Sample sampling locator for biological electron microscope

By introducing a limiting structure and a motor-driven lifting platform system into the sample locator for a bioelectron microscope, the problem of collision between the lifting platform and the microscope head is solved, thus protecting the microscope head and ensuring the accuracy and repeatability of experimental results. This system is suitable for a variety of biological samples.

CN223883490UActive Publication Date: 2026-02-06XI AN JIAOTONG UNIV
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Patent Information

Application Number
CN202520407581.4
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-03-10
Publication Date
2026-02-06
Estimated Expiration
2035-03-10

AI Technical Summary

Technical Problem

Existing bioelectron microscope sample placement instruments lack effective limits on the height of the lifting platform during use, which can lead to collisions between the lifting platform and the microscope due to operator misoperation or misjudgment, damaging the microscope head and affecting its accuracy and performance.

Method used

A sample locator for a bioelectron microscope was designed, comprising a limiting structure, a position sensor, and a motor-driven lifting platform system. The limiting structure prevents the lifting platform from colliding with the microscope lens, and the motor enables automated lifting to ensure that the lifting platform stops at the same position each time.

Benefits of technology

It effectively avoids collisions between the lifting platform and the microscope head, protecting the precision and lifespan of the microscope head, while improving work efficiency and the accuracy and repeatability of experimental results. It is suitable for biological samples of different sizes and shapes.

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Abstract

The utility model discloses a biological electron microscope sample sampling position indicator, which belongs to the field of biological sample sampling position indicators and comprises a base, a support arranged on the base, a microscope lens fixedly arranged on the support and a lifting platform arranged on the support and corresponding to the position between the base and the microscope lens. A limiting structure is arranged on the support and comprises a vertical groove formed in the support, a position sensor arranged at the top in the vertical groove and a position piece arranged at the bottom in the vertical groove and connected with the lifting table. Due to the design of the limiting structure, the stopping positions of the lifting platform are highly consistent every time, so that a powerful guarantee is provided for accurate sampling and positioning of biological samples, and the accuracy and repeatability of experimental results can be improved. Through accurate cooperation of the position sensor and the position piece, the lifting platform is effectively prevented from colliding with the microscope lens in the ascending process, so that the precise part, namely the microscope lens, is protected, and the service life of an instrument is prolonged.
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Description

TECHNICAL FIELD

[0001] The application relates to the technical field of biological sample sampling positioners, and particularly relates to a biological electron microscope sample sampling positioner. BACKGROUND

[0002] A biological electron microscope sample, as an important object of biological electron microscope (such as a scanning electron microscope SEM and a transmission electron microscope TEM) detection and observation, is crucial in a sampling process. In order to ensure the accuracy and representativeness of the sample, a sampling positioner becomes an indispensable tool in the sampling process of the biological sample. The sampling positioner is usually composed of a microscope, a lifting table matched with the microscope and a positioning plate and the like key components. In the sampling process, an operator places the positioning plate with the biological sample on the lifting table, adjusts the distance between the biological sample and the microscope by adjusting the height of the lifting table, so as to realize clear positioning and sampling.

[0003] In the use process of the existing sampling positioner, the operator may cause the lifting table to excessively rise due to misoperation or misjudgment when adjusting the height of the lifting table, and then the lifting table collides with the microscope. The collision not only may damage the lens of the microscope, affect the precision and performance of the microscope, but also may cause irreversible damage to the overall structure of the microscope, and then affect the subsequent normal use of the microscope.

[0004] Therefore, the application provides a biological electron microscope sample sampling positioner to solve the above problems. CONTENT OF THE UTILITY MODEL

[0005] The application provides a biological electron microscope sample sampling positioner, and aims to solve the problems that the existing sampling positioner lacks effective limitation of the rising height of the lifting table in the use process, the operator may cause the lifting table to excessively rise due to misoperation or misjudgment when adjusting the height of the lifting table, and then the lifting table collides with the microscope to affect the normal use of the microscope and the like.

