Blood glucose and uric acid bifunctional electrochemical test strip

Abstract

The utility model provides a blood glucose and uric acid bifunctional electrochemical test strip which comprises an electrode layer and a sample introduction channel, and the electrode layer comprises a plurality of electrodes; at least a part of the plurality of electrodes are transversely arranged in the sample introduction channel side by side front and back; the plurality of electrodes comprise an HTC and blood glucose background electrode, a uric acid working electrode, an HTC and blood glucose working electrode and a reference electrode; the reference electrode respectively forms a current loop with the HTC and blood glucose background electrode, the uric acid working electrode and the HTC and blood glucose working electrode, and the HTC and blood glucose working electrode also forms a current loop with the HTC and blood glucose background electrode. The number of the electrodes is reduced by arranging electrode multiplexing, and at least a part of the plurality of electrodes are transversely arranged in the sample introduction channel side by side front and back, so that the length and the width of the sample introduction channel can be shortened, the blood demand can be reduced, and the sample introduction time can be shortened.

Description

TECHNICAL FIELD

[0001] The utility model relates to electrochemistry detection field, especially point to a kind of blood glucose uric acid bifunctional electrochemical test strip. BACKGROUND

[0002] Diabetes is a metabolic disease characterized by high blood sugar, and long-term high blood sugar can cause chronic damage, dysfunction of eyes, kidneys, hearts, blood vessels and nerves. Hyperuricemia is a chronic metabolic disease caused by purine metabolism disorder, and long-term high uric acid can cause gouty arthritis, kidney disease, and is closely related to the occurrence and development of endocrine metabolism, cardiovascular and cerebrovascular systems, and is an independent risk factor for metabolic diseases. In addition, high uric acid and high blood sugar both belong to metabolic diseases, and influence each other. According to research, for every 60 μmol / L increase in blood uric acid level, the risk of diabetes increases by 18%. Therefore, detecting the content of blood glucose and uric acid in blood has very important significance for the prevention and diagnosis of chronic diseases.

[0003] In order to quickly detect the content of blood glucose and uric acid in blood, blood glucose and uric acid bifunctional electrochemical test strip is generally used. The utility model with publication number CN219590235U provides a blood glucose uric acid test paper with hematocrit correction function, which measures blood glucose and uric acid two indexes in one channel, and the test paper has hematocrit (HCT) correction function, which improves the detection accuracy of the test paper. However, the first electrode and the second electrode in the test paper are designed side by side, and the test electrode is not reused, which is not conducive to reducing the amount of blood needed and shortening the sampling time.

[0004] Therefore, the prior art still needs to be improved and developed. UTILITY MODEL CONTENT

[0005] The utility model aims at the defects and deficiencies of prior art, and provides a blood glucose uric acid bifunctional electrochemical test strip.

[0006] In order to achieve the above purpose, the utility model adopts the following technical scheme:

[0007] The utility model provides a blood glucose uric acid bifunctional electrochemical test strip, which comprises an electrode layer and a sampling channel, the electrode layer comprises a plurality of electrodes; at least a part of the plurality of electrodes is transversely arranged and arranged side by side in front of the sampling channel, the plurality of electrodes comprises HTC and blood glucose background electrode, uric acid working electrode, HTC and blood glucose working electrode, reference electrode; the reference electrode forms a current loop with HTC and blood glucose background electrode, uric acid working electrode, HTC and blood glucose working electrode respectively, and the HTC and blood glucose working electrode also forms a current loop with the HTC and blood glucose background electrode.

[0008] It can be understood that the reference electrode forms a current loop with the HTC and blood glucose background electrode, the uric acid working electrode, the HTC and blood glucose working electrode, respectively, for detecting the blood glucose background signal, the uric acid signal and the blood glucose signal, respectively, and the HTC and blood glucose working electrode also forms a current loop with the HTC and blood glucose background electrode for detecting the HTC. That is, the HCT and blood glucose background electrode is used for detecting both the HTC and the blood glucose background signal; the HCT and blood glucose working electrode is used for detecting both the HTC and the blood glucose signal; and the reference electrode is used for both the reference electrode of the blood glucose and the reference electrode of the uric acid.

[0009] By setting electrode multiplexing, the number of electrodes is reduced, and multiple electrodes are arranged at least partially transversely and side by side in front of and behind the sample inlet channel, which is beneficial to shorten the length and width of the sample inlet channel, thereby reducing the amount of blood required and shortening the sampling time.

[0010] According to the above scheme, the sample inlet channel is provided with a uric acid reagent layer, and the uric acid reagent layer covers the uric acid working electrode. Through the above structure, the detection speed and accuracy of uric acid can be improved.

[0011] According to the above scheme, the HTC and blood glucose working electrode is arranged adjacent to the reference electrode, the sample inlet channel is provided with a blood glucose reagent layer, and the blood glucose reagent layer covers the HTC and blood glucose working electrode and the reference electrode. Through the above structure, the detection speed and accuracy of blood glucose can be improved.

