Single-point sampler suitable for pellet samples

Abstract

The single-point sampler comprises a sampling barrel and a push rod, one end of the push rod is provided with a handle, the other end of the push rod is inserted into and penetrates through the sampling barrel and then is detachably connected with a blocking piece, the push rod is sleeved with a gasket, and the blocking piece is detachably connected with the sampling barrel. A spiral sliding way arranged on the push rod in a sleeving mode is arranged between the blocking piece and the gasket. The use method comprises the following steps: mounting the sampler; putting the mounted sampler into a material to be taken; the rotary buckle is opened, the push rod is rotationally pushed out to a required range, then the push rod is rotationally withdrawn, the rotary buckle is clamped, and sampling is completed; the sampler is taken out, the filling funnel is installed on the blocking piece, the filling funnel is arranged above the receiving container, the buckle is rotated to be opened, the push rod is rotated, and materials enter the filling funnel and then enter the receiving container.

Description

TECHNICAL FIELD

[0001] The utility model relates to the sampling device field, concretely relates to a single point sampler suitable for micro pellet sample and its using method. BACKGROUND

[0002] In the pharmaceutical field, micro pellets are often used as intermediates of preparations, and are widely used due to various characteristics. The diameter of the micro pellets is relatively small (about 0.5-1.5 mm), and the shape is generally spherical or spherical-like. As an intermediate of preparations, the micro pellets have many advantages, such as uniform particle size, good flowability, wide drug loading range, relatively optimal drug absorption speed and efficiency, relatively small irritation to the gastrointestinal tract, high bioavailability, etc. In addition, the micro pellets can be made into sustained-release preparations, enteric preparations, etc. according to requirements. The micro pellets are generally not directly taken orally, but are often used for filling capsules or pressing tablets. Before filling or tablet pressing, batches of micro pellets need to be mixed and then sampled to determine whether the mixing is uniform.

[0003] At present, there are few types of samplers, which are mainly divided into two categories: single point samplers and side slot samplers, and both are used for powder sampling. There is no sampler specially used for micro pellet preparations. The single point sampler is composed of a sampling head and a sampling rod. The sampling head is stretched out at a specific position and then retracted by means of the expansion and contraction of the spring on the rod. The sampling head and the sampling rod are tightly fitted, which can avoid the falling and exposure of the powder during the transfer process. The side slot sampler contains a sampling rod with a slot and a sampling slot. The sampling slot is exposed in the sample for sampling by rotating the sampling rod, and then the sampling rod and the slot are misaligned to seal the sample. In this process, the sampling slot and the sampling barrel also need to be tightly fitted to avoid exposure of the sample. Whether it is a single point sampler or a side slot sampler, due to the tight fit between the structures, when used for micro pellet sampling, the surface of the micro pellets will be damaged, and even the micro pellets will be crushed, resulting in unqualified appearance of the micro pellet product. For the micro pellets with enteric film on the outer layer, the sustained-release effect of the micro pellets will be damaged, and the absorption effect of the preparation will be reduced. At present, micro pellet preparations are also common in major pharmaceutical companies. Therefore, it is particularly necessary to develop a sampler that is convenient to operate and is specially used for micro pellets. CONTENT OF THE UTILITY MODEL

[0004] The utility model wants to solve the technical problem that the sampler of prior art is tightly matched among structures, when being used for micro pellet sampling, the micro pellet surface can be damaged, even the micro pellet can be crushed, which causes the appearance of micro pellet product to be unqualified, the utility model provides a single point sampler suitable for micro pellet sample, the utility model also provides a use method of single point sampler suitable for micro pellet sample, can reduce the damage to the appearance of micro pellet in the sampling process, and the appearance and functional outer membrane of micro pellet are protected, and the integrity is kept, further, the multiple point positions can be equally sampled through the bayonet number on the sampling rod, in addition, the sampler is additionally provided with a loading hopper below, which can make the micro pellet sample accurately fall into the sample loading container, avoid the falling of micro pellet, and improve the work efficiency, so as to solve the defects caused by the prior art.

[0005] To solve the above technical problems, the utility model provides the following technical scheme:

[0006] The first aspect is a single point sampler suitable for micro pellet sample, wherein, containing sampling cylinder and push rod, one end of the push rod is equipped with handle, the other end is inserted and is equipped with baffle after being arranged in the sampling cylinder and can be detachably connected, the push rod is equipped with gasket, the baffle and the gasket are equipped with spiral slide on the push rod, the push rod rotates in and out in the sampling cylinder, can carry out fixed point sampling to the micro pellet in the sample barrel, the gasket can prevent the micro pellet from pouring out, and the spiral slide can guide the micro pellet to slide.

