to operate.
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Description

TECHNICAL FIELD

[0001] The present disclosure relates to the technical field of DNA biosynthesis, and particularly relates to a multi-jet position adjusting device, a DNA biosynthesis multi-jet device and a system. BACKGROUND

[0002] In the technology of synthesizing DNA base chains based on chip surfaces, four chemical reactions are mainly involved, namely coupling, capping, oxidation and deprotection, wherein the coupling is usually achieved through inkjet printing technology. For a high-throughput synthesis chip, the number of reaction sites is usually more than one million, the reaction site is a circle with a diameter of several tens of microns, and the reaction site margin is usually several tens of microns. According to the size of the throughput, the size and spacing of the site are designed differently. In the synthesis process, the coupling reagent is sprayed into the reaction site through inkjet printing. To achieve accurate position printing, the physical position of the jet needs to be accurately calibrated so that multiple jets are parallel and aligned, and each jet can spray the reagent into the reaction site.

[0003] For a high-throughput synthesis chip, the size is generally large, and the area covered by printing is also relatively large. For a multi-jet printing system, if the relative physical position of the jet is not accurate, there is a deviation or misalignment, then the printing accuracy will be greatly reduced, and the reaction reagent sprayed from the jet hole will not fall into the reaction site, causing reaction failure or causing pollution.

[0004] In the inkjet printing industry, there are mainly two existing jet position adjusting technologies. One is that the jet is installed on a small base plate, and the small base plate is installed on a large base plate. The position of the small base plate is adjusted through a design adjustment structure to achieve the position adjustment of the jet. The other is that the jet is directly installed on the same large base plate, and an adjustment structure is made around the jet, but the adjustment mechanism generally occupies a large space. CONTENT OF THE UTILITY MODEL

[0005] Therefore, the present disclosure provides a multi-jet position adjusting device, a DNA biosynthesis multi-jet device and a system, which at least partially solve the problems of complex structure, large volume and poor control accuracy of the existing jet position adjusting device.

[0006] In a first aspect, the present disclosure provides a multi-jet position adjusting device, comprising:

[0007] A carrier plate, a groove is formed in the carrier plate, and a plurality of jet mounting positions are arranged in the groove;

[0008] Each jet mounting position is provided with a horizontal deflection adjusting assembly; the horizontal deflection adjusting assembly comprises an elastic member arranged on a first side of the jet and an adjusting member arranged on a second side of the jet, and a line connecting the center of the adjusting member and the center of the elastic member is arranged at a preset angle with respect to the longitudinal axis of the jet;

[0009] The horizontal movement adjusting assembly is installed on the bearing plate, and comprises a leveling jackscrew and a spring plunger; one side of the bearing plate is provided with a first hole for accommodating the leveling jackscrew, and the other side is provided with a second hole for accommodating the spring plunger, and the second hole is arranged in matching with the first hole; the top of the leveling jackscrew abuts against the third side of the spray head, and the top of the spring plunger abuts against the fourth side of the spray head; the leveling jackscrew has a degree of freedom of moving along the first hole.

[0010] Optionally, a plurality of through holes are arranged in the groove, and each of the through holes is provided with positioning holes on both sides in clearance fit with positioning pins on the spray head.

[0011] Each of the through holes and the corresponding positioning holes constitutes a spray head mounting position.

[0012] Optionally, the longitudinal axis of the through hole is arranged in parallel with the longitudinal axis of the spray head.

[0013] Optionally, the elastic member and the spring plunger each have a compression pre-tightening force.

[0014] The adjusting member is a conical screw.

[0015] The preset angle is α, and 60° < α < 80°.

[0016] Optionally, the distance from the center of the elastic member to the transverse center axis of the spray head is H1, the distance from the center of the adjusting member to the transverse center axis of the spray head is H2, the length of the spray head is H3, and 0 < H1 < H2 < H3 / 2.

[0017] Optionally, the longitudinal center axis of the first hole is arranged in coincidence with the longitudinal center axis of the second hole.

[0018] The longitudinal center axis of the first hole is arranged in coincidence with the longitudinal center axis of the through hole.