[0012] According to the above scheme, the electrode layer includes a first carbon layer and a second carbon layer, the first carbon layer includes the HTC and blood glucose background electrode, the HTC and blood glucose working electrode, and the reference electrode, and the second carbon layer includes the uric acid working electrode.

[0013] According to the above scheme, further comprising a substrate, the substrate is printed with a conductor layer, and the electrode layer is printed on the conductor layer.

[0014] According to the above scheme, the electrode layer is covered with an insulating layer, the insulating layer is provided with a gap, the insulating layer is covered with a double-sided adhesive layer, the double-sided adhesive layer is provided with an opening corresponding to the gap, and the double-sided adhesive layer and the substrate form the sample inlet channel.

[0015] According to the above scheme, the double-sided adhesive layer is covered with a hydrophilic film, and the hydrophilic film is located above the gap. The absorption of the blood sample is realized by the hydrophilicity of the hydrophilic film covering the double-sided adhesive layer and the siphon effect of the sample inlet channel. By setting the hydrophilic film, the diffusion speed of the blood sample in the sample inlet channel can be improved, thereby improving the detection efficiency.

[0016] According to the above scheme, the double-sided adhesive layer is further covered with a cover film.

[0017] According to the above scheme, the substrate is a PET substrate.

[0018] According to the above scheme, the wire layer is a conductive silver paste layer.

[0019] The beneficial effects of the present application are as follows:

[0020] The present application has the advantages that by setting the electrode multiplexing, the number of electrodes is reduced, and at least a part of each of the plurality of electrodes is transversely arranged and arranged in the sample inlet channel in front and rear side by side, which is conducive to shortening the length and width of the sample inlet channel, thereby facilitating the reduction of the amount of blood required and the shortening of the sampling time. BRIEF DESCRIPTION OF DRAWINGS

[0021] Fig. 1 is a structural schematic diagram of the present application;

[0022] Fig. 2 is a structural schematic diagram of the electrode layer in the present application; wherein the dashed box is the position corresponding to the sample inlet channel.

[0023] In the figure: 1, substrate; 2, wire layer; 3, electrode layer; 31, first carbon layer; 311, HTC and blood glucose background electrode; 312, HTC and blood glucose working electrode; 313, reference electrode; 32, second carbon layer; 321, uric acid working electrode; 4, uric acid reagent layer; 5, blood glucose reagent layer; 6, insulating layer; 61, notch; 7, double-sided adhesive layer; 71, opening; 8, hydrophilic film; 9, cover film. DETAILED DESCRIPTION

[0024] The technical solutions of the present application will be described below in conjunction with the drawings and examples.

[0025] As shown in the drawings, Figs. 1-2 The present application provides a blood glucose and uric acid dual functional electrochemical test strip, which comprises an electrode layer 3 and a sample inlet channel, the electrode layer 3 comprises a plurality of electrodes; at least a part of each of the plurality of electrodes is transversely arranged and arranged in the sample inlet channel in front and rear side by side, the plurality of electrodes comprises HTC and blood glucose background electrode 311, uric acid working electrode 321, HTC and blood glucose working electrode 312, reference electrode 313; the reference electrode 313 is respectively connected with the HTC and blood glucose background electrode 311, the uric acid working electrode 321 and the HTC and blood glucose working electrode 312 to form a current loop, and the HTC and blood glucose working electrode 312 is further connected with the HTC and blood glucose background electrode 311 to form a current loop.

[0026] The reference electrode 313 forms a current loop with the HTC and blood glucose background electrode 311, the uric acid working electrode 321 and the HTC and blood glucose working electrode 312 respectively, for detecting the blood glucose background signal, the uric acid signal and the blood glucose signal respectively, and the HTC and blood glucose working electrode 312 also forms a current loop with the HTC and blood glucose background electrode 311, for detecting the HTC. That is, the HCT and blood glucose background electrode is used for detecting both the HTC and the blood glucose background signal; the HCT and blood glucose working electrode is used for detecting both the HTC and the blood glucose signal; and the reference electrode 313 is used for both the blood glucose reference electrode and the uric acid reference electrode.

[0027] By setting the electrode multiplexing, the number of electrodes is reduced, and multiple electrodes are set to have at least a part of them transversely arranged and arranged side by side in front of and behind the sample inlet channel, which is beneficial to shorten the length and width of the sample inlet channel, thereby reducing the amount of blood required and shortening the sampling time.

[0028] Further, the sample inlet channel is provided with a uric acid reagent layer 4, which covers the uric acid working electrode 321. Through the above structure, the detection speed and accuracy of uric acid are improved.

[0029] Further, the HTC and blood glucose working electrode 312 is arranged adjacent to the reference electrode 313, and the sample inlet channel is provided with a blood glucose reagent layer 5, which covers the HTC and blood glucose working electrode 312 and the reference electrode 313. Through the above structure, the detection speed and accuracy of blood glucose are improved.

[0030] Further, the electrode layer 3 includes a first carbon layer 31 and a second carbon layer 32, the first carbon layer 31 includes the HTC and blood glucose background electrode 311, the HTC and blood glucose working electrode 312 and the reference electrode 313, and the second carbon layer 32 includes the uric acid working electrode 321.