[0007] The above-mentioned single point sampler suitable for micro pellet sample, wherein, the sampling cylinder is installed with rotatable buckle near one end of the handle, a plurality of bayonets (which can be designed according to actual demand interval) matched with the buckle are arranged on the push rod, each bayonet is marked with number, the number value of the required amount of micro pellet sampling can be recorded, the micro pellet sampling of other point positions can be quickly carried out, and the efficiency of sampling is improved.

[0008] The above-mentioned single point sampler suitable for micro pellet sample, wherein, the buckle is rotatably connected first branch and second branch, the connecting part of the first branch and the second branch is sleeved on the push rod, and the first branch is fixedly connected to the sampling cylinder.

[0009] The above-mentioned single point sampler suitable for micro pellet sample, wherein, the lowermost bayonet is in the same plane with the port of the sampling cylinder when the sampler is installed, so as to record.

[0010] The above-mentioned single point sampler suitable for micro pellet sample, wherein, further containing loading funnel, the loading funnel is detachably connected to the baffle, the micro pellet can smoothly and quickly enter the bearing container when discharging, the falling loss of micro pellet is avoided, other personnel assistance is not needed, and the sampling speed can be accelerated.

[0011] The single-point sampler for micro-pellet samples, wherein the diameter of the top of the filling funnel is larger than the diameter of the sampling cylinder.

[0012] The single-point sampler for micro-pellet samples, wherein the baffle is provided with an upper screw hole connected with the push rod and a lower screw hole connected with the filling funnel, and the upper screw hole is in communication with the lower screw hole.

[0013] The single-point sampler for micro-pellet samples, wherein the baffle is an elastic baffle made of a material with elastic deformation capacity, such as elastomer or rubber, which can gently close the sampling port after sampling, preventing the micro-pellets from entering or leaving the sampling cylinder and avoiding the micro-pellets being damaged.

[0014] The single-point sampler for micro-pellet samples is combined and comprises the push rod, the buckle, the sampling cylinder, the elastic baffle and the filling funnel, and the push rod is further provided with the bayonet, the gasket and the spiral slide. The push rod rotates in and out of the sampling cylinder to sample the micro-pellets in the mixing barrel containing the samples. The bayonet on the push rod is numbered, and the number value of the required amount of micro-pellets sampled can be recorded to quickly sample the micro-pellets at other points, improving the sampling efficiency. The sampler can be rotated and locked with different bayonets through the buckle to sample different required amounts of samples, increasing the practicability of the current equipment. The push rod is provided with the gasket and the spiral slide. Due to the excellent flowability of the micro-pellets, the gasket can prevent the micro-pellets from falling out of the sampler. The spiral slide can guide the sliding track of the micro-pellets and moderate the outflow of the micro-pellets when the sampler discharges. The baffle is made of a material with elastic deformation capacity, such as elastomer or rubber, which can gently close the sampling port after sampling, preventing the micro-pellets from entering or leaving the sampling barrel and avoiding the micro-pellets being damaged. The baffle is provided with screw holes on both sides. One side is connected with the push rod for sampling, and the other side is connected with the filling funnel when discharging, which can facilitate the micro-pellets to smoothly enter the carrying container when discharging, avoiding the loss of the micro-pellets and accelerating the sampling speed.

[0015] In the second aspect, a method for using the single-point sampler for micro-pellet samples comprises the following steps:

[0016] Installing the sampler;

[0017] Placing the installed sampler into the material to be sampled;

[0018] Rotating the buckle to open, rotating the push rod to the required range, rotating the push rod back, rotating the buckle to lock, and completing the sampling;

[0019] Remove the sampler, install the filling funnel on the baffle, place the filling funnel above the receiving container, rotate the buckle to open, rotate the push rod, and the material enters the receiving container after entering the filling funnel.

[0020] The use method of the single-point sampler for micro-pellet samples, wherein the sampler installation step is as follows:

[0021] Insert the push rod into the sampling cylinder from the buckle, then sequentially install the gasket, spiral chute, and baffle, and lock the push rod by rotating the buckle, and install the plug on the baffle.

[0022] The micro-pellets taken from different points can be all transferred to the receiving container, and the sampling amounts of the micro-pellets from different points are similar, so that the sampling frequency is reduced, the sample loss is reduced, and the micro-pellets are not broken and polluted.

