Synthesis equipment of 3-7 polyglucosamine monomer

Abstract

The synthesis equipment comprises a base, a lifting motor in a lifting mechanism drives a threaded rod to rotate, a sliding block in threaded connection with the outer wall of the threaded rod drives a lifting plate to ascend and descend under the limitation of a guide frame, and the lifting plate drives a kettle cover to ascend and descend, so that when reaction materials in a reaction kettle need to be replaced, the reaction materials can be conveniently replaced; the interior of the reaction kettle and a stirring mechanism on the valve cover are convenient to clean and maintain; the variable frequency motor drives the rotating rod to rotate, so that the anchor type stirring rod on the outer wall of the rotating rod operates close to the wall, a crystallization layer on the kettle wall is effectively broken, local overheating or agglomeration of reactants is avoided, the turbine stirring rod generates strong axial flow, molecule collision between a glucosamine monomer and a catalyst is accelerated, and the reaction rate is increased. Meanwhile, a buffer tank in the negative pressure mechanism balances the instantaneous air suction rate, so that bumping of a reaction system is avoided; the vacuum pump realizes stable negative pressure, promotes directional removal of low-boiling-point impurities (such as unreacted monomers), and improves the product purity.

Description

Technical Field

[0001] This utility model relates to the field of polyglucosamine production technology, specifically to a synthesis device for 3-7 polyglucosamine monomers. Background Technology

[0002] Polyglucosamines are a class of oligosaccharide polymers composed of glucosamine units linked by glycosidic bonds. Oligosaccharides with a degree of polymerization (DP) of 3-7 (referred to as 3-7 polyglucosamines) have wide applications in the fields of biomedicine, functional foods, and cosmetics. Studies have shown that polyglucosamine monomers with specific degrees of polymerization possess excellent biological activities, such as anti-inflammatory, immunomodulatory, and cartilage repair-promoting functions. The production of polyglucosamines often requires corresponding reaction synthesis equipment.

[0003] For example, a polydextrose polymerization reactor (publication number: CN219003086U) includes an installation box, a reaction stirring unit, and a negative pressure treatment unit. The installation box is a square hollow box. The reaction stirring unit includes an electric furnace, support blocks, a motor, a feeding pipe, and a discharging pipe. A cylindrical electric furnace is installed inside the installation box, and the lower end of the electric furnace is a truncated cone. The discharging pipe is fixedly connected to the lower end of the electric furnace. A support block is fixedly connected to the bottom of the installation box on both the left and right sides of the electric furnace. The negative pressure treatment unit is installed on the left side inside the installation box. This invention can extract air from the electric furnace to create a negative pressure environment, which is beneficial for timely discharge of water vapor generated during the synthesis reaction and can stir the materials to make them evenly mixed, thereby making the polymerization reaction more complete.

[0004] Based on the search of the aforementioned patents and the findings of existing equipment, it is found that the aforementioned equipment is inconvenient to clean the inside of the electric furnace during use. After the electric furnace is used, the sticky polymers generated during the reaction (such as incompletely separated oligosaccharides and catalyst residues) easily adhere to the furnace wall and the surface of the heating element. Manual cleaning requires stopping the machine for disassembly, which is inefficient. If the internal residues are not cleaned, they may carry the reaction byproducts from the previous batch, leading to cross-contamination and affecting the purity of the target monomer. Therefore, we need to propose a synthesis device for 3-7 polyglucosamine monomers. Utility Model Content

[0005] The purpose of this invention is to provide a synthesis device for 3-7 polyglucosamine monomers. By setting up a lifting mechanism, the lid of the reactor can be raised and lowered so that when the reaction material inside the reactor needs to be replaced, the lid can be raised and detached from the reactor, thereby facilitating the cleaning and maintenance of the reactor interior and the stirring mechanism on the valve cover, thus solving the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution:

[0007] A synthesis apparatus for 3-7 polyglucosamine monomer includes a base, a reaction vessel fixedly installed inside the base, a heating mechanism for heating the inside of the reaction vessel provided on the outer wall of the reaction vessel, a lid covering the top of the reaction vessel, a feeding port installed on the top of the lid, and a stirring mechanism for stirring the inside of the reaction vessel provided on the lid.