[0006] In order to achieve the above purpose, the application provides the following technical scheme: a biological electron microscope sample sampling positioner, comprising a base, a support arranged on the base, a microscope lens fixedly arranged on the support and a lifting table arranged on the support and corresponding to the base and the microscope lens.

[0007] In order to limit the lifting height of the lifting platform: the support is provided with a limiting structure for preventing the lifting platform from colliding with the microscope head, the limiting structure comprises a vertical slot opened on the support, a position sensor arranged at the top of the vertical slot and a position sheet arranged at the bottom of the vertical slot and connected with the lifting platform. When positioning the biological sample, the biological sample is placed on the lifting platform by the instrument, and then the lifting platform is moved upward to the direction close to the microscope head. The position sheet is lifted synchronously during the lifting of the lifting platform, and stops when the position sheet contacts the position sensor. Through the cooperation of the position sensor and the position sheet, the collision between the lifting platform and the microscope head can be prevented.

[0008] Preferably, in order to facilitate the driving of the lifting platform to lift, a first screw rod is rotatably inserted into the vertical slot, a threaded sleeve plate fixedly connected with the lifting platform is threadedly sleeved on the first screw rod, the position sheet is fixedly installed on the upper end of the threaded sleeve plate, a first motor is fixedly arranged on the support, and the output end of the first motor is fixedly connected with the end of the first screw rod. The introduction of the first motor realizes the automatic lifting of the lifting platform, without manual operation, thereby greatly improving the work efficiency.

[0009] Preferably, in order to prevent the base from sliding with the table top, support legs are fixedly connected with the bottom corners of the base, and anti-skid pads are fixedly connected with the lower ends of the support legs. The anti-skid pads are made of rubber material, and the friction between the support legs and the table top can be improved through the anti-skid pads, so as to avoid the sliding between the base and the table top.

[0010] Preferably, in order to facilitate the adjustment of the height position of the position sensor, an adjusting structure for adjusting the position of the position sensor is arranged on the support, the adjusting structure comprises a second screw rod, bearings are rotatably sleeved on both ends of the second screw rod and fixedly connected with the support, a connecting seat fixedly connected with the position sensor is threadedly sleeved on the second screw rod, the second motor is fixedly installed on the bearing seat, and the output end of the second motor is fixedly connected with the end of the second screw rod. The height of the position sensor can be accurately adjusted by driving the second screw rod to rotate through the second motor, so as to meet the needs of different biological samples and different experimental conditions.

[0011] Preferably, the adjusting structure further comprises a guide rod slidingly inserted into the connecting seat and a fixed plate fixedly sleeved on both ends of the guide rod and fixedly connected with the support. The cooperation of the guide rod and the fixed plate ensures the stability of the connecting seat and the position sensor during lifting, and avoids measurement errors caused by shaking or deviation.

[0012] Preferably, in order to facilitate the observation of the position of the position sensor, a scale plate is fixedly connected to the support, and a pointer adapted to the scale plate is fixedly connected to the connecting seat. Through the cooperation of the pointer and the scale plate, the user can intuitively observe the current height value of the position sensor without complex measurement or calculation, thereby improving the work efficiency.

[0013] The design of the limiting structure of the application ensures that the position of the lifting platform stops consistently each time, which provides a strong guarantee for the accurate sampling and positioning of biological samples and helps to improve the accuracy and repeatability of experimental results. Through the precise cooperation of the position sensor and the position sheet, the lifting platform is effectively prevented from colliding with the microscope lens during the lifting process, thereby protecting the microscope lens as a precision component and prolonging the service life of the instrument.

[0014] The introduction of the adjusting structure enables the device to be applicable to biological samples of different sizes and shapes, thereby improving its versatility and practicality. The height of the position sensor can be accurately adjusted through the rotation of the second lead screw driven by the second motor, thereby meeting the needs of different biological samples and different experimental conditions. The cooperation of the guide rod and the fixed plate ensures the stability of the connecting seat and the position sensor during the lifting process, thereby avoiding measurement errors caused by shaking or deviation.