[0023] The single-point sampler for micro-pellet samples and the use method thereof have the following technical effects:

[0024] The appearance of the micro-pellets can be damaged during sampling, the appearance and the integrity of the functional outer membrane of the micro-pellets are protected, the sampler can be specially used for micro-pellet sampling, can also be used for powder sampling, is high in practicability, simple in structure, easy to improve and clean, and greatly improves the practicability of the equipment in pharmaceutical enterprises. BRIEF DESCRIPTION OF DRAWINGS

[0025] Fig. 1 It is a structural schematic view of the single-point sampler for micro-pellet samples;

[0026] Fig. 2 It is a structural schematic view of the push rod in the single-point sampler for micro-pellet samples;

[0027] Fig. 3 It is a structural schematic view of the buckle in the single-point sampler for micro-pellet samples;

[0028] It is a structural schematic view of the single-point sampler for micro-pellet samples.

[0029] In the drawings, the reference signs are as follows:

[0030] Push rod 1, buckle 2, sampling cylinder 3, baffle 4, filling funnel 5, receiving container 6, micro-pellet 7, bayonet 11, gasket 12, spiral chute 13, first support rod 31, and second support rod 32. DETAILED DESCRIPTION

[0031] In order to make the technical means, inventive features, objectives and effects of the utility model easy to understand, the technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to specific illustrations. Obviously, the described embodiments are some embodiments of the utility model, but not all embodiments.

[0032] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0033] It should be noted that the structures, proportions, sizes, etc., shown in the accompanying drawings of this specification are only used to complement the content disclosed in the specification for those skilled in the art to understand and read, and are not intended to limit the conditions under which this utility model can be implemented. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportional relationships, or adjustments to the size, without affecting the effects and purposes that this utility model can produce, should still fall within the scope of the technical content disclosed in this utility model.

[0034] Meanwhile, the terms such as "upper", "lower", "left", "right", "middle" and "one" used in this specification are only for clarity of description and are not intended to limit the scope of implementation of this utility model. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered as within the scope of implementation of this utility model.

[0035] like Figs. 1-3 As shown, in a first aspect, a first embodiment, a single-point sampler suitable for samples includes a sampling cylinder 3 and a push rod 1. One end of the push rod 1 is provided with a handle, and the other end is inserted into and passes through the sampling cylinder 3 and is detachably connected to a baffle 4. A gasket 12 is fitted on the push rod 1, and a spiral slide 13 fitted on the push rod 1 is provided between the baffle 4 and the gasket 12. The push rod 1 rotates in and out of the sampling cylinder 3, enabling fixed-point sampling of microparticles 7 in the sample container. The gasket 12 prevents the microparticles 7 from spilling out, and the rotating slide guides the microparticles 7 to slide. A rotatable buckle 2 is installed at the end of the sampling cylinder 3 near the handle. The push rod 1 has multiple slots 11 that match the buckle 2. Each slot 11 is marked with a number, which can record the number value when sampling the required amount of microparticles 7, allowing for rapid sampling of microparticles 7 at other locations and improving sampling efficiency. The buckle 2 is a rotatable connection between a first support rod 31 and a second support rod 32. The connecting part of the first support rod 31 and the second support rod 32 is sleeved on the push rod 1, and the first support rod 31 is fixedly connected to the sampling cylinder 3. The lowermost slot 11 is on the same plane as the port of the sampling cylinder 3 when the sampler is installed, so as to facilitate recording.

[0036] Also contains filling funnel 5, which is detachably connected to the baffle 4, the pellets 7 can be smoothly and quickly into the bearing container 6 in the discharge, avoiding the loss of pellets 7, and without the help of other personnel, can speed up the sampling speed. The diameter of the top of the filling funnel 5 is greater than the diameter of the sampling cylinder 3. The baffle 4 is provided with an upper screw hole connected with the push rod 1 and a lower screw hole connected with the filling funnel 5, and the upper screw hole and the lower screw hole are in communication.

[0037] The baffle 4 is an elastic baffle 4 made of a material with elastic deformation ability, such as elastomer or rubber, which can gently close the sampling port after sampling, which can prevent the pellets 7 from entering and exiting the sampling cylinder 3, and can also avoid the pellets 7 from being damaged.