[0019] Optionally, the bottom of the bearing plate comprises a protruding portion and oppositely arranged first and second edge portions, and the protruding portion is located between the first and second edge portions.

[0020] The first edge portion is provided with first and second adjusting through holes, and the second edge portion is provided with third and fourth adjusting through holes; the first and third adjusting through holes are symmetrically arranged relative to the transverse center axis of the bearing plate; and the first and second adjusting through holes are symmetrically arranged relative to the longitudinal center axis of the bearing plate.

[0021] The multi-jet position adjusting device further comprises an overall leveling assembly, which comprises a first adjusting jackscrew, a second adjusting jackscrew, a third adjusting jackscrew and a fourth adjusting jackscrew respectively arranged in the first adjusting through hole, the second adjusting through hole, the third adjusting through hole and the fourth adjusting through hole.

[0022] The first adjusting jackscrew, the second adjusting jackscrew, the third adjusting jackscrew and the fourth adjusting jackscrew all have a degree of freedom of movement.

[0023] Optionally, the area of the protruding part is greater than the area of the groove.

[0024] The distance from the first edge part to the top of the bearing plate is the same as the distance from the second edge part to the top of the bearing plate.

[0025] The distance from the first edge part to the top of the bearing plate is less than the distance from the protruding part to the top of the bearing plate.

[0026] In a second aspect, the application discloses a DNA biosynthesis multi-jet device, comprising a plurality of jets, the multi-jet position adjusting device, and each jet is installed in the jet installation position.

[0027] In a third aspect, the application discloses a DNA biosynthesis system, comprising the DNA biosynthesis multi-jet device.

[0028] The multi-jet position adjusting device disclosed in the application can accurately regulate the position and direction of multiple jets to meet complex application requirements. By providing a groove and a jet installation position on the bearing plate, a horizontal deflection adjusting assembly is provided for the jet installation position to realize small-angle adjustment of the jet. Specifically, the horizontal deflection adjusting assembly can realize deflection of the jet within a specific angle range through cooperation of the elastic member and the adjusting member, allowing each jet to independently adjust the small angle of left and right deflection to adapt to different working scenarios or material processing requirements. By adjusting the position of the leveling jackscrew and the spring plunger in the horizontal movement adjusting assembly, pressure can be applied to both sides of the jet, and accurate movement and positioning of the jet on the horizontal plane can be realized by adjusting the positions of these components. The device not only improves the flexibility and accuracy of the jet, but also facilitates maintenance and replacement of the jet.

[0029] The above description is only a summary of the technical solutions of the present application. In order to more clearly understand the technical means of the present application, the content of the specification can be implemented, and in order to make the above and other purposes, characteristics and advantages of the present application more obvious and easy to understand, the following preferred embodiments are described in detail below, and the accompanying drawings are described as follows. BRIEF DESCRIPTION OF DRAWINGS

[0030] In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings needed to be used in the embodiments will be briefly introduced as follows. Obviously, the drawings in the following description only constitute some embodiments of the present disclosure, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.

[0031] Figure 1 A three-dimensional schematic view of a DNA biosynthesis multi-jet device is provided.

[0032] Figure 2 A three-dimensional schematic view of a multi-jet position adjusting device in Figure 1

[0033] Figure 3 Another angle schematic view of Figure 1

[0034] Legend of reference signs:

[0035] 10, jet;

[0036] 100, bearing plate; 101, groove; 102, through hole; 110, positioning hole;

[0037] 121, protruding part; 122, first edge part; 1221, first adjusting through hole; 1222, second adjusting through hole;

[0038] 123, second edge part; 1231, third adjusting through hole; 1232, fourth adjusting through hole;

[0039] 210, elastic part; 220, adjusting part;

[0040] 310, first hole; 320, second hole; 330, spring plunger;

[0041] 410, first adjusting jackscrew; 420, second adjusting jackscrew; 430, third adjusting jackscrew; 440, fourth adjusting jackscrew. DETAILED DESCRIPTION

[0042] The present disclosure will be described in further detail below with reference to the drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the related content, and not to limit the present disclosure. In addition, it should be noted that only parts related to the present disclosure are shown in the drawings for ease of description.

