Fluorescence analyzer
By integrating a display control module and optical microlenses, the fluorescence analyzer solves the problems of complex structure and high cost of traditional high-throughput analyzers, and realizes efficient and low-cost analysis of multiple items, making it suitable for desktop use.
Patent Information
- Application Number
- CN202520184388.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-06
- Publication Date
- 2026-02-10
- Estimated Expiration
- 2035-02-06
AI Technical Summary
Traditional high-throughput immunoassay analyzers are complex and bulky, have a high failure rate and high cost, and their single-card detection items are limited, which cannot meet the needs of multi-item detection.
Design a desktop fluorescence analyzer that integrates a display control module, a data acquisition module, a data detection module, and a main control board. Employ an optical microlens and light source to achieve stable reagent card insertion and image analysis, simplifying the structure and reducing costs.
It enables efficient and low-cost analysis of multiple items, has a compact structure, is suitable for desktop use, improves imaging quality and detection sensitivity, and reduces failure rate.
Smart Images
Figure CN223897321U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of detection technology, specifically to a fluorescence analyzer. Background Technology
[0002] Immunochromatographic rapid detection technology is based on chromatography, characterized by the application of antigen-antibody immunological reactions and chromatographic reactions. It has advantages such as simple detection method, fast detection speed, and small sample volume requirements, and can be widely used for on-site quantitative detection.
[0003] Traditional high-throughput immunoassay analyzers use a motor-driven scanner to scan a matching immunofluorescence reagent card. During the scan, the card emits excitation light, and a photoelectric sensor receives the excited fluorescence at a specific wavelength. This allows the analyzer to obtain the fluorescence intensity of the CT lines (detection line T and control line C) on the test strip within the immunofluorescence reagent card, thus analyzing information such as the concentration of the analyte. The immunofluorescence reagent cards used are typically single-card, single-item tests, with a maximum of five tests per card. Performing tests beyond five requires multiple reagent cards. To increase throughput, instruments often increase the number of reagent card channels or use parallel immunofluorescence reagent cards. Analyzers employing these methods have complex and bulky structures, high failure rates, and high costs. Utility Model Content
[0004] This invention provides a fluorescence analyzer to solve the problems mentioned in the background art.
[0005] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows:
[0006] A fluorescence analyzer includes a desktop housing consisting of an upper shell and a lower shell. A thermal printer is embedded in the flat surface of the upper shell of the desktop housing. A display control module is embedded in the inclined surface of the upper shell of the desktop housing. A data acquisition module is fixedly installed inside the top of the upper shell on one side of the thermal printer. A data detection module is located below the data acquisition module and inside the bottom of the lower shell. A main control board electrically connected to the thermal printer, the display control module, the data acquisition module, and the data detection module is located on one side of the data detection module. The main control board is located inside the cavity of the desktop housing.
[0007] The display control module includes a display screen embedded in the inclined surface of the upper outer shell of the desktop housing and a controller electrically connected to the display screen and integrated on the main control board;
[0008] The data acquisition module includes an imaging module for capturing images of the data detection module and a light source located on one side of the imaging module. The imaging module includes an optical microlens and a connector. The optical microlens is fixedly mounted on the inner top of the upper housing via the connector.
[0009] The data detection module includes a reagent card holder connected to both the inner side wall and the inner bottom wall of the lower housing, and a reagent card that can be movably inserted into the cavity of the reagent card holder. The reagent card is located on one side of the desktop housing.
[0010] Preferably, the reagent card holder has a card slot and a limiting slide groove communicating with the card slot. The reagent card is inserted into the card slot, and a stopper for fixing the reagent card is provided in the limiting slide groove.
[0011] Preferably, the blocking member includes a blocking plate and a spring disposed on one side of the blocking plate, with the other end of the spring disposed on the inner wall of the limiting groove.
[0012] Preferably, the end face of the abutment plate near the reagent card is a convex surface, and the end face of the abutment plate away from the reagent card is provided with a groove. A positioning shaft is provided in the groove, and one end of the spring is provided in the groove and simultaneously sleeved on the positioning shaft.