[0038] The above-mentioned single-point sampler for sample is installed, the rotating buckle 2 is clamped to the push rod 1 to lock and seal the sampler, the sampler is placed in a specific point of the material container to be taken, the rotating buckle 2 is rotated to open, and the push rod 1 is rotated out, the pellets 7 smoothly enter the spiral slide 13 for sampling, when the required amount of pellets 7 sample is reached, the number of the card hole 11 at this time is recorded, the push rod 1 is rotated back, and the rotating buckle 2 is clamped to the initial card hole 11. Since the baffle 4 has a certain deformation ability, it can block the entry and exit of the pellets 7 without damaging the appearance of the pellets 7, at this time the pellets 7 are stored in the sampling barrel, the sampler is taken out, the lower screw hole of the baffle 4 is connected with the filling funnel 5, and the filling funnel 5 is placed above the receiving container, the buckle 2 on the push rod 1 is rotated to open, and the material is rotated out. The pellets 7 will be guided by the spiral slide 13 to be discharged slowly and smoothly enter the bearing container 6 through the filling funnel 5, avoiding the loss of the pellets 7, so that the pellets 7 can be sampled quickly without loss and pollution, and the appearance of the pellets 7 is almost not damaged.

[0039] In the second aspect, the second embodiment, a method for using a single-point sampler for sample is provided, which comprises the following steps:

[0040] The sampler is installed;

[0041] The installed sampler is placed in the material to be taken;

[0042] The rotating buckle 2 is opened, the push rod 1 is rotated to the required range, then the push rod 1 is rotated back, and the rotating buckle 2 is clamped to complete the sampling;

[0043] The sampler is taken out, the filling funnel 5 is installed on the baffle 4, the filling funnel 5 is placed above the receiving container, the rotating buckle 2 is opened, the push rod 1 is rotated, and the material enters the filling funnel 5 and then enters the receiving container.

[0044] The use method of the single-point sampler for samples, wherein the sampler installation step is as follows:

[0045] Insert the push rod 1 into the sampling cylinder 3 from the buckle 2, then install the gasket 12, the spiral slide 13 and the baffle 4 in sequence, lock the push rod 1 by rotating the buckle 2, and install the plug on the baffle 4.

[0046] The single-point sampler for the pellet 7 samples is used to sample the pellets 7, the pellets 7 taken from different points can be all transferred to the receiving container, the sampling amount of the pellets 7 at different points is similar, the sampling frequency is reduced, the sample loss is reduced, the pellets 7 are not broken and polluted, and the practicality is high.

[0047] In conclusion, the single-point sampler for the pellet samples and the use method thereof can reduce the damage to the appearance of the pellets during the sampling process, protect the integrity of the appearance and the functional outer membrane of the pellets, can be specially used for pellet sampling, can also be used for powder sampling, is high in practicality, simple in structure, easy to improve and clean, and greatly improves the practicality of the equipment in pharmaceutical enterprises.

[0048] The specific embodiments of the utility model are described above. It should be understood that the utility model is not limited to the specific embodiments described above, and the devices and structures not described in detail should be understood as being implemented in the ordinary way in the art; those skilled in the art can make various modifications or changes within the scope of the claims, make several simple deductions, modifications or substitutions, which do not affect the essential content of the utility model.

Claims

1. A single point sampler suitable for use with a sample of pellets, characterized in that, The sampling device comprises a sampling cylinder and a push rod, one end of the push rod is provided with a handle, the other end is inserted into the sampling cylinder and detachably connected with a baffle, a gasket is sleeved on the push rod, a spiral slide is arranged between the baffle and the gasket and sleeved on the push rod.

2. A single point sampler suitable for use with a sample of micro-pellets as claimed in claim 1, characterised in that, A rotatable buckle is arranged on one end of the sampling cylinder close to the handle, a plurality of matching buckles are arranged on the push rod, and each buckle is marked with a number.

3. A single point sampler suitable for use with a sample of micro-pellets as claimed in claim 2, wherein, The buckle is a first branch and a second branch rotatably connected, the connecting part of the first branch and the second branch is sleeved on the push rod, and the first branch is fixedly connected to the sampling cylinder.

4. A single point sampler suitable for use with a sample of micro-pellets as claimed in claim 3, wherein, The lowermost buckle is in the same plane as the port of the sampling cylinder when the sampler is installed.

5. A single-point sampler suitable for use with a sample of micro-pellets as defined in claim 1, wherein, The sampling device further comprises a filling funnel, which is detachably connected to the baffle.

6. A single point sampler suitable for use with a sample of micro-pellets as claimed in claim 5, characterised in that, The diameter of the top of the filling funnel is greater than the diameter of the sampling cylinder.

7. A single point sampler suitable for use with a sample of micro-pellets as claimed in claim 6, wherein, The baffle is provided with an upper screw hole connected with the push rod and a lower screw hole connected with the filling funnel, and the upper screw hole and the lower screw hole are communicated.

8. A single-point sampler suitable for use with a sample of micro-pellets as defined in claim 1, wherein, The baffle is an elastic baffle.

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