[0043] It should be noted that the embodiments and features in the embodiments of the present disclosure can be combined with each other without conflict. The technical solutions of the present disclosure will be described in detail below with reference to the drawings and in combination with the embodiments.

[0044] ​​Unless otherwise stated, the exemplary implementations / examples shown will be understood to provide exemplary features of various details that can be implemented in practice to embody the technological concepts of the present disclosure. Accordingly, features of the various implementations / examples can be additionally combined, separated, interchanged, and / or rearranged, unless otherwise stated, without departing from the technological concepts of the present disclosure.

[0045] The use of cross-hatching and / or shading in the drawings is generally used to illustrate the boundaries, of adjacent sections. As such, unless specified, the presence of cross-hatching or shading in a drawing is not meant to accentuate certain features of a drawing or to serve as an indication of a specific material, material property, dimension, ratio, commonality between elements, or any other feature, attribute, property, etc., of the components being portrayed, unless otherwise noted. Furthermore, in the drawings, the

[0046] When a component is referred to as being “on” or “over” another component, “connected to” or “coupled to” another component, it can be directly on, connected, or coupled to the other component, or intervening components can be present. However, when a component is referred to as being “directly on,” “directly connected to,” or “directly coupled to” another component, there are no intervening components present. To that end, the term “connected” can refer to physical or electrical connection, with or without intervening components.

[0047] For descriptive purposes, the present disclosure can use spatial or relative terms, such as “below,” “lower,” “below,” “low,” “above,” “upper,” “on,” “higher,” and “side” (e.g., as in “side wall”), to describe the relationship between one component and another component as the drawings show. The spatial or relative terms are intended to encompass different orientations of the device in use, operation, and / or manufacture in addition to the orientation depicted in the drawings. For example, if the device in the drawings is turned over, a component described as “below” or “beneath” other components or features would then be oriented “above” the other components or features. Thus, the exemplary term “below” can encompass both an orientation of above and below. Moreover, the device can be otherwise oriented (e.g., rotated 90 degrees or at other orientations) and the spatial or relative descriptors used herein interpreted accordingly.

[0048] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. Furthermore, to the extent that the terms "comprising," "including," "containing," and / or "having" and variations thereof are used herein, such terms are intended to be inclusive, in an aspect, it is noted that the terms "substantial," "approximately," and other similar terms are used as terms of approximation and not as terms of degree, accordingly, they are utilized to account for inherent deviations in measurements, calculations, and / or provided values that would be recognized by those of ordinary skill in the art.

[0049] Referring to Figure 1 The present application discloses a DNA biosynthesis multi-jet device, comprising a plurality of jets 10, a multi-jet position adjusting device, and the plurality of jets 10 are correspondingly installed on the multi-jet position adjusting device; the multi-jet position adjusting device is used for adjusting the position of the multi-jet of inkjet printing, ensuring that the position accuracy of the plurality of jets meets the requirements, and realizing accurate printing.

[0050] Referring to Figure 2 The multi-jet position adjusting device comprises a bearing plate 100, the bearing plate 100 is provided with a groove 101, and the groove 101 is provided with a plurality of jet mounting positions; in this embodiment, five jet mounting positions are provided for correspondingly mounting five jets 10.

[0051] Specifically, a plurality of through holes 102 are formed in the groove 101, each through hole 102 is arranged staggered with the ink ejection area of the jet 10, that is, after the jet 10 is installed, the ink ejection printing of the jet 10 is not affected.

[0052] Both sides of each through hole 102 are provided with a positioning hole 110 which is in clearance fit with the positioning pin on the jet 10, so as to facilitate the preliminary positioning of the jet 10 at each through hole 102, and at the same time, the position of the jet 10 is not affected. Micro-adjustment, so that the positioning pin will not be separated from the corresponding positioning hole 110.

[0053] In this embodiment, each through hole 102 and its corresponding positioning hole 110 constitute a jet mounting position.