[0013] Preferably, a cover plate is fixedly connected to the top of the reagent card holder, and a detection window corresponding to the reagent card window area is opened through the surface of the cover plate.
[0014] Preferably, a guide opening is provided on one side of the desktop housing, the guide opening communicates with the card slot, and the size of the guide opening is slightly larger than the size of the card slot.
[0015] Preferably, a fan and a battery are sequentially arranged on one side of the reagent card holder, and both the fan and the battery are electrically connected to the main control board.
[0016] Preferably, the bottom of the lower outer shell of the desktop housing has a heat dissipation vent, which corresponds to the fan.
[0017] Preferably, the desktop housing has a data interface on the rear end face of its lower outer shell, the data interface including a power port, a USB port, and a network port.
[0018] Preferably, the desktop housing has a power switch on the rear end face of the lower outer shell, and the power switch is located on one side of the data interface.
[0019] By adopting the above technical solution, the beneficial effects achieved by this utility model are as follows:
[0020] In this invention, by integrating the display control module, data acquisition module, data detection module, and main control board inside the desktop housing, after the reagent card is inserted into the slot, the controller can receive the data captured by the optical microlens using the cooperation of the light source and optical microlens, and display the analysis and detection results on the display screen. Thus, this fluorescence analyzer, based on its structural distribution, can meet the requirements of sample detection while being desktop-friendly, compact, low-cost, and easy to promote.
[0021] In this invention, the combination of the abutment plate and the spring, along with the arc-shaped spring sheet on the bottom wall of the card slot, allows the abutment plate and the arc-shaped spring sheet to fix the reagent card after it is inserted into the card slot, ensuring the stability of the reagent card and indirectly improving the image quality captured by the imaging module.
[0022] The analyzer proposed in this invention mainly uses optical microlens technology to spectrally excite microarray biochips, and then completes imaging and image analysis, becoming a new generation of low-cost and high-efficiency biochip analyzer. Moreover, this integrated analyzer is ingeniously designed and is extremely suitable for desktop placement. At the same time, the compact structure not only effectively reduces costs, but also makes the product highly convenient and feasible in terms of market promotion, which is conducive to its widespread application. Attached Figure Description
[0023] Figure 1 This is a schematic diagram of the overall structure of this utility model.
[0024] Figure 2 This is a schematic diagram of the rear view structure of this utility model.
[0025] Figure 3 This is a schematic diagram of the rear cross-sectional structure of this utility model.
[0026] Figure 4 This is a schematic diagram of the overall structure of this utility model.
[0027] Figure 5 This utility model Figure 4 Enlarged structural diagram at point A in the middle.
[0028] Figure 6 This is a schematic diagram of the exploded structure of this utility model.
[0029] Figure 7 This is a schematic diagram of the imaging module structure of this utility model.
[0030] In the diagram: 100, upper outer shell; 200, lower outer shell;
[0031] 1. Desktop casing; 2. Thermal printer;
[0032] 3. Display control module; 31. Display screen;
[0033] 4. Data acquisition module; 41. Imaging module; 42. Light source; 411. Optical microlens; 412. Connector;
[0034] 5. Data detection module; 51. Reagent card holder; 52. Reagent card;
[0035] 6. Main control board; 7. Card slot; 8. Limiting slide; 9. Abutment plate; 10. Spring; 11. Positioning shaft; 12. Cover plate; 13. Detection window; 14. Guide port; 15. Fan; 16. Battery; 17. Heat dissipation port; 18. Data interface; 19. Power switch. Detailed Implementation
[0036] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.
[0037] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification.
[0038] like Figures 1-7 As shown, this utility model provides a fluorescence analyzer, including a desktop housing 1 formed by connecting an upper outer shell 100 and a lower outer shell 200. A thermal printer 2 is embedded on the plane of the upper outer shell 100 of the desktop housing 1, and a display control module 3 is embedded on the inclined surface of the upper outer shell 100 of the desktop housing 1. A data acquisition module 4 is fixedly installed on one side of the thermal printer 2 and inside the top of the upper outer shell 100. A data detection module 5 is located below the data acquisition module 4 and inside the bottom of the lower outer shell 200. A main control board 6 is provided on one side of the data detection module 5 and is electrically connected to the thermal printer 2, the display control module 3, the data acquisition module 4 and the data detection module 5. The main control board 6 is located in the inner cavity of the desktop housing 1.