[0008] A support frame is fixedly installed on one side of the base, and a lifting mechanism for driving the lid of the reactor is provided on the support frame. A negative pressure mechanism for extracting gas pressure inside the reactor is installed on the side of the base away from the support frame.

[0009] Preferably, the stirring mechanism includes a rotating rod, which is rotatably mounted on the vessel lid. A variable frequency motor is fixedly connected to the top of the rotating rod through the vessel lid. An anchor-type stirring rod that is close to the vessel wall to prevent crystallization is fixedly mounted on the bottom of the rotating rod. A turbine stirring rod that accelerates the reaction of raw materials is fixedly mounted on the outer wall of the rotating rod.

[0010] Preferably, the lifting mechanism includes a threaded rod, which is rotatably installed inside the support frame. A lifting motor is fixedly connected to the top of the threaded rod through the support frame. A sliding block is threadedly connected to the outer wall of the threaded rod. A lifting plate is provided on one side of the sliding block. The bottom of one end of the lifting plate is fixedly connected to the top of the vessel lid.

[0011] Preferably, a guide frame is slidably sleeved on the outer wall of the support frame, the inner walls on both sides of the guide frame are fixedly connected to the side walls on both sides of the sliding block, and one end of the lifting plate is welded to one side of the guide frame.

[0012] Preferably, the heating mechanism includes a jacket, which covers the outer wall of the reactor and forms a heat-conducting cavity between the jacket and the outer wall of the reactor. The heat-conducting cavity is filled with heat-conducting oil, and a filling pipe for adding heat-conducting oil to the heat-conducting cavity is installed on one side of the jacket. An electric heating plate for heating the heat-conducting oil is fixedly installed on one side of the jacket.

[0013] Preferably, a circulation pump is fixedly mounted on the surface of the base by a bracket. The inlet of the circulation pump is connected to the bottom outlet of the jacket through a pipe, and the outlet of the circulation pump is connected to the top inlet of the jacket through a pipe.

[0014] Preferably, the negative pressure mechanism includes a mounting frame, which is fixedly mounted on the top of the base. A vacuum pump is installed inside the mounting frame, and a buffer tank is fixedly mounted on the top of the mounting frame. The suction end of the vacuum pump is connected to the inside of the buffer tank through a pipe, and the inlet end of the buffer tank is connected to the inside of the reaction vessel through a pipe.

[0015] Preferably, the bottom of the reactor is connected to a discharge pipe, and an electromagnetic valve is provided on the outer wall of the discharge pipe.

[0016] Compared with the prior art, the beneficial effects of this utility model are:

[0017] 1. This utility model, through the setting of the lifting mechanism, can drive the threaded rod to rotate through the lifting motor in the lifting mechanism, so that the sliding block connected to the threaded rod on the outer wall of the threaded rod drives the lifting plate to rise and fall under the limit of the guide frame, and the lifting plate drives the lid to rise and fall, so that when the reaction material inside the reactor needs to be replaced, it is convenient to clean and maintain the stirring mechanism inside the reactor and on the valve cover.

[0018] 2. By setting up a stirring mechanism and a negative pressure mechanism, the rotating rod is driven by a variable frequency motor to rotate, so that the anchor-type stirring rod on the outer wall of the rotating rod runs against the wall, effectively breaking the crystal layer on the reactor wall and avoiding local overheating or agglomeration of the reactants. The turbine stirring rod generates a strong axial flow, which accelerates the molecular collision between glucosamine monomers and catalysts and increases the reaction rate. At the same time, the buffer tank in the negative pressure mechanism balances the instantaneous gas extraction volume and avoids the reaction system from boiling over. The vacuum pump achieves stable negative pressure, promotes the directional removal of low-boiling-point impurities (such as unreacted monomers), and improves the purity of the product. Attached Figure Description

[0019] Figure 1 This is a side view of the three-dimensional structure of the present invention;

[0020] Figure 2 This is a schematic diagram of the heating mechanism and lifting mechanism of this utility model;

[0021] Figure 3 This is a schematic diagram of the structure of the vessel lid and stirring mechanism of this utility model;

[0022] Figure 4 This is a schematic diagram of the negative pressure mechanism and the reaction vessel of this utility model.