[0054] Further, the longitudinal axis of the through hole 102 is arranged in parallel with the longitudinal axis of the jet 10, that is, the through hole 102 is a long slot hole, which provides a movable space for the front and rear movement and left and right swing of the jet 10.

[0055] Each spray head mounting position is provided with a horizontal deflection adjusting assembly; specifically, the horizontal deflection adjusting assembly comprises an elastic member 210 provided on the first side of the spray head 10 with compression pre-tightening force, and an adjusting member 220 provided on the second side of the spray head 10, the center line of the adjusting member 220 and the center of the elastic member 210 is arranged at a preset angle with the longitudinal axis of the spray head 10.

[0056] Preferably, the elastic member 210 is a spring, and the adjusting member 220 is a conical screw, which is simple and reliable.

[0057] Preferably, the preset angle is α, 60° < α < 80°, that is, the adjusting member 220 and the elastic member 210 are arranged in a staggered manner, which ensures that the spray head 10 can be adjusted in left and right deflection.

[0058] When the adjusting member 220 is a conical screw, the outer side of the conical screw is tapered, that is, the outer diameter increases from the conical head to the conical tail. When the conical screw is moved downward, the outer diameter in contact with the spray head 10 will increase, that is, a leftward thrust will be applied to the second side of the spray head 10, thereby realizing clockwise rotation adjustment (i.e., right deflection adjustment) of the spray head 10 in the horizontal plane. The elastic member 210 provided on the second side of the spray head 10 will be compressed. Under the combined action of the compressed elastic member 210, the adjusted adjusting member 220 on the second side of the spray head 10, and the corresponding positioning pin and positioning hole 110, the position-adjusted spray head 10 is fixed.

[0059] When the conical screw is moved upward, the outer diameter in contact with the spray head 10 will decrease. Under the action of the compression pre-tightening force of the elastic member 210 provided on the first side of the spray head 10, a rightward thrust will be applied to the first side of the spray head 10, thereby realizing counterclockwise rotation adjustment (i.e., left deflection adjustment) of the spray head 10 in the horizontal plane. The stretched elastic member 210 is still in a compressed state. Under the combined action of the elastic member 210 at this time, the adjusted adjusting member 220 on the second side of the spray head 10, and the corresponding positioning pin and positioning hole 110, the position-adjusted spray head 10 is fixed.

[0060] The distance from the center of the elastic member 210 to the transverse center axis of the spray head 10 is H1, the distance from the center of the adjusting member 220 to the transverse center axis of the spray head 10 is H2, and the length of the spray head 10 is H3, 0 < H1 < H2 < H3 / 2, that is, the elastic member 210 and the adjusting member 220 are arranged on one side of the transverse center axis of the spray head 10, and the elastic member 210 and the adjusting member 220 are arranged on both sides of the longitudinal center axis of the spray head 10, respectively; the adjusting member 220 is arranged close to the end of the spray head 10, that is, the elastic member 210 is closer to the transverse center axis of the spray head 10 than the adjusting member 220; by arranging the distance from the center of the adjusting member 220 to the transverse center axis of the spray head 10 to be less than half the length of the spray head 10, the effective action of the elastic member 210 and the adjusting member 220 on the yawing force of the spray head 10 can be effectively ensured.

[0061] In this embodiment, the horizontal movement adjusting assembly is mounted on the bearing plate 100, and the horizontal movement adjusting assembly comprises a leveling jackscrew and a spring plunger 330 with a preset compression elastic force, that is, the spring plunger 330 has a certain compression when assembled, and the size of the compression can be adjusted by adjusting the position of the plunger.

[0062] A first hole 310 for accommodating the leveling jackscrew is formed on one side of the bearing plate 100, and a second hole 320 for accommodating the spring plunger 330 is formed on the other side, and the second hole 320 is arranged in matching with the first hole 310; the top of the leveling jackscrew abuts against the third side of the spray head 10, and the top of the spring plunger 330 abuts against the fourth side of the spray head 10, thereby ensuring the fixation of the spray head 10.

[0063] Preferably, the longitudinal center axis of the first hole 310 is arranged in coincidence with the longitudinal center axis of the second hole 320; and the longitudinal center axis of the first hole 310 is arranged in coincidence with the longitudinal center axis of the through hole 102.