[0015] Through the cooperation of the pointer and the scale plate, the user can intuitively observe the current height value of the position sensor without complex measurement or calculation, thereby improving the work efficiency. The user only needs to observe the position of the pointer on the scale plate to determine whether the height of the position sensor meets the experimental requirements, and the operation is more convenient. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 FIG. 1 is a structural schematic diagram of a biological electron microscope sample sampling and positioning instrument;

[0017] Figure 2 FIG. 2 is a schematic diagram of the lifting platform and the limiting structure in FIG. 1; Figure 1

[0018] Figure 3 FIG. 3 is a schematic diagram of the other side of the structure in FIG. 2. Figure 2

[0019] In the drawings:

[0020] 1, base; 11, support leg; 12, non-slip pad; 2, support; 3, microscope lens; 4, lifting platform; 5, limiting structure; 51, vertical groove; 52, position sensor; 53, position sheet; 6, first lead screw; 61, threaded sleeve plate; 62, first motor; 7, adjusting structure; 71, second lead screw; 72, bearing seat; 73, connecting seat; 74, second motor; 75, guide rod; 76, fixed plate; 8, scale plate; 81, pointer.​​ DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0022] The present embodiment provides a biological electron microscope sample taking and positioning instrument, as shown in the drawings, the positioning instrument comprises a base 1, a support 2 arranged on the base 1, a microscope lens 3 fixedly arranged on the support 2, and a lifting platform 4 arranged on the support 2 corresponding to the base 1 and the microscope lens 3. Figures 1-3

[0023] In order to conveniently limit the rising height of the lifting platform 4, the support 2 is provided with a limiting structure 5 for preventing the lifting platform 4 from colliding with the microscope lens 3, the limiting structure 5 comprises a vertical slot 51 opened on the support 2, a position sensor 52 arranged at the top of the vertical slot 51, and a position sheet 53 arranged at the bottom of the vertical slot 51 and connected with the lifting platform 4. The design of the limiting structure 5 makes the position of the lifting platform 4 stopping each time consistent in height, which provides a strong guarantee for the accurate taking and positioning of biological samples and helps to improve the accuracy and repeatability of experimental results. Through the accurate cooperation of the position sensor 52 and the position sheet 53, the collision of the lifting platform 4 with the microscope lens 3 in the rising process is effectively avoided, so as to protect the microscope lens 3, a precision component, and prolong the service life of the instrument. When taking and positioning the biological sample, the biological sample is placed on the lifting platform 4 through the instrument, and then the lifting platform 4 is moved in the direction of rising close to the microscope lens 3. The position sheet 53 is driven to rise synchronously in the process of the lifting platform 4 rising, and stops when the position sheet 53 contacts the position sensor 52. Through the cooperation of the position sensor 52 and the position sheet 53, the collision of the lifting platform 4 with the microscope lens 3 can be prevented.

[0024] ​In use, before the experiment begins, the user fixes the position sensor 52 at a specified position in the vertical slot 51 according to parameters such as the size and shape of the biological sample and the focal length of the microscope lens 3. This position is usually set as the maximum safe height when the lifting platform 4 is raised, to ensure that the microscope lens 3 does not collide with the sample on the lifting platform 4. The biological sample to be observed is placed on the lifting platform 4 and is ensured to be stable. At this time, the lifting platform 4 is at the initial position, i.e. the lowest point. The lifting function of the lifting platform 4 is started, and the lifting platform 4 begins to move the sample towards the microscope lens 3. During the lifting process, the position sheet 53 connected to the lifting platform 4 also rises. When the lifting platform 4 rises to the predetermined height, the position sheet 53 comes into contact with the position sensor 52. After the position sensor 52 senses this signal, it immediately sends a command to the control system, and the control system immediately stops the lifting action of the lifting platform 4. At this time, the lifting platform 4 and the sample thereon are just within the optimal observation range of the microscope lens 3. The sample is observed through the microscope lens 3, and sampling is performed according to the observation results. After sampling is completed, the lowering function of the lifting platform 4 can be started to send the sample back to the initial position for the next experiment.