[0023] In the diagram: 1. Base; 2. Reactor; 3. Heating mechanism; 31. Jacket; 32. Electric heating plate; 33. Oil filling pipe; 34. Circulating pump; 4. Reactor lid; 5. Feeding port; 6. Stirring mechanism; 61. Rotating rod; 62. Variable frequency motor; 63. Anchor stirring rod; 64. Turbine stirring rod; 7. Support frame; 8. Lifting mechanism; 81. Threaded rod; 82. Lifting motor; 83. Sliding block; 84. Guide frame; 85. Lifting plate; 9. Negative pressure mechanism; 91. Mounting frame; 92. Vacuum pump; 93. Buffer tank; 10. Discharge pipe. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figure 1-4 This utility model provides a technical solution:

[0026] A synthesis apparatus for 3-7 polyglucosamine monomer includes a base 1, a reaction vessel 2 fixedly installed inside the base 1, a heating mechanism 3 for heating the inside of the reaction vessel 2 on the outer wall of the reaction vessel 2, a lid 4 covering the top of the reaction vessel 2, a feeding port 5 installed on the top of the lid 4, and a stirring mechanism 6 for stirring the inside of the reaction vessel 2 on the lid 4.

[0027] A sealing plate and a sealing gasket are installed between the lid 4 and the top of the reactor 2 to increase the sealing performance;

[0028] A support frame 7 is fixedly installed on one side of the base 1. A lifting mechanism 8 for driving the lid 4 to rise and fall is provided on the support frame 7. A negative pressure mechanism 9 for extracting the internal air pressure of the reactor 2 is installed on the side of the base 1 away from the support frame 7.

[0029] Furthermore, the stirring mechanism 6 includes a rotating rod 61, which is rotatably mounted on the vessel cover 4. A variable frequency motor 62 is fixedly connected to the top of the rotating rod 61 through the vessel cover 4. An anchor-type stirring rod 63 that is close to the vessel wall to prevent crystallization is fixedly installed at the bottom of the rotating rod 61. A turbine stirring rod 64 that accelerates the reaction of raw materials is fixedly installed on the outer wall of the rotating rod 61.

[0030] The variable frequency motor 62 drives the rotating rod 61 to rotate, causing the anchor stirring rod 63 on the outer wall of the rotating rod 61 to run against the wall, effectively breaking the crystal layer on the reactor wall and avoiding local overheating or agglomeration of the reactants. The turbine stirring rod 64 generates a strong axial flow, which accelerates the molecular collision between the glucosamine monomer and the catalyst, and increases the reaction rate.

[0031] Furthermore, the lifting mechanism 8 includes a threaded rod 81, which is rotatably installed inside the support frame 7. The top of the threaded rod 81 is fixedly connected to the lifting motor 82 through the support frame 7. A sliding block 83 is threadedly connected to the outer wall of the threaded rod 81. A lifting plate 85 is provided on one side of the sliding block 83. The bottom of one end of the lifting plate 85 is fixedly connected to the top of the lid 4.

[0032] The lifting mechanism 8 converts the rotational motion of the lifting motor 82 into the linear motion of the lifting plate 85 through the threaded transmission between the threaded rod 81 and the sliding block 83. The lifting plate 85 drives the lid 4 to rise and fall, so that when the reaction material inside the reactor 2 needs to be replaced, it is convenient to clean and maintain the inside of the reactor 2 and the stirring mechanism 6 on the valve cover 4.

[0033] Specifically, the outer wall of the support frame 7 is slidably fitted with a guide frame 84, the inner walls on both sides of the guide frame 84 are fixedly connected to the side walls on both sides of the sliding block 83, and one end of the lifting plate 85 is welded to one side of the guide frame 84.

[0034] The guide frame 84 slides with the support frame 7 to guide and limit the lifting and lowering of the sliding block 83, thus restricting the deviation of the lifting trajectory.

[0035] Furthermore, the heating mechanism 3 includes a jacket 31, which covers the outer wall of the reactor 2. A heat-conducting cavity is formed between the jacket 31 and the outer wall of the reactor 2. The heat-conducting cavity is filled with heat-conducting oil, and a filling pipe 33 for adding heat-conducting oil to the heat-conducting cavity is installed on one side of the jacket 31. An electric heating plate 32 for heating the heat-conducting oil is fixedly installed on one side of the jacket 31.

