Reaction kettle for preparing 2, 4, 5-trifluorophenylacetic acid
By designing a reaction vessel that includes a separation tank, a heating mechanism, and an insulation shell, the problems of product loss and environmental pollution caused by the volatilization of organic solvents were solved, achieving efficient solvent recovery and product separation, and improving the preparation efficiency and safety of 2,4,5-trifluorophenylacetic acid.
Patent Information
- Application Number
- CN202520316352.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-26
- Publication Date
- 2026-02-10
- Estimated Expiration
- 2035-02-26
AI Technical Summary
The current process for preparing 2,4,5-trifluorophenylacetic acid involves the volatilization of organic solvents, which leads to product loss, environmental pollution, and health risks. Furthermore, the reaction process is complex and difficult to control effectively.
Design a reaction vessel comprising a vessel body, a separating tank, a heating mechanism, and an insulation shell. The separating tank separates reaction products, a heating wire and a heater provide a heat source, the insulation shell regulates the temperature, and conduits and a water pump remove unwanted components, thereby achieving efficient solvent recovery and product separation.
It reduces the volatilization of organic solvents, lowers environmental pollution and health risks, simplifies the reaction process, and improves product yield and production safety.
Smart Images
Figure CN223888004U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to chemical product preparation technical field, concretely is a kind of reaction kettle for preparing 2,4,5-trifluorophenylacetic acid. BACKGROUND
[0002] 2,4,5-trifluorophenylacetic acid is the key intermediate of novel hypoglycemic drug dipeptidyl peptidase-4 (DPP-4) inhibitor phosphorus sitagliptin, and currently there are more about 2,4,5-trifluorophenylacetic acid preparation process is disclosed, about 2,4,5-trifluorophenylacetic acid preparation, usually need to take a starting material, add catalyst and other required ingredients, by reduction reaction, diazotization reaction, cyanation reaction, heating decomposition reaction, hydrolysis reaction etc. can be made into 2,4,5-trifluorophenylacetic acid finished product, which involves a variety of reaction environments and processing procedures, organic solvent in the reaction process has the characteristics of toxicity, volatile, etc., when it is transferred in multiple processes, the volatilization of organic solvent will cause the loss of product, damage to the environment and affect the health of operating personnel, therefore, a reaction kettle for preparing 2,4,5-trifluorophenylacetic acid is needed, which can meet the basic process of preparing 2,4,5-trifluorophenylacetic acid and reduce the volatilization of organic solvent. SUMMARY
[0003] In view of the above technical problems, the utility model provides a kind of reaction kettle for preparing 2,4,5-trifluorophenylacetic acid, which can meet the basic process of preparing 2,4,5-trifluorophenylacetic acid and reduce the volatilization of organic solvent, to solve the problems of the existing 2,4,5-trifluorophenylacetic acid preparation, which involves a variety of reaction environments and processing procedures, organic solvent in the reaction process has the characteristics of toxicity, volatile, etc., when it is transferred in multiple processes, the volatilization of organic solvent will cause the loss of product, damage to the environment and affect the health of operating personnel.
[0004] To solve the above technical problems, the utility model discloses a kind of reaction kettle for preparing 2,4,5-trifluorophenylacetic acid, including kettle body, the kettle body upper end is fixedly connected with inlet pipe, feed pipe, condenser connecting pipe, drip tube, distillation pipe, the kettle body inside upper portion is provided with liquid separation tank, the liquid separation tank is fixedly connected with the kettle body inner wall by fixed ring, the liquid separation tank bottom is fixedly connected with neck pipe, lower side is fixedly connected with conduit, the neck pipe is fixedly connected with piston at the liquid separation tank connection, the conduit other end extends to the kettle body outside and is fixedly connected with conduit end water pump input end, the kettle body inside lower portion is fixedly connected with liquid collecting tank, the neck pipe lower end extends to the liquid collecting tank bottom, the kettle body outside is fixedly connected with heat preservation shell, the heat preservation shell one side is fixedly connected with inlet pipe, the other side is fixedly connected with outlet pipe, the kettle body inside bottom end is fixedly connected with heating mechanism.
[0005] Further, a plurality of round holes are formed in the fixed ring.
[0006] Further, the kettle body side wall is provided with an observation window.