[0025] In order to facilitate the driving of the lifting motion of the lifting platform 4, a first lead screw 6 is rotatably inserted into the vertical slot 51, a threaded sleeve plate 61 fixedly connected to the lifting platform 4 is threadedly sleeved on the first lead screw 6, and the position sheet 53 is fixedly installed on the upper end of the threaded sleeve plate 61. A first motor 62 is fixedly arranged on the support 2, and the output end of the first motor 62 is fixedly connected to the end of the first lead screw 6. The introduction of the first motor 62 realizes the automatic lifting of the lifting platform 4, without the need for manual operation, greatly improving the work efficiency. The user only needs to set the lifting height through the control panel, and the first motor 62 can automatically drive the lifting platform 4 to the specified position, which is simple and fast. The user inputs the lifting instruction through the control panel, and the control system receives the instruction and starts the first motor 62. After the first motor 62 is started, the output end drives the first lead screw 6 to rotate. Since there is a threaded cooperation between the first lead screw 6 and the threaded sleeve plate 61, the rotation of the lead screw will be converted into the linear motion of the threaded sleeve plate 61. The threaded sleeve plate 61 moves linearly, driving the lifting platform 4 fixedly connected thereto to rise or fall synchronously. When the lifting platform 4 rises to the predetermined height, the position sheet 53 comes into contact with the position sensor 52, and the position sensor 52 sends a signal to the control system, which immediately stops the rotation of the first motor 62, and the lifting platform 4 stops rising. Similarly, when it needs to descend, the control system also controls the first motor 62 to reverse, to realize the descent of the lifting platform 4.

[0026] In order to prevent the base 1 from sliding with the table top, the bottom end of the base 1 is fixedly connected with support legs 11, and the lower end of the support legs 11 is fixedly connected with anti-skid pads 12. The anti-skid pads 12 are made of rubber material, and the friction between the support legs 11 and the table top can be improved through the anti-skid pads 12, so as to prevent the base 1 from sliding with the table top.

[0027] In order to conveniently adjust the height position of the position sensor 52, the bracket 2 is provided with an adjusting structure 7 for adjusting the position of the position sensor 52, the adjusting structure 7 comprises a second lead screw 71, both ends of the second lead screw 71 are rotatably sleeved with bearing seats 72 fixedly connected with the bracket 2, a connecting seat 73 fixedly connected with the position sensor 52 is threadedly sleeved on the second lead screw 71, a second motor 74 is fixedly installed on the bearing seat 72, and the output end of the second motor 74 is fixedly connected with the end of the second lead screw 71. The adjusting structure 7 further comprises a guide rod 75 slidingly inserted into the connecting seat 73 and a fixed plate 76 fixedly sleeved on both ends of the guide rod 75 and fixedly connected with the bracket 2. The height of the position sensor 52 can be accurately adjusted by driving the second lead screw 71 to rotate through the second motor 74, so as to meet the needs of different biological samples and different experimental conditions. The cooperation of the guide rod 75 and the fixed plate 76 ensures the stability of the connecting seat 73 and the position sensor 52 during the lifting process, and avoids measurement errors caused by shaking or deviation. The introduction of the adjusting structure 7 makes the device applicable to biological samples of different sizes and shapes, improves its universality and practicality. Before the experiment starts, the position sensor 52 is fixed at a certain position on the second lead screw 71 through the connecting seat 73, the guide rod 75 is inserted into the connecting seat 73, and the fixed plate 76 is fixedly connected with the bracket 2 to provide support for the guide rod 75. According to the experimental requirements, the user inputs the height adjustment instruction through the control panel, and the control system receives the instruction and starts the second motor 74. After the second motor 74 is started, the output end drives the second lead screw 71 to rotate. Since there is a threaded cooperation between the second lead screw 71 and the connecting seat 73, the rotation of the lead screw will be converted into the linear motion of the connecting seat 73. During the lifting of the connecting seat 73, the guide rod 75 slides in the fixed plate 76, which stabilizes the connecting seat 73 and avoids shaking or deviation during the lifting process. With the lifting of the connecting seat 73, the height of the position sensor 52 also changes until it reaches the target height set by the user. When the position sensor 52 reaches the target height, the control system receives the feedback signal of the position sensor 52, and immediately stops the rotation of the second motor 74, and the adjustment process is completed. After the adjustment is completed, the user can observe and take biological samples.