[0064] Preferably, the leveling jackscrew has a degree of freedom of movement along the first hole 310, and the spring plunger 330 has a degree of freedom of movement along the second hole 320, that is, the position of the spray head 10 before and after can be adjusted by adjusting the screwing depth of the leveling jackscrew in the first hole 310.

[0065] When the leveling jackscrew moves inward, the top of the leveling jackscrew pushes the spray head 10 to move close to the spring plunger 330, and at the same time, the spring plunger 330 is compressed; when the leveling jackscrew moves outward, the spray head 10 moves close to the leveling jackscrew under the push of the preset compression elastic force of the spring plunger 330, and at this time, the spring plunger 330 still has a compression pre-tightening force.

[0066] In this application, a set of horizontal movement adjusting assemblies can be arranged at each spray head mounting position for precise adjustment of the position of each spray head 10.

[0067] Further, in this embodiment, only four groups of horizontal movement adjusting assemblies can be provided, i.e., the number of the provided horizontal movement adjusting assemblies can be less than the number of the nozzles 10 by one; for the nozzles 10 arranged side by side from left to right, for the leftmost nozzle 10, no horizontal movement adjusting assembly can be provided, and thus after the leftmost nozzle 10 is installed, the leftmost nozzle 10 can be taken as a reference, i.e., the leftmost nozzle 10 can be adjusted in left-right yawing, and the front and back positions are taken as reference positions, and no front and back adjustment is needed; for the remaining four nozzles 10, the front and back position adjustment and the left-right yawing position adjustment can be performed through the corresponding horizontal movement adjusting assemblies and horizontal deflection adjusting assemblies; the position of the nozzles 10 can be adjusted by observing the actually printed ink drop landing points, and finally the five nozzles 10 are in a state of mutual parallelism and front and back alignment, so that the ink drop landing points of the five nozzles 10 can all be within the reaction site.

[0068] With reference to Figure 2 and Figure 3 The bottom of the carrier plate 100 includes a protruding portion 121 and oppositely arranged first and second edge portions 122 and 123, the protruding portion 121 is located between the first and second edge portions 122 and 123, and the area of the protruding portion 121 is greater than the area of the groove 101, the bottom surface of the protruding portion 121 is a precision machined surface like the upper surface of the nozzle mounting site, and has a very high flatness.

[0069] The distance from the first edge portion 122 to the top of the carrier plate 100 is the same as the distance from the second edge portion 123 to the top of the carrier plate 100; the distance from the first edge portion 122 to the top of the carrier plate 100 is less than the distance from the protruding portion 121 to the top of the carrier plate 100, i.e., from the side, the bottom surface of the protruding portion 121 is lower than the first and second edge portions 122 and 123.

[0070] The first edge portion 122 is provided with first and second adjusting through holes 1221 and 1222, and the second edge portion 123 is provided with third and fourth adjusting through holes 1231 and 1232; the first adjusting through hole 1221 and the third adjusting through hole 1231 are symmetrically arranged with respect to the transverse center axis of the carrier plate 100; the first adjusting through hole 1221 and the second adjusting through hole 1222 are symmetrically arranged with respect to the longitudinal center axis of the carrier plate 100.

[0071] The multi-nozzle position adjusting device further comprises an overall leveling assembly, which comprises a first adjusting jackscrew 410, a second adjusting jackscrew 420, a third adjusting jackscrew 430, and a fourth adjusting jackscrew 440 respectively arranged in the first adjusting through hole 1221, the second adjusting through hole 1222, the third adjusting through hole 1231, and the fourth adjusting through hole 1232; the first adjusting jackscrew 410, the second adjusting jackscrew 420, the third adjusting jackscrew 430, and the fourth adjusting jackscrew 440 all have a degree of freedom of movement.