[0007] Further, the heating mechanism comprises a heating wire and a heater, the heating wire is fixedly connected with the kettle body inner wall through a fixing frame, and the heater is fixedly connected with the kettle body bottom plate.
[0008] Further, the kettle body is fixedly connected with the heat preservation shell through a plurality of connecting plates.
[0009] Further, the heat preservation shell is fixedly connected with a supporting leg at the lower end.
[0010] Further, one end of the piston is fixedly connected with a piston rod.
[0011] Compared with the prior art, the utility model has the following advantages:
[0012] The utility model discloses a kettle body is provided with the liquid separation groove, and the liquid separation groove is connected with the neck pipe and the piston, and the liquid after layering can be placed in two grooves, and through the water pump at the end of the conduit and the conduit, the component that does not need in the reaction can be removed, and through the heating wire and the heater, the heat source can be provided for the reflux, distillation and concentration process, and through the heat preservation shell and the inlet pipe and the outlet pipe, the hot water vapor or cooling liquid can be input according to the need, and the high-temperature heat preservation or low-temperature cooling environment can be provided in the kettle body. BRIEF DESCRIPTION OF DRAWINGS
[0013] Figure 1 It is the structure schematic diagram of the utility model.
[0014] Figure 2 It is the fixed ring structure schematic diagram of the utility model.
[0015] In the drawing: 1, kettle body, 2, liquid separation groove, 3, fixed ring, 4, conduit, 5, water pump at the end of the conduit, 6, neck pipe, 7, piston, 8, piston rod, 9, liquid collection groove, 10, discharge pipe, 11, water pump at the end of the discharge pipe, 12, fixing frame, 13, heating wire, 14, heater, 15, air inlet pipe, 16, feed pipe, 17, condenser connecting pipe, 18, dropping tube, 19, distillation pipe, 20, heat preservation shell, 21, supporting leg, 22, inlet pipe, 23, outlet pipe, 24, connecting plate. DETAILED DESCRIPTION
[0016] The utility model will be further explained in connection with the drawings.
[0017] As Figure 1 , 2The shown reaction kettle for preparing 2,4,5-trifluorobenzenacetic acid includes a kettle body 1, in order to facilitate the addition of materials required in the preparation process, to meet the requirements of the environment during the reaction process, the upper end of the kettle body 1 is fixedly connected with an air inlet pipe 15, a feed pipe 16, a condenser connecting pipe 17, a dropping pipe 18, and a distillation pipe 19, in order to facilitate the provision of a reaction container, a liquid separation tank 2 is arranged at the upper part of the inside of the kettle body 1 and is fixedly connected with the inner wall of the kettle body 1 through a fixed ring 3, in order to facilitate the separation of the liquid after the reaction is completed, a neck pipe 6 is fixedly connected at the bottom of the liquid separation tank 2 and a catheter 4 is fixedly connected at the lower side, a piston 7 is fixedly connected at the connection between the neck pipe 6 and the liquid separation tank 2, in order to facilitate the extraction of components that are no longer required in the reaction, the other end of the catheter 4 extends to the outside of the kettle body 1 and is fixedly connected with the input end of a catheter end water pump 5, a liquid collecting tank 9 is fixedly connected at the lower part of the inside of the kettle body 1, the lower end of the neck pipe 6 extends to the bottom of the liquid collecting tank 9, in order to provide a high-temperature heat preservation or low-temperature cooling environment for the inside of the kettle body, a heat preservation shell 20 is fixedly connected outside the kettle body 1, an inlet pipe 22 is fixedly connected on one side of the heat preservation shell 20 and an outlet pipe 23 is fixedly connected on the other side, and a heating mechanism is fixedly connected at the bottom end of the inside of the kettle body 1.
[0018] In order to provide space for the vaporized components to rise during the distillation or concentration process of the liquid in the liquid collecting tank 9, a plurality of round holes are formed in the fixed ring 3.
[0019] In order to facilitate the observation of the reaction progress and the separation of the liquid in the liquid separation tank 2, an observation window is arranged on the side wall of the kettle body 1, and the liquid separation tank 2 is a transparent tank.
[0020] In order to provide heat sources for the concentration, distillation, heating reflux and other processes in the reaction process, the heating mechanism includes heating wires 13 and a heater 14, the heating wires 13 are fixedly connected with the inner wall of the kettle body 1 through a fixed frame 12, and the heater 14 is fixedly connected with the bottom plate of the kettle body 1.