[0028] In order to conveniently observe the position height of the position sensor 52, the support 2 is fixedly connected with a scale plate 8, and the connecting seat 73 is fixedly connected with a pointer 81 matched with the scale plate 8. Through cooperation of the pointer 81 and the scale plate 8, the user can intuitively observe the current height value of the position sensor 52, without the need of complicated measurement or calculation, thereby improving work efficiency. The fine scale of the scale plate 8 enables the user to more accurately adjust the height of the position sensor 52, thereby meeting the height precision requirement of the experiment. The user only needs to observe the position of the pointer 81 on the scale plate 8, so as to judge whether the height of the position sensor 52 meets the experiment requirement, and the operation is more convenient. In the lifting process of the connecting seat 73, the pointer 81 moves on the scale plate 8, and the user can judge the height of the position sensor 52 by observing the position of the pointer 81. When the pointer 81 points to the target height set by the user on the scale plate 8, it indicates that the position sensor 52 has reached the specified position, at this time, the control system stops rotation of the second motor 74, and the adjustment process is ended.

[0029] The above merely describes the preferred specific embodiments of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art can make equivalent replacements or changes to the technical solution and concept of the present application within the technical range disclosed by the present application, and all of them should be covered within the protection scope of the present application.

Claims

1. A biological electron microscope sample positioning device, comprising a base (1), a support (2) arranged on the base (1), a microscope lens (3) fixedly arranged on the support (2), and a lifting platform (4) arranged on the support (2) corresponding to the base (1) and the microscope lens (3). characterized in that A limiting structure (5) for preventing the lifting platform (4) from colliding with the microscope lens (3) is arranged on the support (2), and the limiting structure (5) comprises a vertical slot (51) formed in the support (2), a position sensor (52) arranged at the top of the vertical slot (51), and a position sheet (53) arranged at the bottom of the vertical slot (51) and connected with the lifting platform (4).

2. The biological electron microscope sample positioning device of claim 1, wherein: A first lead screw (6) is rotatably inserted into the vertical slot (51), a threaded sleeve plate (61) fixedly connected with the lifting platform (4) is threadedly sleeved on the first lead screw (6), the position sheet (53) is fixedly installed on the upper end of the threaded sleeve plate (61), a first motor (62) is fixedly arranged on the support (2), and the output end of the first motor (62) is fixedly connected with the end of the first lead screw (6).

3. The biological electron microscope sample positioning device of claim 1, wherein: Supporting legs (11) are fixedly connected to the bottom corners of the base (1), and anti-skid pads (12) are fixedly connected to the lower ends of the supporting legs (11).

4. The biological electron microscope sample positioning device of claim 1, wherein: An adjusting structure (7) for adjusting the position of the position sensor (52) is arranged on the support (2), and the adjusting structure (7) comprises a second lead screw (71), bearings (72) fixedly connected with the support (2) are rotatably sleeved on both ends of the second lead screw (71), a connecting seat (73) fixedly connected with the position sensor (52) is threadedly sleeved on the second lead screw (71), a second motor (74) is fixedly installed on the bearing (72), and the output end of the second motor (74) is fixedly connected with the end of the second lead screw (71).

5. The biological electron microscope sample preparation positioner of claim 4, wherein: The adjusting structure (7) further comprises a guide rod (75) slidably inserted into the connecting seat (73), and fixed plates (76) fixedly sleeved on both ends of the guide rod (75) and fixedly connected with the support (2).

6. The biological specimen positioning apparatus of claim 4, wherein: A scale plate (8) is fixedly connected to the support (2), and a pointer (81) matched with the scale plate (8) is fixedly connected to the connecting seat (73).