[0039] The display control module 3 includes a display screen 31 embedded in the inclined surface of the upper outer shell 100 of the desktop housing 1 and a controller electrically connected to the display screen 31 and integrated on the main control board 6.
[0040] The data acquisition module 4 includes an imaging module 41 for capturing data and a light source 42 located on one side of the imaging module 41. The imaging module 41 includes an optical microlens 411 and a connector 412. The optical microlens 411 is fixedly installed on the inner top of the upper housing 100 through the connector 412. The connector 412 has mounting holes at its four corners and is fixedly installed on the inner top of the upper housing 100 by screws, ensuring that there are no moving parts after the optical microlens 411 is installed, thus effectively ensuring the stability of the optical microlens 411.
[0041] It is worth noting that a base for mounting and connecting is also provided on the light source 42.
[0042] The data detection module 5 includes a reagent card holder 51 connected to both the inner side wall and the inner bottom wall of the lower housing 200, and a reagent card 52 that can be movably inserted into the cavity of the reagent card holder 51. The reagent card 52 is located on one side of the desktop housing 1.
[0043] Combination Figure 7 As shown, the imaging module 41 further mainly adopts an optical microlens 411, the specific parameters of which are as follows:
[0044] Resolution: 8.3 million pixels (3840*2160);
[0045] Field of view size: 8*4.5mm;
[0046] Working distance: 43.6mm;
[0047] Sampling rate: 2.08 μm / pixel;
[0048] Spectral range: 606-623nm, 50% transmittance;
[0049] Diagonal mode: Fixed focus;
[0050] Furthermore, the optical microlens 411 corresponds directly to the window area of the reagent card 52, ensuring that the image of the window area is not easily distorted when it is captured. The light source 42 is set at an angle to illuminate the window area of the reagent card 52, ensuring that the weak luminescent material in the reagent card 52 of the fluorescence analyzer is exposed in a short time, which is beneficial for the imaging module 41 to capture a clear and distinguishable image, thereby improving the sensitivity and speed of detection.
[0051] Combination Figure 5 As shown, as a further step, the reagent card holder 51 has a card slot 7 and a limiting slide groove 8 communicating with the card slot 7. The reagent card 52 is inserted into the card slot 7, and a stopper for fixing the reagent card 52 is provided in the limiting slide groove 8.
[0052] The abutment includes an abutment plate 9 and a spring 10 located on one side of the abutment plate 9. The other end of the spring 10 is located on the inner wall of the limiting groove 8. Furthermore, the end face of the abutment plate 9 near the reagent card 52 is a convex surface, and the two ends of the convex surface are inclined surfaces, which facilitates the abutment plate 9 to be pushed into the limiting groove 8 through the inclined surfaces when the reagent card 52 is inserted. Specifically, the abutment plate 9 is convex in shape, and a groove is provided on the end face of the abutment plate 9 away from the reagent card 52. The groove is a circular groove (not shown in the figure). A positioning shaft 11 is provided in the groove. One end of the spring 10 is located in the groove and is simultaneously sleeved on the positioning shaft 11. The fact that one end of the spring 10 is located in the groove can limit the spring 10 and prevent it from falling off or deviating. At the same time, the design of the positioning shaft 11 enhances the stability of the spring 10. Under the action of the spring 10, the convex surface of the abutment plate 9 can tightly abut the reagent card 52, thereby fixing the reagent card 52.
[0053] Furthermore, a buffer groove (not shown in the figure) is provided on the inner bottom wall of the card slot 7, and an arc-shaped spring (not shown in the figure) is provided in the buffer groove. One end of the arc-shaped spring is fixedly installed, and the other end of the arc-shaped spring can move in the buffer groove when force is applied. In this way, when the reagent card 52 is inserted into the card slot 7, the arc-shaped spring can be squeezed. After the reagent card 52 is fully inserted, the force of the arc-shaped spring can make the top of the reagent card 52 contact the bottom surface of the cover plate 12. During this period, in conjunction with the force of the abutment plate 9, the reagent card 52 can be kept stable, which indirectly improves the image quality captured by the imaging module 41.