[0021] In order to improve the connection stability between the heat preservation shell 20 and the kettle body 1 and to form a space sufficient to accommodate water vapor or cooling liquid, the kettle body 1 is fixedly connected with the heat preservation shell 20 through a plurality of connecting plates 24.
[0022] In order to improve the overall stability of the reaction kettle, the lower end of the heat preservation shell 20 is fixedly connected with a supporting leg 21.
[0023] In order to facilitate the control of the piston 7, one end of the piston 7 is fixedly connected with a piston rod 8.
[0024] The working process of the embodiment is as follows:
[0025] In the preparation of 2,4,5-trifluorobenzenacetic acid, the starting material can be put into the partial liquid tank 2 in the kettle body 1 through the feeding pipe 16, and other materials can be added as needed to wait for reaction. The reaction in the partial liquid tank 2 can be protected by introducing inert gas through the gas inlet pipe 15. The end of the dropping pipe 18 is connected to the liquid preparation tank, and liquid is added to the partial liquid tank 2 at a constant speed. In order to promote the progress of the reaction and make the reaction proceed fully, heating reflux can be realized through the condenser connection pipe 17 and the condenser. Hot medium or cooling liquid can be introduced through the inlet pipe 22 and the outlet pipe 23 to provide a high-temperature insulation or low-temperature cooling environment in the kettle body. After the reaction is completed, the liquid in the partial liquid tank 2 is allowed to separate into layers, the lower layer liquid is made to enter the liquid collection tank 9 through the neck pipe by rotating the piston 7 with the piston rod 8, then the upper layer liquid is left in the partial liquid tank 2 by rotating the piston 7, then the unnecessary upper layer liquid is introduced out of the conduit 4 through the conduit end water pump 5, then continuous heating is carried out through the heating wire 13 and the heater 14, distillation is carried out, and the volatile liquid is discharged from the distillation pipe 19. After the preparation is completed, the material is introduced out of the kettle body 1 through the outlet pipe 10 by the outlet pipe end water pump 11, and is uniformly stored.
Claims
1. A reaction vessel for preparing 2,4,5-trifluorophenylacetic acid, comprising a vessel body (1), wherein an inlet pipe (15), a feed pipe (16), a condenser connecting pipe (17), a dripping pipe (18), and a distillation pipe (19) are fixedly connected to the upper end of the vessel body (1), characterized in that: A liquid distribution tank (2) is provided inside the upper part of the vessel body (1). The liquid distribution tank (2) is fixedly connected to the inner wall of the vessel body (1) by a fixing ring (3). A neck tube (6) is fixedly connected to the bottom of the liquid distribution tank (2), and a guide tube (4) is fixedly connected to the lower side. A piston (7) is fixedly connected at the connection between the neck tube (6) and the liquid distribution tank (2). The other end of the guide tube (4) extends to the outside of the vessel body (1) and is fixedly connected to the input end of the water pump (5) at the end of the guide tube. A liquid collection tank (9) is fixedly connected inside the lower part of the vessel body (1). The lower end of the neck tube (6) extends to the bottom of the liquid collection tank (9). A heat insulation shell (20) is fixedly connected to the outside of the vessel body (1). An inlet pipe (22) is fixedly connected to one side of the heat insulation shell (20), and an outlet pipe (23) is fixedly connected to the other side. A heating mechanism is fixedly connected to the bottom of the vessel body (1).
2. The reaction vessel for preparing 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The fixing ring (3) has several round holes.
3. The reaction vessel for preparing 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: An observation window is provided on the side wall of the vessel body (1).
4. The reaction vessel for preparing 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The heating mechanism includes a heating wire (13) and a heater (14). The heating wire (13) is fixedly connected to the inner wall of the vessel body (1) through a fixing frame (12), and the heater (14) is fixedly connected to the bottom plate of the vessel body (1).
5. The reaction vessel for preparing 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The vessel body (1) is fixedly connected to the heat insulation shell (20) by several connecting plates (24).
6. The reaction vessel for preparing 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The lower end of the insulation shell (20) is fixedly connected to a support leg (21).
7. The reaction vessel for preparing 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: A piston rod (8) is fixedly connected to one end of the piston (7).