[0036] A circulation pump 34 is fixedly mounted on the surface of the base 1 by a bracket. The inlet end of the circulation pump 34 is connected to the bottom outlet of the jacket 31 through a pipe, and the outlet end of the circulation pump 34 is connected to the top inlet of the jacket 31 through a pipe.

[0037] The jacket 31 covers the outer wall of the reactor 2 to form an annular cavity. The electric heating plate 32 is embedded in the side wall of the jacket 31 to directly heat the heat transfer oil. The circulating pump 34 drives the heat transfer oil to circulate in the jacket 31. The oil filling pipe 33 is used to replenish or replace the heat transfer medium.

[0038] Furthermore, the negative pressure mechanism 9 includes a mounting frame 91, which is fixedly mounted on the top of the base 1. A vacuum pump 92 is installed inside the mounting frame 91, and a buffer tank 93 is fixedly mounted on the top of the mounting frame 91. The suction end of the vacuum pump 92 is connected to the inside of the buffer tank 93 through a pipe, and the air inlet end of the buffer tank 93 is connected to the inside of the reactor 2 through a pipe.

[0039] The buffer tank 93 is connected to the top of the reactor 2 and the vacuum pump 92 through a pipe. The tank is equipped with a baffle structure to reduce the airflow speed, and the vacuum pump 92 is equipped with a filter at the suction end to intercept particulate matter.

[0040] The buffer tank 93 is equipped with a condensation recovery device, which liquefies and recovers the solvents, unreacted monomers or by-products (such as water, organic solvents, etc.) volatilized during the reaction through low-temperature condensation (such as a -20℃ cold trap) or a high-efficiency heat exchanger.

[0041] The buffer tank 93 increases the system volume, reducing the drastic pressure fluctuations caused by the start-up and shutdown of the vacuum pump 92 or the sudden release of gas in the reactor 2 (such as reducing pressure fluctuations to within ±1 kPa), protecting the vacuum pump 92 from the impact of pulsed gas flow, and extending the pump's lifespan.

[0042] Specifically, the bottom of the reactor 2 is connected to a discharge pipe 10, and a solenoid valve is installed on the outer wall of the discharge pipe 10.

[0043] The solenoid valve supports remote control of opening and closing, which facilitates the control of the discharge of reaction materials from the material pipe 10 into the reactor 2.

[0044] Working principle: When this utility model is used, the circulation pump 34 is started to force the heat transfer oil to circulate in the annular cavity between the jacket 31 and the outer wall of the reactor 2. The electric heating plate 32 preheats the heat transfer oil to the set temperature to form a uniform heat field. The lifting motor 82 drives the threaded rod 81 to rotate, which drives the lifting plate 85 and the reactor cover 4 to descend, so as to achieve a tight seal.

[0045] Through the feed port 5 at the top of the vessel lid 4, glucosamine monomer, catalyst (such as acidic ionic liquid or immobilized enzyme), and solvent (such as DMSO) are added sequentially. Vacuum pump 92 is started, and air is extracted from the reactor 2 through buffer tank 93, reducing the system pressure to -0.08 to -0.06 MPa to suppress solvent evaporation and byproduct formation at high temperatures. Variable frequency motor 62 drives rotating rod 61 to rotate at a preset speed. Anchor stirring rod 63 scrapes against the vessel wall to break up the crystallized layer. Turbine stirring rod 64 generates strong axial vortexes, promoting molecular diffusion between monomer and catalyst and shortening the reaction time. During the induction period, the buffer tank 93 increases the gas path volume to smooth the pumping pulses of the vacuum pump 92, maintains stable pressure inside the vessel, and avoids boiling or local overheating. After the reaction reaches the preset time, a quencher (such as ethanol) is quickly injected through the feed port 5. The stirring system runs continuously for 10 minutes to terminate chain growth. The vacuum pump 92 deepens the negative pressure to -0.09MPa. The condensation device (such as a -20℃ cold trap) in the buffer tank 93 recovers the volatilized monomers and solvents, improving the product yield. The solenoid valve opens the discharge pipe 10, and the material is output to the post-processing unit through a closed pipeline to avoid oxidation by contact with air.