[0054] Combination Figure 3 As shown, as a further step, a cover plate 12 is fixedly connected to the top of the reagent card holder 51. A detection window 13 corresponding to the window area of the reagent card 52 is opened through the surface of the cover plate 12. The bottom of the cover plate 12 has a pressure plate (not shown in the figure). After the reagent card 52 is inserted into the card slot 7, the top of the reagent card 52 can abut against the bottom surface of the pressure plate due to the force of the arc-shaped spring, ensuring the stability of the reagent card 52. This avoids the problem of poor image quality caused by the reagent card 52 being displaced due to external forces such as vibration during detection.
[0055] It is worth noting that although the circular groove, buffer groove, arc-shaped spring and pressure plate are not illustrated in this article, the above structures are all expressed literally and can be conceived and applied by those skilled in the art.
[0056] Combination Figure 2 As shown, as a further step, a guide opening 14 is provided on one side of the desktop housing 1. The guide opening 14 communicates with the card slot 7, and the size of the guide opening 14 is slightly larger than the size of the card slot 7, so as to facilitate the insertion of the reagent card 52.
[0057] Combination Figure 4 As shown, as a further step, a fan 15 and a battery 16 are sequentially arranged on one side of the reagent card holder 51. Both the fan 15 and the battery 16 are electrically connected to the main control board 6. A heat dissipation vent 17 is provided through the bottom of the lower outer shell 200 of the desktop housing 1, corresponding to the fan 15. The fan 15 and the battery 16 are both electrically connected to the main control board 6 to realize the power supply and heat dissipation control of this analyzer. The positions of the heat dissipation vent 17 and the fan 15 correspond to each other, so that when the fan 15 is working, it can effectively dissipate the heat inside the analyzer through the heat dissipation vent 17, ensuring the normal operation of the analyzer.
[0058] Combination Figure 2 As shown, as a further step, a data interface 18 is provided on the rear end face of the lower outer shell 200 of the desktop housing 1. The data interface 18 includes a power port, a USB port, and a network port. The data interface 18 includes, but is not limited to, a power port, a USB port, and a network port, and can also be other interfaces used for data transmission. A power switch 19 is provided on the rear end face of the lower outer shell 200 of the desktop housing 1. The power switch 19 is located on one side of the data interface 18 and is used to start and stop the analyzer.
[0059] The working principle and usage process of this utility model are as follows: During use, the fluorescence analyzer is turned on via the switch 19. After the sample to be tested is added to the reagent card 52, the operator can insert the reagent card 52 into the card slot 7 for testing. During this process, the reagent card holder 51 maintains stability thanks to the arc-shaped spring sheet on the bottom wall of the card slot 7, the spring 10, and the abutment plate 9, preventing the reagent card 52 from shifting during testing. Then, the light source 42 illuminates the window area of the reagent card 52 at the detection window 13, exposing the faint luminescent material in the reagent card 52 for a short time, prompting the imaging module 41 to capture a clear and recognizable image. After capturing the image, the imaging module 41 transmits the captured data to the controller integrated on the main control board 6, and displays the analysis and testing results on the display screen 31. The reagent card 52 provided by this solution can perform multiple testing items on one card through different detection methods, thereby achieving quantitative analysis of multiple testing items on one card. In addition, the imaging module 41 is fixedly mounted on the upper housing 100 with a base, so that the imaging module 41 and the central axis of the detection area of the fluorescence analyzer will not be offset, thus ensuring that the imaging will not be displaced, making it easier to obtain higher quality images, and eliminating moving parts in the instrument, thereby increasing the stability of the instrument.
[0060] In this invention, the term "plural" refers to two or more items unless otherwise expressly defined. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items. The terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; "linking" can be a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.