[0072] Specifically, when the first adjusting jackscrew 410 and the second adjusting jackscrew 420 on the left are rotated or pushed to move downward, the left side of the overall carrier plate 100 is pushed to move upward; when the third adjusting jackscrew 430 and the fourth adjusting jackscrew 440 on the right are rotated or pushed to move downward, the right side of the overall carrier plate 100 is pushed to move upward, thereby achieving adjustment of the overall flatness. By repeatedly fine-tuning the four adjusting jackscrews, the overall flatness of the carrier plate 100 can meet the design requirements, and the flatness of the upper surface of the nozzle mounting position can be ensured.

[0073] The multi-nozzle position adjusting device disclosed in the present application can accurately control the positions and directions of multiple nozzles to meet complex application requirements. By providing grooves and nozzle mounting positions on the carrier plate and equipping the nozzle mounting positions with horizontal deflection adjusting assemblies, the device can achieve small-angle adjustment of the nozzles. Specifically, the horizontal deflection adjusting assemblies can achieve deflection of the nozzles within a specific angle range through the cooperation of elastic members and adjusting members, allowing each nozzle to independently adjust the small angle of left and right deflection to adapt to different working scenarios or material processing requirements. By adjusting the positions of the leveling jackscrews and spring plungers in the horizontal movement adjusting assemblies, pressure can be applied to both sides of the nozzles, and the nozzles can be accurately moved and positioned on the horizontal plane by adjusting the positions of these components. The device not only improves the flexibility and accuracy of nozzle use, but also facilitates maintenance and replacement of the nozzles.

[0074] The multi-nozzle position adjusting device disclosed in the present application addresses the deficiencies of existing technologies, particularly the challenges in precise calibration and adjustment of nozzle positions in high-throughput synthesis chips. Specifically, the device comprises a carrier plate, horizontal deflection adjusting assemblies, and horizontal movement adjusting assemblies that work together to ensure high-precision position adjustment of the nozzles in complex operating environments, thereby improving the accuracy and efficiency of printing. Through the combination of the horizontal deflection adjusting assemblies and the horizontal movement adjusting assemblies, precise adjustment of the nozzle positions can be achieved. The horizontal deflection adjusting assemblies utilize the cooperative action of elastic members and adjusting members to ensure that the nozzles can freely deflect in the horizontal direction, thereby adapting to different printing requirements. The horizontal movement adjusting assemblies further improve the accuracy of position adjustment of the nozzles in the vertical direction through the arrangement of leveling jackscrews and spring plungers, enabling the reaction reagents sprayed from the nozzle holes to accurately fall within the reaction sites.

[0075] The conventional nozzle position adjusting technology usually needs to set a large adjusting structure around the nozzle, occupying a large space; the device of the present application reduces the occupied space of the adjusting mechanism through optimization design, so that more nozzles can be installed in a limited space, thereby improving the overall flux of the system.

[0076] The design of the device takes into account the simplicity of operation, and the user can achieve precise adjustment of the nozzle through simple mechanical operation without complex calibration process, greatly reducing the operation difficulty. Through precise position adjustment, the reaction reagent is avoided from being sprayed to the non-target area, thereby reducing the possibility of reaction failure and pollution and improving the success rate of DNA synthesis reaction.

[0077] The device is particularly suitable for high-throughput synthesis chips and can cope with complex situations such as a large number of reaction sites, small spacing, and different sizes of sites, ensuring high precision under a large printing coverage area.

[0078] In summary, the multi-nozzle position adjusting device of the present application has significant advantages in improving the printing precision, space utilization, operation simplicity, and reaction success rate of the synthesis chip, and provides reliable technical support for high-throughput synthesis of DNA base chains.

[0079] In a second aspect, the present application discloses a DNA biosynthesis system comprising the DNA biosynthesis multi-nozzle device.

[0080] In the description of the present application, the description of the terms "one embodiment / way", "some embodiments / ways", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment / way or example are included in at least one embodiment / way or example of the present application. In the present application, the illustrative description of the above terms does not necessarily refer to the same embodiment / way or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments / ways or examples. In addition, the skilled in the art can combine and combine the different embodiments / ways or examples described in the present application and the features of the different embodiments / ways or examples without contradiction.

[0081] In addition, the terms "first", "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Therefore, the features defined with "first", "second" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "multiple" is at least two, for example, two, three, etc., unless otherwise specifically limited.