[0046] In this application, the electric heating plate, circulating pump, variable frequency motor, lifting motor, vacuum pump, and solenoid valve are controlled automatically by a controller. The control circuit of the controller can be implemented by a person skilled in the art through simple programming and is common knowledge in the field. Furthermore, this application is mainly used to protect the structure, shape, and their combination, so this application will not explain the control method and circuit connection in detail.

[0047] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A device for synthesizing 3-7 polyglucosamine monomers, characterized by, Include: Base (1); The inside of the base (1) is fixedly installed with a reaction kettle (2), the outer wall of the reaction kettle (2) is provided with a heating mechanism (3) for heating the inside of the reaction kettle (2), the top of the reaction kettle (2) is covered with a kettle cover (4), the top of the kettle cover (4) is provided with a feeding port (5), and the kettle cover (4) is provided with a stirring mechanism (6) for stirring the inside of the reaction kettle (2); The stirring mechanism (6) comprises a rotating rod (61), the rotating rod (61) is rotatably installed on the kettle cover (4), the top of the rotating rod (61) penetrates the kettle cover (4) and is fixedly connected with a variable frequency motor (62), the bottom of the rotating rod (61) is fixedly installed with an anchor stirring rod (63) close to the kettle wall to prevent crystallization, and the outer wall of the rotating rod (61) is fixedly installed with a turbine stirring rod (64) for accelerating the reaction of raw materials; One side of the base (1) is fixedly installed with a support frame (7), the support frame (7) is provided with a lifting mechanism (8) for driving the kettle cover (4) to lift, and the side of the base (1) away from the support frame (7) is provided with a negative pressure mechanism (9) for extracting the internal gas pressure of the reaction kettle (2); The negative pressure mechanism (9) comprises a mounting frame (91), the mounting frame (91) is fixedly installed on the top of the base (1), the inside of the mounting frame (91) is installed with a vacuum pump (92), the top of the mounting frame (91) is fixedly installed with a buffer tank (93), the gas suction end of the vacuum pump (92) is communicated with the inside of the buffer tank (93) through a pipeline, and the gas inlet end of the buffer tank (93) penetrates the reaction kettle (2) and is communicated with the inside of the reaction kettle (2) through a pipeline.

2. The apparatus for synthesizing 3-7 polyglucosamine monomer according to claim 1, wherein: The lifting mechanism (8) comprises a threaded rod (81), the threaded rod (81) is rotatably installed in the inside of the support frame (7), the top of the threaded rod (81) penetrates the support frame (7) and is fixedly connected with a lifting motor (82), the outer wall of the threaded rod (81) is threadedly connected with a sliding block (83), one side of the sliding block (83) is provided with a lifting plate (85), and the bottom of one end of the lifting plate (85) is fixedly connected with the top of the kettle cover (4).

3. The apparatus for synthesizing 3-7 polyglucosamine monomer according to claim 2, wherein: The outer wall of the support frame (7) is slidably sleeved with a guide frame (84), the inner walls of the two sides of the guide frame (84) are fixedly connected with the side walls of the two sides of the sliding block (83), and one end of the lifting plate (85) is welded with one side of the guide frame (84).

4. The device for synthesizing 3-7 polyglucosamine monomers according to claim 1, characterized in that: The heating mechanism (3) comprises a jacket (31), the jacket (31) is arranged on the outer wall of the reaction kettle (2), a heat conduction cavity is formed between the jacket (31) and the outer wall of the reaction kettle (2), the heat conduction cavity is provided with heat conduction oil, one side of the jacket (31) is provided with an oil adding pipe (33) for adding heat conduction oil into the heat conduction cavity, and the other side of the jacket (31) is fixedly installed with an electric heating plate (32) for heating the heat conduction oil.

5. The apparatus for synthesizing 3-7 polyglucosamine monomer according to claim 4, wherein: The surface of the base (1) is fixedly provided with a circulating pump (34) through a support, the liquid inlet end of the circulating pump (34) is communicated with the bottom outlet of a jacket (31) through a pipeline, and the liquid outlet end of the circulating pump (34) is communicated with the top inlet of the jacket (31) through a pipeline.

6. The device for synthesizing 3-7 polyglucosamine monomers according to claim 1, characterized in that: The bottom of the reaction kettle (2) is communicated with a discharge pipe (10), and the outer wall of the discharge pipe (10) is provided with an electromagnetic valve.

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