[0031] Further, it further includes a substrate 1, and the substrate 1 is printed with a conductor layer 2, and the electrode layer 3 is printed on the conductor layer 2.

[0032] Further, the electrode layer 3 is covered with an insulating layer 6, and the insulating layer 6 is provided with a gap 61; the insulating layer 6 is covered with a double-sided adhesive layer 7, and the double-sided adhesive layer 7 is provided with an opening 71 corresponding to the gap 61; and the double-sided adhesive layer 7 and the substrate 1 form the sample inlet channel.

[0033] Further, the double-sided adhesive layer 7 is covered with a hydrophilic film 8, and the hydrophilic film 8 is located above the notch 61. The blood sample is sucked by the hydrophilic property of the hydrophilic film 8 and the siphon effect of the sample channel. By setting the hydrophilic film 8, the diffusion speed of the blood sample in the sample channel can be improved, thereby improving the detection efficiency.

[0034] Further, the double-sided adhesive layer 7 is covered with a hydrophilic film 8, and the hydrophilic film 8 is located above the notch 61. The blood sample is sucked by the hydrophilic property of the hydrophilic film 8 and the siphon effect of the sample channel. By setting the hydrophilic film 8, the diffusion speed of the blood sample in the sample channel can be improved, thereby improving the detection efficiency.

[0035] The blood glucose and uric acid dual-function electrochemical test strip is used, blood sample enters the sample channel from the sample inlet of the sample channel, and the blood sample diffuses in the sample channel under the hydrophilic property of the hydrophilic film 8 and the siphon effect of the sample channel; the HTC and the blood glucose background electrode 311 form a current loop with the reference electrode 313, which is used for blood glucose background signal and calibration for blood glucose detection; the uric acid working electrode 321 and the reference electrode 313 form a current loop, which is used for uric acid signal detection; the HTC and the blood glucose working electrode 312 form a loop with the reference electrode 313, which is used for blood glucose signal detection; the HTC and the blood glucose working electrode 312 form a current loop with the HTC and the blood glucose background electrode 311, which is used for detecting the HTC.

[0036] The above is only a preferred embodiment of the utility model, therefore, equivalent changes or modifications made according to the structure, features and principles of the utility model patent application range are included in the utility model patent application range.

Claims

1. A bifunctional electrochemical test strip for blood glucose and uric acid, comprising an electrode layer (3) and a sample inlet channel, wherein the electrode layer (3) comprises a plurality of electrodes, characterized in that the plurality of electrodes are arranged in the sample inlet channel in a transverse direction and side by side in front and back, and the plurality of electrodes comprise an HTC and blood glucose background electrode (311), a uric acid working electrode (321), an HTC and blood glucose working electrode (312), and a reference electrode (313); the reference electrode (313) forms a current loop with the HTC and blood glucose background electrode (311), the uric acid working electrode (321), and the HTC and blood glucose working electrode (312) respectively; and the HTC and blood glucose working electrode (312) further forms a current loop with the HTC and blood glucose background electrode (311). A uric acid reagent layer (4) is arranged in the sample inlet channel and covers the uric acid working electrode (321).

2. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 1, characterized in that, The HTC and blood glucose working electrode (312) is arranged adjacent to the reference electrode (313), a blood glucose reagent layer (5) is arranged in the sample inlet channel and covers the HTC and blood glucose working electrode (312) and the reference electrode (313).

3. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 1, characterized in that, The electrode layer (3) comprises a first carbon layer (31) and a second carbon layer (32), wherein the first carbon layer (31) comprises the HTC and blood glucose background electrode (311), the HTC and blood glucose working electrode (312), and the reference electrode (313), and the second carbon layer (32) comprises the uric acid working electrode (321).

4. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 1, characterized in that, A substrate (1) is further included, wherein a conductor layer (2) is printed on the substrate (1), and the electrode layer (3) is printed on the conductor layer (2).

5. The bifunctional electrochemical test strip for blood glucose and uric acid according to any one of claims 1 to 4, characterized in that, An insulating layer (6) is arranged on the electrode layer (3), wherein a gap (61) is arranged on the insulating layer (6); 6. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 5, characterized in that, A double-sided adhesive layer (7) is arranged on the insulating layer (6), wherein an opening (71) corresponding to the gap (61) is arranged on the double-sided adhesive layer (7); The double-sided adhesive layer (7) and the substrate (1) form the sample inlet channel. A hydrophilic membrane (8) is arranged on the double-sided adhesive layer (7) and above the gap (61).

7. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 6, characterized in that, A cover membrane (9) is further arranged on the double-sided adhesive layer (7).

8. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 7, characterized in that, The substrate (1) is a PET substrate.

9. The bifunctional electrochemical test strip of claim 5, wherein, The conductor layer (2) is a conductive silver paste layer.

10. The bifunctional electrochemical test strip for blood glucose and uric acid according to claim 5, wherein, ​

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