[0082] Those skilled in the art will understand that the above-described embodiments are merely intended to clarify the present disclosure, and are not intended to limit the scope of the present disclosure. Other changes or modifications can be made by those skilled in the art based on the above disclosure, and the changes or modifications are still within the scope of the present disclosure.

Claims

1. A multi-jet position adjustment device, characterized by, The utility model relates to a multi-nozzle position adjusting device, comprising: a bearing plate with a groove, the groove has a plurality of nozzle mounting positions; each nozzle mounting position is provided with a horizontal deflection adjusting component; the horizontal deflection adjusting component comprises an elastic element arranged on the first side of the nozzle, an adjusting element arranged on the second side of the nozzle, and the center line of the center of the adjusting element and the center of the elastic element is arranged at a preset angle with the longitudinal axis of the nozzle; the bearing plate is provided with a horizontal movement adjusting component, and the horizontal movement adjusting component comprises a leveling top wire and a spring plunger; one side of the bearing plate is provided with a first hole for accommodating the leveling top wire, and the other side is provided with a second hole for accommodating the spring plunger; the second hole is matched with the first hole; the top of the leveling top wire abuts against the third side of the nozzle, and the top of the spring plunger abuts against the fourth side of the nozzle; the leveling top wire has the freedom of movement along the first hole.

2. The multi-jet position adjustment apparatus according to claim 1, wherein a plurality of through holes are arranged in the groove, and a positioning hole matched with a positioning pin on the nozzle is arranged on both sides of each through hole; each through hole and its corresponding positioning hole constitute a nozzle mounting position.

3. The multi-jet position adjustment apparatus according to claim 2, wherein The longitudinal axis of the through hole is arranged in parallel with the longitudinal axis of the nozzle.

4. The multi-jet position adjustment apparatus according to claim 1, wherein The elastic element and the spring plunger both have a compression pre-tightening force; the adjusting element is a conical screw; the preset angle is alpha, 60° < alpha < 80°.

5. The multi-jet position adjustment apparatus according to claim 1, wherein The distance from the center of the elastic element to the transverse center axis of the nozzle is H1, the distance from the center of the adjusting element to the transverse center axis of the nozzle is H2, and the length of the nozzle is H3, 0 < H1 < H2 < H3 / 2.

6. The multi-jet position adjustment apparatus according to claim 2, wherein The longitudinal center axis of the first hole is arranged in coincidence with the longitudinal center axis of the second hole; The longitudinal center axis of the first hole is arranged in coincidence with the longitudinal center axis of the through hole.

7. The multi-jet position adjustment apparatus according to any one of claims 1 to 6, wherein The bottom of the bearing plate comprises a protruding part and oppositely arranged first and second edge parts, and the protruding part is located between the first and second edge parts; the first edge part is provided with a first adjusting through hole and a second adjusting through hole, and the second edge part is provided with a third adjusting through hole and a fourth adjusting through hole; the first adjusting through hole and the third adjusting through hole are symmetrically arranged relative to the transverse center axis of the bearing plate; the first adjusting through hole and the second adjusting through hole are symmetrically arranged relative to the longitudinal center axis of the bearing plate; the multi-nozzle position adjusting device further comprises a whole leveling component, and the whole leveling component comprises first, second, third and fourth adjusting top wires respectively arranged in the first, second, third and fourth adjusting through holes; the first, second, third and fourth adjusting top wires all have the freedom of movement.

8. The multi-jet position adjustment apparatus according to claim 7, wherein The area of the protruding part is larger than the area of the groove; the distance from the first edge part to the top of the bearing plate is the same as the distance from the second edge part to the top of the bearing plate; the distance from the first edge part to the top of the bearing plate is smaller than the distance from the protruding part to the top of the bearing plate.

9. A DNA biosynthesis multi-jet device, characterized by, The multi-nozzle position adjusting device of claim 8, wherein a plurality of nozzles are included, each of the nozzles being installed in the nozzle installation position.

10. A DNA biosynthesis system, characterized by, The DNA biosynthesis multi-nozzle device of claim 9.