[0061] It should be noted that when a component is referred to as being "assembled on," "mounted on," "fixed to," or "set on" another component, it can be directly on the other component or there may be an intermediate component. When a component is considered to be "connected to" another component, it can be directly connected to the other component or there may be an intermediate component present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.
[0062] In the description of this specification, the terms "one embodiment," "some embodiments," "specific embodiment," etc., refer to a specific feature, structure, material, or characteristic described in connection with that embodiment or example, which is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0063] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.
Claims
1. A fluorescence analyzer, characterized in that, The desktop housing (1) consists of an upper shell (100) and a lower shell (200) connected together. A thermal printer (2) is embedded on the plane of the upper shell (100) of the desktop housing (1). A display control module (3) is embedded on the inclined surface of the upper shell (100) of the desktop housing (1). A data acquisition module (4) is fixedly installed on one side of the thermal printer (2) and the data acquisition module (4) is located at the bottom of the lower shell (200). A main control board (6) is provided on one side of the data detection module (5) and electrically connected to the thermal printer (2), the display control module (3), the data acquisition module (4) and the data detection module (5). The main control board (6) is located in the inner cavity of the desktop housing (1). The display control module (3) includes a display screen (31) embedded in the inclined surface of the upper outer shell (100) of the desktop housing (1) and a controller electrically connected to the display screen (31) and integrated on the main control board (6); The data acquisition module (4) includes an imaging module (41) for capturing images of the data detection module (5) and a light source (42) disposed on one side of the imaging module (41). The imaging module (41) includes an optical microlens (411) and a connector (412). The optical microlens (411) is fixedly mounted on the inner top of the upper housing (100) via the connector (412). The data detection module (5) includes a reagent card holder (51) connected to the inner side wall and the inner bottom wall of the lower outer shell (200) and a reagent card (52) that can be movably inserted into the inner cavity of the reagent card holder (51). The reagent card (52) is located on one side of the desktop shell (1).
2. The fluorescence analyzer according to claim 1, characterized in that, The reagent card holder (51) has a card slot (7) and a limiting slide groove (8) communicating with the card slot (7). The reagent card (52) is inserted into the card slot (7). The limiting slide groove (8) is provided with a stop for fixing the reagent card (52).
3. A fluorescence analyzer according to claim 2, characterized in that, The blocking component includes a blocking plate (9) and a spring (10) disposed on one side of the blocking plate (9), with the other end of the spring (10) disposed on the inner wall of the limiting groove (8).
4. A fluorescence analyzer according to claim 3, characterized in that, The end face of the abutment plate (9) near the reagent card (52) is convex, and the end face of the abutment plate (9) away from the reagent card (52) is provided with a groove. A positioning shaft (11) is provided in the groove, and one end of the spring (10) is provided in the groove and simultaneously sleeved on the positioning shaft (11).
5. A fluorescence analyzer according to claim 4, characterized in that, The top of the reagent card holder (51) is fixedly connected to a cover plate (12), and the surface of the cover plate (12) is provided with a detection window (13) corresponding to the window area of the reagent card (52).
6. A fluorescence analyzer according to claim 1, characterized in that, The desktop housing (1) has a guide opening (14) on one side, which is connected to the card slot (7), and the size of the guide opening (14) is slightly larger than the size of the card slot (7).
7. A fluorescence analyzer according to claim 1, characterized in that, A fan (15) and a battery (16) are arranged sequentially on one side of the reagent card holder (51), and both the fan (15) and the battery (16) are electrically connected to the main control board (6).
8. A fluorescence analyzer according to claim 7, characterized in that, The bottom of the lower outer shell (200) of the desktop housing (1) is provided with a heat dissipation vent (17), which corresponds to the fan (15).
9. A fluorescence analyzer according to claim 1, characterized in that, The lower shell (200) of the desktop housing (1) is provided with a data interface (18) on its rear end face. The data interface (18) includes a power port, a USB port, and a network port.
10. A fluorescence analyzer according to claim 9, characterized in that, A power switch (19) is provided on the rear end face of the lower outer shell (200) of the desktop housing (1), and the power switch (19) is located on one side of the data interface (18).